IS7803A - Ný aðferð við nýmyndun tetraestera 5-[bis(karboxýmetýl)amínó]-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru í iðnaði og notkun þeirra í nýmyndun tvígildra salta ranelsýru og hýdrata þeirra - Google Patents

Ný aðferð við nýmyndun tetraestera 5-[bis(karboxýmetýl)amínó]-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru í iðnaði og notkun þeirra í nýmyndun tvígildra salta ranelsýru og hýdrata þeirra

Info

Publication number: IS7803A
Authority: IS; Iceland
Prior art keywords: carboxymethyl; synthesis; acid; hydrates; cyano
Prior art date: 2002-09-24

Application number

IS7803A

Other languages

English (en)

Other versions

IS2728B (is

Inventor

Vaysse-Ludot Lucile

Lecouve Jean-Pierre

Langlois Pascal

Original Assignee

Les Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2005-04-18

Publication date

2005-04-18

2005-04-18 Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier

2005-04-18 Publication of IS7803A publication Critical patent/IS7803A/is

2011-04-15 Publication of IS2728B publication Critical patent/IS2728B/is

Links

230000015572 biosynthetic process Effects 0.000 title 2
DJSXNILVACEBLP-UHFFFAOYSA-N ranelic acid Chemical compound OC(=O)CN(CC(O)=O)C=1SC(C(O)=O)=C(CC(O)=O)C=1C#N DJSXNILVACEBLP-UHFFFAOYSA-N 0.000 title 2
238000003786 synthesis reaction Methods 0.000 title 2
150000002148 esters Chemical class 0.000 title 1
150000004677 hydrates Chemical class 0.000 title 1
238000000034 method Methods 0.000 title 1
229950003464 ranelic acid Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IS7803A 2002-09-24 2005-04-18 Ný aðferð til að nota í iðnaði til nýmyndunar á 5-bis(karboxýmetýl)amínó-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru tetraestera og notkun þeirra í nýmyndun tvígildra salta ranelsýru og hýdrata þeirra IS2728B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0211765A FR2844797B1 (fr)	2002-09-24	2002-09-24	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
PCT/FR2003/002775 WO2004029034A1 (fr)	2002-09-24	2003-09-22	Synthese d’esters d’acide thiophenecarboxyliques pour la fabrication de sels de l’acide ranelique

Publications (2)

Publication Number	Publication Date
IS7803A true IS7803A (is)	2005-04-18
IS2728B IS2728B (is)	2011-04-15

Family

ID=29415191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS7803A IS2728B (is)	2002-09-24	2005-04-18	Ný aðferð til að nota í iðnaði til nýmyndunar á 5-bis(karboxýmetýl)amínó-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru tetraestera og notkun þeirra í nýmyndun tvígildra salta ranelsýru og hýdrata þeirra

Country Status (38)

Country	Link
US (1)	US7091364B2 (is)
EP (1)	EP1403265B1 (is)
JP (1)	JP4136866B2 (is)
KR (1)	KR100551502B1 (is)
CN (1)	CN1280286C (is)
AP (1)	AP1972A (is)
AR (1)	AR041357A1 (is)
AT (1)	ATE449767T1 (is)
AU (2)	AU2003299095A1 (is)
BR (1)	BR0304203A (is)
CA (1)	CA2442881C (is)
CY (1)	CY1109831T1 (is)
DE (1)	DE60330213D1 (is)
DK (1)	DK1403265T3 (is)
EA (1)	EA007108B1 (is)
EC (1)	ECSP055743A (is)
ES (1)	ES2337348T3 (is)
FR (1)	FR2844797B1 (is)
GE (1)	GEP20074139B (is)
HR (1)	HRP20050361B1 (is)
IL (1)	IL167315A (is)
IS (1)	IS2728B (is)
MA (1)	MA26100A1 (is)
ME (1)	ME00453B (is)
MX (1)	MXPA03008647A (is)
MY (1)	MY134924A (is)
NO (1)	NO328626B1 (is)
NZ (1)	NZ528401A (is)
OA (1)	OA12932A (is)
PL (1)	PL215879B1 (is)
PT (1)	PT1403265E (is)
RS (1)	RS51551B (is)
SG (1)	SG110069A1 (is)
SI (1)	SI1403265T1 (is)
TN (1)	TNSN05088A1 (is)
UA (1)	UA79157C2 (is)
WO (1)	WO2004029034A1 (is)
ZA (1)	ZA200307411B (is)

Families Citing this family (19)

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Publication number	Priority date	Publication date	Assignee	Title
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
ES2275218T3 (es) *	2003-05-07	2007-06-01	Osteologix A/S	Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos.
EP1622630B1 (en) *	2003-05-07	2012-08-29	Osteologix A/S	Strontium combinations for the prophylaxis/treatment of cartilage and/or bone conditions
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
US20080167513A1 (en) *	2004-02-26	2008-07-10	Osteologlx A/S	Strontium-Containing Compounds for Use in the Prevention or Treatment of Necrotic Bone Conditions
CA2571449C (en)	2004-06-25	2015-12-08	John Nikolaj Hvarre Christensen	Compositions comprising strontium and vitamin d and uses thereof
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN100391955C (zh) *	2005-04-30	2008-06-04	河北医科大学	一种雷尼酸锶中间体的合成方法
US20070292535A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating arthritic and or osteoporitic conditions
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
US20120123131A1 (en) *	2008-08-22	2012-05-17	Koilpillai Joseph Prabahar	Process for the preparation of strontium ranelate
CN101665483B (zh) *	2008-09-01	2013-01-23	河北医科大学	一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011124992A1 (en) *	2010-03-24	2011-10-13	Actavis Group Ptc Ehf	Substantially pure strontium ranelate
CN101812048B (zh) *	2010-04-06	2012-11-14	浙江东亚药业有限公司	雷尼酸锶及其水合物的合成方法
EP2602248A1 (en)	2011-12-05	2013-06-12	University Of Leicester	Novel pyrrole compounds
WO2013113319A1 (en)	2012-01-31	2013-08-08	Pharmathen S.A.	Process for the preparation of strontium ranelate, intermediate or hydrates thereof
EP2756841B1 (en)	2013-01-21	2015-05-13	Galenicum Health S.L.	Pharmaceutical compositions comprising an acid salt
GB201310126D0 (en) *	2013-06-06	2013-07-24	Univ Leicester	Novel pyrrole derivatives

Family Cites Families (7)

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Publication number	Priority date	Publication date	Assignee	Title
DE3624304A1 (de)	1986-07-18	1988-01-28	Bayer Ag	Fungizide verwendung von substituierten thienylaminen
GB8715925D0 (en) *	1987-07-07	1987-08-12	Shell Int Research	Thiapentanamide derivatives
FR2651497B1 (fr) *	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE19528380A1 (de) *	1995-08-02	1997-02-06	Hoechst Ag	Heterogene Vinylacetat/Ethylen-Dispersion
FR2749759B1 (fr) *	1996-06-17	1999-11-26	Adir	Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
DE19650196A1 (de) *	1996-12-04	1998-06-10	Bayer Ag	Thienylsulfonylamino(thio)carbonylverbindungen
US6835745B2 (en) *	2002-01-15	2004-12-28	Wyeth	Phenyl substituted thiophenes as estrogenic agents

2002
- 2002-09-24 FR FR0211765A patent/FR2844797B1/fr not_active Expired - Fee Related
2003
- 2003-09-17 MY MYPI20033533A patent/MY134924A/en unknown
- 2003-09-22 ME MEP-2008-687A patent/ME00453B/me unknown
- 2003-09-22 SI SI200331715T patent/SI1403265T1/sl unknown
- 2003-09-22 AP AP2005003255A patent/AP1972A/xx active
- 2003-09-22 HR HRP20050361AA patent/HRP20050361B1/hr not_active IP Right Cessation
- 2003-09-22 EP EP03292318A patent/EP1403265B1/fr not_active Expired - Lifetime
- 2003-09-22 RS YUP-2005/0241A patent/RS51551B/sr unknown
- 2003-09-22 AT AT03292318T patent/ATE449767T1/de active
- 2003-09-22 WO PCT/FR2003/002775 patent/WO2004029034A1/fr not_active Ceased
- 2003-09-22 ES ES03292318T patent/ES2337348T3/es not_active Expired - Lifetime
- 2003-09-22 UA UAA200503860A patent/UA79157C2/uk unknown
- 2003-09-22 AU AU2003299095A patent/AU2003299095A1/en not_active Abandoned
- 2003-09-22 PT PT03292318T patent/PT1403265E/pt unknown
- 2003-09-22 AU AU2003248280A patent/AU2003248280B2/en not_active Ceased
- 2003-09-22 DK DK03292318.7T patent/DK1403265T3/da active
- 2003-09-22 OA OA1200500081A patent/OA12932A/en unknown
- 2003-09-22 JP JP2003330439A patent/JP4136866B2/ja not_active Expired - Fee Related
- 2003-09-22 GE GEAP20038759A patent/GEP20074139B/en unknown
- 2003-09-22 DE DE60330213T patent/DE60330213D1/de not_active Expired - Lifetime
- 2003-09-23 ZA ZA200307411A patent/ZA200307411B/xx unknown
- 2003-09-23 CA CA2442881A patent/CA2442881C/fr not_active Expired - Fee Related
- 2003-09-23 NZ NZ528401A patent/NZ528401A/en not_active IP Right Cessation
- 2003-09-23 KR KR1020030065784A patent/KR100551502B1/ko not_active Expired - Fee Related
- 2003-09-23 MX MXPA03008647A patent/MXPA03008647A/es active IP Right Grant
- 2003-09-23 BR BR0304203-0A patent/BR0304203A/pt not_active Application Discontinuation
- 2003-09-23 EA EA200300927A patent/EA007108B1/ru not_active IP Right Cessation
- 2003-09-23 AR ARP030103455A patent/AR041357A1/es not_active Application Discontinuation
- 2003-09-23 PL PL362366A patent/PL215879B1/pl unknown
- 2003-09-23 NO NO20034236A patent/NO328626B1/no not_active IP Right Cessation
- 2003-09-24 SG SG200305553A patent/SG110069A1/en unknown
- 2003-09-24 CN CNB031348122A patent/CN1280286C/zh not_active Expired - Fee Related
- 2003-09-24 US US10/669,302 patent/US7091364B2/en not_active Expired - Fee Related
- 2003-09-24 MA MA27319A patent/MA26100A1/fr unknown
2005
- 2005-03-08 IL IL167315A patent/IL167315A/en not_active IP Right Cessation
- 2005-03-23 TN TNP2005000088A patent/TNSN05088A1/fr unknown
- 2005-04-18 IS IS7803A patent/IS2728B/is unknown
- 2005-04-22 EC EC2005005743A patent/ECSP055743A/es unknown
2010
- 2010-01-19 CY CY20101100055T patent/CY1109831T1/el unknown

Also Published As

Publication number	Publication date
EP1403265B1 (fr)	2009-11-25
AU2003248280B2 (en)	2009-01-08
NO328626B1 (no)	2010-04-12
FR2844797B1 (fr)	2004-10-22
RS51551B (sr)	2011-06-30
JP4136866B2 (ja)	2008-08-20
JP2004269496A (ja)	2004-09-30
ES2337348T3 (es)	2010-04-23
EA200300927A1 (ru)	2004-04-29
EA007108B1 (ru)	2006-06-30
IS2728B (is)	2011-04-15
ECSP055743A (es)	2005-07-06
PT1403265E (pt)	2009-12-16
AP1972A (en)	2009-03-12
GEP20074139B (en)	2007-06-25
FR2844797A1 (fr)	2004-03-26
CN1280286C (zh)	2006-10-18
MA26100A1 (fr)	2004-04-01
US20040059134A1 (en)	2004-03-25
EP1403265A1 (fr)	2004-03-31
AU2003248280A1 (en)	2004-04-08
TNSN05088A1 (fr)	2007-05-14
HRP20050361A2 (en)	2005-06-30
WO2004029034A1 (fr)	2004-04-08
ME00453B (me)	2011-10-10
UA79157C2 (en)	2007-05-25
AU2003299095A1 (en)	2004-04-19
SI1403265T1 (sl)	2010-01-29
IL167315A (en)	2009-08-03
CA2442881A1 (fr)	2004-03-24
DK1403265T3 (da)	2010-04-06
AR041357A1 (es)	2005-05-11
US7091364B2 (en)	2006-08-15
RS20050241A (sr)	2007-06-04
AP2005003255A0 (en)	2005-03-31
OA12932A (en)	2006-10-13
CA2442881C (fr)	2010-06-29
DE60330213D1 (de)	2010-01-07
NO20034236L (no)	2004-03-25
SG110069A1 (en)	2005-04-28
MXPA03008647A (es)	2005-04-19
KR20040026626A (ko)	2004-03-31
BR0304203A (pt)	2004-08-24
HK1061846A1 (en)	2004-10-08
CY1109831T1 (el)	2014-09-10
PL362366A1 (en)	2004-04-05
ZA200307411B (en)	2004-07-07
KR100551502B1 (ko)	2006-02-13
NO20034236D0 (no)	2003-09-23
PL215879B1 (pl)	2014-02-28
MY134924A (en)	2008-01-31
ATE449767T1 (de)	2009-12-15
NZ528401A (en)	2004-05-28
HRP20050361B1 (hr)	2014-03-14
CN1500784A (zh)	2004-06-02

Publication	Publication Date	Title
IS7803A (is)	2005-04-18	Ný aðferð við nýmyndun tetraestera 5-[bis(karboxýmetýl)amínó]-3-karboxýmetýl-4-sýanó-2-þíófenkarboxýlsýru í iðnaði og notkun þeirra í nýmyndun tvígildra salta ranelsýru og hýdrata þeirra
IS7434A (is)	2004-09-02	N-amínóasetýl-pýrrólídín-2-karbónítríl og notkun þeirra sem DDP-IV tálma
SI1758905T1 (sl)	2009-10-31	8-(3-amino-piperidin-1-il)-ksantini, njihova priprava in njihova uporaba kot inhibitor DPP-IV
EG25655A (en)	2012-05-02	Benzamide derivatives useful as histone deacetylase inhibitors
ZA200900779B (en)	2009-12-30	Process for preparating biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of nep inhibitors
EP1507541A4 (en)	2009-06-03	HEMMER AND APPLICATION METHOD THEREFOR
EP1510210A4 (en)	2009-01-07	IMMUNITY-CONTAINING PROTEIN KINASE HEMMER
EP1945617A4 (en)	2010-06-30	HISTONDEACETYLASEINHIBITORS WITH ARYLPYRAZOLYL MOTIVES
EP1644323A4 (en)	2007-06-20	HISTONDEACETYLASEINHIBITORS AND METHODS FOR THEIR APPLICATION
ITMI20021399A0 (it)	2002-06-25	Inibitori della cicloossigenasi 2
HRP20050359A2 (en)	2005-06-30	Novel method for the industrial synthesis of strontium ranelate and the hydrates thereof
AU2003282178A1 (en)	2004-04-19	Novel method for the industrial synthesis of the methyl diester of 5-amino-3-carboxymethyl-4-cyano-2-thiophenecarboxylic acid and application of divalent salts of ranelic acid and the hydrates thereof in said synthesis
NO20040133L (no)	2004-01-12	Additiv og anvendelse derav som korrosjonsinhibitor
DE60224548D1 (de)	2008-02-21	Zuführvorrichtung für ein klebeband zum verbinden von bahnen
MXPA05010398A (es)	2005-11-04	Nuevo metodo para la sintesis del acido (2s)-indolin-2-carboxilico y aplicacion de mismo en la sintesis del perindopril.
EP1784194A4 (en)	2010-12-29	Histone deacetylase INHIBITORS
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EP1858535A4 (en)	2012-05-02	COMPOSITIONS WITH ACTINIDIA AND METHOD OF USE THEREOF
EP1625141A4 (en)	2007-07-04	COMPOSITIONS BASED ON GRP94 AND METHOD FOR THEIR APPLICATION
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SI1616007T1 (sl)	2013-12-31	Inhibitor proteini proteaze in njih uporaba
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