NO20034236L - Ny fremgangsmate for den industrielle syntese av tetraestere av 5-[bis(karboksymetyl)amino]-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater - Google Patents

Ny fremgangsmate for den industrielle syntese av tetraestere av 5-[bis(karboksymetyl)amino]-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater

Info

Publication number: NO20034236L
Authority: NO; Norway
Prior art keywords: carboxymethyl; synthesis; acid; tetraesters; hydrates
Prior art date: 2002-09-24

Application number

NO20034236A

Other languages

English (en)

Other versions

NO20034236D0 (no

NO328626B1 (no

Inventor

Jean-Pierre Lecouve

Lucile Vaysse-Ludot

Pascal Langlois

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2003-09-23

Publication date

2004-03-25

2003-09-23 Application filed by Servier Lab filed Critical Servier Lab

2003-09-23 Publication of NO20034236D0 publication Critical patent/NO20034236D0/no

2004-03-25 Publication of NO20034236L publication Critical patent/NO20034236L/no

2010-04-12 Publication of NO328626B1 publication Critical patent/NO328626B1/no

Links

230000015572 biosynthetic process Effects 0.000 title 2
DJSXNILVACEBLP-UHFFFAOYSA-N ranelic acid Chemical compound OC(=O)CN(CC(O)=O)C=1SC(C(O)=O)=C(CC(O)=O)C=1C#N DJSXNILVACEBLP-UHFFFAOYSA-N 0.000 title 2
238000003786 synthesis reaction Methods 0.000 title 2
150000004677 hydrates Chemical class 0.000 title 1
238000000034 method Methods 0.000 title 1
229950003464 ranelic acid Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO20034236A 2002-09-24 2003-09-23 Ny fremgangsmate for den industrielle syntese av tetraestere av 5-[bis(karboksymetyl)amino]-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater NO328626B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0211765A FR2844797B1 (fr)	2002-09-24	2002-09-24	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Publications (3)

Publication Number	Publication Date
NO20034236D0 NO20034236D0 (no)	2003-09-23
NO20034236L true NO20034236L (no)	2004-03-25
NO328626B1 NO328626B1 (no)	2010-04-12

Family

ID=29415191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20034236A NO328626B1 (no)	2002-09-24	2003-09-23	Ny fremgangsmate for den industrielle syntese av tetraestere av 5-[bis(karboksymetyl)amino]-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater

Country Status (38)

Country	Link
US (1)	US7091364B2 (no)
EP (1)	EP1403265B1 (no)
JP (1)	JP4136866B2 (no)
KR (1)	KR100551502B1 (no)
CN (1)	CN1280286C (no)
AP (1)	AP1972A (no)
AR (1)	AR041357A1 (no)
AT (1)	ATE449767T1 (no)
AU (2)	AU2003248280B2 (no)
BR (1)	BR0304203A (no)
CA (1)	CA2442881C (no)
CY (1)	CY1109831T1 (no)
DE (1)	DE60330213D1 (no)
DK (1)	DK1403265T3 (no)
EA (1)	EA007108B1 (no)
EC (1)	ECSP055743A (no)
ES (1)	ES2337348T3 (no)
FR (1)	FR2844797B1 (no)
GE (1)	GEP20074139B (no)
HR (1)	HRP20050361B1 (no)
IL (1)	IL167315A (no)
IS (1)	IS2728B (no)
MA (1)	MA26100A1 (no)
ME (1)	ME00453B (no)
MX (1)	MXPA03008647A (no)
MY (1)	MY134924A (no)
NO (1)	NO328626B1 (no)
NZ (1)	NZ528401A (no)
OA (1)	OA12932A (no)
PL (1)	PL215879B1 (no)
PT (1)	PT1403265E (no)
RS (1)	RS51551B (no)
SG (1)	SG110069A1 (no)
SI (1)	SI1403265T1 (no)
TN (1)	TNSN05088A1 (no)
UA (1)	UA79157C2 (no)
WO (1)	WO2004029034A1 (no)
ZA (1)	ZA200307411B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
ES2394782T3 (es) *	2003-05-07	2013-02-05	Osteologix A/S	Composición con estroncio y vitamina D para la profilaxis y/o tratamiento de afecciones de cartílagos y/o huesos
EP1745791B1 (en) *	2003-05-07	2013-06-26	Osteologix A/S	Treating cartilage/bone conditions with water-soluble strontium salts
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
CA2557324C (en)	2004-02-26	2012-10-16	Osteologix A/S	Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
ATE443541T1 (de)	2004-06-25	2009-10-15	Strontin Aps	Zusammensetzungen mit strontium und vitamin d und ihre verwendungen
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN100391955C (zh) *	2005-04-30	2008-06-04	河北医科大学	一种雷尼酸锶中间体的合成方法
US20070292535A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating arthritic and or osteoporitic conditions
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
US20120123131A1 (en) *	2008-08-22	2012-05-17	Koilpillai Joseph Prabahar	Process for the preparation of strontium ranelate
CN101665483B (zh) *	2008-09-01	2013-01-23	河北医科大学	一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011124992A1 (en) *	2010-03-24	2011-10-13	Actavis Group Ptc Ehf	Substantially pure strontium ranelate
CN101812048B (zh) *	2010-04-06	2012-11-14	浙江东亚药业有限公司	雷尼酸锶及其水合物的合成方法
EP2602248A1 (en)	2011-12-05	2013-06-12	University Of Leicester	Novel pyrrole compounds
WO2013113319A1 (en)	2012-01-31	2013-08-08	Pharmathen S.A.	Process for the preparation of strontium ranelate, intermediate or hydrates thereof
ES2505716T3 (es)	2013-01-21	2015-09-04	Galenicum Health S.L.	Composiciones farmacéuticas que comprenden una sal de ácido
GB201310126D0 (en) *	2013-06-06	2013-07-24	Univ Leicester	Novel pyrrole derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3624304A1 (de)	1986-07-18	1988-01-28	Bayer Ag	Fungizide verwendung von substituierten thienylaminen
GB8715925D0 (en) *	1987-07-07	1987-08-12	Shell Int Research	Thiapentanamide derivatives
FR2651497B1 (fr)	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE19528380A1 (de) *	1995-08-02	1997-02-06	Hoechst Ag	Heterogene Vinylacetat/Ethylen-Dispersion
FR2749759B1 (fr) *	1996-06-17	1999-11-26	Adir	Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
DE19650196A1 (de) *	1996-12-04	1998-06-10	Bayer Ag	Thienylsulfonylamino(thio)carbonylverbindungen
US6835745B2 (en) *	2002-01-15	2004-12-28	Wyeth	Phenyl substituted thiophenes as estrogenic agents

2002
- 2002-09-24 FR FR0211765A patent/FR2844797B1/fr not_active Expired - Fee Related
2003
- 2003-09-17 MY MYPI20033533A patent/MY134924A/en unknown
- 2003-09-22 EP EP03292318A patent/EP1403265B1/fr not_active Expired - Lifetime
- 2003-09-22 AP AP2005003255A patent/AP1972A/xx active
- 2003-09-22 AU AU2003248280A patent/AU2003248280B2/en not_active Ceased
- 2003-09-22 OA OA1200500081A patent/OA12932A/en unknown
- 2003-09-22 ME MEP-2008-687A patent/ME00453B/me unknown
- 2003-09-22 RS YUP-2005/0241A patent/RS51551B/sr unknown
- 2003-09-22 WO PCT/FR2003/002775 patent/WO2004029034A1/fr not_active Ceased
- 2003-09-22 DE DE60330213T patent/DE60330213D1/de not_active Expired - Lifetime
- 2003-09-22 JP JP2003330439A patent/JP4136866B2/ja not_active Expired - Fee Related
- 2003-09-22 UA UAA200503860A patent/UA79157C2/uk unknown
- 2003-09-22 AT AT03292318T patent/ATE449767T1/de active
- 2003-09-22 PT PT03292318T patent/PT1403265E/pt unknown
- 2003-09-22 HR HRP20050361AA patent/HRP20050361B1/hr not_active IP Right Cessation
- 2003-09-22 ES ES03292318T patent/ES2337348T3/es not_active Expired - Lifetime
- 2003-09-22 SI SI200331715T patent/SI1403265T1/sl unknown
- 2003-09-22 DK DK03292318.7T patent/DK1403265T3/da active
- 2003-09-22 GE GEAP20038759A patent/GEP20074139B/en unknown
- 2003-09-22 AU AU2003299095A patent/AU2003299095A1/en not_active Abandoned
- 2003-09-23 BR BR0304203-0A patent/BR0304203A/pt not_active Application Discontinuation
- 2003-09-23 MX MXPA03008647A patent/MXPA03008647A/es active IP Right Grant
- 2003-09-23 CA CA2442881A patent/CA2442881C/fr not_active Expired - Fee Related
- 2003-09-23 AR ARP030103455A patent/AR041357A1/es not_active Application Discontinuation
- 2003-09-23 NO NO20034236A patent/NO328626B1/no not_active IP Right Cessation
- 2003-09-23 NZ NZ528401A patent/NZ528401A/en not_active IP Right Cessation
- 2003-09-23 EA EA200300927A patent/EA007108B1/ru not_active IP Right Cessation
- 2003-09-23 PL PL362366A patent/PL215879B1/pl unknown
- 2003-09-23 ZA ZA200307411A patent/ZA200307411B/xx unknown
- 2003-09-23 KR KR1020030065784A patent/KR100551502B1/ko not_active Expired - Fee Related
- 2003-09-24 US US10/669,302 patent/US7091364B2/en not_active Expired - Fee Related
- 2003-09-24 SG SG200305553A patent/SG110069A1/en unknown
- 2003-09-24 CN CNB031348122A patent/CN1280286C/zh not_active Expired - Fee Related
- 2003-09-24 MA MA27319A patent/MA26100A1/fr unknown
2005
- 2005-03-08 IL IL167315A patent/IL167315A/en not_active IP Right Cessation
- 2005-03-23 TN TNP2005000088A patent/TNSN05088A1/fr unknown
- 2005-04-18 IS IS7803A patent/IS2728B/is unknown
- 2005-04-22 EC EC2005005743A patent/ECSP055743A/es unknown
2010
- 2010-01-19 CY CY20101100055T patent/CY1109831T1/el unknown

Also Published As

Publication number	Publication date
ES2337348T3 (es)	2010-04-23
AU2003248280B2 (en)	2009-01-08
EP1403265A1 (fr)	2004-03-31
CN1280286C (zh)	2006-10-18
NO20034236D0 (no)	2003-09-23
KR20040026626A (ko)	2004-03-31
PL215879B1 (pl)	2014-02-28
RS51551B (sr)	2011-06-30
EP1403265B1 (fr)	2009-11-25
EA200300927A1 (ru)	2004-04-29
IS7803A (is)	2005-04-18
HRP20050361B1 (hr)	2014-03-14
UA79157C2 (en)	2007-05-25
GEP20074139B (en)	2007-06-25
CY1109831T1 (el)	2014-09-10
ZA200307411B (en)	2004-07-07
OA12932A (en)	2006-10-13
FR2844797B1 (fr)	2004-10-22
AU2003248280A1 (en)	2004-04-08
MXPA03008647A (es)	2005-04-19
AP2005003255A0 (en)	2005-03-31
KR100551502B1 (ko)	2006-02-13
SI1403265T1 (sl)	2010-01-29
US20040059134A1 (en)	2004-03-25
JP2004269496A (ja)	2004-09-30
MA26100A1 (fr)	2004-04-01
WO2004029034A1 (fr)	2004-04-08
DE60330213D1 (de)	2010-01-07
HRP20050361A2 (en)	2005-06-30
SG110069A1 (en)	2005-04-28
EA007108B1 (ru)	2006-06-30
CN1500784A (zh)	2004-06-02
FR2844797A1 (fr)	2004-03-26
IL167315A (en)	2009-08-03
ECSP055743A (es)	2005-07-06
JP4136866B2 (ja)	2008-08-20
IS2728B (is)	2011-04-15
ATE449767T1 (de)	2009-12-15
PT1403265E (pt)	2009-12-16
DK1403265T3 (da)	2010-04-06
AP1972A (en)	2009-03-12
AU2003299095A1 (en)	2004-04-19
CA2442881A1 (fr)	2004-03-24
US7091364B2 (en)	2006-08-15
MY134924A (en)	2008-01-31
HK1061846A1 (en)	2004-10-08
NO328626B1 (no)	2010-04-12
CA2442881C (fr)	2010-06-29
NZ528401A (en)	2004-05-28
RS20050241A (sr)	2007-06-04
PL362366A1 (en)	2004-04-05
BR0304203A (pt)	2004-08-24
TNSN05088A1 (fr)	2007-05-14
AR041357A1 (es)	2005-05-11
ME00453B (me)	2011-10-10

Legal Events

Date	Code	Title	Description
2018-04-23	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO20034236L (no)	2004-03-25	Ny fremgangsmate for den industrielle syntese av tetraestere av 5-[bis(karboksymetyl)amino]-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater
DK1261600T3 (da)	2004-08-16	Heteroaromatiske carboxamidderivater og deres anvendelse som inhibitorer af enzymet IKK-2
CY1107817T1 (el)	2013-06-19	Καρβοξαμιδια θειοφαινιου ως αναστολεις του ενζυμου ικκ-2
CY1111543T1 (el)	2015-08-05	Νεες ενωσεις
NO20033546D0 (no)	2003-08-11	4-fluor-N-indan-2-yl-benzamid og dets anvendelse som legemiddel
DK1347955T3 (da)	2010-06-07	Nye mandelsyrederivater og deres anvendelse som throbin-hæmmere
NO20050077L (no)	2005-02-03	Substituerte heterocykliske derivater som er anvendelige som antidiabetes- og antiovervektsmidler
NO20050883L (no)	2005-11-21	Ny fremgangsmate for syntesen (IS)-4,5-dimetoksy-1-(metylaminometyl)-benzocyklobutan og addisjonssalter derav, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre
NO20042719L (no)	2004-06-28	Substituerte 2-amino-cykloalkankarboksamider og deres anvendelse som protease-inhibitorer
NO20031482L (no)	2003-04-01	Nye tiadiazoler og oksadiazoler, og anvendelse derav som fosfodiesterase-7inhibitorer
NO20034235L (no)	2004-03-25	Ny fremgangsmate for den industrielle syntese av strontiumranelat og dets hydrater
NO20034237L (no)	2004-03-25	Ny fremgangsmate for den industrielle syntese av metyldiesteren av 5-amino-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater
ATE303384T1 (de)	2005-09-15	1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
DE60324357D1 (de)	2008-12-11	Zuführung eines Entwicklerpulvers ohne Klumpenbildung
SI1973539T1 (sl)	2010-08-31	Uporaba benzokondenziranih heterocikličnih sulfamidnih derivatov za zdravljenje depresije
DK1531675T3 (da)	2007-07-30	Midler, som indeholder carboxylsyre, og deres anvendelse i plantedyrkning
NO20055257L (no)	2005-11-09	Ny fremgangsmate for syntesen av s-indolin-2-karboksylsyre og anvendelse derav i syntesen av perindopril
DK1446402T3 (da)	2006-03-06	2-Amino-4-heteroarylethylthiazolinderivater og deres anvendelse som inhibitorer for inducerbar NO-synthase
ITMI20032172A1 (it)	2004-05-13	Procedimento atto alla correzione dell'arricchimento di
NO20044321L (no)	2004-10-12	Piperazinyl- eller piperidinylamin-sulfaminsyreamider som inhibitorer av steroid sulfatase
DE602005010607D1 (de)	2008-12-04	Zyklosporinanalog
ATE284703T1 (de)	2005-01-15	Kristallmodifikation eines cyclischen depsipeptids mit besserer wirksamkeit
SE0201938D0 (sv)	2002-06-20	New process
DK1560578T3 (da)	2006-10-02	Anvendelse af distrontiumsaltet af 3-[N,N-di(carboxymethyl)-amino]-3-cyano-4-carboxymethyl-thiophen-5-carboxylsyre til opnåelse af et lægemiddel beregnet til behandling af gastroduodenale smerter
DK1648906T3 (da)	2008-02-04	Organo-silicium-forbindelser og deres anvendelse