ECSP055765A - Nuevos compuestos de amida con efecto antagónico de la hcm y medicamentos que contienen estos compuestos - Google Patents

Nuevos compuestos de amida con efecto antagónico de la hcm y medicamentos que contienen estos compuestos

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Publication number
ECSP055765A
ECSP055765A EC2005005765A ECSP055765A ECSP055765A EC SP055765 A ECSP055765 A EC SP055765A EC 2005005765 A EC2005005765 A EC 2005005765A EC SP055765 A ECSP055765 A EC SP055765A EC SP055765 A ECSP055765 A EC SP055765A
Authority
EC
Ecuador
Prior art keywords
compounds
hcm
new
amida
medicines containing
Prior art date
Application number
EC2005005765A
Other languages
English (en)
Inventor
Gerald Juergen Roth
Thorsten Lehmann-Lintz
Dirk Stenkamp
Martin Lenter
Heike-Andrea Wieland
Klaus Rudolf
Stephan Georg Mueller
Ralf R H Lotz
Kirsten Arndt
Philipp Lustenberger
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of ECSP055765A publication Critical patent/ECSP055765A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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    • C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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Abstract

La presente invención se refiere a compuestos de amida de fórmula general Ien la cual los grupos y radicales A, B, b, W, X, Y, Z, R1, R2 y R3 tienen los significados indicados en la reivindicación 1. La invención se refiere además a medicamentos que contienen al menos una amida de acuerdo con la invención. Gracias a su actividad antagonista hacia receptor de MCH, los medicamentos de acuerdo con la invención son adecuados para el tratamiento de trastornos metabólicos y/o trastornos de la alimentación, en especial la obesidad, bulimia, anorexia, hiperfagia y diabetes.
EC2005005765A 2002-10-31 2005-04-27 Nuevos compuestos de amida con efecto antagónico de la hcm y medicamentos que contienen estos compuestos ECSP055765A (es)

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