ECSP055856A - Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina - Google Patents

Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina

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Publication number
ECSP055856A
ECSP055856A EC2005005856A ECSP055856A ECSP055856A EC SP055856 A ECSP055856 A EC SP055856A EC 2005005856 A EC2005005856 A EC 2005005856A EC SP055856 A ECSP055856 A EC SP055856A EC SP055856 A ECSP055856 A EC SP055856A
Authority
EC
Ecuador
Prior art keywords
chemokine
derivatives
aminopirrolidine
chemocine
compounds
Prior art date
Application number
EC2005005856A
Other languages
English (en)
Inventor
Hao Feng
Chu Biao Xue
Brian Metcalf
Ganfeng Cao
Taishing Huang
Changshen Zheng
Darius J Robinson
Amy Qi Han
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of ECSP055856A publication Critical patent/ECSP055856A/es

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    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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Abstract

La presente invención se refiere a derivados de 3-aminopirrolidina de fórmula I: (donde R1, R2, R3, R4, R5, R6, R7, R8, X, Y y X como se los define aquí) dichos compuestos son útiles como moduladores de la actividad del receptor de quimocina. En particular estos compuestos son útiles como moduladores de los receptores de quimocina, y más específicamente como moduladores del receptor de CCR2 y/o de CCR5. Los compuestos y las composiciones de la invención se pueden unir a los receptores de quimocina, ejemplo, a los receptores de quimocina CCR2 y/o CCR5, y son útiles para tratar las enfermedades asociadas con la quimocina, por ejemplo, actividad CCr2 y/o CCR5, tal como arterioesclerosis, restenosis, lupus, rechazo de transplantes de órganos, y artritis reumatoidea.
EC2005005856A 2002-11-27 2005-06-15 Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina ECSP055856A (es)

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TWI410406B (zh) 2005-05-13 2013-10-01 Otsuka Pharma Co Ltd 吡咯烷化合物
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AU2003293129B2 (en) 2009-03-12
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US8729063B2 (en) 2014-05-20
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HUP0500848A3 (en) 2012-08-28
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