ECSP055862A - Fungicidas basados en heterociclos que contienen nitrógeno - Google Patents
Fungicidas basados en heterociclos que contienen nitrógenoInfo
- Publication number
- ECSP055862A ECSP055862A EC2005005862A ECSP055862A ECSP055862A EC SP055862 A ECSP055862 A EC SP055862A EC 2005005862 A EC2005005862 A EC 2005005862A EC SP055862 A ECSP055862 A EC SP055862A EC SP055862 A ECSP055862 A EC SP055862A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- alkoxy
- cycloalkyl
- halo
- alkylthio
- Prior art date
Links
- 229910052757 nitrogen Inorganic materials 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 239000000417 fungicide Substances 0.000 title 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 7
- 125000005843 halogen group Chemical group 0.000 abstract 7
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 6
- -1 morpholino, piperidino Chemical group 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 4
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 4
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000005103 alkyl silyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- BWOVZCWSJFYBRM-UHFFFAOYSA-N carbononitridic isocyanate Chemical compound O=C=NC#N BWOVZCWSJFYBRM-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 125000005368 heteroarylthio group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 150000002540 isothiocyanates Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000858 thiocyanato group Chemical group *SC#N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compuestos fungicidas que tienen la fórmula general (1): fórmula (1) donde W, Z y uno de X y Y son N, y el otro de X y Y es CR8; R8 es H, halo, C1-4 alquilo, C1-4 alcoxi, C1-4 alquiltio o halo(C1-4)alquilo; R y R2 son en forma independiente H, halo, C1-8 alquilo, C1-8 alcoxi, C1-8 alquiltio, C2-8 alquenilo, C2-8 alquinilo, ciano o NR3R4, con la condición de que al menos uno de R y R2 es NR3R4; R1 es halo, C1-8 alquilo, C2-8 alquenilo, C2-8 alquinilo, C3-8 cicloalquilo, C3-8 cicloalquil(C1-6)alquilo, C1-8 alcoxi, C1-8 alquiltio, arilo, ariloxi, ariltio, heteroarilo, heteroariloxi, heteroariltio, aril(C1-4)alquilo, aril (C1-4)alcoxi, heteroarilo (C1-4)alquilo, heteroaril(C1-4)alcoxi, aril(C1-4)alquiltio, heteroaril(C1-4)alquiltio, morfolino, piperidino o pirrolidino; R3 y R4 son en forma independiente H, C1-8 alquilo, C2-8 alquenilo, C2-8 alquinilo, arilo, aril(C1-8) alquilo, C3-8 cicloalquilo, C3-8 cicloalquil (C1-6) alquilo, heteroarilo, heteroaril(C1-8)alquilo, NR5R6, con la condición de que R3 y R4 no sean ambos H o NR5R6, o R3 y R4 juntos forman una cadena C3-7 alquileno o C3-7 alquenileno opcionalmente sustituida con uno o más grupos C1-4 alquilo o C1-4 alcoxi, o, junto con el átomo de nitrógeno al cual están unidos, R3 y R4 forman un anillo de morfolina, tiomorfolina, S-óxido de tiomorfolina o S-dióxido de tiomorfolina o un anillo de piperacina o N-(C1-4)alquil (especialmente N-metil) piperacina; y R5 y R6 son en forma independiente H, C1-8 alquilo, C2-8 alquenilo, C2-8 alquinilo, arilo, aril(C1-8) alquilo, C3-8 cicloalquilo, C3-8 cicloalquil(C1-6)alquilo, heteroarilo o heteroaril(C1-8)alquilo; cualquiera de los grupos o porciones alquilo, alquenilo, alquinilo o cicloalquilo precedentes (diferente para R8) está opcionalmente sustituido con halógeno, ciano, C1-6 alcoxi, C1-6 alquilcarbonilo, C1-6 alcoxicarbonilo, C1-6 haloalcoxi, C1-6 alquiltio, tri(C1-4) alquilsililo, C1-6 alquilamino o C1-6 dialquilamino, cualquiera de los anillos de morfolina, tiomorfolina, piperidina, piperacina y pirrolidina anteriores está siendo opcionalmente sustituido con C1-4 alquilo (especialmente metilo), y cualquiera de los grupos o porciones arilo o heteroarilo precedentes está opcionalmente sustituido con uno o más sustituyentes seleccionados entre halo, hidroxi, mercapto, C1-6 alquilo, C2-6 alquenilo, C2-6 alquinilo, C1-6 alcoxi, C2-6 alqueniloxi, C2-6 alquiniloxi, halo(C1-6)alquilo, halo(C1-6)alcoxi, C1-6 alquiltio, halo(C1-6) alquiltio, hidroxi(C1-6)alquilo, C1-4 alcoxi(C1-6)alquilo, C3-6 cicloalquilo, C3-6 cicloalquil(C1-4)alquilo, fenoxi, benciloxi, benzoiloxi, ciano, isociano, tiocianato, isotiocianato, nitro, ?NR'''R'''', ?NHCOR''', -NHCONR'''R'''', -CONR'''R'''', -SO2R''', ?OSO2R''', ?COR''', ?CR'''=NR'''' o ?N=CR'''R'''', en donde R''' y R'''' son en forma independiente hidrógeno, C1-4 alquilo, halo(C1-4)alquilo, C1-4 alcoxi, halo(C1-4)alcoxi, C1-4 alquiltio, C3-6 cicloalquilo, C3-6 cicloalquil(C1-4)alquilo, fenilo o bencilo, donde los grupos fenilo y bencilo están opcionalmente sustituidos con halógeno, C1-4 alquilo o C1-4 alcoxi.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0230021.8A GB0230021D0 (en) | 2002-12-23 | 2002-12-23 | Fungicides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP055862A true ECSP055862A (es) | 2005-09-20 |
Family
ID=9950324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2005005862A ECSP055862A (es) | 2002-12-23 | 2005-06-17 | Fungicidas basados en heterociclos que contienen nitrógeno |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20060100203A1 (es) |
| EP (1) | EP1575956B1 (es) |
| JP (1) | JP2006516130A (es) |
| KR (1) | KR20050088210A (es) |
| CN (1) | CN100338065C (es) |
| AR (1) | AR042662A1 (es) |
| AT (1) | ATE358131T1 (es) |
| AU (1) | AU2003288412A1 (es) |
| BR (1) | BR0317728A (es) |
| CA (1) | CA2510376A1 (es) |
| CR (1) | CR7861A (es) |
| DE (1) | DE60312889T2 (es) |
| DK (1) | DK1575956T3 (es) |
| EC (1) | ECSP055862A (es) |
| EG (1) | EG23771A (es) |
| ES (1) | ES2283845T3 (es) |
| GB (1) | GB0230021D0 (es) |
| GT (1) | GT200300301A (es) |
| IL (1) | IL169187A0 (es) |
| MX (1) | MXPA05006669A (es) |
| PT (1) | PT1575956E (es) |
| RU (1) | RU2005123332A (es) |
| TW (1) | TW200425834A (es) |
| WO (1) | WO2004056829A1 (es) |
| ZA (1) | ZA200504297B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0230018D0 (en) | 2002-12-23 | 2003-01-29 | Syngenta Ltd | Fungicides |
| GB0230020D0 (en) | 2002-12-23 | 2003-01-29 | Syngenta Ltd | Fungicides |
| KR101078098B1 (ko) | 2003-01-14 | 2011-10-28 | 아레나 파마슈티칼스, 인크. | 대사 조절제로서의 １,２,３-삼치환된 아릴 및 헤테로아릴유도체, 및 당뇨병 및 고혈당증을 비롯한 이에 관련된장애의 예방 및 치료 |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| GB0413955D0 (en) * | 2004-06-22 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
| GB0614471D0 (en) | 2006-07-20 | 2006-08-30 | Syngenta Ltd | Herbicidal Compounds |
| JP5142492B2 (ja) * | 2006-08-01 | 2013-02-13 | 東ソー株式会社 | （１−メチル−２，２，２−トリフルオロ）エチルアミン類およびその製造方法 |
| US20100093738A1 (en) * | 2006-10-06 | 2010-04-15 | Basf Se | Fungicidal Compounds and Fungicidal Compositions |
| GB0800855D0 (en) * | 2008-01-17 | 2008-02-27 | Syngenta Ltd | Herbicidal compounds |
| SG188548A1 (en) | 2010-09-22 | 2013-04-30 | Arena Pharm Inc | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| PL3242666T3 (pl) | 2015-01-06 | 2025-02-17 | Arena Pharmaceuticals, Inc. | Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1 |
| HUE060476T2 (hu) | 2015-06-22 | 2023-03-28 | Arena Pharm Inc | (R)-2-(7-(4-ciklopentil-3-(trifluormetil)benziloxi)-1,2,3,4- tetrahidrociklopenta[B]indol-3-il)ecetsav kristályos L-arginin-sója S1P1 receptorral kapcsolatos rendellenességek esetén való alkalmazásra |
| EP3475273B1 (de) * | 2016-06-24 | 2021-02-24 | Bayer CropScience Aktiengesellschaft | 3-amino-1,2,4-triazinderivate und deren verwendung zur bekämpfung unerwünschten pflanzenwachstums |
| WO2018151873A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
| US12156866B2 (en) | 2018-06-06 | 2024-12-03 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3984412A (en) * | 1974-07-25 | 1976-10-05 | E. R. Squibb & Sons, Inc. | Amino derivatives of pyrido[2,3-b]pyrazine carboxylic acids and esters |
| DE4131029A1 (de) * | 1991-09-18 | 1993-07-29 | Basf Ag | Substituierte pyrido (2,3-d) pyrimidine als antidots |
| DE4308014A1 (de) * | 1993-03-13 | 1994-09-15 | Hoechst Schering Agrevo Gmbh | Kondensierte Stickstoffheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| DE10121101A1 (de) * | 2001-04-27 | 2002-10-31 | Bayer Ag | Triazolopyrimidine |
| DE10121162A1 (de) * | 2001-04-30 | 2002-10-31 | Bayer Ag | Triazolopyrimidine |
-
2002
- 2002-12-23 GB GBGB0230021.8A patent/GB0230021D0/en not_active Ceased
-
2003
- 2003-12-03 PT PT03780333T patent/PT1575956E/pt unknown
- 2003-12-03 AT AT03780333T patent/ATE358131T1/de not_active IP Right Cessation
- 2003-12-03 AU AU2003288412A patent/AU2003288412A1/en not_active Abandoned
- 2003-12-03 DE DE60312889T patent/DE60312889T2/de not_active Expired - Fee Related
- 2003-12-03 RU RU2005123332/04A patent/RU2005123332A/ru not_active Application Discontinuation
- 2003-12-03 CA CA002510376A patent/CA2510376A1/en not_active Abandoned
- 2003-12-03 BR BR0317728-9A patent/BR0317728A/pt not_active IP Right Cessation
- 2003-12-03 JP JP2004561604A patent/JP2006516130A/ja active Pending
- 2003-12-03 WO PCT/GB2003/005261 patent/WO2004056829A1/en not_active Ceased
- 2003-12-03 ES ES03780333T patent/ES2283845T3/es not_active Expired - Lifetime
- 2003-12-03 US US10/540,039 patent/US20060100203A1/en not_active Abandoned
- 2003-12-03 KR KR1020057011794A patent/KR20050088210A/ko not_active Ceased
- 2003-12-03 CN CNB200380107318XA patent/CN100338065C/zh not_active Expired - Fee Related
- 2003-12-03 MX MXPA05006669A patent/MXPA05006669A/es active IP Right Grant
- 2003-12-03 EP EP03780333A patent/EP1575956B1/en not_active Expired - Lifetime
- 2003-12-03 DK DK03780333T patent/DK1575956T3/da active
- 2003-12-22 AR ARP030104803A patent/AR042662A1/es unknown
- 2003-12-23 GT GT200300301A patent/GT200300301A/es unknown
- 2003-12-23 TW TW092136602A patent/TW200425834A/zh unknown
-
2005
- 2005-05-26 ZA ZA200504297A patent/ZA200504297B/en unknown
- 2005-06-07 CR CR7861A patent/CR7861A/es not_active Application Discontinuation
- 2005-06-15 IL IL169187A patent/IL169187A0/en unknown
- 2005-06-17 EC EC2005005862A patent/ECSP055862A/es unknown
- 2005-06-21 EG EGNA2005000341 patent/EG23771A/xx active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050088210A (ko) | 2005-09-02 |
| EP1575956A1 (en) | 2005-09-21 |
| DK1575956T3 (da) | 2007-08-06 |
| MXPA05006669A (es) | 2005-08-16 |
| DE60312889D1 (de) | 2007-05-10 |
| CN100338065C (zh) | 2007-09-19 |
| TW200425834A (en) | 2004-12-01 |
| GB0230021D0 (en) | 2003-01-29 |
| AU2003288412A1 (en) | 2004-07-14 |
| US20060100203A1 (en) | 2006-05-11 |
| EG23771A (en) | 2007-08-08 |
| RU2005123332A (ru) | 2006-05-10 |
| EP1575956B1 (en) | 2007-03-28 |
| CR7861A (es) | 2005-12-02 |
| ZA200504297B (en) | 2005-11-28 |
| IL169187A0 (en) | 2008-02-09 |
| GT200300301A (es) | 2006-10-03 |
| DE60312889T2 (de) | 2008-01-17 |
| JP2006516130A (ja) | 2006-06-22 |
| CA2510376A1 (en) | 2004-07-08 |
| ES2283845T3 (es) | 2007-11-01 |
| ATE358131T1 (de) | 2007-04-15 |
| AR042662A1 (es) | 2005-06-29 |
| BR0317728A (pt) | 2005-11-22 |
| PT1575956E (pt) | 2007-07-03 |
| WO2004056829A1 (en) | 2004-07-08 |
| CN1729194A (zh) | 2006-02-01 |
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