BRPI0406701A - Compostos tricìclicos inibidores da proteìna cinase para melhorar a eficácia de agentes antineoplásicos e da terapia de radiação - Google Patents

Compostos tricìclicos inibidores da proteìna cinase para melhorar a eficácia de agentes antineoplásicos e da terapia de radiação

Info

Publication number
BRPI0406701A
BRPI0406701A BR0406701-0A BRPI0406701A BRPI0406701A BR PI0406701 A BRPI0406701 A BR PI0406701A BR PI0406701 A BRPI0406701 A BR PI0406701A BR PI0406701 A BRPI0406701 A BR PI0406701A
Authority
BR
Brazil
Prior art keywords
protein kinase
improve
radiation therapy
effectiveness
tricyclic
Prior art date
Application number
BR0406701-0A
Other languages
English (en)
Inventor
Sacha Ninkovic
Michael John Bennett
Eugene Yuanjin Rui
Fen Wang
Suzanne Pritchett Benedict
Min Teng
Yong Wang
Jinjiang Zhu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0406701A publication Critical patent/BRPI0406701A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSTOS TRICìCLICOS INIBIDORES DA PROTEìNA CINASE PARA MELHORAR A EFICáCIA DE AGENTES AN-TINEOPLáSICOS E DA TERAPIA DE RADIAçãO". A presente invenção refere-se a compostos tricíclicos inibidores de proteína cinase, tais como CHK-1, da fórmula seguinte (em que R¬ 2¬, R¬ 3¬ e R¬ 4¬ são como definidos na especificação). Composições farmacêuticas contendo quantidades eficazes dos referidos compostos ou dos seus sais que são úteis como um agente sozinho ou associado a um agente antineoplásico ou radiação terapêutica possuindo um efeito antineoplásico para tratar distúrbios ou condições, tais como cânceres.
BR0406701-0A 2003-01-09 2004-01-05 Compostos tricìclicos inibidores da proteìna cinase para melhorar a eficácia de agentes antineoplásicos e da terapia de radiação BRPI0406701A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09
PCT/IB2004/000026 WO2004063198A1 (en) 2003-01-09 2004-01-05 Diazepinoindole derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0406701A true BRPI0406701A (pt) 2005-12-20

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0406701-0A BRPI0406701A (pt) 2003-01-09 2004-01-05 Compostos tricìclicos inibidores da proteìna cinase para melhorar a eficácia de agentes antineoplásicos e da terapia de radiação

Country Status (34)

Country Link
US (3) US6967198B2 (pt)
EP (2) EP1585749B1 (pt)
JP (1) JP3990718B2 (pt)
KR (1) KR100697746B1 (pt)
CN (1) CN1759118B (pt)
AP (1) AP2048A (pt)
AT (1) ATE404564T1 (pt)
AU (1) AU2004203977B2 (pt)
BR (1) BRPI0406701A (pt)
CA (1) CA2512683C (pt)
CR (1) CR7899A (pt)
CY (1) CY1108408T1 (pt)
DE (1) DE602004015724D1 (pt)
DK (1) DK1585749T3 (pt)
EA (1) EA009337B1 (pt)
EC (1) ECSP055911A (pt)
ES (1) ES2309484T3 (pt)
GE (1) GEP20084367B (pt)
HR (1) HRP20050624A2 (pt)
IL (1) IL169082A (pt)
IS (1) IS7884A (pt)
MA (1) MA27703A1 (pt)
MX (1) MXPA05007352A (pt)
NO (1) NO20053775L (pt)
NZ (1) NZ540638A (pt)
OA (1) OA13017A (pt)
PL (1) PL378372A1 (pt)
PT (1) PT1585749E (pt)
RS (1) RS20050522A (pt)
SI (1) SI1585749T1 (pt)
TN (1) TNSN05176A1 (pt)
UA (1) UA80733C2 (pt)
WO (1) WO2004063198A1 (pt)
ZA (1) ZA200504674B (pt)

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US8663210B2 (en) 2009-05-13 2014-03-04 Novian Health, Inc. Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
US8211901B2 (en) 2009-05-22 2012-07-03 Shenzhen Chipscreen Biosciences Ltd. Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
CN101906076B (zh) 2009-06-04 2013-03-13 深圳微芯生物科技有限责任公司 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
AU2012253759B2 (en) 2011-05-06 2016-01-21 Zafgen Inc. Tricyclic sulfonamide compounds and methods of making and using same
US9254299B2 (en) 2011-12-22 2016-02-09 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with Chk1 inhibitors for treating cancer
SG11201403538TA (en) 2011-12-31 2014-09-26 Beigene Ltd Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors
NO2797921T3 (pt) * 2011-12-31 2018-02-03
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
TWI633107B (zh) * 2013-05-22 2018-08-21 開曼群島商百濟神州生物科技有限公司 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮
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PL3157566T3 (pl) 2014-06-17 2019-10-31 Vertex Pharma Metoda leczenia nowotworu przy użyciu kombinacji inhibitorów chk1 i atr
IL257442B2 (en) 2015-08-25 2023-03-01 Beigene Ltd Process for preparing parp inhibitor, crystalline forms and their uses
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JP6541635B2 (ja) * 2016-10-28 2019-07-10 ベイジーン リミテッド Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン
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US11661581B2 (en) * 2017-05-25 2023-05-30 University Of Massachusetts Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells
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JP2022523028A (ja) * 2019-01-25 2022-04-21 ヌメディー， インコーポレイテッド 特発性肺線維症を処置するための方法
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Also Published As

Publication number Publication date
IS7884A (is) 2005-06-09
CA2512683A1 (en) 2004-07-29
DE602004015724D1 (de) 2008-09-25
JP2006516274A (ja) 2006-06-29
IL169082A (en) 2011-02-28
ECSP055911A (es) 2005-11-22
KR100697746B1 (ko) 2007-03-22
NO20053775L (no) 2005-09-16
AU2004203977A1 (en) 2004-07-29
MA27703A1 (fr) 2006-01-02
EP1947102A1 (en) 2008-07-23
EA009337B1 (ru) 2007-12-28
PT1585749E (pt) 2008-10-23
NO20053775D0 (no) 2005-08-08
ATE404564T1 (de) 2008-08-15
HK1086257A1 (en) 2006-09-15
US20060004052A1 (en) 2006-01-05
AU2004203977B2 (en) 2010-06-17
WO2004063198A1 (en) 2004-07-29
US6967198B2 (en) 2005-11-22
UA80733C2 (en) 2007-10-25
SI1585749T1 (sl) 2008-10-31
US7462713B2 (en) 2008-12-09
CA2512683C (en) 2010-03-16
CN1759118A (zh) 2006-04-12
CN1759118B (zh) 2010-12-08
ES2309484T3 (es) 2008-12-16
NZ540638A (en) 2007-12-21
RS20050522A (sr) 2007-12-31
EP1585749A1 (en) 2005-10-19
TNSN05176A1 (fr) 2007-06-11
ZA200504674B (en) 2006-07-26
PL378372A1 (pl) 2006-04-03
HRP20050624A2 (en) 2006-02-28
CY1108408T1 (el) 2014-02-12
OA13017A (en) 2006-11-10
KR20050092397A (ko) 2005-09-21
EP1585749B1 (en) 2008-08-13
MXPA05007352A (es) 2006-02-17
AP2048A (en) 2009-09-24
EA200500893A1 (ru) 2006-02-24
US20070135415A1 (en) 2007-06-14
JP3990718B2 (ja) 2007-10-17
AP2005003353A0 (en) 2005-09-30
US20050075499A1 (en) 2005-04-07
DK1585749T3 (da) 2008-09-22
US7132533B2 (en) 2006-11-07
GEP20084367B (en) 2008-05-13
CR7899A (es) 2005-08-05

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