MA27703A1 - Derives de diazepino-indole servant d'inhibiteurs de kinases - Google Patents

Derives de diazepino-indole servant d'inhibiteurs de kinases

Info

Publication number
MA27703A1
MA27703A1 MA28375A MA28375A MA27703A1 MA 27703 A1 MA27703 A1 MA 27703A1 MA 28375 A MA28375 A MA 28375A MA 28375 A MA28375 A MA 28375A MA 27703 A1 MA27703 A1 MA 27703A1
Authority
MA
Morocco
Prior art keywords
inhibitors
diazepino
kinases
indole derivatives
kinase inhibitors
Prior art date
Application number
MA28375A
Other languages
English (en)
Inventor
Sacha Ninkovic
Michael John Bennett
Eugene Yuanjin Rui
Fen Wang
Suzanne Pritchett Benedict
Min Teng
Yong Wang
Jinjiang Zhu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA27703A1 publication Critical patent/MA27703A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DEPOSANT Société dite : PFIZER INC. REVENDICATION DE PRIORITES US 9 Janvier 2003 60/439,396 Dérivés de diazépino-indole servant d'inhibiteurs de kinases Des composés tricycliques, inhibiteurs de protéine-kinases, telle que la CHK-1, répondant à la formule suivante (dans laquelle R2, R3 et R4 répondent aux définitions figurant dans le présent mémoire), des compositions pharmaceutiques contenant des quantités efficaces desdits composés ou leurs sels sont utiles, sous forme d'un agent unique ou en association avec un agent antinéoplasique ou un rayonnement thérapeutique ayant un effet antinéoplasique, pour le traitement de maladies ou d'affections, telles que des cancers.
MA28375A 2003-01-09 2005-07-08 Derives de diazepino-indole servant d'inhibiteurs de kinases MA27703A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09

Publications (1)

Publication Number Publication Date
MA27703A1 true MA27703A1 (fr) 2006-01-02

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28375A MA27703A1 (fr) 2003-01-09 2005-07-08 Derives de diazepino-indole servant d'inhibiteurs de kinases

Country Status (34)

Country Link
US (3) US6967198B2 (fr)
EP (2) EP1947102A1 (fr)
JP (1) JP3990718B2 (fr)
KR (1) KR100697746B1 (fr)
CN (1) CN1759118B (fr)
AP (1) AP2048A (fr)
AT (1) ATE404564T1 (fr)
AU (1) AU2004203977B2 (fr)
BR (1) BRPI0406701A (fr)
CA (1) CA2512683C (fr)
CR (1) CR7899A (fr)
CY (1) CY1108408T1 (fr)
DE (1) DE602004015724D1 (fr)
DK (1) DK1585749T3 (fr)
EA (1) EA009337B1 (fr)
EC (1) ECSP055911A (fr)
ES (1) ES2309484T3 (fr)
GE (1) GEP20084367B (fr)
HR (1) HRP20050624A2 (fr)
IL (1) IL169082A (fr)
IS (1) IS7884A (fr)
MA (1) MA27703A1 (fr)
MX (1) MXPA05007352A (fr)
NO (1) NO20053775L (fr)
NZ (1) NZ540638A (fr)
OA (1) OA13017A (fr)
PL (1) PL378372A1 (fr)
PT (1) PT1585749E (fr)
RS (1) RS20050522A (fr)
SI (1) SI1585749T1 (fr)
TN (1) TNSN05176A1 (fr)
UA (1) UA80733C2 (fr)
WO (1) WO2004063198A1 (fr)
ZA (1) ZA200504674B (fr)

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AU2003214879B2 (en) * 2002-01-22 2008-02-07 The Regents Of The University Of California Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof
DK1585749T3 (da) * 2003-01-09 2008-09-22 Pfizer Diazepinoindol-derivater som kinaseinhibitorer
PL1853721T3 (pl) * 2005-02-18 2010-08-31 Astrazeneca Ab Sposób określania wrażliwości na inhibitory CHK1
WO2006105262A1 (fr) 2005-03-29 2006-10-05 Icos Corporation Derives d'uree d'heteroaryle utilises pour inhiber chk1
GB0510390D0 (en) * 2005-05-20 2005-06-29 Novartis Ag Organic compounds
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JP2009505989A (ja) * 2005-08-15 2009-02-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ＶＥＧＦによって活性化されるＦａｓリガンド
EP1942193A4 (fr) 2005-08-25 2010-10-27 Ube Industries PROCÉDÉ DE PRODUCTION D ACIDE (S OU R)-a -AMINÉ OPTIQUEMENT ACTIF OU D ESTER D ACIDE (S OU R)-a-AMINÉ OPTIQUEMENT ACTIF
EP1916896A4 (fr) * 2005-08-26 2010-08-11 Univ California Antiandrogenes non steroidiens
RU2409361C2 (ru) * 2006-04-04 2011-01-20 Пфайзер Продактс Инк. КОМБИНИРОВАННАЯ ТЕРАПИЯ (2R,Z)-2-АМИНО-2-ЦИКЛОГЕКСИЛ-N-(5-(1-МЕТИЛ-1Н-ПИРАЗОЛ-4-ИЛ)-1-ОКСО-2,6-ДИГИДРО-1Н-[1,2]ДИАЗЕПИНО[4,5,6-cd]ИНДОЛ-8-ИЛ)АЦЕТАМИДОМ
CA2648369A1 (fr) * 2006-04-04 2007-10-11 Pfizer Products Inc. Formes polymorphes de (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4?l)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide
EP2086644A2 (fr) * 2006-11-17 2009-08-12 Schering Corporation Combinaison d'un inhibiteur de l'adn polymerase-alpha avec un inhibiteur d'une kinase de point de controle pour le traitement des maladies proliferatives
US8158656B2 (en) * 2008-05-16 2012-04-17 Shenzhen Chipscreen Biosciences Ltd. 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
ES2378513T3 (es) * 2008-08-06 2012-04-13 Pfizer Inc. Compuestos 2-heterociclilamino piracinas sustituidas en posición 6 como inhibidores de CHK-1
WO2010040527A1 (fr) * 2008-10-10 2010-04-15 Priaxon Ag Nouveaux composés qui modulent l'activité kinase
US8314108B2 (en) 2008-12-17 2012-11-20 Eli Lilly And Company 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, pharmaceutically acceptable salts thereof, or solvate of salts
US8663210B2 (en) 2009-05-13 2014-03-04 Novian Health, Inc. Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
US8211901B2 (en) 2009-05-22 2012-07-03 Shenzhen Chipscreen Biosciences Ltd. Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
CN101906076B (zh) 2009-06-04 2013-03-13 深圳微芯生物科技有限责任公司 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
CN103748094B (zh) 2011-05-06 2016-06-29 扎夫根股份有限公司 三环磺酰胺化合物及其制备和使用方法
EP2793882A4 (fr) 2011-12-22 2015-04-29 Threshold Pharmaceuticals Inc Administration de promédicaments activés par l'hypoxie en combinaison à des inhibiteurs de chk1 pour le traitement du cancer
NZ626937A (en) 2011-12-31 2016-09-30 Beigene Ltd Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors
RS56616B1 (sr) * 2011-12-31 2018-02-28 Beigene Ltd Kondenzovani tetra ili penta-ciklični dihidrodiazepinokarbazoloni kao parp inhibitori
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
TWI633107B (zh) * 2013-05-22 2018-08-21 開曼群島商百濟神州生物科技有限公司 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮
CA2938626A1 (fr) 2013-07-26 2015-01-29 John Rothman Compositions permettant d'ameliorer l'avantage therapeutique du bisantrene
US10071109B2 (en) 2013-11-06 2018-09-11 Molecular Templates, Inc. Predictive biomarker for hypoxia-activated prodrug therapy
JP6936007B2 (ja) 2014-06-17 2021-09-15 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ｃｈｋ１阻害剤とａｔｒ阻害剤との組み合わせを使用してがんを処置する方法
CN107922425B (zh) * 2015-08-25 2021-06-01 百济神州有限公司 制备parp抑制剂、结晶形式的方法及其用途
EP3355926B1 (fr) 2015-09-30 2025-12-24 Vertex Pharmaceuticals Inc. Association d'agents endommageant l'adn et d'inhibiteurs de l'atr pour son utilisation dans une méthode de traitement du cancer
US11202782B2 (en) 2016-09-27 2021-12-21 Beigene, Ltd. Treatment cancers using a combination comprising PARP inhibitors
JP6541635B2 (ja) * 2016-10-28 2019-07-10 ベイジーン リミテッド Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン
US10899763B2 (en) 2017-02-28 2021-01-26 Beigene, Ltd. Crystalline forms of salts of fused penta-cyclic dihydrodiazepinocarbazolones, and uses thereof
US11661581B2 (en) * 2017-05-25 2023-05-30 University Of Massachusetts Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells
BR112020005489A2 (pt) * 2017-09-22 2020-09-24 Jubilant Epipad Llc, composto da fórmula (i), composto de fórmula (ii), composto de fórmula (iii), processo de preparação de compostos de fórmula (i), processo de preparação de compostos de fórmula (ii), processo de preparação de compostos de fórmula (iii), composição farmacêutica, método para inibir uma ou mais famílias pad em uma célula, método para tratar uma afeção mediada por um ou mais pads, utilização do composto, método para o tratamento e/ou prevenção de uma afeção mediada por um ou mais distúrbios da família pad, método para o tratamento de artrite reumatoide e método de tratamento de câncer
EP3461480A1 (fr) 2017-09-27 2019-04-03 Onxeo Combinaison d'inhibiteurs de point de contrôle du cycle cellulaire de réponse à un dommage à l'adn et de belinostat pour traiter le cancer
JP2022523028A (ja) * 2019-01-25 2022-04-21 ヌメディー， インコーポレイテッド 特発性肺線維症を処置するための方法
WO2021018298A1 (fr) * 2019-08-01 2021-02-04 南京明德新药研发有限公司 Composés acyloxime à sept chaînons indolo servant d'inhibiteurs de parp
ES3014705T3 (en) 2019-11-29 2025-04-24 Novaonco Js Therapeutics Co Ltd Diazaindole derivative and use thereof as chk1 inhibitor
WO2022011458A1 (fr) * 2020-07-13 2022-01-20 Ontario Institute For Cancer Research (Oicr) Conjugués inhibiteurs de nicotinamide phosphoribosyltransférase (nampt) et leurs utilisations
US20230331739A1 (en) * 2020-07-31 2023-10-19 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Indolo heptamyl oxime analog crystal as parp inhibitor and method for preparing same

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Also Published As

Publication number Publication date
CY1108408T1 (el) 2014-02-12
RS20050522A (sr) 2007-12-31
ES2309484T3 (es) 2008-12-16
US20060004052A1 (en) 2006-01-05
KR20050092397A (ko) 2005-09-21
BRPI0406701A (pt) 2005-12-20
EA009337B1 (ru) 2007-12-28
SI1585749T1 (sl) 2008-10-31
CR7899A (es) 2005-08-05
OA13017A (en) 2006-11-10
WO2004063198A1 (fr) 2004-07-29
US7462713B2 (en) 2008-12-09
NO20053775D0 (no) 2005-08-08
GEP20084367B (en) 2008-05-13
CN1759118A (zh) 2006-04-12
CN1759118B (zh) 2010-12-08
US20050075499A1 (en) 2005-04-07
NO20053775L (no) 2005-09-16
US7132533B2 (en) 2006-11-07
NZ540638A (en) 2007-12-21
ATE404564T1 (de) 2008-08-15
EA200500893A1 (ru) 2006-02-24
IS7884A (is) 2005-06-09
US6967198B2 (en) 2005-11-22
JP3990718B2 (ja) 2007-10-17
AU2004203977A1 (en) 2004-07-29
EP1585749B1 (fr) 2008-08-13
JP2006516274A (ja) 2006-06-29
AU2004203977B2 (en) 2010-06-17
HK1086257A1 (en) 2006-09-15
TNSN05176A1 (fr) 2007-06-11
MXPA05007352A (es) 2006-02-17
IL169082A (en) 2011-02-28
ZA200504674B (en) 2006-07-26
AP2048A (en) 2009-09-24
HRP20050624A2 (en) 2006-02-28
ECSP055911A (es) 2005-11-22
CA2512683A1 (fr) 2004-07-29
US20070135415A1 (en) 2007-06-14
EP1947102A1 (fr) 2008-07-23
UA80733C2 (en) 2007-10-25
DK1585749T3 (da) 2008-09-22
EP1585749A1 (fr) 2005-10-19
DE602004015724D1 (de) 2008-09-25
KR100697746B1 (ko) 2007-03-22
PT1585749E (pt) 2008-10-23
CA2512683C (fr) 2010-03-16
AP2005003353A0 (en) 2005-09-30
PL378372A1 (pl) 2006-04-03

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