ECSP056180A - Alquil-estra-1,3,5(10)-trienos 8beta-vinil-11beta-(omega-sustituidos) - Google Patents

Alquil-estra-1,3,5(10)-trienos 8beta-vinil-11beta-(omega-sustituidos)

Info

Publication number
ECSP056180A
ECSP056180A EC2005006180A ECSP056180A ECSP056180A EC SP056180 A ECSP056180 A EC SP056180A EC 2005006180 A EC2005006180 A EC 2005006180A EC SP056180 A ECSP056180 A EC SP056180A EC SP056180 A ECSP056180 A EC SP056180A
Authority
EC
Ecuador
Prior art keywords
estra
triens
vinil
8beta
11beta
Prior art date
Application number
EC2005006180A
Other languages
English (en)
Inventor
Nico Braeuer
Olaf Peters
Rolf Bohlmann
Margit Richter
Hans Peter Muhn
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ECSP056180A publication Critical patent/ECSP056180A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a alquil-estra-1,3,5(10)-trienos 8 -vinil-11ß-( -sustituidos) de la fórmula general I con actividad antagonista de ERß, a procedimientos para su preparación, a sus productos intermediarios, a preparados farmacéuticos que contienen los compuestos según la invención, así como a su uso para preparar medicamentos. Los nuevos compuestos pueden aplicarse para la anticoncepción en el hombre y en la mujer, sin que afecten otros órganos sensibles a los estrógenos, tales como el útero o el hígado. También son apropiados para el tratamiento de enfermedades proliferativas benignas o malignas del ovario como carcinomas de ovario y tumores de células granulosas.
EC2005006180A 2003-04-22 2005-11-21 Alquil-estra-1,3,5(10)-trienos 8beta-vinil-11beta-(omega-sustituidos) ECSP056180A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10318896A DE10318896A1 (de) 2003-04-22 2003-04-22 8beta-Vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene

Publications (1)

Publication Number Publication Date
ECSP056180A true ECSP056180A (es) 2006-04-19

Family

ID=33304956

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005006180A ECSP056180A (es) 2003-04-22 2005-11-21 Alquil-estra-1,3,5(10)-trienos 8beta-vinil-11beta-(omega-sustituidos)

Country Status (21)

Country Link
US (1) US7375098B2 (es)
EP (1) EP1622924A2 (es)
JP (1) JP2006524202A (es)
KR (1) KR20060005386A (es)
CN (1) CN100381457C (es)
AR (1) AR044056A1 (es)
AU (1) AU2004232462A1 (es)
BR (1) BRPI0409794A (es)
CA (1) CA2522354A1 (es)
CL (1) CL2004000856A1 (es)
CR (1) CR8053A (es)
DE (1) DE10318896A1 (es)
EA (1) EA009606B1 (es)
EC (1) ECSP056180A (es)
MX (1) MXPA05011386A (es)
NO (1) NO20055493L (es)
PE (1) PE20050423A1 (es)
RS (1) RS20050793A (es)
UY (1) UY28284A1 (es)
WO (1) WO2004094451A2 (es)
ZA (1) ZA200509447B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK14632002A3 (sk) * 2000-04-12 2003-03-04 Schering Aktiengesellschaft Substituované estratriény a ich použitie ako selektívne účinných estrogénov
BRPI0514974A (pt) 2004-09-07 2008-07-01 Wyeth Corp composto, composição, métodos de tratar ou inibir uma doença ou condição, estados de doença induzidos por radical livre em um mamìfero, dano à junta secundário aos procedimentos artroscópicos ou cirúrgicos em um mamìfero, infertilidade em um mamìfero, de diminuir os nìveis de colesterol, triglicerìdeos, lp(a), ou ldl, de fornecer realce na cognição ou neuroproteção, de contracepção em um mamìfero, e para preparar um composto, e, produto
MX2007006653A (es) * 2005-10-05 2009-02-17 Sicor Inc Separacion de isomeros de fulvestrant.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1226155B1 (de) * 1999-11-02 2007-05-02 Bayer Schering Pharma AG 18-nor-steroide als selektiv wirksame estrogene
SK14632002A3 (sk) * 2000-04-12 2003-03-04 Schering Aktiengesellschaft Substituované estratriény a ich použitie ako selektívne účinných estrogénov
DE10151114A1 (de) * 2001-10-15 2003-04-17 Schering Ag 8ß-Substituierte-11ß-aryl-estra-2,3,5(10)-trienderivate

Also Published As

Publication number Publication date
NO20055493L (no) 2006-01-18
EP1622924A2 (de) 2006-02-08
EA200501568A1 (ru) 2006-06-30
BRPI0409794A (pt) 2006-05-30
WO2004094451A2 (de) 2004-11-04
PE20050423A1 (es) 2005-08-13
CL2004000856A1 (es) 2005-03-28
EA009606B1 (ru) 2008-02-28
MXPA05011386A (es) 2006-04-18
ZA200509447B (en) 2009-08-26
JP2006524202A (ja) 2006-10-26
CA2522354A1 (en) 2004-11-04
KR20060005386A (ko) 2006-01-17
US7375098B2 (en) 2008-05-20
CN1777618A (zh) 2006-05-24
AR044056A1 (es) 2005-08-24
WO2004094451A3 (de) 2004-12-23
US20050065135A1 (en) 2005-03-24
AU2004232462A1 (en) 2004-11-04
CN100381457C (zh) 2008-04-16
NO20055493D0 (no) 2005-11-21
DE10318896A1 (de) 2004-11-25
CR8053A (es) 2006-05-29
RS20050793A (sr) 2008-04-04
UY28284A1 (es) 2004-11-30

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