ECSP066589A - Análogos oligonucleótidos clase c con potencia inmunoestimulante mejorada - Google Patents

Análogos oligonucleótidos clase c con potencia inmunoestimulante mejorada

Info

Publication number
ECSP066589A
ECSP066589A EC2006006589A ECSP066589A ECSP066589A EC SP066589 A ECSP066589 A EC SP066589A EC 2006006589 A EC2006006589 A EC 2006006589A EC SP066589 A ECSP066589 A EC SP066589A EC SP066589 A ECSP066589 A EC SP066589A
Authority
EC
Ecuador
Prior art keywords
immune
class
oligonucleotid
analogs
improved power
Prior art date
Application number
EC2006006589A
Other languages
English (en)
Inventor
Arthur M Krieg
Joerg Vollmer
Eugen Uhlmann
Bernhard O Noll
Original Assignee
Coley Pharm Gmbh
Coley Pharm Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Gmbh, Coley Pharm Group Inc filed Critical Coley Pharm Gmbh
Publication of ECSP066589A publication Critical patent/ECSP066589A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/05—Adjuvants
    • C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • AIDS & HIV (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

La invención se refiere a una clase de oligonucleótidos inmunoestimulantes CpG que contienen un análogo inmunoestimulante CpG y un segundo análogo que es capaz de formar una estructura secundaria, incluyendo estructuras dobles y de orden superior, in vitro e in vivo. Los oligonucleótidos de la invención son útiles como adyuvantes en la vacunación. Los oligonucleótidos también son útiles para inducir una respuesta inmunitaria, para inducir la expresión de interferón (IFN) tipo I, para inducir la expresión de interferón gama (IFN- ) y para tratar una variedad de condiciones, incluyendo la alergia, el asma, las enfermedades infecciosas y el cáncer.
EC2006006589A 2003-10-30 2006-05-29 Análogos oligonucleótidos clase c con potencia inmunoestimulante mejorada ECSP066589A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51619303P 2003-10-30 2003-10-30

Publications (1)

Publication Number Publication Date
ECSP066589A true ECSP066589A (es) 2006-10-17

Family

ID=34549500

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006589A ECSP066589A (es) 2003-10-30 2006-05-29 Análogos oligonucleótidos clase c con potencia inmunoestimulante mejorada

Country Status (23)

Country Link
US (1) US8188254B2 (es)
EP (2) EP1728863A3 (es)
JP (1) JP2007509983A (es)
KR (1) KR101107818B1 (es)
CN (1) CN101454451A (es)
AP (1) AP2006003611A0 (es)
AU (2) AU2004285561C1 (es)
BR (1) BRPI0416079A (es)
CA (1) CA2540949A1 (es)
CR (1) CR8423A (es)
EA (1) EA008741B1 (es)
EC (1) ECSP066589A (es)
GE (1) GEP20094767B (es)
IL (2) IL174428A0 (es)
MA (1) MA28182A1 (es)
NO (1) NO20061857L (es)
NZ (2) NZ546275A (es)
OA (1) OA13278A (es)
SG (2) SG122973A1 (es)
TN (1) TNSN06123A1 (es)
UA (1) UA88457C2 (es)
WO (1) WO2005042018A2 (es)
ZA (2) ZA200602352B (es)

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WO2005042018A2 (en) 2005-05-12
SG122973A1 (en) 2006-06-29
EP1728863A2 (en) 2006-12-06
TNSN06123A1 (en) 2007-11-15

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