CR8423A - Analogos nucleotidos clase c con potencia inmunoestimulante mejorada - Google Patents

Analogos nucleotidos clase c con potencia inmunoestimulante mejorada

Info

Publication number
CR8423A
CR8423A CR8423A CR8423A CR8423A CR 8423 A CR8423 A CR 8423A CR 8423 A CR8423 A CR 8423A CR 8423 A CR8423 A CR 8423A CR 8423 A CR8423 A CR 8423A
Authority
CR
Costa Rica
Prior art keywords
class
nucleotid
inducing
analogs
oligonucleotides
Prior art date
Application number
CR8423A
Other languages
English (en)
Inventor
Uhlmann Eugen
Vollmer Joerg
M Krieg Arthur
O Noll Bernhard
Original Assignee
Coley Pharm Gmbh
Coley Pharm Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Gmbh, Coley Pharm Group Inc filed Critical Coley Pharm Gmbh
Publication of CR8423A publication Critical patent/CR8423A/es

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    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/05—Adjuvants
    • C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • AIDS & HIV (AREA)
  • Hematology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La invencion trata sobre una clase de oligonucleotidos inmunoestimuladores CpG que contienen una secuencia inmunoestimuladora CpG y una segunda secuencia la cual es capaz de formar estructuras secundarias, incluyendo estructuras bicatenarias y de orden superior, tanto in vitro como in vivo. Los oligonucleotidos de la invencion son utiles como adyuvantes para vacunacion. Los oligonucleotidos son utiles tambien para inducir una respuesta inmune, inducir la expresion de un interferon de tipo I (IFN), para inducir la expresion de interferon gama (IFN-y) y para el tratamiento de varios de estados de enfermedad incluyendo a la alergia, el asma, las infecciones y el cancer.
CR8423A 2003-10-30 2006-05-29 Analogos nucleotidos clase c con potencia inmunoestimulante mejorada CR8423A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51619303P 2003-10-30 2003-10-30

Publications (1)

Publication Number Publication Date
CR8423A true CR8423A (es) 2007-09-03

Family

ID=34549500

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8423A CR8423A (es) 2003-10-30 2006-05-29 Analogos nucleotidos clase c con potencia inmunoestimulante mejorada

Country Status (23)

Country Link
US (1) US8188254B2 (es)
EP (2) EP1728863A3 (es)
JP (1) JP2007509983A (es)
KR (1) KR101107818B1 (es)
CN (1) CN101454451A (es)
AP (1) AP2006003611A0 (es)
AU (2) AU2004285561C1 (es)
BR (1) BRPI0416079A (es)
CA (1) CA2540949A1 (es)
CR (1) CR8423A (es)
EA (1) EA008741B1 (es)
EC (1) ECSP066589A (es)
GE (1) GEP20094767B (es)
IL (2) IL174428A0 (es)
MA (1) MA28182A1 (es)
NO (1) NO20061857L (es)
NZ (2) NZ546275A (es)
OA (1) OA13278A (es)
SG (2) SG122973A1 (es)
TN (1) TNSN06123A1 (es)
UA (1) UA88457C2 (es)
WO (1) WO2005042018A2 (es)
ZA (2) ZA200602352B (es)

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SG122973A1 (en) 2006-06-29
EP1728863A2 (en) 2006-12-06
TNSN06123A1 (en) 2007-11-15

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