MA28182A1 - Analogues d'oligonucleotides de classe c presentant des proprietes immunostimulatrices accrues - Google Patents

Analogues d'oligonucleotides de classe c presentant des proprietes immunostimulatrices accrues

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Publication number
MA28182A1
MA28182A1 MA29062A MA29062A MA28182A1 MA 28182 A1 MA28182 A1 MA 28182A1 MA 29062 A MA29062 A MA 29062A MA 29062 A MA29062 A MA 29062A MA 28182 A1 MA28182 A1 MA 28182A1
Authority
MA
Morocco
Prior art keywords
class
induce
oligonucleotide analogues
immunostimulatory properties
oligonucleotides
Prior art date
Application number
MA29062A
Other languages
English (en)
Inventor
Eugen Uhlmann
Joerg Vollmer
Arthur M Krieg
Bernhard O Noll
Original Assignee
Coley Pharm Group Inc
Coley Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Group Inc, Coley Pharm Gmbh filed Critical Coley Pharm Group Inc
Publication of MA28182A1 publication Critical patent/MA28182A1/fr

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/53—Physical structure partially self-complementary or closed
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/05—Adjuvants
    • C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
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  • Epidemiology (AREA)
  • Zoology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne une catégorie d'oligonucléotides immunostimulateurs CpG contenant un motif immunostimulateur CpG et un deuxième motif pouvant former une structure secondaire, notamment des structures duplex et d'ordre élevé, in vitro et in vivo. Les oligonucléotides selon l'invention sont utiles en tant qu'adjuvants pour la vaccination. Ces oligonucléotides servent également à induire une réponse immunitaire, à induire l'expression d'un interféron de type I(INF), à induire l'expression d'un interféron gamma (INF-$g(g)), et à traiter divers états, notamment les allergies, l'asthme, les infections et le cancer.
MA29062A 2003-10-30 2006-05-29 Analogues d'oligonucleotides de classe c presentant des proprietes immunostimulatrices accrues MA28182A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51619303P 2003-10-30 2003-10-30

Publications (1)

Publication Number Publication Date
MA28182A1 true MA28182A1 (fr) 2006-09-01

Family

ID=34549500

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29062A MA28182A1 (fr) 2003-10-30 2006-05-29 Analogues d'oligonucleotides de classe c presentant des proprietes immunostimulatrices accrues

Country Status (23)

Country Link
US (1) US8188254B2 (fr)
EP (2) EP1728863A3 (fr)
JP (1) JP2007509983A (fr)
KR (1) KR101107818B1 (fr)
CN (1) CN101454451A (fr)
AP (1) AP2006003611A0 (fr)
AU (2) AU2004285561C1 (fr)
BR (1) BRPI0416079A (fr)
CA (1) CA2540949A1 (fr)
CR (1) CR8423A (fr)
EA (1) EA008741B1 (fr)
EC (1) ECSP066589A (fr)
GE (1) GEP20094767B (fr)
IL (2) IL174428A0 (fr)
MA (1) MA28182A1 (fr)
NO (1) NO20061857L (fr)
NZ (2) NZ546275A (fr)
OA (1) OA13278A (fr)
SG (2) SG123799A1 (fr)
TN (1) TNSN06123A1 (fr)
UA (1) UA88457C2 (fr)
WO (1) WO2005042018A2 (fr)
ZA (2) ZA200602352B (fr)

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BRPI0811621A2 (pt) 2007-05-17 2014-10-21 Coley Pharm Group Inc Oligonucleotídeos de classe a com potência imunoestimuladora, composição contendo os mesmos e uso da referida composição

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KR101107818B1 (ko) 2012-01-31
NZ546275A (en) 2009-05-31
TNSN06123A1 (en) 2007-11-15
NO20061857L (no) 2006-07-31
AU2004285561C1 (en) 2012-06-21
AU2004285561A1 (en) 2005-05-12
AP2006003611A0 (en) 2006-06-30
AU2004285561B2 (en) 2011-11-24
SG123799A1 (en) 2006-07-26
ECSP066589A (es) 2006-10-17
US20050239734A1 (en) 2005-10-27
CN101454451A (zh) 2009-06-10
EP1728863A3 (fr) 2006-12-20
NZ546475A (en) 2008-08-29
EA008741B1 (ru) 2007-08-31
CA2540949A1 (fr) 2005-05-12
ZA200603212B (en) 2008-03-26
KR20060109443A (ko) 2006-10-20
JP2007509983A (ja) 2007-04-19
OA13278A (en) 2007-01-31
ZA200602352B (en) 2007-09-26
SG122973A1 (en) 2006-06-29
AU2006201495A1 (en) 2006-04-27
EP1678303A2 (fr) 2006-07-12
WO2005042018A2 (fr) 2005-05-12
CR8423A (es) 2007-09-03
IL175215A0 (en) 2006-09-05
EA200600865A1 (ru) 2006-10-27
UA88457C2 (ru) 2009-10-26
BRPI0416079A (pt) 2007-01-02
IL174428A0 (en) 2006-08-01
GEP20094767B (en) 2009-09-10
US8188254B2 (en) 2012-05-29
WO2005042018A3 (fr) 2005-07-21
EP1728863A2 (fr) 2006-12-06

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