ECSP066770A - Nuevos ésteres de quinuclidina cuaternizados - Google Patents

Nuevos ésteres de quinuclidina cuaternizados

Info

Publication number
ECSP066770A
ECSP066770A EC2006006770A ECSP066770A ECSP066770A EC SP066770 A ECSP066770 A EC SP066770A EC 2006006770 A EC2006006770 A EC 2006006770A EC SP066770 A ECSP066770 A EC SP066770A EC SP066770 A ECSP066770 A EC SP066770A
Authority
EC
Ecuador
Prior art keywords
compounds
cuaternized
new
quinuclidine esters
urological
Prior art date
Application number
EC2006006770A
Other languages
English (en)
Inventor
Albero Maria Antonia Buil
Quinones Maria Prat
Forner Maria Dolors Fernandez
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of ECSP066770A publication Critical patent/ECSP066770A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención comprende los compuestos de la fórmula (I) donde los diferentes substituyentes y/o radicales tienen los valores definidos en las reivindicaciones. La invención además se refiere a un proceso para la preparación de los mencionados compuestos, a composiciones farmacéuticas que contengan éstos, así como combinaciones de los mencionados compuestos con otros compuestos los cuáles son activos en el tratamiento de desórdenes o enfermedades respiratorias, urológicas o gastrointestinales. Finalmente la invención también se refiere al uso de los compuestos de la fórmula (I) para el tratamiento de desórdenes o enfermedades respiratorias, urológicas o gastrointestinales.
EC2006006770A 2004-03-15 2006-08-14 Nuevos ésteres de quinuclidina cuaternizados ECSP066770A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200400638A ES2239546B1 (es) 2004-03-15 2004-03-15 Nuevos esteres de quinuclidina cuaternizados.

Publications (1)

Publication Number Publication Date
ECSP066770A true ECSP066770A (es) 2006-11-16

Family

ID=34955916

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006770A ECSP066770A (es) 2004-03-15 2006-08-14 Nuevos ésteres de quinuclidina cuaternizados

Country Status (30)

Country Link
US (1) US20080214600A1 (es)
EP (1) EP1725552B1 (es)
JP (1) JP2007529444A (es)
KR (1) KR20070003940A (es)
CN (1) CN1930158A (es)
AR (1) AR048004A1 (es)
AT (1) ATE399166T1 (es)
AU (1) AU2005223310A1 (es)
BR (1) BRPI0508177A (es)
CA (1) CA2560157A1 (es)
CY (1) CY1108324T1 (es)
DE (1) DE602005007714D1 (es)
DK (1) DK1725552T3 (es)
EC (1) ECSP066770A (es)
ES (2) ES2239546B1 (es)
HR (1) HRP20080338T3 (es)
IL (1) IL177341A0 (es)
MY (1) MY142036A (es)
NO (1) NO20064659L (es)
NZ (1) NZ548583A (es)
PE (1) PE20060005A1 (es)
PL (1) PL1725552T3 (es)
PT (1) PT1725552E (es)
RS (1) RS50566B (es)
RU (1) RU2382041C2 (es)
SI (1) SI1725552T1 (es)
TW (1) TW200604196A (es)
UA (1) UA88634C2 (es)
WO (1) WO2005090342A1 (es)
ZA (1) ZA200605931B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
GB0424284D0 (en) * 2004-11-02 2004-12-01 Novartis Ag Organic compounds
ES2298049B1 (es) * 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
JP2010519193A (ja) * 2007-02-15 2010-06-03 アージェンタ ディスカバリー リミテッド Ｍ３ムスカリン受容体としての複素環式誘導体
JP5656288B2 (ja) 2007-09-07 2015-01-21 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ムスカリン受容体アンタゴニストとして有用なグアジニン含有化合物
CA2608561A1 (en) * 2007-10-29 2009-04-29 Carl Paluszkiewicz Motorcycle wind deflector accessory support
EP2222637A1 (en) 2007-12-14 2010-09-01 Theravance, Inc. Amidine-containing compounds useful as muscarinic receptor antagonists
EP2100598A1 (en) * 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
US20090326004A1 (en) 2008-06-03 2009-12-31 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
PL2417106T3 (pl) 2009-04-09 2017-05-31 Novartis Ag Sposób wytwarzania soli pirolidyniowych
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
KR20150092173A (ko) * 2012-12-05 2015-08-12 키에시 파르마슈티시 엣스. 피. 에이. Pde4-억제제로서 페닐에틸피리딘 유도체
CN103755699A (zh) * 2014-01-06 2014-04-30 万特制药(海南)有限公司 一种2-羟基-2,2-二噻吩-2-基乙酸-1-氮杂二环[2,2,2]辛-3(r)-基酯制备方法
CN103755698A (zh) * 2014-01-06 2014-04-30 万特制药(海南)有限公司 一锅法制备阿地溴铵的工艺
KR101511090B1 (ko) 2014-04-24 2015-04-10 고려대학교 산학협력단 염증성 질환의 예방 또는 치료용 약학 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
US4843074A (en) * 1988-05-17 1989-06-27 Marion Laboratories, Inc. 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts
NO2005012I1 (no) * 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
WO2002053564A2 (en) * 2000-12-28 2002-07-11 Almirall Prodesfarma Ag Quinuclidine derivatives and their use as m3 antagonists
KR20050030169A (ko) * 2001-10-17 2005-03-29 유씨비 소시에떼아노님 퀴누클리딘 유도체, 이의 제조 방법 및 ｍ2 및/또는 ｍ3무스카린 수용체 억제제로서의 이의 용도
ES2204295B1 (es) * 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
AR044134A1 (es) * 2003-05-02 2005-08-24 Novartis Ag Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas.

Also Published As

Publication number Publication date
JP2007529444A (ja) 2007-10-25
IL177341A0 (en) 2006-12-10
RU2382041C2 (ru) 2010-02-20
US20080214600A1 (en) 2008-09-04
ES2239546A1 (es) 2005-09-16
ZA200605931B (en) 2007-11-28
AR048004A1 (es) 2006-03-15
RU2006136085A (ru) 2008-04-27
AU2005223310A1 (en) 2005-09-29
TW200604196A (en) 2006-02-01
HK1101855A1 (en) 2007-10-26
HRP20080338T3 (hr) 2008-07-31
CN1930158A (zh) 2007-03-14
DE602005007714D1 (de) 2008-08-07
DK1725552T3 (da) 2008-10-13
ES2307168T3 (es) 2008-11-16
NZ548583A (en) 2010-05-28
EP1725552A1 (en) 2006-11-29
WO2005090342A1 (en) 2005-09-29
ATE399166T1 (de) 2008-07-15
PT1725552E (pt) 2008-09-18
KR20070003940A (ko) 2007-01-05
CA2560157A1 (en) 2005-09-29
CY1108324T1 (el) 2014-02-12
MY142036A (en) 2010-08-16
SI1725552T1 (sl) 2008-10-31
EP1725552B1 (en) 2008-06-25
BRPI0508177A (pt) 2007-08-07
UA88634C2 (en) 2009-11-10
PE20060005A1 (es) 2006-01-28
RS50566B (sr) 2010-05-07
ES2239546B1 (es) 2006-12-01
NO20064659L (no) 2006-12-13
PL1725552T3 (pl) 2008-12-31

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