ECSP078025A - Nuevos compuestos de oxabispidina para el tratamiento de las arritmias cardíacas - Google Patents

Nuevos compuestos de oxabispidina para el tratamiento de las arritmias cardíacas

Info

Publication number
ECSP078025A
ECSP078025A EC2007008025A ECSP078025A ECSP078025A EC SP078025 A ECSP078025 A EC SP078025A EC 2007008025 A EC2007008025 A EC 2007008025A EC SP078025 A ECSP078025 A EC SP078025A EC SP078025 A ECSP078025 A EC SP078025A
Authority
EC
Ecuador
Prior art keywords
treatment
arritmies
heart
compounds
oxabispidine compounds
Prior art date
Application number
EC2007008025A
Other languages
English (en)
Inventor
Annika Bjoere
David Cladingboel
Gareth Ensor
Adam Herring
Johan Kajanus
Robert Lundqvist
Christina Olsson
Carl-Gustav Sigfridsson
Gert Strandlund
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/SE2005/000891 external-priority patent/WO2005123748A1/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP078025A publication Critical patent/ECSP078025A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se proporcionan compuestos de fórmula I, donde R1, R2, R3, R41 a R46, X, Y y Z tienen los significados dados en la descripción, dichos compuestos son útiles para la profilaxis y el tratamiento de las arritmias, en particular arritmias atrial y ventricular.
EC2007008025A 2005-06-13 2007-12-17 Nuevos compuestos de oxabispidina para el tratamiento de las arritmias cardíacas ECSP078025A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/SE2005/000891 WO2005123748A1 (en) 2004-06-15 2005-06-13 Novel oxabispidine compounds and their use in the treatment of cardiac arrhythmias
SE0502775 2005-12-15

Publications (1)

Publication Number Publication Date
ECSP078025A true ECSP078025A (es) 2008-01-23

Family

ID=37532579

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007008025A ECSP078025A (es) 2005-06-13 2007-12-17 Nuevos compuestos de oxabispidina para el tratamiento de las arritmias cardíacas

Country Status (12)

Country Link
US (1) US7928225B2 (es)
EP (1) EP1893619A1 (es)
JP (1) JP2008543750A (es)
KR (1) KR20080021114A (es)
CN (1) CN101243093A (es)
AR (1) AR057064A1 (es)
AU (1) AU2006258293B2 (es)
CA (1) CA2609938A1 (es)
EC (1) ECSP078025A (es)
MX (1) MX2007015800A (es)
NO (1) NO20076052L (es)
WO (1) WO2006135316A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703821B2 (en) 2006-04-18 2014-04-22 Emisphere Technologies Inc. Dialkyl ether delivery agents
TW200940110A (en) * 2008-02-22 2009-10-01 Astrazeneca Ab Pharmaceutical formulation comprising oxabispidines
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
WO2010059119A1 (en) * 2008-11-21 2010-05-27 Astrazeneca Ab A combination of tert -butyl (2-{7- [2- (4-cyano-2- f luorophenoxy) ethyl] -9-oxa-3, 7-diazabicyclo [3.3.1] non-3- yl } ethyl) carbamate and certain antiarrhythmic benzofurans

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196154A (en) * 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) * 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
DE2428792A1 (de) * 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
JPS5772977A (en) 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) * 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
PT88381B (pt) 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en) * 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FI100151B (fi) 1992-09-04 1997-09-30 Nokia Mobile Phones Ltd Tehonsäästö matkaviestimessä
JPH06284071A (ja) 1993-01-27 1994-10-07 Casio Comput Co Ltd 無線受信機
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
FR2713081B1 (fr) 1993-11-29 1996-01-12 Celsa Lg Filtre sanguin perfectionné à deux séries de pattes en pétales.
US5831099A (en) * 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
TR200102911T2 (tr) 1999-04-09 2002-01-21 Astrazeneca Ab Adamantan türevleri.
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
SE0101323D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101324D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101327D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
TWI259836B (en) 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0201662D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
EA200500234A1 (ru) * 2002-08-19 2005-08-25 Пфайзер Продактс Инк. Комбинированная терапия гиперпролиферативных болезней
GB0223712D0 (en) 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401540D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds

Also Published As

Publication number Publication date
WO2006135316A1 (en) 2006-12-21
US7928225B2 (en) 2011-04-19
AU2006258293A1 (en) 2006-12-21
AU2006258293B2 (en) 2010-06-17
AR057064A1 (es) 2007-11-14
US20090054422A1 (en) 2009-02-26
CA2609938A1 (en) 2006-12-21
KR20080021114A (ko) 2008-03-06
EP1893619A1 (en) 2008-03-05
MX2007015800A (es) 2008-03-04
NO20076052L (no) 2008-03-11
CN101243093A (zh) 2008-08-13
JP2008543750A (ja) 2008-12-04

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