ECSP078059A - Tigeciclina y métodos de preparación - Google Patents

Tigeciclina y métodos de preparación

Info

Publication number
ECSP078059A
ECSP078059A EC2007008059A ECSP078059A ECSP078059A EC SP078059 A ECSP078059 A EC SP078059A EC 2007008059 A EC2007008059 A EC 2007008059A EC SP078059 A ECSP078059 A EC SP078059A EC SP078059 A ECSP078059 A EC SP078059A
Authority
EC
Ecuador
Prior art keywords
tigecicline
preparation methods
methods
disclosed
tigecycline
Prior art date
Application number
EC2007008059A
Other languages
English (en)
Inventor
Sylvain Daigneault
Michel Bernatchez
Phaik-Eng Sum
Anthony Scott Pilcher
Lalitha Krishnan
Jeffrey Marshall Horne
Adam Joseph Tuper
Joseph James Mccauley Iii
Adam P Michaud
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP078059A publication Critical patent/ECSP078059A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se revelan métodos para preparar y purificar tetraciclinas, tales como tigeciclina. También se revelan composiciones de tetraciclinas, tales como composiciones de tigeciclina, preparadas por estos métodos.
EC2007008059A 2005-05-27 2007-12-27 Tigeciclina y métodos de preparación ECSP078059A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68528505P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
ECSP078059A true ECSP078059A (es) 2008-01-23

Family

ID=37023025

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007008059A ECSP078059A (es) 2005-05-27 2007-12-27 Tigeciclina y métodos de preparación

Country Status (21)

Country Link
US (1) US20070049562A1 (es)
EP (1) EP1888507A1 (es)
JP (1) JP2008545701A (es)
KR (1) KR20080015470A (es)
CN (1) CN101228112A (es)
AR (1) AR057032A1 (es)
AU (1) AU2006252783A1 (es)
BR (1) BRPI0610648A2 (es)
CA (1) CA2609306A1 (es)
CR (1) CR9541A (es)
EC (1) ECSP078059A (es)
GT (1) GT200600221A (es)
IL (1) IL187360A0 (es)
MX (1) MX2007014731A (es)
NI (1) NI200700301A (es)
NO (1) NO20076001L (es)
PE (1) PE20070009A1 (es)
RU (1) RU2007143157A (es)
TW (1) TW200718676A (es)
WO (1) WO2006130418A1 (es)
ZA (1) ZA200710153B (es)

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* Cited by examiner, † Cited by third party
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AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
EP2007713A2 (en) * 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
ES2622356T3 (es) * 2006-04-24 2017-07-06 Teva Pharmaceutical Industries, Ltd. Formas cristalinas de tigeciclina y procesos para su preparación
EP2086926A2 (en) * 2006-11-29 2009-08-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
EP2084126A1 (en) * 2006-11-30 2009-08-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
EP2114865A1 (en) * 2007-03-01 2009-11-11 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
WO2009052152A2 (en) * 2007-10-16 2009-04-23 Wyeth Tigecycline and methods of preparing intermediates
WO2009062963A1 (en) * 2007-11-14 2009-05-22 Sandoz Ag Crystalline forms of tigecycline hydrochloride
WO2009092680A2 (en) * 2008-01-23 2009-07-30 Sandoz Ag Antibiotic compounds
WO2010032219A1 (en) * 2008-09-18 2010-03-25 Ranbaxy Laboratories Limited Process for the preparation of tigecycline
CA2746585C (en) 2008-12-18 2017-08-29 Sandoz Ag Crystalline form c of tigecycline dihydrochloride and methods for its preparation
US20120059190A1 (en) 2009-03-12 2012-03-08 Wyeth Llc Novel nitration of tetracyclines
ES2469829T3 (es) * 2009-11-26 2014-06-20 Sandoz Ag Reacción de compuestos orgánicos con bajas cantidades de hidrógeno
WO2011109899A1 (en) * 2010-03-10 2011-09-15 University Health Network Use of tigecycline for treatment of cancer
CN102276497A (zh) * 2010-06-10 2011-12-14 武汉启瑞药业有限公司 替加环素的合成方法
CN102746183B (zh) * 2011-04-20 2014-12-17 胡梨芳 替加环素结晶水合物及其制备方法和用途
CN104619683B (zh) 2012-09-27 2017-05-10 拜耳农作物科学股份公司 用于制备任选地取代的苯基和吡啶基吡咯烷类的方法
CN102911077B (zh) * 2012-11-12 2015-01-07 成都百裕科技制药有限公司 4r-替加环素的制备方法
CN103044281A (zh) * 2013-01-02 2013-04-17 湖南赛隆药业有限公司 高纯度替加环素的制法
CN104230744B (zh) * 2014-09-01 2016-06-08 湖南尔康制药股份有限公司 一种替加环素原料药的生产方法
CN107365359B (zh) * 2017-07-17 2021-06-04 昆明理工大学 一种万古霉素手性功能单体合成方法
JP7364841B2 (ja) * 2018-02-14 2023-10-19 智彦 大和田 酸ハロゲン化物による化合物の製造方法

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US3026248A (en) * 1959-09-11 1962-03-20 Pfizer & Co C Thioglycerol and formaldehyde sulfoxylate stabilized tetracycline antibiotics in polyhydric alcohol solvents
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US3250809A (en) * 1962-09-06 1966-05-10 Pfizer & Co C 6-deoxy-6-demethyl-6-halomethylene tetracyclines and their 11a-chloro and fluoro derivatives
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Also Published As

Publication number Publication date
AU2006252783A1 (en) 2006-12-07
EP1888507A1 (en) 2008-02-20
IL187360A0 (en) 2008-04-13
CA2609306A1 (en) 2006-12-07
AR057032A1 (es) 2007-11-14
GT200600221A (es) 2009-08-28
TW200718676A (en) 2007-05-16
ZA200710153B (en) 2009-08-26
KR20080015470A (ko) 2008-02-19
JP2008545701A (ja) 2008-12-18
MX2007014731A (es) 2008-02-15
CR9541A (es) 2008-02-20
BRPI0610648A2 (pt) 2010-07-13
PE20070009A1 (es) 2007-01-29
CN101228112A (zh) 2008-07-23
NI200700301A (es) 2008-07-24
US20070049562A1 (en) 2007-03-01
WO2006130418A1 (en) 2006-12-07
RU2007143157A (ru) 2009-07-10
NO20076001L (no) 2008-02-19

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