ECSP078055A - Formas sólidas cristalinas de tigeciclina y métodos para preparar las mismas - Google Patents

Formas sólidas cristalinas de tigeciclina y métodos para preparar las mismas

Info

Publication number
ECSP078055A
ECSP078055A EC2007008055A ECSP078055A ECSP078055A EC SP078055 A ECSP078055 A EC SP078055A EC 2007008055 A EC2007008055 A EC 2007008055A EC SP078055 A ECSP078055 A EC SP078055A EC SP078055 A ECSP078055 A EC SP078055A
Authority
EC
Ecuador
Prior art keywords
crystalline
tigecicline
solid forms
prepare
methods
Prior art date
Application number
EC2007008055A
Other languages
English (en)
Inventor
Mannching Sherry Ku
Subodh S Deshmukh
Anthony F Hadfield
Lalitha Krishnan
James W Huang
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37026996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP078055(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP078055A publication Critical patent/ECSP078055A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

Se describen en la presente las formas sólidas cristalinas de tigeciclina, Forma I, Forma II, Forma III, Forma IV y Forma V, composiciones que comprenden estas formas sólidas cristalinas, y procesos para preparar estas formas sólidas cristalinas
EC2007008055A 2005-05-27 2007-12-26 Formas sólidas cristalinas de tigeciclina y métodos para preparar las mismas ECSP078055A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68495505P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
ECSP078055A true ECSP078055A (es) 2008-01-23

Family

ID=37026996

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007008055A ECSP078055A (es) 2005-05-27 2007-12-26 Formas sólidas cristalinas de tigeciclina y métodos para preparar las mismas

Country Status (27)

Country Link
US (1) US8372995B2 (es)
EP (1) EP1890996B1 (es)
JP (2) JP2008545717A (es)
KR (1) KR20080016890A (es)
CN (1) CN101248038B (es)
AR (1) AR057649A1 (es)
AU (1) AU2006251954A1 (es)
BR (1) BRPI0610653A2 (es)
CA (1) CA2609875C (es)
CL (1) CL2006001266A1 (es)
CR (1) CR9540A (es)
DK (1) DK1890996T3 (es)
EC (1) ECSP078055A (es)
ES (1) ES2415518T3 (es)
GT (1) GT200600227A (es)
IL (1) IL187359A (es)
MX (1) MX2007014735A (es)
NO (1) NO20076005L (es)
PE (1) PE20070024A1 (es)
PL (1) PL1890996T3 (es)
PT (1) PT1890996E (es)
RU (1) RU2478612C2 (es)
SI (1) SI1890996T1 (es)
SV (1) SV2008002542A (es)
TW (1) TWI421232B (es)
WO (1) WO2006128150A2 (es)
ZA (1) ZA200710151B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2007713A2 (en) * 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
ES2622356T3 (es) 2006-04-24 2017-07-06 Teva Pharmaceutical Industries, Ltd. Formas cristalinas de tigeciclina y procesos para su preparación
EP2086926A2 (en) 2006-11-29 2009-08-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
EP2084126A1 (en) * 2006-11-30 2009-08-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
PT103661B (pt) * 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
EP2114865A1 (en) * 2007-03-01 2009-11-11 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
AT13157U1 (de) * 2007-04-24 2013-07-15 Teva Pharma Tigecyclin, kristalline Formen und Herstellungsverfahren dafür
EP2178827A1 (en) 2007-06-21 2010-04-28 Sandoz AG Crystalline solid forms
WO2009062964A1 (en) * 2007-11-14 2009-05-22 Sandoz Ag Novel solvate
WO2009062963A1 (en) * 2007-11-14 2009-05-22 Sandoz Ag Crystalline forms of tigecycline hydrochloride
WO2009070799A1 (en) * 2007-11-29 2009-06-04 Teva Pharmaceutical Industries Ltd. Processes for preparation of crystalline tigecycline form ii
WO2009092680A2 (en) * 2008-01-23 2009-07-30 Sandoz Ag Antibiotic compounds
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202332671A (zh) * 2008-05-19 2023-08-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
CA2746585C (en) 2008-12-18 2017-08-29 Sandoz Ag Crystalline form c of tigecycline dihydrochloride and methods for its preparation
PT104350A (pt) 2009-01-23 2010-07-23 Hovione Farmaci Ncia S A Processo de isolamento de tigeciclina
CN102746183B (zh) * 2011-04-20 2014-12-17 胡梨芳 替加环素结晶水合物及其制备方法和用途
CN102295576A (zh) * 2011-06-29 2011-12-28 赵军旭 替加环素的晶型及其制备方法
CN102898325B (zh) * 2011-07-29 2015-07-08 江苏奥赛康药业股份有限公司 替加环素晶体及其制备方法
CN102924322B (zh) * 2012-11-05 2014-09-17 赵军旭 一种替加环素的新晶型及其制备方法
CN103833590A (zh) * 2012-11-26 2014-06-04 石药集团中奇制药技术（石家庄）有限公司 替加环素晶型及其制备方法
RU2764723C2 (ru) * 2016-06-22 2022-01-19 Кбп Байосайенсиз Ко., Лтд. Кристаллические формы 9-аминометил-замещенного соединения тетрациклина и способ их получения
CA3196954A1 (en) 2020-11-03 2022-05-12 Josep Bassaganya-Riera Crystalline forms of piperazine-1,4-diylbis((6-(1h-benzoi[d]imidazo-2-yl)pyridin-2yl)methanone) as lancl2 modulators
CN116917009A (zh) 2021-02-19 2023-10-20 美国迈胜医疗系统有限公司 用于粒子治疗系统的机架

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2168254T3 (es) 1991-10-04 2002-06-16 American Cyanamid Co Nuevas 7-sustituidas-9-(amino sustituido)-6-desmetil-6-desoxitetraciclinas.
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
NZ519984A (en) * 2000-01-07 2004-03-26 Transform Pharmaceuticals Inc High-throughput formation, identification, and analysis of diverse solid-forms
CN102512429A (zh) * 2005-03-14 2012-06-27 惠氏公司 替加环素组合物及制备方法
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina

Also Published As

Publication number Publication date
AR057649A1 (es) 2007-12-12
EP1890996A2 (en) 2008-02-27
NO20076005L (no) 2008-02-22
JP2008545717A (ja) 2008-12-18
PL1890996T3 (pl) 2013-08-30
WO2006128150A3 (en) 2007-03-08
SV2008002542A (es) 2008-02-22
ES2415518T3 (es) 2013-07-25
TWI421232B (zh) 2014-01-01
HK1113786A1 (en) 2008-10-17
CR9540A (es) 2008-02-21
RU2007143160A (ru) 2009-07-10
CN101248038B (zh) 2014-03-05
IL187359A0 (en) 2008-04-13
GT200600227A (es) 2007-01-12
IL187359A (en) 2013-04-30
AU2006251954A1 (en) 2006-11-30
EP1890996B1 (en) 2013-04-24
DK1890996T3 (da) 2013-05-13
TW200720232A (en) 2007-06-01
RU2478612C2 (ru) 2013-04-10
MX2007014735A (es) 2008-02-15
CA2609875A1 (en) 2006-11-30
BRPI0610653A2 (pt) 2010-07-13
CL2006001266A1 (es) 2008-05-16
CN101248038A (zh) 2008-08-20
PE20070024A1 (es) 2007-02-06
KR20080016890A (ko) 2008-02-22
US20070123497A1 (en) 2007-05-31
JP2013100354A (ja) 2013-05-23
CA2609875C (en) 2014-01-07
WO2006128150A2 (en) 2006-11-30
ZA200710151B (en) 2010-05-26
SI1890996T1 (sl) 2013-06-28
PT1890996E (pt) 2013-06-24
US8372995B2 (en) 2013-02-12

Similar Documents

Publication Publication Date Title
ECSP078055A (es) Formas sólidas cristalinas de tigeciclina y métodos para preparar las mismas
HN2006011218A (es) Composiciones de tigeciclina y métodos de preparación
DOP2010000351A (es) Activadores de glucoquinasa
MX2007007189A (es) Prodrogas de compuestos de 2,4-pirimidindiamina y sus usos.
CR9569A (es) Modificaciones cristalinas de la piraclostrobina
MX355428B (es) Formas cristalinas del acido [ (4-hidroxi-1-metil-7-fenoxi-isoquin olin-3-carbonil) -amino] -acetico inhibidor de prolil hidroxilasa.
CR9538A (es) Tigeciclina y metodos para preparar 9-aminominociclina
CR9541A (es) Tigeciclina y metodos de preparacion
HN2005029978A (es) Formulaciones
MX375111B (es) Fenil acetato de l-ornitina y métodos para elaborar el mismo.
AR061311A1 (es) Procesos para preparar clorhidrato de cinacalcet y formas polimorficas del mismo
UY32704A (es) Compuestos de 2,3-dihidro-1h-indeno
GT200600346A (es) Nueva fórmula cristalina v de la agomelatina, un proceso para su preparación y composiciones farmacéuticas que la contienen
CO6551754A2 (es) 7-[3.5-dihidroxi-2-(3-hidrixi-5-fenil-pent-1-enil)- ciclopentil] -n-etil-hept-5-enamida(bimatoprost) en forma cristalina ii, mètodos para la preparaciòn y mètodo para su uso
CU23757B7 (es) Bencilaminas, un proceso para su producción y su uso como agentes anti-inflamatorios
BRPI0606132A2 (pt) formas cristalinas de docetaxel e processos para seu preparo
ECSP088740A (es) Derivados de tetrahidronaftalina, procedimientos para prepararlos y su uso como antiinflamatorios
ECSP077306A (es) Derivados de alquiliden-tetrahidronaftaleno, procedimiento para su preparación y su uso como antiinflamatorios
NI200700175A (es) Procesos para la preparación de alcoholes de aminoetoxibencilo
UY29434A1 (es) Derivados de tetrahidronaftalina, procedimientos para su preparación y su uso como inhibidores de la inflamacinn
ECSP109874A (es) Nuevos compuestos 892
AR058253A1 (es) Procedimiento para la preparacion de ferri-succinilcaseina
UY29481A1 (es) Derivados de tetrahidronaftalina, procedimientos para su preparación y su uso como antiinflamatorios.
CR9988A (es) Procedimiento para la preparación del inhibidor del ciclo celular-779 cristalino y purificado
ECSP088340A (es) Procesos para la síntesis de los compuestos para inhibición de selectina