ECSP088413A - Preparación y uso de derivados de tetrahidropirrolo[3,2-c]piridin-4-ona para el tratamiento de la obesidad, trastornos psiquiátricos y neurológicos - Google Patents

Preparación y uso de derivados de tetrahidropirrolo[3,2-c]piridin-4-ona para el tratamiento de la obesidad, trastornos psiquiátricos y neurológicos

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Publication number
ECSP088413A
ECSP088413A EC2008008413A ECSP088413A ECSP088413A EC SP088413 A ECSP088413 A EC SP088413A EC 2008008413 A EC2008008413 A EC 2008008413A EC SP088413 A ECSP088413 A EC SP088413A EC SP088413 A ECSP088413 A EC SP088413A
Authority
EC
Ecuador
Prior art keywords
psychiatric
obesity
treatment
neurological disorders
tetrahydropirrolo
Prior art date
Application number
EC2008008413A
Other languages
English (en)
Inventor
Leifeng Cheng
Original Assignee
Astrazeneca Ab
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37781800&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088413(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP088413A publication Critical patent/ECSP088413A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

La presente invención se refiere a compuestos de 4, 5, 6, 7 -tetrahidropirrolo[3,2-c]piridin-4-ona y 4, 5-dihidropirrolo[3,2-c]piridin-4-ona de la fórmula (I) y a procesos para preparar dichos compuestos, a su uso en el tratamiento de la obesidad, trastornos psiquiátricos y neurológicos, a métodos para su uso terapéutico y a composiciones farmacéuticas que los contienen.
EC2008008413A 2005-10-06 2008-04-30 Preparación y uso de derivados de tetrahidropirrolo[3,2-c]piridin-4-ona para el tratamiento de la obesidad, trastornos psiquiátricos y neurológicos ECSP088413A (es)

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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR056560A1 (es) * 2005-10-06 2007-10-10 Astrazeneca Ab Pirrolopiridinonas como moduladores cb1
PL1973910T3 (pl) * 2006-01-27 2013-11-29 Shanghai hengrui pharmaceutical co ltd Pirolo[3,2-c]pirydyn-4-onowo-2-indolinonowe inhibitory kinazy białkowej
JP2010500300A (ja) 2006-08-08 2010-01-07 サノフィ−アベンティス アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
AR065909A1 (es) * 2007-04-03 2009-07-08 Astrazeneca Ab Agentes terapeuticos 685
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CN102015705B (zh) * 2008-02-26 2013-11-13 武田药品工业株式会社 稠合的杂环衍生物及其用途
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
SG178880A1 (en) 2009-08-26 2012-04-27 Sanofi Sa Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
KR101273643B1 (ko) * 2010-10-12 2013-06-11 한국화학연구원 5,6-디하이드로-피롤로［3,4-ｂ］피리딘-7-온 유도체 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 약학적 조성물
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US9560630B2 (en) * 2011-08-12 2017-01-31 Qualcomm Incorporated Devices for reduced overhead paging
JO3516B1 (ar) 2013-03-06 2020-07-05 Janssen Pharmaceutica Nv مُعدِّلات بنزإيميدازول-2-يل بيريميدين لمستقبل الهستامين h4
CN107406417B (zh) 2015-01-28 2020-06-09 拜耳制药股份公司 4H-吡咯并[3,2-c]吡啶-4-酮衍生物
WO2020074403A1 (en) * 2018-10-08 2020-04-16 Universität Zürich Appetite-modulating molecules
EP3921317B1 (en) 2019-02-07 2023-08-02 Bayer Aktiengesellschaft 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors
US20210015762A1 (en) * 2019-07-16 2021-01-21 TRUETIVA, Inc. Compositions for treating obesity
KR20210103688A (ko) 2020-02-14 2021-08-24 (주) 디엔테크 오링용 고무조성물
US20230365554A1 (en) 2020-07-29 2023-11-16 The Broad Institute, Inc. Substituted pyrrolo-pyridinone derivatives and therapeutic uses thereof
WO2022023339A1 (en) 2020-07-29 2022-02-03 Bayer Aktiengesellschaft Aryl substituted pyrrolo-pyridinones and therapeutic uses thereof
CN115108895A (zh) * 2022-07-06 2022-09-27 四川东材科技集团成都新材料有限公司 一种1-(1-乙氧基乙氧基)-4-乙烯基苯的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
FR2714057B1 (fr) * 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
FR2758723B1 (fr) * 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
US6858616B2 (en) * 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
PL208098B1 (pl) 2000-03-23 2011-03-31 Solvay Pharm Bv Pochodne 4,5-dihydro-1H-pirazolu, kompozycja farmaceutyczna, sposób wytwarzania związków oraz ich zastosowanie
EP1432708B1 (en) * 2001-09-24 2005-11-30 Bayer Pharmaceuticals Corporation Preparation and use of 1,5,6,7-tetrahydropyrrolo 3,2-c]pyridine derivatives for treatment of obesity
US20090149463A1 (en) 2004-02-20 2009-06-11 Leifeng Cheng Therapeutic agents
GB0403780D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Therapeutic agents
JP4177435B2 (ja) 2004-04-03 2008-11-05 アストラゼネカ アクチボラグ 治療薬
AR056560A1 (es) * 2005-10-06 2007-10-10 Astrazeneca Ab Pirrolopiridinonas como moduladores cb1

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RU2415856C2 (ru) 2011-04-10
UY29838A1 (es) 2007-05-31
ZA200802946B (en) 2009-03-25
US7576095B2 (en) 2009-08-18
JP4277062B2 (ja) 2009-06-10
WO2007039740A3 (en) 2007-05-31
JP2009504722A (ja) 2009-02-05
EP1937679A2 (en) 2008-07-02
AU2006298530B2 (en) 2009-10-29
HK1122808A1 (en) 2009-05-29
ATE440099T1 (de) 2009-09-15
IL190025A0 (en) 2008-08-07
AU2006298530A1 (en) 2007-04-12
WO2007039740A2 (en) 2007-04-12
EP1937679B1 (en) 2009-08-19
US7875626B2 (en) 2011-01-25
US20080312269A1 (en) 2008-12-18
RU2008109185A (ru) 2009-11-20
US20080009513A1 (en) 2008-01-10
CA2624495A1 (en) 2007-04-12
CN101277957A (zh) 2008-10-01
NO20081523L (no) 2008-07-02
TW200730525A (en) 2007-08-16
DE602006008641D1 (de) 2009-10-01
KR20080058456A (ko) 2008-06-25
BRPI0616653A2 (pt) 2011-06-28
ES2329616T3 (es) 2009-11-27

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