ECSP094948A - Combinaciones que comprenden epotilonas y sus usos farmaceuticos - Google Patents

Combinaciones que comprenden epotilonas y sus usos farmaceuticos

Info

Publication number
ECSP094948A
ECSP094948A EC2009004948A ECSP094948A ECSP094948A EC SP094948 A ECSP094948 A EC SP094948A EC 2009004948 A EC2009004948 A EC 2009004948A EC SP094948 A ECSP094948 A EC SP094948A EC SP094948 A ECSP094948 A EC SP094948A
Authority
EC
Ecuador
Prior art keywords
treatment
combination
progression
delay
hydrogen
Prior art date
Application number
EC2009004948A
Other languages
English (en)
Inventor
Jeannette Marjorie Wood
John David Rothermel
Markus Wartmann
Tianling Chen
Diane Greeley
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP094948A publication Critical patent/ECSP094948A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a una combinación que comprende (a) un bisfosfonato, un compuesto de platino o un compuesto vasculoestático, y (b) un derivado de epotilona de la fórmula I, en donde A representa O u NRN, en donde RN es hidrógeno o alquilo inferior, R es hidrógeno o alquilo inferior, y Z es O, o un enlace, en donde los ingredientes activos (a) y (b) están presentes en cada caso en forma libre o en la forma de una sal farmacéuticamente aceptable y opcionalmente por lo menos un vehículo farmacéuticamente aceptable para el uso simultáneo, separado o secuencial, en particular para el retraso de la progresión o para el tratamiento de una enfermedad proliferativa, especialmente una enfermedad de tumor sólido; una composición farmacéutica, un paquete comercial o un producto que comprende dicha combinación; el uso de dicha combinación para la preparación de un medicamento para el retraso de la progresión o para el tratamiento de una enfermedad proliferativa y a un método para el tratamiento de un animal de sangre caliente.
EC2009004948A 2001-07-19 2009-11-19 Combinaciones que comprenden epotilonas y sus usos farmaceuticos ECSP094948A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30656001P 2001-07-19 2001-07-19
US30655901P 2001-07-19 2001-07-19
US30657101P 2001-07-19 2001-07-19

Publications (1)

Publication Number Publication Date
ECSP094948A true ECSP094948A (es) 2009-12-28

Family

ID=27405180

Family Applications (2)

Application Number Title Priority Date Filing Date
EC2008004948A ECSP084948A (es) 2001-07-19 2008-07-04 Combinaciones que comprenden epotilonas y sus usos farmaceuticos
EC2009004948A ECSP094948A (es) 2001-07-19 2009-11-19 Combinaciones que comprenden epotilonas y sus usos farmaceuticos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EC2008004948A ECSP084948A (es) 2001-07-19 2008-07-04 Combinaciones que comprenden epotilonas y sus usos farmaceuticos

Country Status (19)

Country Link
US (3) US20040235796A1 (es)
EP (2) EP2210643A3 (es)
JP (2) JP2005501825A (es)
KR (2) KR20090040925A (es)
CN (2) CN101791308A (es)
AU (2) AU2002328921B2 (es)
BR (1) BR0211271A (es)
CA (1) CA2453108A1 (es)
CO (1) CO5560565A2 (es)
EC (2) ECSP084948A (es)
HU (1) HUP0401153A3 (es)
IL (2) IL159517A0 (es)
MX (1) MXPA04000567A (es)
NO (1) NO20040214L (es)
NZ (2) NZ530572A (es)
PL (1) PL365030A1 (es)
RU (1) RU2375058C2 (es)
TW (1) TWI315982B (es)
WO (1) WO2003007924A2 (es)

Families Citing this family (15)

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US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
CA2273083C (en) 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
HRP20030831B1 (en) 2001-03-14 2012-08-31 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
TWI315982B (en) * 2001-07-19 2009-10-21 Novartis Ag Combinations comprising epothilones and pharmaceutical uses thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
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BRPI0416680A (pt) 2003-11-18 2007-02-13 Novartis Ag inibidores da forma mutante de kit
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US20060121511A1 (en) 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
PT1879585E (pt) 2005-05-02 2013-07-23 Novartis Ag Utilização de derivados de pirimidilaminobenzamida para o tratamento de mastocitose sistémica
CN100384419C (zh) * 2005-12-02 2008-04-30 菏泽睿鹰制药集团有限公司 一种埃坡霉素缓释植入组合物及应用
MX2012013100A (es) 2010-05-18 2013-01-22 Cerulean Pharma Inc Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades.
RU2478407C1 (ru) * 2011-09-05 2013-04-10 Федеральное государственное бюджетное учреждение Министерства здравоохранения и социального развития Российской Федерации "Медицинский радиологический научный центр" (ФГБУ МРНЦ Минздравсоцразвития России) Способ комбинированного лечения местно-распространенного рака желудка

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Also Published As

Publication number Publication date
CN101791308A (zh) 2010-08-04
KR20040030808A (ko) 2004-04-09
EP2210643A3 (en) 2010-11-24
CO5560565A2 (es) 2005-09-30
PL365030A1 (en) 2004-12-27
NZ530572A (en) 2006-11-30
JP2010159271A (ja) 2010-07-22
AU2005246964A1 (en) 2006-01-12
KR20090040925A (ko) 2009-04-27
BR0211271A (pt) 2004-08-03
IL159517A (en) 2012-04-30
US8008330B2 (en) 2011-08-30
CA2453108A1 (en) 2003-01-30
NO20040214L (no) 2004-03-18
NZ550174A (en) 2008-04-30
CN1283248C (zh) 2006-11-08
AU2005246964B2 (en) 2008-04-24
MXPA04000567A (es) 2004-04-20
HUP0401153A3 (en) 2008-01-28
US7612052B2 (en) 2009-11-03
US20040235796A1 (en) 2004-11-25
RU2004105144A (ru) 2005-04-20
IL159517A0 (en) 2004-06-01
ECSP084948A (es) 2008-08-29
WO2003007924A2 (en) 2003-01-30
JP2005501825A (ja) 2005-01-20
CN1533293A (zh) 2004-09-29
TWI315982B (en) 2009-10-21
WO2003007924A3 (en) 2003-09-25
RU2375058C2 (ru) 2009-12-10
AU2002328921B2 (en) 2006-11-02
EP1412029A2 (en) 2004-04-28
US20080119529A1 (en) 2008-05-22
HUP0401153A2 (hu) 2004-10-28
US20090318390A1 (en) 2009-12-24
EP2210643A2 (en) 2010-07-28

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