ECSP10010439A - Antagonistas n,n-disustituidos de aminoalquilbifenilo de receptores d2 de prostaglandina - Google Patents

Antagonistas n,n-disustituidos de aminoalquilbifenilo de receptores d2 de prostaglandina

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Publication number
ECSP10010439A
ECSP10010439A EC2010010439A ECSP10010439A ECSP10010439A EC SP10010439 A ECSP10010439 A EC SP10010439A EC 2010010439 A EC2010010439 A EC 2010010439A EC SP10010439 A ECSP10010439 A EC SP10010439A EC SP10010439 A ECSP10010439 A EC SP10010439A
Authority
EC
Ecuador
Prior art keywords
antagonists
receptors
bifenyl
prostaglandine
disabled
Prior art date
Application number
EC2010010439A
Other languages
English (en)
Inventor
John H Hutchinson
Brian Andrew Stearns
Jill Melissa Scott
Yen Pham Truong
Jeffrey Roger Roppe
Nicholas Simon Stock
Jeannie M Arruda
Thomas Jon Seiders
Bowei Wang
Deborah Volkots
Original Assignee
Amira Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amira Pharmaceuticals Inc filed Critical Amira Pharmaceuticals Inc
Publication of ECSP10010439A publication Critical patent/ECSP10010439A/es

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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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Abstract

Se describen aquí compuestos que son antagonistas de receptores PGD2. También se describe composiciones farmacéuticas y medicamentos que incluyen los compuestos aquí descritos que son antagonistas de receptores PGD2. También se describe aquí métodos para utilizar tales antagonistas de receptores PGD2, solos y en combinaciones con otros compuestos, para tratar condiciones o enfermedades respiratorias, cardiovasculares y otras dependientes de PGD2 o mediadas por PGD2.
EC2010010439A 2008-02-01 2010-09-01 Antagonistas n,n-disustituidos de aminoalquilbifenilo de receptores d2 de prostaglandina ECSP10010439A (es)

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US20120058123A1 (en) 2012-03-08
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US8067445B2 (en) 2011-11-29
IL207130A (en) 2014-07-31
KR20100125268A (ko) 2010-11-30
US20130158036A1 (en) 2013-06-20
US20090197959A1 (en) 2009-08-06
NZ587709A (en) 2012-06-29
EP2257524B1 (en) 2016-01-06
HK1149928A1 (en) 2011-10-21
CR11621A (es) 2010-10-11
IL207130A0 (en) 2010-12-30
CN101952244B (zh) 2014-11-05
JP2011511781A (ja) 2011-04-14
AU2009210446B2 (en) 2012-07-26
WO2009099902A1 (en) 2009-08-13
US20120059055A1 (en) 2012-03-08
US8338484B2 (en) 2012-12-25
TWI432402B (zh) 2014-04-01
AU2009210446C1 (en) 2013-01-10
EP2257524A4 (en) 2011-08-17
ES2566739T3 (es) 2016-04-15
CA2713139C (en) 2013-04-23
TW200951104A (en) 2009-12-16
US8362044B2 (en) 2013-01-29
EA018901B1 (ru) 2013-11-29
EP2257524A1 (en) 2010-12-08
MX2010008260A (es) 2010-12-20
AU2009210446A1 (en) 2009-08-13
CA2713139A1 (en) 2009-08-13
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US8168678B2 (en) 2012-05-01
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