ECSP13012824A - Derivados de (1,2,4)triazolo[4,3-a)quinoxalina como inhibidores de fosfodiesterasas - Google Patents

Derivados de (1,2,4)triazolo[4,3-a)quinoxalina como inhibidores de fosfodiesterasas

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Publication number
ECSP13012824A
ECSP13012824A EC2013012824A ECSP13012824A ECSP13012824A EC SP13012824 A ECSP13012824 A EC SP13012824A EC 2013012824 A EC2013012824 A EC 2013012824A EC SP13012824 A ECSP13012824 A EC SP13012824A EC SP13012824 A ECSP13012824 A EC SP13012824A
Authority
EC
Ecuador
Prior art keywords
triazolo
quinoxaline
inhibitors
derivatives
phosphodesterase
Prior art date
Application number
EC2013012824A
Other languages
English (en)
Inventor
Hans-Joachim Lankau
Barbara Langen
Christian Grunwald
Norbert Höfgen
Hans Stange
Rita Dost
Ute Egerland
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ECSP13012824A publication Critical patent/ECSP13012824A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Obesity (AREA)
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  • Hematology (AREA)
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  • Anesthesiology (AREA)
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  • Vascular Medicine (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

La invención se refiere a derivados de (1,2,4)triazolo[4,3-a)quinoxalina que son inhibidores de fosfodiesterasa 2 y/o 10, útiles en el tratamiento de enfermedades del sistema nervioso central.
EC2013012824A 2011-01-31 2013-08-13 Derivados de (1,2,4)triazolo[4,3-a)quinoxalina como inhibidores de fosfodiesterasas ECSP13012824A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161437848P 2011-01-31 2011-01-31

Publications (1)

Publication Number Publication Date
ECSP13012824A true ECSP13012824A (es) 2013-10-31

Family

ID=45833359

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2013012824A ECSP13012824A (es) 2011-01-31 2013-08-13 Derivados de (1,2,4)triazolo[4,3-a)quinoxalina como inhibidores de fosfodiesterasas

Country Status (25)

Country Link
US (1) US9540379B2 (es)
EP (1) EP2670754B1 (es)
JP (1) JP6027547B2 (es)
KR (1) KR20140019342A (es)
CN (1) CN103459395A (es)
AR (1) AR085099A1 (es)
AU (1) AU2012213471B2 (es)
BR (1) BR112013019354A2 (es)
CA (1) CA2824929A1 (es)
CL (1) CL2013002003A1 (es)
CO (1) CO6811848A2 (es)
EA (1) EA023792B1 (es)
EC (1) ECSP13012824A (es)
GE (1) GEP20156333B (es)
IL (1) IL226826A (es)
MA (1) MA34844B1 (es)
MX (1) MX2013008667A (es)
PE (1) PE20141023A1 (es)
PH (1) PH12013501355A1 (es)
SG (1) SG192210A1 (es)
TN (1) TN2013000325A1 (es)
TW (1) TWI535718B (es)
UA (1) UA111963C2 (es)
UY (1) UY33888A (es)
WO (1) WO2012104293A1 (es)

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WO2013034761A1 (en) 2011-09-09 2013-03-14 H. Lundbeck A/S Pyridine compounds and uses thereof
WO2013034758A1 (en) 2011-09-09 2013-03-14 H. Lundbeck A/S Substituted triazolopyrazines and uses thereof
AU2013283426B2 (en) 2012-06-26 2018-02-22 Janssen Pharmaceutica Nv Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological or metabolic disorders
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Publication number Publication date
CN103459395A (zh) 2013-12-18
KR20140019342A (ko) 2014-02-14
US20120302564A1 (en) 2012-11-29
JP2014503576A (ja) 2014-02-13
AU2012213471A1 (en) 2013-07-04
AU2012213471B2 (en) 2016-07-14
MA34844B1 (fr) 2014-01-02
PE20141023A1 (es) 2014-09-04
GEP20156333B (en) 2015-07-27
CL2013002003A1 (es) 2013-12-06
TWI535718B (zh) 2016-06-01
TN2013000325A1 (en) 2015-01-20
UA111963C2 (uk) 2016-07-11
JP6027547B2 (ja) 2016-11-16
CO6811848A2 (es) 2013-12-16
BR112013019354A2 (pt) 2019-09-24
PH12013501355A1 (en) 2013-09-02
SG192210A1 (en) 2013-09-30
NZ611630A (en) 2015-03-27
EA201300871A1 (ru) 2014-01-30
EP2670754A1 (en) 2013-12-11
TW201245198A (en) 2012-11-16
UY33888A (es) 2012-08-31
US9540379B2 (en) 2017-01-10
AR085099A1 (es) 2013-09-11
EP2670754B1 (en) 2017-05-24
MX2013008667A (es) 2013-10-01
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