MA34844B1 - Derives de (1,2,4) triazolo[4,3-a]quinoxaline comme inhibiteurs de phosphodiestérases - Google Patents

Derives de (1,2,4) triazolo[4,3-a]quinoxaline comme inhibiteurs de phosphodiestérases

Info

Publication number
MA34844B1
MA34844B1 MA36142A MA36142A MA34844B1 MA 34844 B1 MA34844 B1 MA 34844B1 MA 36142 A MA36142 A MA 36142A MA 36142 A MA36142 A MA 36142A MA 34844 B1 MA34844 B1 MA 34844B1
Authority
MA
Morocco
Prior art keywords
triazolo
inhibitors
phosphodiesterases
quinoxaline derivatives
quinoxaline
Prior art date
Application number
MA36142A
Other languages
English (en)
Inventor
Christian Grunwald
Norbert Hoefgen
Hans Stange
Rita Dost
Ute Egerland
Hans-Joachim Lankau
Barbara Langen
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA34844B1 publication Critical patent/MA34844B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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Abstract

L'invention concerne des dérivés de (1,2,4)triazolo[4,3-a]quinoxaline représentés par la formule (I) qui sont des inhibiteurs de la phosphodiestérase 2 et/ou 10, utilisés pour traiter les maladies du système nerveux central.
MA36142A 2011-01-31 2012-01-31 Derives de (1,2,4) triazolo[4,3-a]quinoxaline comme inhibiteurs de phosphodiestérases MA34844B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161437848P 2011-01-31 2011-01-31
PCT/EP2012/051546 WO2012104293A1 (fr) 2011-01-31 2012-01-31 Dérivés de (1,2,4)triazolo[4,3-a]quinoxaline utilisés comme inhibiteurs des phosphodiestérases

Publications (1)

Publication Number Publication Date
MA34844B1 true MA34844B1 (fr) 2014-01-02

Family

ID=45833359

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36142A MA34844B1 (fr) 2011-01-31 2012-01-31 Derives de (1,2,4) triazolo[4,3-a]quinoxaline comme inhibiteurs de phosphodiestérases

Country Status (25)

Country Link
US (1) US9540379B2 (fr)
EP (1) EP2670754B1 (fr)
JP (1) JP6027547B2 (fr)
KR (1) KR20140019342A (fr)
CN (1) CN103459395A (fr)
AR (1) AR085099A1 (fr)
AU (1) AU2012213471B2 (fr)
BR (1) BR112013019354A2 (fr)
CA (1) CA2824929A1 (fr)
CL (1) CL2013002003A1 (fr)
CO (1) CO6811848A2 (fr)
EA (1) EA023792B1 (fr)
EC (1) ECSP13012824A (fr)
GE (1) GEP20156333B (fr)
IL (1) IL226826A (fr)
MA (1) MA34844B1 (fr)
MX (1) MX2013008667A (fr)
PE (1) PE20141023A1 (fr)
PH (1) PH12013501355A1 (fr)
SG (1) SG192210A1 (fr)
TN (1) TN2013000325A1 (fr)
TW (1) TWI535718B (fr)
UA (1) UA111963C2 (fr)
UY (1) UY33888A (fr)
WO (1) WO2012104293A1 (fr)

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JP6115962B2 (ja) 2011-06-27 2017-04-19 ヤンセン ファーマシューティカ エヌ．ベー． １−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体
US9056863B2 (en) 2011-09-09 2015-06-16 H. Lundbeck A/S Substituted 2,3,5,9,9B-pentaazacyclopenta[a]naphthalenes and uses thereof
WO2013034758A1 (fr) 2011-09-09 2013-03-14 H. Lundbeck A/S Triazolopyrazines substituées et leurs utilisations
WO2014001314A1 (fr) 2012-06-26 2014-01-03 Janssen Pharmaceutica Nv Combinaisons comprenant des inhibiteurs de la pde 2 tels que des composés 1-aryl-4-méthyl-[1, 2, 4] triazolo [4, 3-a]-quinoxaline et des inhibiteurs de la pde 10 pour utilisation dans le traitement de troubles neurologiques ou métaboliques
US20140045856A1 (en) 2012-07-31 2014-02-13 Boehringer Ingelheim International Gmbh 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes

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PH12013501355A1 (en) 2013-09-02
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