ECSP13012928A - Derivados de fluoro-piridinona útiles como agentes antibacterianos - Google Patents

Derivados de fluoro-piridinona útiles como agentes antibacterianos

Info

Publication number
ECSP13012928A
ECSP13012928A ECSP13012928A ECSP13012928A EC SP13012928 A ECSP13012928 A EC SP13012928A EC SP13012928 A ECSP13012928 A EC SP13012928A EC SP13012928 A ECSP13012928 A EC SP13012928A
Authority
EC
Ecuador
Prior art keywords
derivatives
piridinone
antibacterial agents
fluoro
useful
Prior art date
Application number
Other languages
English (en)
Inventor
Matthew Frank Brown
Mark Stephen Plummer
Usa Reilly
Ye Che
Justin Ian Montgomery
Loren Michael Price
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP13012928A publication Critical patent/ECSP13012928A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a una nueva clase de derivados de ácido hidroxámico, su uso como inhibidores de LpxC y, más específicamente, a su uso para tratar infecciones bacterianas.
ECSP13012928 2011-03-07 2013-10-07 Derivados de fluoro-piridinona útiles como agentes antibacterianos ECSP13012928A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161449825P 2011-03-07 2011-03-07

Publications (1)

Publication Number Publication Date
ECSP13012928A true ECSP13012928A (es) 2013-11-29

Family

ID=45841548

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012928 ECSP13012928A (es) 2011-03-07 2013-10-07 Derivados de fluoro-piridinona útiles como agentes antibacterianos

Country Status (34)

Country Link
US (2) US8624034B2 (es)
EP (1) EP2683689B1 (es)
JP (1) JP5620020B2 (es)
KR (1) KR101593288B1 (es)
CN (2) CN104529883A (es)
AP (1) AP3336A (es)
AR (1) AR085615A1 (es)
AU (1) AU2012226473B8 (es)
BR (1) BR112013022536B1 (es)
CA (1) CA2828337C (es)
CL (1) CL2013002417A1 (es)
CO (1) CO6761338A2 (es)
CR (1) CR20130403A (es)
CU (1) CU20130117A7 (es)
DO (1) DOP2013000200A (es)
EA (1) EA024782B1 (es)
EC (1) ECSP13012928A (es)
ES (1) ES2626457T3 (es)
GE (1) GEP20156370B (es)
GT (1) GT201300213A (es)
HK (1) HK1209734A1 (es)
IL (1) IL228100A0 (es)
MA (1) MA34963B1 (es)
MX (1) MX341977B (es)
NI (1) NI201300077A (es)
PE (1) PE20140397A1 (es)
PH (1) PH12013501780A1 (es)
SG (1) SG192766A1 (es)
TN (1) TN2013000353A1 (es)
TW (1) TWI453197B (es)
UA (1) UA107423C2 (es)
UY (1) UY33936A (es)
WO (1) WO2012120397A1 (es)
ZA (1) ZA201306515B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8722686B2 (en) 2008-09-19 2014-05-13 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
JP5793766B2 (ja) 2009-12-16 2015-10-14 ファイザー・インク 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体
AP3336A (en) 2011-03-07 2015-07-31 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
WO2012137099A1 (en) * 2011-04-08 2012-10-11 Pfizer Inc. Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
WO2012137094A1 (en) 2011-04-08 2012-10-11 Pfizer Inc. Isoxazole derivatives useful as antibacterial agents
AR097617A1 (es) * 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
WO2015085238A1 (en) * 2013-12-05 2015-06-11 The Regents Of The University Of California, A California Corporation Inhibitors of lpxc
KR20160098503A (ko) * 2013-12-19 2016-08-18 액테리온 파마슈티칼 리미티드 항균성 1h-인다졸 및 1h-인돌 유도체
AR099612A1 (es) * 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
CN106573924B (zh) 2014-04-22 2019-06-25 诺华股份有限公司 作为LpxC抑制剂的异噁唑啉异羟肟酸衍生物
WO2015173329A1 (en) * 2014-05-16 2015-11-19 Actelion Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
TN2016000542A1 (en) 2014-06-03 2018-04-04 Idorsia Pharmaceuticals Ltd Pyrazole compounds and their use as t-type calcium channel blockers
BR112017010474A2 (pt) 2014-11-19 2017-12-26 Actelion Pharmaceuticals Ltd derivados antibacterianos de benzotiazol
HUE047225T2 (hu) 2014-12-16 2020-04-28 Novartis Ag LpxC inhibitor izoxazol hidroxámsav-vegyületek
CN104876883B (zh) * 2015-06-05 2017-11-28 安徽联创生物医药股份有限公司 抗失眠药物苏沃雷生中间体的合成方法
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
SMT202000524T1 (it) 2016-06-14 2020-11-10 Novartis Ag Forma cristallina di (r)-4-(5-(ciclopropiletinil)isossazol-3-il)-n-idrossi-2-metil-2-(metilsolfonil)butanammide come agente antibatterico
HRP20220463T1 (hr) 2016-12-16 2022-05-27 Idorsia Pharmaceuticals Ltd Farmaceutska kombinacija koja sadrži blokator kalcijevih kanala t-tipa
WO2018141961A1 (en) 2017-02-06 2018-08-09 Idorsia Pharmaceuticals Ltd A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes
CN111867600A (zh) * 2018-03-15 2020-10-30 辉瑞大药厂 用作抗菌剂的吡啶酮和嘧啶酮磷酸盐和硼酸盐
US11981696B2 (en) 2018-03-15 2024-05-14 Pfizer Inc. Fluoro-pyridinone phosphates and boronates useful as antibacterial agents
CN110699312B (zh) * 2019-11-28 2022-08-12 西北农林科技大学 一种猪种布鲁氏菌bi-1基因缺失菌株及其构建方法和应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769461A (en) 1986-09-16 1988-09-06 American Home Products Corporation Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents
US5110831A (en) 1990-11-30 1992-05-05 Du Pont Merck Pharmaceutical Company Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors
PL194240B1 (pl) 1998-02-07 2007-05-31 British Biotech Pharm Zastosowanie pochodnych N-formylohydroksyloaminy i amidowa pochodna N-formylohydroksyloaminy
GB9925470D0 (en) 1999-10-27 1999-12-29 Smithkline Beecham Plc Novel compounds
WO2002074298A1 (en) 2001-03-21 2002-09-26 Ono Pharmaceutical Co., Ltd. Il-6 production inhibitors
ES2180456B1 (es) 2001-07-20 2004-05-01 Laboratorios S.A.L.V.A.T., S.A. Isoxazoles sustituidos y su utilizacion como antibioticos.
AP1822A (en) * 2002-02-14 2008-01-30 Pharmacia Corp Substituted pyridinones as modulators of P38 MAP kinase.
ES2387803T3 (es) 2003-01-08 2012-10-02 Novartis Vaccines And Diagnostics, Inc. Agentes antibacterianos
GB0302431D0 (en) 2003-01-30 2003-03-05 Glaxo Group Ltd Novel compounds
EP1828145A4 (en) 2004-12-10 2009-08-19 Univ Emory 2'- AND 3'-SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGUE FOR THE TREATMENT OF VIRAL INFECTIONS AND ANORMAL CELL PROLIFERATION
WO2006118155A1 (ja) 2005-04-27 2006-11-09 Ishihara Sangyo Kaisha, Ltd. ビフェニル誘導体又はその塩、並びにそれらを有効成分として含有する農園芸用殺菌剤
WO2006124897A2 (en) 2005-05-13 2006-11-23 Lexicon Genetics Incorporated Methods and compositions for improving cognition
JP2009520695A (ja) * 2005-12-15 2009-05-28 ヴィキュロン ファーマシューティカルズ インコーポレイテッド 抗菌活性を有するｎ−ヒドロキシアミド誘導体
WO2008045671A1 (en) 2006-10-06 2008-04-17 Janssen Pharmaceutica, N.V. Matrix metalloprotease inhibitors
US7879911B2 (en) 2007-02-01 2011-02-01 Johnson Alan T Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning
WO2008105515A1 (ja) 2007-02-28 2008-09-04 Taisho Pharmaceutical Co., Ltd. 新規なヒドロキサム酸誘導体
WO2008115262A2 (en) 2007-03-20 2008-09-25 Curis, Inc. Hsp90 inhibitors containing a zinc binding moiety
CN101239978A (zh) * 2008-03-05 2008-08-13 南方医科大学 一种咪唑并吡啶类化合物
WO2010017060A1 (en) * 2008-08-04 2010-02-11 Schering Corporation Urea derivatives as antibacterial agents
WO2010024356A1 (ja) 2008-08-27 2010-03-04 大正製薬株式会社 ナフチリジン－ｎ－オキシドを有する新規ヒドロキサム酸誘導体
US8372885B2 (en) 2008-09-17 2013-02-12 Novartis Ag Organic compounds and their uses
US8722686B2 (en) 2008-09-19 2014-05-13 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
WO2010100475A1 (en) 2009-03-02 2010-09-10 Astrazeneca Ab Hydroxamic acid derivatives as gram-negative antibacterial agents
WO2010147969A2 (en) * 2009-06-16 2010-12-23 Schering Corporation Gamma secretase modulators
US20120245158A1 (en) * 2009-06-16 2012-09-27 Xianhai Huang Gamma secretase modulators
JP5793766B2 (ja) 2009-12-16 2015-10-14 ファイザー・インク 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体
AP3336A (en) 2011-03-07 2015-07-31 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
WO2012137099A1 (en) 2011-04-08 2012-10-11 Pfizer Inc. Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
WO2012137094A1 (en) 2011-04-08 2012-10-11 Pfizer Inc. Isoxazole derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
CR20130403A (es) 2013-09-18
AU2012226473B8 (en) 2015-10-15
MX341977B (es) 2016-09-07
EA201391072A1 (ru) 2014-02-28
SG192766A1 (en) 2013-09-30
CN103443079A (zh) 2013-12-11
AU2012226473A1 (en) 2013-09-05
TWI453197B (zh) 2014-09-21
ES2626457T3 (es) 2017-07-25
JP2014507464A (ja) 2014-03-27
MX2013010276A (es) 2013-10-01
TN2013000353A1 (fr) 2015-01-20
PH12013501780A1 (en) 2019-07-03
ZA201306515B (en) 2014-05-28
TW201249798A (en) 2012-12-16
CO6761338A2 (es) 2013-09-30
CA2828337C (en) 2016-05-03
EP2683689B1 (en) 2017-04-12
GT201300213A (es) 2014-06-06
KR101593288B1 (ko) 2016-02-11
AR085615A1 (es) 2013-10-16
HK1209734A1 (en) 2016-04-08
AU2012226473B2 (en) 2015-06-11
IL228100A0 (en) 2013-09-30
CL2013002417A1 (es) 2013-12-13
EP2683689A1 (en) 2014-01-15
US8779148B2 (en) 2014-07-15
AP3336A (en) 2015-07-31
UA107423C2 (en) 2014-12-25
JP5620020B2 (ja) 2014-11-05
DOP2013000200A (es) 2014-06-15
CN103443079B (zh) 2015-06-03
US8624034B2 (en) 2014-01-07
AP2013007074A0 (en) 2013-08-31
KR20130131459A (ko) 2013-12-03
NZ614205A (en) 2014-06-27
WO2012120397A1 (en) 2012-09-13
US20120232083A1 (en) 2012-09-13
HK1191951A1 (en) 2014-08-08
CA2828337A1 (en) 2012-09-13
GEP20156370B (en) 2015-09-25
NI201300077A (es) 2014-01-07
UY33936A (es) 2012-10-31
PE20140397A1 (es) 2014-03-28
CN104529883A (zh) 2015-04-22
EA024782B1 (ru) 2016-10-31
US20140057919A1 (en) 2014-02-27
BR112013022536B1 (pt) 2020-05-26
CU20130117A7 (es) 2013-10-29
BR112013022536A2 (pt) 2016-11-29
MA34963B1 (fr) 2014-03-01

Similar Documents

Publication Publication Date Title
NI201300077A (es) Derivados de fluoro-piridinona útiles como agentes antibacterianos.
UY33754A (es) Monobactamas
CR20140231A (es) Derivados de ácido benzotiazol-6-il acético y su uso para tratar una infección por vih
CU20160006A7 (es) Derivados de piperidinil-indol como inhibidores de factor de complemento b
MX2013011526A (es) Derivados de isoxazol utiles como agentes antibacteriales .
CL2012003385A1 (es) Tratamiento para la incontinencia.
UY34414A (es) Composiciones hemostáticas
WO2011045703A3 (en) C-linked hydroxamic acid derivatives useful as antibacterial agents
UY33943A (es) Derivados espirocíclicos de isoxazolina como agentes antiparasitarios.
UY34472A (es) Derivados modificados de 4-fenil-piridina
UY34541A (es) ?derivados de dihidro-benzo-oxazina y dihidro-pirido-oxazina?.
UY34051A (es) Derivados de pirrolotriazinona como inhibidores de pi3k
UY33925A (es) Inhibidores tricíclicos de quinasas
MX391043B (es) Formulaciones de anticuerpo y metodos.
CO7091177A2 (es) Inhibidores de la beta-secretasa
DOP2014000033A (es) Aminoquinazolinas como inhibidores de quinasa
CL2014000470A1 (es) Compuestos derivados del acido 2-oxo-piridin-3-carboxilico; composicion farmaceutica; combinacion; y su uso para tratar o mejorar una infeccion bacteriana.
TN2015000519A1 (en) Small molecule inhibitors of fibrosis
UY34415A (es) Composiciones hemostáticas
CY1117163T1 (el) Ιμιδαζοπυριδαζινες ως αναστολεις κινασης ακτ
CR20150447A (es) Nuevos derivados de pirazol
UY35274A (es) Compuestos y métodos para tratar infecciones bacterianas
BR112014003027A2 (pt) formulação herbicida melhorada
EA201690894A1 (ru) Феноксиэтилы
CL2014003059A1 (es) Uso de seaprose para eliminar biopelículas bacterianas; composicion de seaprose.