ECSP13013002A - Nuevos inmunoconjugados - Google Patents

Nuevos inmunoconjugados

Info

Publication number
ECSP13013002A
ECSP13013002A ECSP13013002A ECSP13013002A EC SP13013002 A ECSP13013002 A EC SP13013002A EC SP13013002 A ECSP13013002 A EC SP13013002A EC SP13013002 A ECSP13013002 A EC SP13013002A
Authority
EC
Ecuador
Prior art keywords
immunoconjugates
immunocate
players
new
antigen
Prior art date
Application number
Other languages
English (en)
Inventor
Christian Klein
Ekkehard Moessner
Pablo Umana
Ralf Hosse
Thomas Hofer
Oliver Ast
Peter Bruenker
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46022216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP13013002(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of ECSP13013002A publication Critical patent/ECSP13013002A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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Abstract

La presente invención en general está relacionada con inmunoconjugados específicos de antígeno para la liberación selectiva de porciones efectoras que influyen en la actividad celular. Más específicamente, la invención proporciona nuevos inmunoconjugados que comprenden una primera porción de unión a antígeno, un dominio Fc y una única porción efectora. Además, la presente invención está relacionada con los polinucleótidos que codifican tales inmunoconjugados, y con los vectores y células huésped que comprenden tales polinucleótidos. La invención además está relacionada con los métodos para producir los inmunoconjugados de la invención, y con los métodos de utilización de estos inmunoconjugados en el tratamiento de una enfermedad.
ECSP13013002 2011-04-29 2013-10-28 Nuevos inmunoconjugados ECSP13013002A (es)

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