ECSP13013076A - Novedosos derivados de ftalazinona-pirrolopirimidinacarboxamida - Google Patents

Novedosos derivados de ftalazinona-pirrolopirimidinacarboxamida

Info

Publication number
ECSP13013076A
ECSP13013076A ECSP13013076A ECSP13013076A EC SP13013076 A ECSP13013076 A EC SP13013076A EC SP13013076 A ECSP13013076 A EC SP13013076A EC SP13013076 A ECSP13013076 A EC SP13013076A
Authority
EC
Ecuador
Prior art keywords
pirrolopirimidinacarboxamida
ftalazinona
news
derived
compounds
Prior art date
Application number
Other languages
English (en)
Inventor
Torsten Dunkern
Armin Hatzelmann
Josef Stadlwieser
Rolf-Peter Hummel
Christof Zitt
Dieter Flockerzi
Hermann Tenor
Ewald Benediktus
Andreas Pahl
Ragna Hussong
Martin Viertelhaus
Thomas Stengel
Thomas Maier
Alexander Mann
Manuela Hessmann
Tobias Kanacher
Hans Christof Holst
Christian Hesslinger
Original Assignee
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44764312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP13013076(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Gmbh filed Critical Takeda Gmbh
Publication of ECSP13013076A publication Critical patent/ECSP13013076A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Los compuestos de fórmula (1), en los cuales R1, R7, R8, R9, R10, R17, R18, R19, R20 y m tienen los significados que se dan en la descripción, son novedosos inhibidores efectivos de la fosfodiesterasa del tipo 4 y 5.
ECSP13013076 2011-06-17 2013-12-11 Novedosos derivados de ftalazinona-pirrolopirimidinacarboxamida ECSP13013076A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11170440 2011-06-17

Publications (1)

Publication Number Publication Date
ECSP13013076A true ECSP13013076A (es) 2014-01-31

Family

ID=44764312

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13013076 ECSP13013076A (es) 2011-06-17 2013-12-11 Novedosos derivados de ftalazinona-pirrolopirimidinacarboxamida

Country Status (22)

Country Link
US (2) US20140112945A1 (es)
EP (1) EP2721030B1 (es)
JP (1) JP5980318B2 (es)
KR (1) KR20140037195A (es)
CN (1) CN103582644B (es)
AR (1) AR086915A1 (es)
AU (1) AU2012269133A1 (es)
BR (1) BR112013031791A2 (es)
CA (1) CA2837248A1 (es)
CL (1) CL2013003556A1 (es)
CO (1) CO6852074A2 (es)
CR (1) CR20130656A (es)
DO (1) DOP2013000298A (es)
EA (1) EA023713B1 (es)
EC (1) ECSP13013076A (es)
ES (1) ES2564882T3 (es)
MA (1) MA35269B1 (es)
MX (1) MX2013014888A (es)
PE (1) PE20140648A1 (es)
PH (1) PH12013502546A1 (es)
TN (1) TN2013000439A1 (es)
WO (1) WO2012171900A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016162488A1 (en) * 2015-04-09 2016-10-13 Galderma Sa Treatment of atopic dermatitis with indigo naturalis or indigo producing plant extract
ES2709359T3 (es) 2015-04-09 2019-04-16 Galderma Sa Un extracto de Indigo naturalis y un procedimiento para preparar el mismo
WO2016162485A1 (en) 2015-04-09 2016-10-13 Galderma Sa A pharmaceutical composition and the use thereof
WO2016162490A1 (en) 2015-04-09 2016-10-13 Galderma Sa Antibacterial indigo naturalis or indigo-producing plant extract and use thereof
US12383547B2 (en) 2020-07-01 2025-08-12 Vanderbilt University Methods of treatment for a kidney disease

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8828477D0 (en) 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
ES2060040T5 (es) 1989-05-31 1999-09-16 Fisons Plc Dispositivo y formulacion de inhalacion de medicamento.
GB8921222D0 (en) 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
IL97065A (en) 1990-02-02 1994-01-25 Fisons Plc Repellent preparations for aerosol
DE4003272A1 (de) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
ES2071306T3 (es) 1990-03-23 1995-06-16 Minnesota Mining & Mfg El uso de tensioactivos fluorados solubles para la preparacion de formulaciones aerosoles dosificadas.
JP2769925B2 (ja) 1990-10-18 1998-06-25 ミネソタ マイニング アンド マニュファクチャリング カンパニー ベクロメタゾン１７，２１ジプロピオネートを含んで成るエアロゾル製剤
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
IL104068A (en) 1991-12-12 1998-10-30 Glaxo Group Ltd Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
GB9213874D0 (en) 1992-06-30 1992-08-12 Fisons Plc Process to novel medicament form
GB9306703D0 (en) 1993-03-31 1993-05-26 Fisons Plc Inhalation device
IL111194A (en) 1993-10-08 1998-02-08 Fisons Plc Process for the production of medicament formulations
CZ293815B6 (cs) * 1997-01-15 2004-08-18 Altanaápharmaáag Ftalazinonové deriváty
AU3328499A (en) * 1998-03-14 1999-10-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone pde iii/iv inhibitors
AU749697B2 (en) 1998-08-04 2002-07-04 Jagotec Ag Medicinal aerosol formulations
US6397838B1 (en) 1998-12-23 2002-06-04 Battelle Pulmonary Therapeutics, Inc. Pulmonary aerosol delivery device and method
JP4677102B2 (ja) 1999-04-23 2011-04-27 バテル・メモリアル・インスティテュート エーロゾル給送装置及びエーロゾル小滴を給送する方法
BR0009992A (pt) 1999-04-23 2002-01-08 Battelle Memorial Institute Pulverizador de aerossol eletro-hidrodinâmico, aparelho e processo para administrar um aerossol e processo para produzir e administrar um aerossol
SK17052002A3 (sk) * 2000-06-05 2003-12-02 Altana Pharma Ag Pyridazinónové zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
CA2425035A1 (en) 2000-10-09 2002-04-18 3M Innovative Properties Company Medicinal aerosol formulations
JP4301812B2 (ja) 2001-02-15 2009-07-22 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしてのフタラインオン−ピペリジノ−誘導体
SK14342003A3 (sk) * 2001-04-25 2004-05-04 Altana Pharma Ag Ftalazinóny, farmaceutický prostriedok s ich obsahom a ich použitie
DE60313472T2 (de) * 2002-08-10 2008-01-24 Nycomed Gmbh Pyrrolidindion-substituierte piperidin-phthalazone als pde4-inhibitoren
WO2004018449A1 (en) 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
EP1556369A1 (en) * 2002-08-10 2005-07-27 ALTANA Pharma AG Pyridazinone-derivatives as pde4 inhibitors
CA2512819A1 (en) * 2003-01-14 2004-07-29 Altana Pharma Ag Pde4 inhibitors for the treatment of neoplasms of lymphoid cells
EP1720854A1 (en) * 2004-02-04 2006-11-15 Altana Pharma AG Phthalzinone derivatives as pde4 inhibitors
EP1716133B1 (en) 2004-02-04 2008-03-26 Nycomed GmbH 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors
AR070454A1 (es) * 2008-02-27 2010-04-07 Nycomed Gmbh Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprenden
AR077898A1 (es) * 2009-08-26 2011-09-28 Nycomed Gmbh Metilpirrolopirimidincarboxamidas

Also Published As

Publication number Publication date
EP2721030A1 (en) 2014-04-23
EA201400001A1 (ru) 2014-05-30
MA35269B1 (fr) 2014-07-03
CL2013003556A1 (es) 2014-06-13
CR20130656A (es) 2014-02-18
MX2013014888A (es) 2014-02-27
KR20140037195A (ko) 2014-03-26
JP5980318B2 (ja) 2016-08-31
CO6852074A2 (es) 2014-01-30
CN103582644B (zh) 2016-07-20
EA023713B1 (ru) 2016-07-29
AR086915A1 (es) 2014-01-29
PH12013502546A1 (en) 2014-01-27
TN2013000439A1 (en) 2015-03-30
CA2837248A1 (en) 2012-12-20
JP2014517021A (ja) 2014-07-17
US20160108049A1 (en) 2016-04-21
AU2012269133A1 (en) 2014-01-30
BR112013031791A2 (pt) 2017-01-31
WO2012171900A1 (en) 2012-12-20
CN103582644A (zh) 2014-02-12
PE20140648A1 (es) 2014-05-30
EP2721030B1 (en) 2015-12-16
ES2564882T3 (es) 2016-03-29
DOP2013000298A (es) 2014-03-31
US20140112945A1 (en) 2014-04-24

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