ECSP14013329A - Compuestos de arylcarbonil-4-oxy-piperidina utilizados para el tratamiento de enfermedades neurodegenerativas - Google Patents
Compuestos de arylcarbonil-4-oxy-piperidina utilizados para el tratamiento de enfermedades neurodegenerativasInfo
- Publication number
- ECSP14013329A ECSP14013329A ECSP14013329A ECSP14013329A EC SP14013329 A ECSP14013329 A EC SP14013329A EC SP14013329 A ECSP14013329 A EC SP14013329A EC SP14013329 A ECSP14013329 A EC SP14013329A
- Authority
- EC
- Ecuador
- Prior art keywords
- treatment
- arylcarbonil
- oxy
- compounds used
- neurodegenerative diseases
- Prior art date
Links
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
Abstract
La presente invención proporciona un compuesto de utilidad como un agente para la prevención o el tratamiento de enfermedad neurodegenerativa, y similares o una de sus sales. La presente invención se refiere a un compuesto representado por la fórmula en donde cada símbolo es como se define en la memoria descriptiva, o una de sus sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011222741 | 2011-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP14013329A true ECSP14013329A (es) | 2014-05-31 |
Family
ID=47143241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP14013329 ECSP14013329A (es) | 2011-10-07 | 2014-04-29 | Compuestos de arylcarbonil-4-oxy-piperidina utilizados para el tratamiento de enfermedades neurodegenerativas |
Country Status (43)
Families Citing this family (30)
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| US8648079B2 (en) * | 2011-10-07 | 2014-02-11 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
| WO2014061676A1 (ja) | 2012-10-16 | 2014-04-24 | 武田薬品工業株式会社 | 複素環化合物 |
| EA029056B1 (ru) | 2012-12-11 | 2018-02-28 | Такеда Фармасьютикал Компани Лимитед | Гетероциклическое соединение |
| FI3932932T3 (fi) | 2013-03-13 | 2025-10-15 | Sage Therapeutics Inc | Neuroaktiivisia steroideja ja niiden käyttömenetelmiä |
| WO2014163161A1 (ja) | 2013-04-04 | 2014-10-09 | 武田薬品工業株式会社 | 複素環化合物 |
| US9624184B2 (en) | 2013-04-04 | 2017-04-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2015190613A1 (en) | 2014-06-09 | 2015-12-17 | Takeda Pharmaceutical Company Limited | Radiolabeled compounds |
| JP6628745B2 (ja) | 2014-06-18 | 2020-01-15 | セージ セラピューティクス， インコーポレイテッド | オキシステロールおよびその使用方法 |
| CN104803922A (zh) * | 2015-03-14 | 2015-07-29 | 长沙深橙生物科技有限公司 | 一种嘧啶衍生物的制备方法 |
| PT3319611T (pt) | 2015-07-06 | 2021-04-22 | Sage Therapeutics Inc | Oxisteróis e métodos de utilização dos mesmos |
| DK3812392T3 (da) | 2015-07-06 | 2025-07-21 | Sage Therapeutics Inc | Oxysteroler og fremgangsmåder til anvendelse deraf |
| JP6807322B2 (ja) * | 2015-10-16 | 2021-01-06 | 武田薬品工業株式会社 | 複素環化合物の製造方法 |
| GB201604029D0 (en) * | 2016-03-09 | 2016-04-20 | Ctxt Pty Ltd | Compounds |
| ES2921010T3 (es) | 2016-04-01 | 2022-08-16 | Sage Therapeutics Inc | Oxisteroles y procedimientos de uso de los mismos |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| WO2017195894A1 (ja) * | 2016-05-13 | 2017-11-16 | 日産化学工業株式会社 | ２－アセチルピリジン化合物の製造方法 |
| MA46351A (fr) | 2016-09-30 | 2021-06-02 | Sage Therapeutics Inc | Oxystérols substitués en c7 et procédés en tant que modulateurs nmda |
| GB201617758D0 (en) * | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| US11285139B2 (en) | 2017-08-31 | 2022-03-29 | Takeda Pharmaceutical Company Limited | Treatment of CNS conditions |
| WO2020027344A1 (en) | 2018-08-03 | 2020-02-06 | Takeda Pharmaceutical Company Limited | Ch24h inhibitors for mdd use |
| JP7443255B2 (ja) * | 2018-09-20 | 2024-03-05 | 武田薬品工業株式会社 | 疼痛使用のためのｃｈ２４ｈ阻害剤 |
| TWI855081B (zh) * | 2019-05-24 | 2024-09-11 | 美商賽吉醫療公司 | 化合物、組合物及使用方法 |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| IL303170A (en) * | 2020-11-25 | 2023-07-01 | Sage Therapeutics Inc | 4-fluoro-(4-(4-benzyl)piperidin-1-yl)(2-(pyrimidin-4-yl)pyridin-3-yl)methanone derivatives and similar compounds as cyp46a1 inhibitors for the treatment of neurodegenerative disorders |
| EP4351588A1 (en) | 2021-06-11 | 2024-04-17 | Sage Therapeutics, Inc. | Neuroactive steroid for the treatment of alzheimer's disease |
| IL313039A (en) * | 2021-12-17 | 2024-07-01 | Athira Pharma Inc | Uses of bicyclic compounds for the treatment of diseases |
| CN116444477B (zh) * | 2023-04-04 | 2026-01-02 | 宁波九胜创新医药科技有限公司 | 一种溴代胡椒环羧酸的制备方法及其用途 |
| CN122249207A (zh) * | 2023-07-18 | 2026-06-19 | 总医院公司 | 用于治疗神经变性的蛋白降解靶向嵌合体 |
| WO2025126159A1 (en) | 2023-12-15 | 2025-06-19 | Takeda Pharmaceutical Company Limited | A method for treating a neurological disease in a recreational drug user |
| WO2025257799A1 (en) | 2024-06-14 | 2025-12-18 | Takeda Pharmaceutical Company Limited | Methods of treating dravet syndrome |
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| DE102009022894A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
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2012
- 2012-10-03 US US13/633,995 patent/US8648079B2/en active Active
- 2012-10-03 KR KR1020147011963A patent/KR101967497B1/ko active Active
- 2012-10-03 ES ES12781479T patent/ES2716531T3/es active Active
- 2012-10-03 AR ARP120103691A patent/AR088226A1/es active IP Right Grant
- 2012-10-03 TR TR2019/02788T patent/TR201902788T4/tr unknown
- 2012-10-03 BR BR122022001219-1A patent/BR122022001219B1/pt active IP Right Grant
- 2012-10-03 ME MEP-2019-69A patent/ME03372B/me unknown
- 2012-10-03 MY MYPI2014700836A patent/MY176126A/en unknown
- 2012-10-03 UA UAA201404855A patent/UA115133C2/uk unknown
- 2012-10-03 UY UY0001034365A patent/UY34365A/es not_active Application Discontinuation
- 2012-10-03 AU AU2012321815A patent/AU2012321815B2/en active Active
- 2012-10-03 WO PCT/JP2012/076257 patent/WO2013054822A1/en not_active Ceased
- 2012-10-03 CN CN201280049068.8A patent/CN103842356B/zh active Active
- 2012-10-03 EA EA201490747A patent/EA025662B1/ru not_active IP Right Cessation
- 2012-10-03 PT PT12781479T patent/PT2763979T/pt unknown
- 2012-10-03 PH PH1/2014/500759A patent/PH12014500759A1/en unknown
- 2012-10-03 DK DK12781479.6T patent/DK2763979T3/en active
- 2012-10-03 PL PL12781479T patent/PL2763979T3/pl unknown
- 2012-10-03 HU HUE12781479A patent/HUE043171T2/hu unknown
- 2012-10-03 HR HRP20190491TT patent/HRP20190491T1/hr unknown
- 2012-10-03 BR BR112014007257-4A patent/BR112014007257B1/pt active IP Right Grant
- 2012-10-03 PE PE2014000466A patent/PE20141120A1/es active IP Right Grant
- 2012-10-03 EP EP12781479.6A patent/EP2763979B1/en active Active
- 2012-10-03 LT LTEP12781479.6T patent/LT2763979T/lt unknown
- 2012-10-03 GE GEAP201213457A patent/GEP201706608B/en unknown
- 2012-10-03 MX MX2014004253A patent/MX360706B/es active IP Right Grant
- 2012-10-03 JP JP2014513813A patent/JP6117191B2/ja active Active
- 2012-10-03 SG SG2014010417A patent/SG2014010417A/en unknown
- 2012-10-03 CA CA2851087A patent/CA2851087C/en active Active
- 2012-10-03 RS RS20190304A patent/RS58470B1/sr unknown
- 2012-10-03 SM SM20190173T patent/SMT201900173T1/it unknown
- 2012-10-03 TW TW101136475A patent/TWI582084B/zh active
- 2012-10-03 AP AP2014007606A patent/AP2014007606A0/xx unknown
- 2012-10-03 US US14/349,201 patent/US9193709B2/en active Active
- 2012-10-03 SI SI201231548T patent/SI2763979T1/sl unknown
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2013
- 2013-07-17 US US13/944,042 patent/US8871766B2/en active Active
- 2013-07-17 US US13/944,000 patent/US8865717B2/en active Active
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2014
- 2014-03-24 IL IL231678A patent/IL231678A/en active IP Right Grant
- 2014-03-25 TN TNP2014000122A patent/TN2014000122A1/en unknown
- 2014-04-02 CL CL2014000806A patent/CL2014000806A1/es unknown
- 2014-04-02 ZA ZA2014/02424A patent/ZA201402424B/en unknown
- 2014-04-03 CR CR20140151A patent/CR20140151A/es unknown
- 2014-04-04 DO DO2014000064A patent/DOP2014000064A/es unknown
- 2014-04-29 EC ECSP14013329 patent/ECSP14013329A/es unknown
- 2014-05-02 CO CO14094354A patent/CO6940432A2/es unknown
- 2014-05-04 MA MA36973A patent/MA35623B1/fr unknown
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2015
- 2015-09-08 US US14/847,703 patent/US9440990B2/en active Active
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2016
- 2016-07-28 US US15/221,761 patent/US9586930B2/en active Active
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2017
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2018
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2019
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2020
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- 2020-07-20 US US16/933,092 patent/US11174272B2/en active Active
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