ECSP17025787A - Uso de paneles de genes mutantes de fgfr en la identificación de pacientes con cáncer que responderán al tratamiento con un inhibidor de fgfr - Google Patents

Uso de paneles de genes mutantes de fgfr en la identificación de pacientes con cáncer que responderán al tratamiento con un inhibidor de fgfr

Info

Publication number
ECSP17025787A
ECSP17025787A ECIEPI201725787A ECPI201725787A ECSP17025787A EC SP17025787 A ECSP17025787 A EC SP17025787A EC IEPI201725787 A ECIEPI201725787 A EC IEPI201725787A EC PI201725787 A ECPI201725787 A EC PI201725787A EC SP17025787 A ECSP17025787 A EC SP17025787A
Authority
EC
Ecuador
Prior art keywords
fgfr
respond
treatment
cancer patients
mutant gene
Prior art date
Application number
ECIEPI201725787A
Other languages
English (en)
Inventor
Bimbo S A B De C V Grupo
S A R L Abbvie
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54337343&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP17025787(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP17025787A publication Critical patent/ECSP17025787A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113—PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

En la presente descripción, se describen métodos para identificar un paciente con cáncer que responderá al tratamiento con un inhibidor del receptor del factor de crecimiento de fibroblastos (FGFR) y métodos para tratar pacientes con cáncer. Los métodos implican evaluar una muestra biológica del paciente para detectar la presencia de uno o más mutantes de FGFR a partir de un panel de genes mutantes de FGFR. En la presente descripción se describen, además, estuches e iniciadores para identificar la presencia de uno o más genes mutantes de FGFR en una muestra biológica.
ECIEPI201725787A 2014-09-26 2017-04-26 Uso de paneles de genes mutantes de fgfr en la identificación de pacientes con cáncer que responderán al tratamiento con un inhibidor de fgfr ECSP17025787A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462056159P 2014-09-26 2014-09-26

Publications (1)

Publication Number Publication Date
ECSP17025787A true ECSP17025787A (es) 2018-07-31

Family

ID=54337343

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201725787A ECSP17025787A (es) 2014-09-26 2017-04-26 Uso de paneles de genes mutantes de fgfr en la identificación de pacientes con cáncer que responderán al tratamiento con un inhibidor de fgfr

Country Status (38)

Country Link
US (3) US20160090633A1 (es)
EP (2) EP4063516A1 (es)
JP (4) JP6766037B2 (es)
KR (3) KR102839867B1 (es)
CN (1) CN107002141B (es)
AR (1) AR102345A1 (es)
AU (3) AU2015321626B2 (es)
CA (1) CA2962075C (es)
CO (1) CO2017003528A2 (es)
CR (1) CR20170104A (es)
CY (1) CY1125190T1 (es)
DK (1) DK3198033T3 (es)
EA (1) EA037920B1 (es)
EC (1) ECSP17025787A (es)
ES (1) ES2912567T3 (es)
GT (1) GT201700059A (es)
HR (1) HRP20220496T1 (es)
HU (1) HUE058219T2 (es)
IL (3) IL324511A (es)
JO (1) JO3681B1 (es)
LT (1) LT3198033T (es)
MA (1) MA40761B1 (es)
MX (2) MX392774B (es)
MY (1) MY194567A (es)
NI (1) NI201700035A (es)
PH (1) PH12017500556A1 (es)
PL (1) PL3198033T3 (es)
PT (1) PT3198033T (es)
RS (1) RS63178B1 (es)
SG (1) SG11201702381QA (es)
SI (1) SI3198033T1 (es)
SM (1) SMT202200177T1 (es)
SV (1) SV2017005415A (es)
TW (1) TWI706136B (es)
UA (1) UA122564C2 (es)
UY (1) UY36325A (es)
WO (1) WO2016048833A2 (es)
ZA (1) ZA201702899B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107501413A (zh) 2012-09-27 2017-12-22 中外制药株式会社 Fgfr3融合基因和以其作为标靶的药物
JP6731254B2 (ja) * 2014-01-24 2020-07-29 公益財団法人がん研究会 新規融合体及びその検出法
WO2015144804A1 (en) 2014-03-26 2015-10-01 Astex Therapeutics Ltd Combinations
PT3198033T (pt) 2014-09-26 2022-05-25 Janssen Pharmaceutica Nv Utilização de painéis de genes mutantes de fgfr na identificação de pacientes com cancro que serão sensíveis ao tratamento com um inibidor de fgfr
TWI834020B (zh) 2015-02-10 2024-03-01 英商阿斯迪克治療公司 新穎組成物
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
JP7085985B2 (ja) * 2016-03-04 2022-06-17 大鵬薬品工業株式会社 悪性腫瘍治療用製剤及び組成物
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
JOP20190280A1 (ar) 2017-06-02 2019-12-02 Janssen Pharmaceutica Nv مثبطات fgfr2 لعلاج سرطان الأوعية الصفراوية
EP3628071B1 (en) 2018-07-27 2022-07-06 Zepto Life Technology, LLC System and method for sample preparation in gmr-based detection of biomarkers
EA202190826A1 (ru) * 2018-09-21 2021-06-16 Янссен Фармацевтика Нв Лечение холангиокарциномы
PH12021551949A1 (en) * 2019-02-12 2022-07-18 Janssen Pharmaceutica Nv Cancer treatment
PH12021552352A1 (en) 2019-03-29 2022-09-05 Janssen Pharmaceutica Nv Fgfr tyrosine kinase inhibitors for the treatment of urothelial carcinoma
CA3130460A1 (en) * 2019-03-29 2020-10-08 Anne Elizabeth O'HAGAN Fgfr tyrosine kinase inhibitors for the treatment of urothelial carcinoma
PH12021552973A1 (en) * 2019-05-31 2022-07-11 Qed Therapeutics Inc Methods of treating urinary system cancers
CN110241183B (zh) * 2019-06-13 2022-10-28 南京世和基因生物技术股份有限公司 一种fgfr融合基因的检测方法、试剂盒以及探针库
JPWO2021010326A1 (es) * 2019-07-12 2021-01-21
CN115335701A (zh) * 2019-09-09 2022-11-11 泽普托生命技术有限责任公司 用于检测核酸中基因变异的系统和方法
KR20220070243A (ko) 2019-09-26 2022-05-30 얀센 파마슈티카 엔.브이. 순차적 치료 환경에서 면역 체크포인트 억제제에 대한 환자 반응을 향상시키기 위한 fgfr-유전적으로 변경된 암에서의 fgfr 억제제의 용도
KR20220140781A (ko) 2020-02-12 2022-10-18 얀센 파마슈티카 엔.브이. 고위험 비근침윤성 방광암 치료를 위한 fgfr 티로신 키나제 억제제
TWI900527B (zh) 2020-02-12 2025-10-11 比利時商健生藥品公司 用於治療尿路上皮癌的ｆｇｆｒ酪胺酸激酶抑制劑和抗ｐｄ１藥劑
BR112022020846A2 (pt) * 2020-04-15 2022-12-27 Alkermes Pharma Ireland Ltd Agentes imunoestimuladores em combinação com inibidores de angiogênese
CN111440790A (zh) * 2020-05-08 2020-07-24 公安部物证鉴定中心 唾液斑迹dna和rna同时提取的方法
JP2023542296A (ja) 2020-09-14 2023-10-06 ヤンセン ファーマシューティカ エヌ．ベー． Ｆｇｆｒ阻害剤の併用療法
CN112143815B (zh) * 2020-11-25 2021-02-26 江苏申基生物科技有限公司 一种用于检测人fgfr2基因融合突变的核酸组合物、试剂盒及检测方法
AU2022277796A1 (en) 2021-05-19 2024-01-18 Janssen Pharmaceutica Nv Fgfr tyrosine kinase inhibitors for the treatment of advanced solid tumors
EP4415692A1 (en) 2021-10-12 2024-08-21 TARIS Biomedical LLC Erdafitinib formulations and systems for intravesical administration
KR20240145513A (ko) 2022-02-18 2024-10-07 타리스 바이오메디컬 엘엘씨 에르다피티닙 제형 및 방광내 투여를 위한 삼투성 시스템
AU2024222187A1 (en) 2023-02-13 2025-10-02 Janssen Pharmaceutica Nv Fgfr tyrosine kinase inhibitors for the treatment of high-risk non-muscle invasive bladder cancer
IL322667A (en) 2023-02-13 2025-10-01 Taris Biomedical Llc Ardepitinib for intravesical administration for use in the treatment of bladder cancer
EP4665343A1 (en) 2023-02-17 2025-12-24 TARIS Biomedical LLC Erdafitinib for intravesical administration for use in the treatment of bladder cancer
WO2025059602A1 (en) 2023-09-14 2025-03-20 Taris Biomedical Llc Methods of treating bladder cancer using intravesical administration of erdafitinib
CN119219611B (zh) * 2024-12-03 2025-04-18 南京诺源医疗器械有限公司 用于主动靶向成纤维细胞生长因子受体的近红外荧光探针及其制备方法与应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135311B1 (en) 1999-05-05 2006-11-14 Institut Curie Means for detecting and treating pathologies linked to FGFR3
CA2372990C (en) 1999-05-05 2007-06-19 Institut Curie Means for detecting and treating pathologies linked to fgfr3
ES2447566T3 (es) 2002-10-01 2014-03-12 Epigenomics Ag Uso de ácidos nucleicos de PITX2 para mejorar el tratamiento de trastornos proliferativos de células mamarias
WO2004085676A1 (en) * 2003-03-26 2004-10-07 Progenika Biopharma, S.A. In vitro method to detect bladder transitional cell carcinoma
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
EP1659175A1 (en) * 2004-11-18 2006-05-24 Institut Curie Alterations in seborrheic keratoses and their applications
EP2266974A1 (en) 2005-05-23 2010-12-29 Novartis AG Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-Quinolin-2-one lactic acid salts
WO2007061127A1 (ja) * 2005-11-22 2007-05-31 Eisai R & D Management Co., Ltd. 多発性骨髄腫に対する抗腫瘍剤
JP2009523410A (ja) 2005-12-08 2009-06-25 ノバルティス アクチエンゲゼルシャフト 遺伝子転写に対するｆｇｆｒ３の阻害剤の効果
EP1918376A1 (en) 2006-11-03 2008-05-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs
US20100075337A1 (en) 2007-02-27 2010-03-25 Diana Graus Porta Method of identification of cells that show sensitivity to modulation of signalingh mediated by fibroblast growth factor receptor or a variant thereof
WO2008109369A2 (en) 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting tnf gene expression and uses thereof
US8163923B2 (en) 2007-03-14 2012-04-24 Advenchen Laboratories, Llc Spiro substituted compounds as angiogenesis inhibitors
WO2008157801A2 (en) 2007-06-21 2008-12-24 Gen-Probe Incorporated Instrument and receptacles for performing processes
US8071338B2 (en) 2007-08-08 2011-12-06 Roche Molecular Systems, Inc. Suppression of amplification using an oligonucleotide and a polymerase significantly lacking 5′-3′ nuclease activity
WO2013173485A1 (en) 2012-05-15 2013-11-21 Predictive Biosciences, Inc. Detection of bladder cancers
WO2013173480A1 (en) 2012-05-15 2013-11-21 Predictive Biosciences, Inc. Detection of bladder cancer recurrence
GB0718542D0 (en) 2007-09-22 2007-10-31 Univ Dundee Targeted modulation of gene expression
AR073770A1 (es) 2008-10-20 2010-12-01 Imclone Llc Anticuerpo aislado que se enlaza especificamente con, e induce la degradacion del receptor-3 del factor de crecimiento del fibroblasto humano (fgfr-3), fragmento de enlace fgfr-3 humano del mismo, composicion farmaceutica y producto que lo comprenden
CN102448984A (zh) 2009-03-27 2012-05-09 酶遗传学股份有限公司 使用包含抗体-受体组合的多特异性结合蛋白的组合物和方法
WO2011027219A1 (en) 2009-09-04 2011-03-10 Progenika Biopharma, S.A. High throughput detection of small genomic deletions and insertions
WO2011115937A1 (en) * 2010-03-14 2011-09-22 The Translational Genomics Research Institute Methods of determining susceptibility of tumors to tyrosine kinase inhibitors
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
CN102293770A (zh) * 2011-05-25 2011-12-28 温州医学院 新型成纤维细胞生长因子受体酪氨酸激酶抑制剂
CN102319224B (zh) * 2011-07-27 2013-03-20 赛乐医药科技(上海)有限公司 复方甲氧那明的速释－缓释渗透泵制剂
WO2013026027A1 (en) 2011-08-18 2013-02-21 Nestec S.A. Compositions and methods for detecting allelic variants
EP2761300A4 (en) * 2011-09-27 2015-12-02 Univ Michigan Recurrent genital fusion in breast cancer
AR088941A1 (es) 2011-11-23 2014-07-16 Bayer Ip Gmbh Anticuerpos anti-fgfr2 y sus usos
WO2013088191A1 (en) * 2011-12-12 2013-06-20 Institut National De La Sante Et De La Recherche Medicale (Inserm) Antagonist of the fibroblast growth factor receptor 3 (fgfr3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of fgfr3
PT2824181T (pt) 2012-03-08 2018-12-20 Astellas Pharma Inc Novo produto de fusão de fgfr3
US9254288B2 (en) * 2012-05-07 2016-02-09 The Translational Genomics Research Institute Susceptibility of tumors to tyrosine kinase inhibitors and treatment thereof
GB201209609D0 (en) * 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
CN104619840A (zh) * 2012-07-05 2015-05-13 日本国立癌症研究中心 Fgfr2融合基因
CN104797936B (zh) * 2012-07-24 2017-11-24 纽约市哥伦比亚大学理事会 融合蛋白及其方法
RU2015102194A (ru) * 2012-07-27 2016-09-20 Дженентек, Инк. Способы лечения связанных с fgfr3 состояний
CN107501413A (zh) 2012-09-27 2017-12-22 中外制药株式会社 Fgfr3融合基因和以其作为标靶的药物
ES2949394T3 (es) * 2012-11-05 2023-09-28 Found Medicine Inc Moléculas de fusión novedosas y usos de las mismas
CA3150658A1 (en) * 2013-01-18 2014-07-24 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
EP2981621B1 (en) 2013-04-05 2019-05-22 Life Technologies Corporation Gene fusions
WO2014193229A2 (en) 2013-05-27 2014-12-04 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Novel translocations in lung cancer
WO2015006723A1 (en) 2013-07-12 2015-01-15 The Regents Of The University Of Michigan Recurrent gene fusions in cancer
PT3198033T (pt) 2014-09-26 2022-05-25 Janssen Pharmaceutica Nv Utilização de painéis de genes mutantes de fgfr na identificação de pacientes com cancro que serão sensíveis ao tratamento com um inibidor de fgfr
US20200208224A1 (en) 2014-09-26 2020-07-02 Janssen Pharmaceutica Nv Use Of FGFR Mutant Gene Panels In Identifying Cancer Patients That Will Be Responsive To Treatment With An FGFR Inhibitor
BR112019016043A2 (pt) 2017-02-06 2020-03-31 Janssen Pharmaceutica Nv Tratamento de câncer

Also Published As

Publication number Publication date
MY194567A (en) 2022-12-02
US20190078166A1 (en) 2019-03-14
JO3681B1 (ar) 2020-08-27
CA2962075C (en) 2025-09-09
WO2016048833A3 (en) 2016-05-19
KR102470456B1 (ko) 2022-11-23
DK3198033T3 (da) 2022-04-11
JP7051920B2 (ja) 2022-04-11
IL291633A (en) 2022-05-01
AU2025201448A1 (en) 2025-03-20
KR102839867B1 (ko) 2025-07-28
MA40761A (fr) 2017-08-01
SG11201702381QA (en) 2017-04-27
EA037920B1 (ru) 2021-06-07
CY1125190T1 (el) 2024-12-13
GT201700059A (es) 2019-08-21
KR20250119657A (ko) 2025-08-07
CO2017003528A2 (es) 2017-07-11
UY36325A (es) 2016-04-01
CN107002141B (zh) 2021-11-02
KR20220162823A (ko) 2022-12-08
CN113957146A (zh) 2022-01-21
AU2015321626B2 (en) 2021-12-16
UA122564C2 (uk) 2020-12-10
JP7558216B2 (ja) 2024-09-30
CN107002141A (zh) 2017-08-01
JP2024112991A (ja) 2024-08-21
IL251264A0 (en) 2017-05-29
JP2020124192A (ja) 2020-08-20
SI3198033T1 (sl) 2022-06-30
JP2017529090A (ja) 2017-10-05
EP4063516A1 (en) 2022-09-28
WO2016048833A2 (en) 2016-03-31
HRP20220496T1 (hr) 2022-05-27
MA40761B1 (fr) 2022-04-29
ZA201702899B (en) 2019-06-26
MX2022006536A (es) 2022-07-11
EP3198033B1 (en) 2022-02-16
LT3198033T (lt) 2022-05-10
US12037644B2 (en) 2024-07-16
US20160090633A1 (en) 2016-03-31
PT3198033T (pt) 2022-05-25
TW201619609A (zh) 2016-06-01
NZ730886A (en) 2024-08-30
MX2017003954A (es) 2017-12-14
AR102345A1 (es) 2017-02-22
NI201700035A (es) 2017-06-22
IL251264B (en) 2022-04-01
MX392774B (es) 2025-03-24
AU2021277633A1 (en) 2021-12-23
SV2017005415A (es) 2017-07-03
IL291633B1 (en) 2025-12-01
AU2021277633B2 (en) 2024-11-28
HUE058219T2 (hu) 2022-07-28
EA201790716A1 (ru) 2017-10-31
ES2912567T3 (es) 2022-05-26
JP6766037B2 (ja) 2020-10-07
SMT202200177T1 (it) 2022-05-12
JP2022109910A (ja) 2022-07-28
KR20170062495A (ko) 2017-06-07
US20240309463A1 (en) 2024-09-19
PH12017500556A1 (en) 2017-08-30
TWI706136B (zh) 2020-10-01
PL3198033T3 (pl) 2022-08-29
BR112017006088A2 (pt) 2017-12-19
IL324511A (en) 2026-01-01
CR20170104A (es) 2017-05-31
RS63178B1 (sr) 2022-06-30
EP3198033A2 (en) 2017-08-02
CA2962075A1 (en) 2016-03-31
AU2015321626A1 (en) 2017-04-06

Similar Documents

Publication Publication Date Title
ECSP17025787A (es) Uso de paneles de genes mutantes de fgfr en la identificación de pacientes con cáncer que responderán al tratamiento con un inhibidor de fgfr
MX2017008421A (es) Métodos terapéuticos, diagnósticos y pronósticos para el cáncer de vejiga.
MX2019010958A (es) Metodos de tratamiento de tumores.
PH12019502710A1 (en) Fgfr2 inhibitors for the treatment of cholangiocarcinoma
MX2017014736A (es) Metodos terapeuticos y diagnosticos para cancer.
BR112015023120A2 (pt) método para identificar um indivíduo com uma doença ou disfunção, método para prever a responsividade de um indivíduo com uma doença ou disfunção, método para determinar a probabilidade de que um indivíduo com uma doença ou disfunção exibirá benefício do tratamento, método para selecionar uma terapia, usos de um antagonista de ligação do eixo pd-l1, ensaio para identificar um indivíduo com uma doença, kit de diagnóstico, método para avaliar uma resposta ao tratamento e método para monitorar a resposta de um indivíduo tratado
BR112014011925A2 (pt) mutações no receptor notch humano e seu uso
MX2022014633A (es) Metodos para detectar norovirus.
EP4249608A3 (en) Early lung cancer detection by dna methylation phenotyping of sputum-derived cells
MX2025004103A (es) Metodos de identificacion de pacientes con posibilidad de beneficiarse de un tratamiento con un inhibidor de la telomerasa
WO2018064013A8 (en) METHODS FOR TREATING CANCER WITH BAVITUXIMAB BASED ON LEVELS OF β2-GLYCOPROTEIN 1, AND ASSAYS THEREFOR
MX2022014741A (es) Metodos para detectar bordetella.
BR112016028838A2 (pt) anticorpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, métodos de detecção de lgr5 humano em uma amostra biológica, de detecção de um câncer, de identificação de um paciente com câncer, de seleção de um paciente com câncer para tratamento com um imunoconjugado e de tratamento de um paciente com câncer
MX2021003320A (es) Tratamiento del colangiocarcinoma.
WO2019140008A3 (en) Methods for using dna methylation as a biomarker for identification and treatment of metabolic syndrome
PL408727A1 (pl) Zestaw diagnostyczny i sposób jednoczesnego wykrywania mutacji w obrębie genu NF1 dla grupy pacjentów z podejrzeniem choroby Recklinghausena
UA92246U (ru) Спектрофотометрический способ количественного определения зопиклона
EA201992849A1 (ru) Ингибиторы fgfr2 для лечения холангиокарциномы
PE20142434A1 (es) Metodo para la identificacion del origen de un cancer de origen primario desconocido
AR086571A1 (es) Metodo para la identificacion del origen de un cancer de origen primario desconocido
BR112017020582A2 (pt) composições e métodos para a detecção de um contaminante biológico