MA40761A - Utilisation de panels de gènes mutants du fgfr dans l'identification de patients atteints de cancer qui seront sensibles à un traitement avec un inhibiteur du fgfr - Google Patents

Utilisation de panels de gènes mutants du fgfr dans l'identification de patients atteints de cancer qui seront sensibles à un traitement avec un inhibiteur du fgfr

Info

Publication number
MA40761A
MA40761A MA040761A MA40761A MA40761A MA 40761 A MA40761 A MA 40761A MA 040761 A MA040761 A MA 040761A MA 40761 A MA40761 A MA 40761A MA 40761 A MA40761 A MA 40761A
Authority
MA
Morocco
Prior art keywords
fgfr
cancer
sensitive
treatment
mutant gene
Prior art date
Application number
MA040761A
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English (en)
Other versions
MA40761B1 (fr
Inventor
Jayaprakash Karkera
Suso Jesus Platero
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54337343&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA40761(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA40761A publication Critical patent/MA40761A/fr
Publication of MA40761B1 publication Critical patent/MA40761B1/fr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00Reactions of nucleic acids characterised by
    • C12Q2531/10Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113PCR
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
MA40761A 2014-09-26 2015-09-18 Utilisation de panels de gènes mutants du fgfr dans l'identification de patients atteints de cancer qui seront sensibles à un traitement avec un inhibiteur du fgfr MA40761B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462056159P 2014-09-26 2014-09-26
PCT/US2015/050996 WO2016048833A2 (fr) 2014-09-26 2015-09-18 Utilisation de panels de gènes mutants du fgfr dans l'identification de patients atteints de cancer qui seront sensibles à un traitement avec un inhibiteur du fgfr

Publications (2)

Publication Number Publication Date
MA40761A true MA40761A (fr) 2017-08-01
MA40761B1 MA40761B1 (fr) 2022-04-29

Family

ID=54337343

Family Applications (1)

Application Number Title Priority Date Filing Date
MA40761A MA40761B1 (fr) 2014-09-26 2015-09-18 Utilisation de panels de gènes mutants du fgfr dans l'identification de patients atteints de cancer qui seront sensibles à un traitement avec un inhibiteur du fgfr

Country Status (38)

Country Link
US (3) US20160090633A1 (fr)
EP (2) EP3198033B1 (fr)
JP (4) JP6766037B2 (fr)
KR (3) KR102470456B1 (fr)
CN (2) CN107002141B (fr)
AR (1) AR102345A1 (fr)
AU (3) AU2015321626B2 (fr)
CA (2) CA2962075C (fr)
CO (1) CO2017003528A2 (fr)
CR (1) CR20170104A (fr)
CY (1) CY1125190T1 (fr)
DK (1) DK3198033T3 (fr)
EA (1) EA037920B1 (fr)
EC (1) ECSP17025787A (fr)
ES (1) ES2912567T3 (fr)
GT (1) GT201700059A (fr)
HR (1) HRP20220496T1 (fr)
HU (1) HUE058219T2 (fr)
IL (3) IL291633B2 (fr)
JO (1) JO3681B1 (fr)
LT (1) LT3198033T (fr)
MA (1) MA40761B1 (fr)
MX (2) MX392774B (fr)
MY (1) MY194567A (fr)
NI (1) NI201700035A (fr)
PH (1) PH12017500556A1 (fr)
PL (1) PL3198033T3 (fr)
PT (1) PT3198033T (fr)
RS (1) RS63178B1 (fr)
SG (1) SG11201702381QA (fr)
SI (1) SI3198033T1 (fr)
SM (1) SMT202200177T1 (fr)
SV (1) SV2017005415A (fr)
TW (1) TWI706136B (fr)
UA (1) UA122564C2 (fr)
UY (1) UY36325A (fr)
WO (1) WO2016048833A2 (fr)
ZA (1) ZA201702899B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2886002C (fr) 2012-09-27 2020-06-09 Chugai Seiyaku Kabushiki Kaisha Gene de fusion fgfr3 et medicament pharmaceutique ciblant celui-ci
EP3098312B1 (fr) * 2014-01-24 2023-07-19 Japanese Foundation For Cancer Research Nouvelle élément de fusion et son procédé de détection
MA39784B1 (fr) 2014-03-26 2021-03-31 Astex Therapeutics Ltd Combinaisons des inhibiteurs du fgfr et du cmet destinées au traitement du cancer
CR20170104A (es) 2014-09-26 2017-05-31 Janssen Pharmaceutica Nv Uso de paneles de genes mutantes de fgfr en la identificación de pacientes con cáncer que responderán al tratamiento con un inhibidor de fgfr
JO3695B1 (ar) 2015-02-10 2020-08-27 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n- (3.5- ثنائي ميثوكسي فينيل)-n-(1-ميثيل إيثيل)-n- 3-( ميثيل-h1-بيرازول-4-يل) كينوكسالين-6-يل) إيثان- 1.2-ثنائي الأمين)
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
EP3424505A4 (fr) * 2016-03-04 2019-10-16 Taiho Pharmaceutical Co., Ltd. Préparation et composition de traitement de tumeurs malignes
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
JOP20190280A1 (ar) 2017-06-02 2019-12-02 Janssen Pharmaceutica Nv مثبطات fgfr2 لعلاج سرطان الأوعية الصفراوية
EP3639039A4 (fr) 2018-07-27 2021-05-19 Zepto Life Technology, LLC Système et procédé de détection basée sur gmr de biomarqueurs
EA202190826A1 (ru) * 2018-09-21 2021-06-16 Янссен Фармацевтика Нв Лечение холангиокарциномы
CN113423402A (zh) * 2019-02-12 2021-09-21 詹森药业有限公司 癌症治疗
EP3946340A1 (fr) 2019-03-29 2022-02-09 Janssen Pharmaceutica NV Inhibiteurs de la tyrosine kinase fgfr pour le traitement du carcinome urothélial
CN113645974A (zh) * 2019-03-29 2021-11-12 詹森药业有限公司 用于治疗尿路上皮癌的fgfr酪氨酸激酶抑制剂
US20220233537A1 (en) * 2019-05-31 2022-07-28 Qed Therapeutics, Inc. Methods of treating urinary system cancers
CN110241183B (zh) * 2019-06-13 2022-10-28 南京世和基因生物技术股份有限公司 一种fgfr融合基因的检测方法、试剂盒以及探针库
US20220267452A1 (en) * 2019-07-12 2022-08-25 Chugai Seiyaku Kabushiki Kaisha Anti-mutation type fgfr3 antibody and use therefor
CN115335701A (zh) * 2019-09-09 2022-11-11 泽普托生命技术有限责任公司 用于检测核酸中基因变异的系统和方法
US20220348662A1 (en) 2019-09-26 2022-11-03 Janssen Pharmaceutica Nv Use of fgfr inhibitors in fgfr-genetically altered cancers to enhance patient response to immune checkpoint inhibitors in sequential treatment settings
US12600825B2 (en) 2020-01-08 2026-04-14 Zepto Life Technology, Inc. Polymer compositions and biosurfaces comprising them on sensors
TWI900527B (zh) 2020-02-12 2025-10-11 比利時商健生藥品公司 用於治療尿路上皮癌的fgfr酪胺酸激酶抑制劑和抗pd1藥劑
PH12022552093A1 (en) * 2020-02-12 2023-11-29 Janssen Pharmaceutica Nv Fgfr tyrosine kinase inhibitors for the treatment of high-risk non-muscle invasive bladder cancer
AU2021254793A1 (en) * 2020-04-15 2022-11-17 Clovis Oncology, Inc. Immunostimulatory agents in combination with angiogenesis inhibitors
CN111440790A (zh) * 2020-05-08 2020-07-24 公安部物证鉴定中心 唾液斑迹dna和rna同时提取的方法
US20230321087A1 (en) 2020-09-14 2023-10-12 Janssen Pharmaceutica Nv Fgfr inhibitor combination therapies
CN112143815B (zh) * 2020-11-25 2021-02-26 江苏申基生物科技有限公司 一种用于检测人fgfr2基因融合突变的核酸组合物、试剂盒及检测方法
US20250000858A1 (en) 2021-05-19 2025-01-02 Janssen Pharmaceutica Nv Fgfr tyrosine kinase inhibitors for the treatment of advanced solid tumors
EP4415692A1 (fr) 2021-10-12 2024-08-21 TARIS Biomedical LLC Formulations d'erdafitinib et systèmes d'administration intravésicale
KR20240145513A (ko) 2022-02-18 2024-10-07 타리스 바이오메디컬 엘엘씨 에르다피티닙 제형 및 방광내 투여를 위한 삼투성 시스템
EP4665342A1 (fr) 2023-02-13 2025-12-24 TARIS Biomedical LLC Erdafitinib pour administration intravésicale destiné à être utilisé dans le traitement du cancer de la vessie
CN120813357A (zh) 2023-02-13 2025-10-17 詹森药业有限公司 用于治疗高风险非肌层浸润性膀胱癌的fgfr酪氨酸激酶抑制剂
JP2026506041A (ja) 2023-02-17 2026-02-20 タリス バイオメディカル エルエルシー 膀胱がんの治療における使用のための膀胱内投与のためのエルダフィチニブ
WO2025059602A1 (fr) 2023-09-14 2025-03-20 Taris Biomedical Llc Méthodes de traitement du cancer de la vessie à l'aide d'une administration intravésicale d'erdafitinib
CN119219611B (zh) * 2024-12-03 2025-04-18 南京诺源医疗器械有限公司 用于主动靶向成纤维细胞生长因子受体的近红外荧光探针及其制备方法与应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135311B1 (en) 1999-05-05 2006-11-14 Institut Curie Means for detecting and treating pathologies linked to FGFR3
AU5214500A (en) 1999-05-05 2000-11-21 Centre National De La Recherche Scientifique (C.N.R.S.) Means for detecting and treating pathologies linked to fgfr3
CA2500255A1 (fr) 2002-10-01 2004-04-29 Epigenomics Ag Procede et acides nucleiques permettant d'ameliorer le traitement de troubles de la proliferation de celllules mammaires
EP1611252B1 (fr) * 2003-03-26 2009-07-29 Progenika Biopharma, S.A. Methode de detection in vitro du carcinome a cellules transitionnelles de la vessie
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
EP1659175A1 (fr) * 2004-11-18 2006-05-24 Institut Curie Altérations des kératoses séborrhéiques et applications dérivées
EP2270000B1 (fr) 2005-05-23 2015-07-29 Novartis AG Formes cristallines et autres de sels d'acide lactique 4-amino-5-fluoro-3-[6-(4-méthylpipérazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one
WO2007061127A1 (fr) * 2005-11-22 2007-05-31 Eisai R & D Management Co., Ltd. Agent antitumeur pour myelomes multiples
EP2546359A1 (fr) * 2005-12-08 2013-01-16 Novartis AG Effets d'inhibiteurs de FGFR3 sur la transcription génétique
EP1918376A1 (fr) * 2006-11-03 2008-05-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. FGFR4 favorise la résistance des cellules cancéreuses en réponse aux agents chimiothérapeutiques
US20100075337A1 (en) 2007-02-27 2010-03-25 Diana Graus Porta Method of identification of cells that show sensitivity to modulation of signalingh mediated by fibroblast growth factor receptor or a variant thereof
WO2008109369A2 (fr) 2007-03-02 2008-09-12 Mdrna, Inc. Composés d'acide nucléique permettant d'inhiber l'expression de gène tnf et utilisations de ceux-ci
US8163923B2 (en) 2007-03-14 2012-04-24 Advenchen Laboratories, Llc Spiro substituted compounds as angiogenesis inhibitors
JP5282088B2 (ja) 2007-06-21 2013-09-04 ジェン−プロウブ インコーポレイテッド 処理実行に使用する機器および容器
US8071338B2 (en) 2007-08-08 2011-12-06 Roche Molecular Systems, Inc. Suppression of amplification using an oligonucleotide and a polymerase significantly lacking 5′-3′ nuclease activity
WO2013173480A1 (fr) 2012-05-15 2013-11-21 Predictive Biosciences, Inc. Détection de récurrence de cancer de la vessie
WO2013173485A1 (fr) 2012-05-15 2013-11-21 Predictive Biosciences, Inc. Détection de cancers de la vessie
GB0718542D0 (en) 2007-09-22 2007-10-31 Univ Dundee Targeted modulation of gene expression
AR073770A1 (es) 2008-10-20 2010-12-01 Imclone Llc Anticuerpo aislado que se enlaza especificamente con, e induce la degradacion del receptor-3 del factor de crecimiento del fibroblasto humano (fgfr-3), fragmento de enlace fgfr-3 humano del mismo, composicion farmaceutica y producto que lo comprenden
WO2010111625A1 (fr) 2009-03-27 2010-09-30 Zymogenetics, Inc. Compositions et procédés permettant d'utiliser des protéines de liaison multispécifiques comprenant une combinaison anticorps-récepteur
WO2011027219A1 (fr) 2009-09-04 2011-03-10 Progenika Biopharma, S.A. Détection à rendement élevé de petites délétions et insertions génomiques
EP2547698B1 (fr) * 2010-03-14 2015-07-29 The Translational Genomics Research Institute Procédés de détermination de la sensibilité de tumeurs à des inhibiteurs de la tyrosine kinase
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201020179D0 (en) * 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
CN102293770A (zh) * 2011-05-25 2011-12-28 温州医学院 新型成纤维细胞生长因子受体酪氨酸激酶抑制剂
CN102319224B (zh) * 2011-07-27 2013-03-20 赛乐医药科技(上海)有限公司 复方甲氧那明的速释-缓释渗透泵制剂
KR20140057343A (ko) 2011-08-18 2014-05-12 네스텍 소시에테아노님 대립형질 변이 검출을 위한 조성물 및 방법
EP2761300A4 (fr) * 2011-09-27 2015-12-02 Univ Michigan Fusions de gènes récurrentes dans le cancer du sein
AR088941A1 (es) 2011-11-23 2014-07-16 Bayer Ip Gmbh Anticuerpos anti-fgfr2 y sus usos
WO2013088191A1 (fr) * 2011-12-12 2013-06-20 Institut National De La Sante Et De La Recherche Medicale (Inserm) Antagoniste du récepteur 3 du facteur de croissance des fibroblastes (fgfr3) à utiliser dans le traitement ou la prévention de troubles squelettiques liés à une activation anormale du fgfr3
UA114501C2 (uk) * 2012-02-28 2017-06-26 Астеллас Фарма Інк. Азотовмісна ароматична гетероциклічна сполука
BR112014021897B1 (pt) 2012-03-08 2022-06-14 Astellas Pharma Inc Método, kit, conjunto de iniciadores e conjuntos de sondas para detectar um gene de fusão composto por um gene fgfr3 e um gene tacc3
US9254288B2 (en) * 2012-05-07 2016-02-09 The Translational Genomics Research Institute Susceptibility of tumors to tyrosine kinase inhibitors and treatment thereof
GB201209609D0 (en) * 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
EP2871236A4 (fr) * 2012-07-05 2016-03-09 Nat Cancer Ct Gène fgfr2 hybride
ES2932954T5 (en) * 2012-07-24 2025-10-28 Univ Columbia Fgfr-tacc fusion proteins and methods thereof
US20140030259A1 (en) * 2012-07-27 2014-01-30 Genentech, Inc. Methods of treating fgfr3 related conditions
CA2886002C (fr) * 2012-09-27 2020-06-09 Chugai Seiyaku Kabushiki Kaisha Gene de fusion fgfr3 et medicament pharmaceutique ciblant celui-ci
WO2014071419A2 (fr) * 2012-11-05 2014-05-08 Foundation Medicine, Inc. Nouvelles molécules de fusion et leurs utilisations
WO2014113729A2 (fr) * 2013-01-18 2014-07-24 Foundation Mecicine, Inc. Méthodes de traitement du cholangiocarcinome
EP2981621B1 (fr) 2013-04-05 2019-05-22 Life Technologies Corporation Fusions géniques
WO2014193229A2 (fr) 2013-05-27 2014-12-04 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Nouvelles translocations dans le cancer du poumon
EP3019628A4 (fr) 2013-07-12 2017-05-10 The Regents Of The University Of Michigan Fusions de gènes récurrentes dans le cancer
US20200208224A1 (en) 2014-09-26 2020-07-02 Janssen Pharmaceutica Nv Use Of FGFR Mutant Gene Panels In Identifying Cancer Patients That Will Be Responsive To Treatment With An FGFR Inhibitor
CR20170104A (es) 2014-09-26 2017-05-31 Janssen Pharmaceutica Nv Uso de paneles de genes mutantes de fgfr en la identificación de pacientes con cáncer que responderán al tratamiento con un inhibidor de fgfr
HRP20230697T1 (hr) 2017-02-06 2023-10-13 Janssen Pharmaceutica Nv Liječenje karcinoma

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KR102470456B1 (ko) 2022-11-23
JP2017529090A (ja) 2017-10-05
EP3198033A2 (fr) 2017-08-02
JO3681B1 (ar) 2020-08-27
CA2962075A1 (fr) 2016-03-31
AU2021277633A1 (en) 2021-12-23
SV2017005415A (es) 2017-07-03
KR20220162823A (ko) 2022-12-08
EP4063516A1 (fr) 2022-09-28
MX392774B (es) 2025-03-24
CN107002141B (zh) 2021-11-02
KR20170062495A (ko) 2017-06-07
IL251264A0 (en) 2017-05-29
EA037920B1 (ru) 2021-06-07
MX2022006536A (es) 2022-07-11
US12037644B2 (en) 2024-07-16
EA201790716A1 (ru) 2017-10-31
AU2015321626A1 (en) 2017-04-06
CN113957146B (zh) 2026-04-03
IL324511A (en) 2026-01-01
JP2020124192A (ja) 2020-08-20
CY1125190T1 (el) 2024-12-13
UY36325A (es) 2016-04-01
JP7051920B2 (ja) 2022-04-11
US20160090633A1 (en) 2016-03-31
ECSP17025787A (es) 2018-07-31
JP7558216B2 (ja) 2024-09-30
CO2017003528A2 (es) 2017-07-11
PH12017500556A1 (en) 2017-08-30
WO2016048833A3 (fr) 2016-05-19
UA122564C2 (uk) 2020-12-10
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CR20170104A (es) 2017-05-31
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MY194567A (en) 2022-12-02
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TW201619609A (zh) 2016-06-01
AU2021277633B2 (en) 2024-11-28
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JP2022109910A (ja) 2022-07-28
US20190078166A1 (en) 2019-03-14
HUE058219T2 (hu) 2022-07-28
WO2016048833A2 (fr) 2016-03-31
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