ECSP17064188A - Formulación estable para administración parenteral de tapentadol - Google Patents
Formulación estable para administración parenteral de tapentadolInfo
- Publication number
- ECSP17064188A ECSP17064188A ECIEPI201764188A ECPI201764188A ECSP17064188A EC SP17064188 A ECSP17064188 A EC SP17064188A EC IEPI201764188 A ECIEPI201764188 A EC IEPI201764188A EC PI201764188 A ECPI201764188 A EC PI201764188A EC SP17064188 A ECSP17064188 A EC SP17064188A
- Authority
- EC
- Ecuador
- Prior art keywords
- tapentadol
- parenteral administration
- relates
- pharmaceutical composition
- stable formulation
- Prior art date
Links
- KWTWDQCKEHXFFR-SMDDNHRTSA-N tapentadol Chemical compound CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-SMDDNHRTSA-N 0.000 title abstract 4
- 229960005126 tapentadol Drugs 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000007911 parenteral administration Methods 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 208000002193 Pain Diseases 0.000 abstract 2
- 208000005298 acute pain Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se relaciona con una composición farmacéutica acuosa para administración parenteral que comprende Tapentadol o un sal fisiológicamente aceptable del mismo, en donde la concentración de Tapentadol queda dentro de la variación de 0.10 hasta 8.00 mg/mL, con base en el peso de la base libre de Tapentadol y con base en el volumen total de la composición; y en donde el valor de pH de la composición se amortigua y queda dentro de la variación de 4.0 hasta 6.0. La invención también se relaciona con un recipiente que comprende la composición farmacéutica y un proceso para la preparación del mismo. La invención también se relaciona con un kit que comprende el contenido de acuerdo con la invención en un empaque. La composición farmacéutica de acuerdo con la invención es particularmente útil para tratar dolor, en especial dolor agudo, de preferencia en pacientes pediátricos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15161487 | 2015-03-27 | ||
| EP15169730 | 2015-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP17064188A true ECSP17064188A (es) | 2018-03-31 |
Family
ID=55661386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI201764188A ECSP17064188A (es) | 2015-03-27 | 2017-09-26 | Formulación estable para administración parenteral de tapentadol |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US20160279078A1 (es) |
| EP (2) | EP3479823B1 (es) |
| JP (1) | JP6923447B2 (es) |
| KR (1) | KR20170132282A (es) |
| CN (1) | CN107847471A (es) |
| AU (1) | AU2016239772B2 (es) |
| BR (1) | BR112017018569A2 (es) |
| CA (1) | CA2979034A1 (es) |
| CL (1) | CL2017002306A1 (es) |
| CO (1) | CO2017009400A2 (es) |
| CY (1) | CY1121371T1 (es) |
| DK (1) | DK3273953T3 (es) |
| EA (1) | EA036258B1 (es) |
| EC (1) | ECSP17064188A (es) |
| ES (2) | ES2710299T3 (es) |
| HK (1) | HK1252705A1 (es) |
| HR (1) | HRP20190231T1 (es) |
| HU (1) | HUE042612T2 (es) |
| IL (1) | IL254136A0 (es) |
| LT (1) | LT3273953T (es) |
| MX (1) | MX2017012312A (es) |
| PE (1) | PE20171651A1 (es) |
| PL (1) | PL3273953T3 (es) |
| PT (2) | PT3273953T (es) |
| RS (1) | RS58301B1 (es) |
| SI (1) | SI3273953T1 (es) |
| TW (1) | TW201642843A (es) |
| WO (1) | WO2016156147A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX388963B (es) | 2011-03-04 | 2025-03-20 | Gruenenthal Gmbh | Formulacion farmaceutica acuosa de tapentadol para administracion oral |
| PE20171651A1 (es) | 2015-03-27 | 2017-11-13 | Gruenenthal Chemie | Formulacion estable para administracion parenteral de tapentadol |
| EP3515412B1 (en) | 2016-09-23 | 2025-04-23 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
| EP3585370A1 (en) | 2017-02-23 | 2020-01-01 | Grünenthal GmbH | Tapentadol as local anesthetic |
| CN114788814B (zh) * | 2021-01-26 | 2023-10-13 | 浙江创新生物有限公司 | 一种高稳定性的注射用达托霉素组合物及其制备方法和其应用 |
| IT202400002503A1 (it) * | 2024-02-07 | 2025-08-07 | S A L F S P A Laboratorio Farm | Formulazione iniettabile sterile a base di rocuronio |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8334422D0 (en) | 1983-12-23 | 1984-02-01 | Sterwin Ag | Composition |
| GB8334423D0 (en) | 1983-12-23 | 1984-02-01 | Sterwin Ag | Composition |
| US4775678A (en) | 1984-10-01 | 1988-10-04 | Schering Corporation | Clotrimazole cream |
| AU614465B2 (en) | 1989-04-05 | 1991-08-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
| DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| US6183758B1 (en) | 1998-01-29 | 2001-02-06 | Highland Laboratories, Inc. | Phytochemicals, nutrients & medication absorption &/or treatment |
| US6211169B1 (en) | 1999-09-29 | 2001-04-03 | Aesgen, Inc. | Stable calcitriol solution for packaging into vials |
| FR2809619B1 (fr) * | 2000-06-06 | 2004-09-24 | Pharmatop | Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention |
| US6399087B1 (en) | 2000-12-20 | 2002-06-04 | Amphastar Pharmaceuticals, Inc. | Propofol formulation with enhanced microbial inhibition |
| US20050176790A1 (en) | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
| DE10109763A1 (de) | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
| DE10112325A1 (de) | 2001-03-13 | 2002-10-02 | Fresenius Kabi De Gmbh | Lagerstabile Fertiginfusionslösungen des Paracetamols |
| JP4905616B2 (ja) | 2001-04-19 | 2012-03-28 | ライオン株式会社 | ソフトコンタクトレンズ用点眼剤 |
| US6638981B2 (en) | 2001-08-17 | 2003-10-28 | Epicept Corporation | Topical compositions and methods for treating pain |
| PE20030527A1 (es) | 2001-10-24 | 2003-07-26 | Gruenenthal Chemie | Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen |
| FR2832063B1 (fr) | 2001-11-15 | 2004-08-27 | Aguettant Lab | Procede de production de solutions stables de substances phenoliques et les solutions en resultant |
| CA2479350A1 (en) | 2002-03-15 | 2003-09-25 | Cypress Bioscience, Inc. | Ne and 5-ht reuptake inhibitors for treating visceral pain syndromes |
| US20030191187A1 (en) | 2002-04-01 | 2003-10-09 | Lee Fang Yu | Injectable pharmaceutical composition containing a non-steroidal anti-inflammatory drug and method for preparing the same |
| US20040101563A1 (en) | 2002-07-18 | 2004-05-27 | Kundu Subhas C. | Storage stable antihistaminic syrup formulations |
| RU2359698C2 (ru) | 2002-09-13 | 2009-06-27 | Сайдекс, Инк. | Капсулы, содержащие водные наполняющие композиции, стабилизированные производным циклодекстрина |
| US6888993B2 (en) | 2002-11-27 | 2005-05-03 | Corning Incorporated | Dispersion compensating optical fiber for SMF and transmission link including same |
| ITMI20022748A1 (it) | 2002-12-23 | 2004-06-24 | Eurand Int | Dispersioni solide stabilizzate di farmaco in un carrier organico e procedimento per la loro preparazione. |
| DE602004019761D1 (de) | 2003-01-08 | 2009-04-16 | Novartis Vaccines & Diagnostic | Stabilisierte wässrige zusammensetzungen mit gewebefaktorinhibitor (tfpi) oder gewebefaktorinhibitor-variante |
| US20040180915A1 (en) | 2003-03-14 | 2004-09-16 | Xanodyne Pharmacal, Inc. | Methadone-containing compositions for parenteral administration and method of use thereof |
| US20060111382A1 (en) | 2004-05-17 | 2006-05-25 | Pharmacofore, Inc. | Compositions and methods for treating or preventing pain |
| PT1612203E (pt) | 2004-06-28 | 2007-08-20 | Gruenenthal Gmbh | ''formas cristalinas de cloridrato de (-) - (1r,2r) - 3 -(3-dimetilamino-l-etil - 2 - metilpropil) fenol'' |
| BRPI0513300B1 (pt) | 2004-07-01 | 2018-11-06 | Gruenenthal Gmbh | forma farmacêutica oral, protegida frente ao abuso, contendo (1r, 2r)-3-(3-dimetilamino-1-etil-2- metil-lpropil)-fenol |
| DE102004032103A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| EP1893190A4 (en) | 2005-04-28 | 2010-07-28 | Theraquest Biosciences Llc | METHODS AND COMPOSITIONS FOR TREATING PAIN |
| CA2618799C (en) * | 2005-08-12 | 2013-06-04 | Bharat Serums & Vaccines Ltd. | Aqueous anaesthetic compositions comprising propofol |
| TWI329334B (en) | 2005-12-02 | 2010-08-21 | Chung Shan Inst Of Science | Manufacture method of electromagnetic interference layer for the plasma display panel |
| US8176534B2 (en) | 2005-12-30 | 2012-05-08 | General Instrument Corporation | Method and apparatus for provisioning a device to access digital rights management (DRM) services in a universal plug and play (UPnP) network |
| WO2007127158A2 (en) | 2006-04-25 | 2007-11-08 | Croda, Inc | Modification of percutaneous absorption of topically active materials |
| ATE502629T1 (de) | 2006-04-28 | 2011-04-15 | Gruenenthal Gmbh | Pharmazeutische kombination mit 3- (3- dimethylamino-1-ethyl-2-methyl-propyl) phenol und einem nsar |
| PL2012764T3 (pl) | 2006-04-28 | 2011-04-29 | Gruenenthal Gmbh | Kombinacja farmaceutyczna zawierająca 3-(3-dimetyloamino-1-etylo-2-metylopropylo)fenol i Paracetamol |
| BRPI0714671B8 (pt) | 2006-07-24 | 2023-03-21 | Janssen Pharmaceutica Nv | Preparação de (2r,3r)-3-(3-metoxifenil)-n,n,2-trimetilpentanamina e compostos intermediários |
| EP1905440A1 (de) | 2006-09-06 | 2008-04-02 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verwendung einer pharmazeutischen Zusammensetzung enthaltend ein Anticholinergikum zur Abtötung von Mikroorganismen und zur Behandlung von Atemwegsinfektionen |
| TWI394564B (zh) | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
| DE102007012165A1 (de) | 2007-03-12 | 2008-09-18 | Grünenthal GmbH | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes |
| JP2008266168A (ja) | 2007-04-18 | 2008-11-06 | Teika Seiyaku Kk | 眼科用剤 |
| EP1985292A1 (en) | 2007-04-23 | 2008-10-29 | Grünenthal GmbH | Titration of tapentadol |
| EP1992334A1 (en) | 2007-05-08 | 2008-11-19 | Docpharma NV/SA | Storage-stable formulation of oxidation-sensitive phenolic drug, especially paracetamol, comprises aqueous drug solution deoxygenated by a temperature-controlled manufacturing process of the formulation |
| RS55769B1 (sr) | 2007-11-23 | 2017-07-31 | Gruenenthal Gmbh | Kompozicije tapentadola |
| AU2008335360A1 (en) | 2007-12-06 | 2009-06-18 | Pain Therapeutics, Inc. | Micronized opioid compositions, formulations and dosage forms and methods of making same |
| CA2713128C (en) | 2008-01-25 | 2016-04-05 | Gruenenthal Gmbh | Pharmaceutical dosage form |
| EP2280688B1 (en) | 2008-04-08 | 2012-01-25 | Acino Pharma AG | Aqueous pharmaceutical formulation |
| RU2673882C1 (ru) | 2008-10-30 | 2018-12-03 | Грюненталь Гмбх | Новые и эффективные лекарственные формы тапентадола |
| RU2011133020A (ru) | 2009-01-09 | 2013-02-20 | Панацеа Биотек Лтд. | Фармацевтические суспензии двойного высвобождения |
| WO2010100477A2 (en) | 2009-03-03 | 2010-09-10 | Shire Llc | Amino acid and peptide carbamate prodrugs of tapentadol and uses thereof |
| EP2246044A1 (en) | 2009-04-21 | 2010-11-03 | Pierre Fabre Dermo-Cosmétique | Paediatric solutions comprising a beta-blocker |
| US20100272815A1 (en) | 2009-04-28 | 2010-10-28 | Actavis Group Ptc Ehf | Amorphous form of tapentadol hydrochloride |
| JP5615821B2 (ja) | 2009-08-05 | 2014-10-29 | ナガセ医薬品株式会社 | インジゴカルミン製剤 |
| CN102711726A (zh) * | 2009-12-10 | 2012-10-03 | 特克尼梅德医疗技术股份公司 | 用于制备扑热息痛稳定液体制剂的方法和组合物 |
| US20110190267A1 (en) | 2010-01-05 | 2011-08-04 | Shire Pharmaceuticals, Inc. | Prodrugs of opioids and uses thereof |
| ES2829386T3 (es) | 2010-03-30 | 2021-05-31 | Phosphagenics Ltd | Parche de administración transdérmica |
| GB201006200D0 (en) | 2010-04-14 | 2010-06-02 | Ayanda As | Composition |
| US20120270848A1 (en) | 2010-10-22 | 2012-10-25 | Galleon Pharmaceuticals, Inc. | Novel Compositions and Therapeutic Methods Using Same |
| CN103501775A (zh) * | 2011-03-04 | 2014-01-08 | 格吕伦塔尔有限公司 | 他喷他多的胃肠外给药 |
| ES2910085T3 (es) * | 2011-03-04 | 2022-05-11 | Gruenenthal Gmbh | Composición farmacéutica acuosa semisólida que contiene tapentadol |
| MX388963B (es) * | 2011-03-04 | 2025-03-20 | Gruenenthal Gmbh | Formulacion farmaceutica acuosa de tapentadol para administracion oral |
| US20150073000A1 (en) | 2012-03-27 | 2015-03-12 | Fresenius Kabi Oncology Limited | Stable ready-to-use pharmaceutical composition of pemetrexed |
| CN103159633B (zh) | 2012-07-06 | 2015-08-12 | 江苏恩华药业股份有限公司 | 他喷他多的制备方法及用于制备他喷他多的化合物 |
| GB201309654D0 (en) | 2013-05-30 | 2013-07-17 | Euro Celtique Sa | Method |
| CN103735500B (zh) | 2014-01-28 | 2016-01-20 | 江苏华泽医药科技有限公司 | 盐酸他喷他多注射液及其制备方法 |
| PE20171651A1 (es) | 2015-03-27 | 2017-11-13 | Gruenenthal Chemie | Formulacion estable para administracion parenteral de tapentadol |
-
2016
- 2016-03-23 PE PE2017001503A patent/PE20171651A1/es unknown
- 2016-03-23 ES ES16714327T patent/ES2710299T3/es active Active
- 2016-03-23 PT PT16714327T patent/PT3273953T/pt unknown
- 2016-03-23 EP EP18206581.3A patent/EP3479823B1/en active Active
- 2016-03-23 AU AU2016239772A patent/AU2016239772B2/en active Active
- 2016-03-23 TW TW105108920A patent/TW201642843A/zh unknown
- 2016-03-23 KR KR1020177031299A patent/KR20170132282A/ko not_active Withdrawn
- 2016-03-23 LT LTEP16714327.0T patent/LT3273953T/lt unknown
- 2016-03-23 HU HUE16714327A patent/HUE042612T2/hu unknown
- 2016-03-23 EA EA201792144A patent/EA036258B1/ru not_active IP Right Cessation
- 2016-03-23 EP EP16714327.0A patent/EP3273953B1/en active Active
- 2016-03-23 HK HK18112014.7A patent/HK1252705A1/zh unknown
- 2016-03-23 CA CA2979034A patent/CA2979034A1/en not_active Abandoned
- 2016-03-23 MX MX2017012312A patent/MX2017012312A/es active IP Right Grant
- 2016-03-23 PT PT182065813T patent/PT3479823T/pt unknown
- 2016-03-23 PL PL16714327T patent/PL3273953T3/pl unknown
- 2016-03-23 RS RS20190174A patent/RS58301B1/sr unknown
- 2016-03-23 ES ES18206581T patent/ES2822113T3/es active Active
- 2016-03-23 CN CN201680019084.0A patent/CN107847471A/zh active Pending
- 2016-03-23 BR BR112017018569A patent/BR112017018569A2/pt not_active Application Discontinuation
- 2016-03-23 JP JP2017550592A patent/JP6923447B2/ja active Active
- 2016-03-23 SI SI201630181T patent/SI3273953T1/sl unknown
- 2016-03-23 DK DK16714327.0T patent/DK3273953T3/en active
- 2016-03-23 HR HRP20190231TT patent/HRP20190231T1/hr unknown
- 2016-03-23 WO PCT/EP2016/056376 patent/WO2016156147A1/en not_active Ceased
- 2016-03-23 US US15/078,631 patent/US20160279078A1/en not_active Abandoned
-
2017
- 2017-08-24 IL IL254136A patent/IL254136A0/en unknown
- 2017-09-12 CL CL2017002306A patent/CL2017002306A1/es unknown
- 2017-09-15 CO CONC2017/0009400A patent/CO2017009400A2/es unknown
- 2017-09-26 EC ECIEPI201764188A patent/ECSP17064188A/es unknown
-
2018
- 2018-01-10 US US15/867,254 patent/US11013701B2/en active Active
-
2019
- 2019-02-06 CY CY20191100162T patent/CY1121371T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP17064188A (es) | Formulación estable para administración parenteral de tapentadol | |
| CY1126062T1 (el) | Σταθερη φαρμακοτεχνικη μορφη anti-ifnar1 | |
| CY1122516T1 (el) | Ετοιμες προς χρηση διατυπωσεις κετορολακης | |
| RU2017132877A (ru) | Комбинация антагониста pd-1 и эрибулина для лечения рака | |
| BR112015018252A2 (pt) | composição farmacêutica aquosa de dose fixa estável para administração nasal para um ser humano, composição de suspensão aquosa farmacêutica de dose fixa estável para administração nasal para um ser humano, suspensão estável adequada para administração nasal a um ser humano, método para tratar rinite em um ser humano necessitando do mesmo, uso da composição farmacêutica para administração nasal, método para liberar uma composição farmacêutica e kit | |
| EA201492021A1 (ru) | Антительный состав | |
| JP2014510067A5 (es) | ||
| JP2016539921A5 (es) | ||
| NZ702342A (en) | Pharmaceutical formulation | |
| UY31790A (es) | Utilización de dronedarona para preparar un medicamento para el tratamiento de pacientes con arritmia y que tienen un incremento del nivel de creatinina debido a la administración de dronedarona | |
| BR112017025527A2 (pt) | preparação farmacêutica líquida, e, método para fabricar uma suspensão de celocoxibe. | |
| BR112016009214A8 (pt) | uso de um composto para preparação de um medicamento para o tratamento de distrofia muscular e composição farmacêutica | |
| AR104051A1 (es) | Formulación estable para administración parenteral de tapentadol | |
| CO2019002557A2 (es) | Formulación estable para la administración parenteral de tapentadol | |
| MX387263B (es) | Composición farmacéutica de liberación prolongada que comprende cisteamina o sal de la misma. | |
| TW200626133A (en) | Oral medication for twice-daily administration | |
| CY1120282T1 (el) | Φαρμακευτικη συνθεση κιτρικης σιλδεναφιλης με την μορφη ενος εναιωρηματος για εκ του στοματος χρηση | |
| MA44557A1 (fr) | Vaccin contre le rotavirus sans tampon, stable en milieu acide, et d'un faible volume de dose à administrer | |
| JP2019529554A5 (es) | ||
| Khrystiuk et al. | The study of the rheological properties of paste with natural zeolite | |
| MX2016007881A (es) | Uso de un extracto de ageratina pichinchensis para el tratamiento de estomatitis aftosa recidivante menor. | |
| MX2022000418A (es) | Composicion farmaceutica de imatinib. | |
| UA123395U (uk) | Фармацевтична композиція ністатину у формі оральної суспензії | |
| MY194675A (en) | Use of parkia speciosa empty pod extract in alleviating cardiac hypertrophy | |
| PL408096A1 (pl) | Produkt farmaceutyczny z ekstraktem roślinnym oraz zestaw produktu farmaceutycznego z ekstraktem roślinnym |