MA54538B1 - Inhibiteurs d'apol1 et leurs procédés d'utilisation - Google Patents
Inhibiteurs d'apol1 et leurs procédés d'utilisationInfo
- Publication number
- MA54538B1 MA54538B1 MA54538A MA54538A MA54538B1 MA 54538 B1 MA54538 B1 MA 54538B1 MA 54538 A MA54538 A MA 54538A MA 54538 A MA54538 A MA 54538A MA 54538 B1 MA54538 B1 MA 54538B1
- Authority
- MA
- Morocco
- Prior art keywords
- methods
- apol1
- inhibitors
- ndkd
- fsgs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
L'invention concerne au moins une entité choisie parmi des composés de formule (I), des formes à l'état solide de ceux-ci, des compositions les comprenant, et des procédés d'utilisation de ceux-ci, comprenant l'utilisation dans le traitement de la glomérulosclérose segmentaire focale (FSGS) et/ou d'une maladie rénale non diabétique (NDKD).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862780667P | 2018-12-17 | 2018-12-17 | |
| PCT/US2019/066746 WO2020131807A1 (fr) | 2018-12-17 | 2019-12-17 | Inhibiteurs d'apol1 et leurs procédés d'utilisation |
| EP19839496.7A EP3897833B1 (fr) | 2018-12-17 | 2019-12-17 | Inhibiteurs d'apol1 et leurs procédés d'utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA54538A MA54538A (fr) | 2021-10-27 |
| MA54538B1 true MA54538B1 (fr) | 2026-04-30 |
Family
ID=69182627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA54538A MA54538B1 (fr) | 2018-12-17 | 2019-12-17 | Inhibiteurs d'apol1 et leurs procédés d'utilisation |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US11618746B2 (fr) |
| EP (1) | EP3897833B1 (fr) |
| JP (1) | JP7573528B2 (fr) |
| KR (2) | KR20260020195A (fr) |
| CN (1) | CN113453760B (fr) |
| AR (1) | AR116913A1 (fr) |
| AU (1) | AU2019405477B2 (fr) |
| CA (1) | CA3121910A1 (fr) |
| CL (1) | CL2021001561A1 (fr) |
| CO (1) | CO2021009053A2 (fr) |
| CR (1) | CR20210383A (fr) |
| DK (1) | DK3897833T3 (fr) |
| DO (1) | DOP2021000116A (fr) |
| EC (1) | ECSP21052184A (fr) |
| FI (1) | FI3897833T3 (fr) |
| IL (2) | IL283592B2 (fr) |
| JO (3) | JOP20210131A1 (fr) |
| LT (1) | LT3897833T (fr) |
| MA (1) | MA54538B1 (fr) |
| MX (1) | MX2021007152A (fr) |
| PE (1) | PE20212302A1 (fr) |
| PT (1) | PT3897833T (fr) |
| SA (1) | SA521422270B1 (fr) |
| SG (1) | SG11202105769XA (fr) |
| SM (1) | SMT202600169T1 (fr) |
| TW (1) | TWI848031B (fr) |
| UA (1) | UA128375C2 (fr) |
| UY (1) | UY38514A (fr) |
| WO (1) | WO2020131807A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL283592B2 (en) | 2018-12-17 | 2025-08-01 | Vertex Pharma | Inhibitors of apol1 and methods of using same |
| EP4097083A1 (fr) * | 2020-01-29 | 2022-12-07 | Vertex Pharmaceuticals Incorporated | Inhibiteurs d'apol1 et leurs méthodes d'utilisation |
| US20210246121A1 (en) * | 2020-02-04 | 2021-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of apol1 inhibitor and methods of using same |
| CN115209894B (zh) * | 2020-03-06 | 2025-05-02 | 弗特克斯药品有限公司 | 治疗apol-1依赖性局灶节段性肾小球硬化的方法 |
| CA3185144A1 (fr) * | 2020-06-12 | 2021-12-16 | Vertex Pharmaceuticals Incorporated | Inhibiteurs d'apol1 et leur utilisation |
| CN116157393A (zh) | 2020-06-12 | 2023-05-23 | 弗特克斯药品有限公司 | Apol1的抑制剂及其用途 |
| EP4165036A1 (fr) * | 2020-06-12 | 2023-04-19 | Vertex Pharmaceuticals Incorporated | Formes solides d'un inhibiteur d'apol1 et utilisation de celles-ci |
| UY39395A (es) * | 2020-08-26 | 2022-03-31 | Vertex Pharma | Inhibidores de apol1 y métodos para usar los mismos |
| WO2022178315A1 (fr) | 2021-02-19 | 2022-08-25 | Maze Therapeutics, Inc. | Inhibiteurs d'apol1 et méthodes d'utilisation |
| KR20240051990A (ko) * | 2021-08-26 | 2024-04-22 | 버텍스 파마슈티칼스 인코포레이티드 | 스피로트리시클릭 apol1 억제제의 고형분 형태 및 이의 사용 방법 |
| US12612379B2 (en) | 2021-11-30 | 2026-04-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of APOL1 and methods of using same |
| JP2024544060A (ja) * | 2021-11-30 | 2024-11-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | Apol1のスピロ環式阻害剤およびこれを使用する方法 |
| KR20240149461A (ko) * | 2022-01-18 | 2024-10-14 | 메이즈 테라퓨틱스, 인코퍼레이티드 | Apol1 저해제 및 사용 방법 |
| CA3251050A1 (fr) * | 2022-02-08 | 2023-08-17 | Vertex Pharmaceuticals Incorporated | Dérivés de 2-méthyl-4',5'-dihydrospiro[pipéridine-4,7'-thiéno[2,3-c]pyran] utilisés en tant qu'inhibiteurs de apol1 et leurs procédés d'utilisation |
| WO2023194895A1 (fr) | 2022-04-06 | 2023-10-12 | Glaxosmithkline Intellectual Property Development Limited | Dérivés pyrroliques utilisés en tant qu'inhibiteurs de l'apolipoprotéine l-1 |
| EP4573077A1 (fr) * | 2022-08-19 | 2025-06-25 | Maze Therapeutics, Inc. | Inhibiteurs d'apol1 et procédés d'utilisation |
| WO2025006262A1 (fr) * | 2023-06-29 | 2025-01-02 | Omniab, Inc. | Composés tétracycliques contenant un indole fusionné pour le traitement d'une maladie rénale chronique médiée par apol1 |
| GB202401326D0 (en) * | 2024-02-01 | 2024-03-20 | Podium Bio Ltd | Novel compounds |
| KR20250122547A (ko) | 2024-02-05 | 2025-08-14 | 서주사이언티픽 주식회사 | AIoT 기반 방사성 동위원소 관리 시스템 |
| WO2026012338A1 (fr) * | 2024-07-09 | 2026-01-15 | 上海旭成医药科技有限公司 | Inhibiteur d'apol |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4039676A (en) | 1975-06-23 | 1977-08-02 | Ciba-Geigy Corporation | 2-piperidinoalkyl-1,4-benzodioxans |
| ZA977103B (en) | 1996-08-09 | 1999-02-08 | Eisai Co Ltd | Benzopiperidine derivatives |
| AU2201699A (en) | 1997-12-19 | 1999-07-12 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
| GB9905010D0 (en) | 1999-03-04 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
| WO2001017965A2 (fr) | 1999-09-07 | 2001-03-15 | Syngenta Participations Ag | Cyanopiperidines |
| FR2801585B1 (fr) | 1999-11-25 | 2002-02-15 | Fournier Ind & Sante | Nouveaux antagonistes des recepteurs de l'ii-8 |
| GB0003397D0 (en) | 2000-02-14 | 2000-04-05 | Merck Sharp & Dohme | Therapeutic agents |
| CA2424222A1 (fr) | 2000-10-02 | 2002-04-11 | Merck & Co., Inc. | Inhibiteurs de la prenyl-proteine transferase |
| FR2824827B1 (fr) | 2001-05-17 | 2004-02-13 | Fournier Lab Sa | Nouveaux derives de 5-phenyl-1h-indole antagoniste des recepteurs de l'interleukine-8 |
| FR2824826B1 (fr) | 2001-05-17 | 2003-11-07 | Fournier Lab Sa | Nouveaux derives de 5-cyano-1h-indole antagonistes des recepteurs de l'interleukine-8 |
| CA2672549A1 (fr) | 2001-11-14 | 2003-06-12 | Ben-Zion Dolitzky | Formes cristallines amorphes de losartan potassique et leur procede de preparation |
| WO2003104180A1 (fr) | 2002-06-05 | 2003-12-18 | Natco Pharma Limited | Procede de preparation d'acide 4-(4-fluorobenzoyl) butyrique |
| EP1572660B1 (fr) | 2002-12-20 | 2011-01-26 | X-Ceptor Therapeutics, Inc. | Dérives d'isoquinolinone et leur utilisation comme agents thérapeutiques |
| EP1663972A1 (fr) | 2003-09-03 | 2006-06-07 | Galapagos N.V. | Nouveau 4-piperidine-carboxamide et leur utilisation pour preparer des medicaments contre des troubles lies au recepteur de la 5-ht2a |
| ES2414604T3 (es) | 2004-03-03 | 2013-07-22 | Eli Lilly And Company | Moduladores del receptor nuclear de hormonas esteroides de derivados bicíclicos sustituidos con indol |
| AR048523A1 (es) | 2004-04-07 | 2006-05-03 | Kalypsys Inc | Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos |
| CA2629192A1 (fr) | 2005-11-22 | 2007-05-31 | Merck & Co., Inc. | Antagonistes des recepteurs de l'indole orexine |
| US8222288B2 (en) | 2006-08-30 | 2012-07-17 | The Regents Of The University Of Michigan | Small molecule inhibitors of MDM2 and the uses thereof |
| EP2086935A1 (fr) | 2006-10-16 | 2009-08-12 | Grünenthal GmbH | Derives de sulfonamide substitues en tant que modulateurs du recepteur de bradykinine-1 |
| MX2009006454A (es) | 2006-12-22 | 2009-06-26 | Hoffmann La Roche | Derivados de espiro-piperidina. |
| DK2118074T3 (en) | 2007-02-01 | 2014-03-10 | Resverlogix Corp | Compounds for the prevention and treatment of cardiovascular diseases |
| EP2020414A1 (fr) | 2007-06-20 | 2009-02-04 | Laboratorios del Dr. Esteve S.A. | Derivés spiro[piperidine-4,4'-thieno[3,2-c]pyran] et composés similaires en tant que inhibiteurs du recepteur sigma pour le traitement de pyschose |
| JP5323834B2 (ja) | 2007-08-17 | 2013-10-23 | エルジー・ライフ・サイエンシーズ・リミテッド | 細胞壊死阻害剤としてのインドール化合物 |
| CN105254557A (zh) | 2009-05-29 | 2016-01-20 | 拉夸里亚创药株式会社 | 作为钙或钠通道阻滞剂的芳基取代羧酰胺衍生物 |
| DK2501704T3 (da) | 2009-11-16 | 2013-10-14 | Lilly Co Eli | Spiropiperidinforbindelser som oral-1-receptorantagonister |
| UA107943C2 (xx) | 2009-11-16 | 2015-03-10 | Lilly Co Eli | Сполуки спіропіперидину як антагоністи рецептора orl-1 |
| WO2012025155A1 (fr) | 2010-08-26 | 2012-03-01 | Novartis Ag | Composés à base d'hydroxamate en tant qu'inhibiteurs des désacétylases |
| BR102012024778A2 (pt) | 2012-09-28 | 2014-08-19 | Cristalia Prod Quimicos Farm | Compostos heteroaromáticos; processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica |
| WO2014085154A1 (fr) | 2012-11-27 | 2014-06-05 | Beth Israel Deaconess Medical Center, Inc. | Méthodes de traitement d'une maladie rénale |
| EP3049405A4 (fr) | 2013-09-26 | 2017-03-08 | Pharmakea Inc. | Composés inhibiteurs de l'autotaxine |
| EP3122726B1 (fr) | 2014-03-27 | 2018-08-29 | Academisch Medisch Centrum | Iminosucres n-(5-((aryl ou hétéroaryl)méthyloxy)pentyl)-substitués comme inhibiteurs de glucosylcéramide synthase |
| EP3186225A4 (fr) | 2014-08-27 | 2018-02-28 | The Governing Council of the University of Toronto | Modulateurs du récepteur cannabinoïde de type 1 |
| ES2751623T3 (es) | 2014-10-08 | 2020-04-01 | Inst Nat Sante Rech Med | Nuevos compuestos de aminopiridina útiles como inhibidores de la prenilación de proteínas |
| JP2017535545A (ja) | 2014-11-21 | 2017-11-30 | ラボラトリオス・デル・デエレ・エステベ・エセ・ア | 疼痛に対する多様な活性を有するスピロ−イソキノリン−1,4’−ピペリジン化合物 |
| RS61719B1 (sr) | 2015-08-27 | 2021-05-31 | Pfizer | Biciklična fuzionisana hetaroaril ili aril jedinjenja kao modulatori irak4 |
| EP3414247B1 (fr) | 2016-02-08 | 2021-04-21 | F. Hoffmann-La Roche AG | Spiroindolinones utilisés en tant qu'inhibiteurs de ddr1 |
| AU2019263176B2 (en) | 2018-04-30 | 2025-02-27 | The Trustees Of Indiana University | Compounds for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease |
| IL316397A (en) | 2018-05-22 | 2024-12-01 | Ionis Pharmaceuticals Inc | Modulators of APOL1 expression |
| IL283592B2 (en) | 2018-12-17 | 2025-08-01 | Vertex Pharma | Inhibitors of apol1 and methods of using same |
| WO2020186220A1 (fr) | 2019-03-13 | 2020-09-17 | Immunophage Biomedical Co., Ltd. | Composés en tant qu'inhibiteurs du facteur inhibiteur de la migration des macrophages |
| KR20220130127A (ko) | 2019-12-19 | 2022-09-26 | 카스마 테라퓨틱스, 인코포레이티드 | Trpml 조절제 |
| EP4097083A1 (fr) | 2020-01-29 | 2022-12-07 | Vertex Pharmaceuticals Incorporated | Inhibiteurs d'apol1 et leurs méthodes d'utilisation |
| US20210246121A1 (en) * | 2020-02-04 | 2021-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of apol1 inhibitor and methods of using same |
| CN115209894B (zh) | 2020-03-06 | 2025-05-02 | 弗特克斯药品有限公司 | 治疗apol-1依赖性局灶节段性肾小球硬化的方法 |
| US20230150980A1 (en) | 2020-04-22 | 2023-05-18 | Anima Biotech Inc. | Collagen 1 translation inhibitors and methods of use thereof |
| WO2021220178A1 (fr) | 2020-04-29 | 2021-11-04 | Cominnex Zrt. | Antagonistes d'iap et leurs applications thérapeutiques |
| EP4146633A4 (fr) | 2020-05-07 | 2024-09-25 | Rambam Med-Tech Ltd. | Composition destinée à être utilisée dans le traitement d'une maladie associée à apol1 |
| CA3185144A1 (fr) | 2020-06-12 | 2021-12-16 | Vertex Pharmaceuticals Incorporated | Inhibiteurs d'apol1 et leur utilisation |
| EP4165036A1 (fr) | 2020-06-12 | 2023-04-19 | Vertex Pharmaceuticals Incorporated | Formes solides d'un inhibiteur d'apol1 et utilisation de celles-ci |
| CN116157393A (zh) | 2020-06-12 | 2023-05-23 | 弗特克斯药品有限公司 | Apol1的抑制剂及其用途 |
| UY39395A (es) | 2020-08-26 | 2022-03-31 | Vertex Pharma | Inhibidores de apol1 y métodos para usar los mismos |
| KR20240051990A (ko) | 2021-08-26 | 2024-04-22 | 버텍스 파마슈티칼스 인코포레이티드 | 스피로트리시클릭 apol1 억제제의 고형분 형태 및 이의 사용 방법 |
| US12612379B2 (en) | 2021-11-30 | 2026-04-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of APOL1 and methods of using same |
| JP2024544060A (ja) | 2021-11-30 | 2024-11-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | Apol1のスピロ環式阻害剤およびこれを使用する方法 |
| WO2023154310A1 (fr) | 2022-02-08 | 2023-08-17 | Vertex Pharmaceuticals Incorporated | Dérivés de 2-méthyl-4-phénylpipéridin-4-ol utilisés en tant qu'inhibiteurs de apol1 et leurs procédés d'utilisation |
| JP2025505644A (ja) | 2022-02-08 | 2025-02-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | Apol1の阻害剤としての4’,5’-ジヒドロスピロ[ピペリジン-4,7’-チエノ[2,3-c]ピラン]誘導体、及びそれを使用する方法 |
| CA3251050A1 (fr) | 2022-02-08 | 2023-08-17 | Vertex Pharmaceuticals Incorporated | Dérivés de 2-méthyl-4',5'-dihydrospiro[pipéridine-4,7'-thiéno[2,3-c]pyran] utilisés en tant qu'inhibiteurs de apol1 et leurs procédés d'utilisation |
| CA3251155A1 (fr) | 2022-02-08 | 2023-08-17 | Vertex Pharmaceuticals Incorporated | Dérivés de spiro pipéridine utilisés en tant qu'inhibiteurs de apol1 et leurs procédés d'utilisation |
-
2019
- 2019-12-17 IL IL283592A patent/IL283592B2/en unknown
- 2019-12-17 CN CN201980092356.3A patent/CN113453760B/zh active Active
- 2019-12-17 AR ARP190103717A patent/AR116913A1/es unknown
- 2019-12-17 CA CA3121910A patent/CA3121910A1/fr active Pending
- 2019-12-17 FI FIEP19839496.7T patent/FI3897833T3/fi active
- 2019-12-17 PE PE2021000896A patent/PE20212302A1/es unknown
- 2019-12-17 WO PCT/US2019/066746 patent/WO2020131807A1/fr not_active Ceased
- 2019-12-17 MA MA54538A patent/MA54538B1/fr unknown
- 2019-12-17 TW TW108146307A patent/TWI848031B/zh active
- 2019-12-17 SM SM20260169T patent/SMT202600169T1/it unknown
- 2019-12-17 KR KR1020267000658A patent/KR20260020195A/ko active Pending
- 2019-12-17 JO JOP/2021/0131A patent/JOP20210131A1/ar unknown
- 2019-12-17 LT LTEPPCT/US2019/066746T patent/LT3897833T/lt unknown
- 2019-12-17 IL IL319575A patent/IL319575A/en unknown
- 2019-12-17 US US16/717,099 patent/US11618746B2/en active Active
- 2019-12-17 KR KR1020217022550A patent/KR102912203B1/ko active Active
- 2019-12-17 CR CR20210383A patent/CR20210383A/es unknown
- 2019-12-17 JP JP2021534284A patent/JP7573528B2/ja active Active
- 2019-12-17 UY UY0001038514A patent/UY38514A/es active IP Right Grant
- 2019-12-17 MX MX2021007152A patent/MX2021007152A/es unknown
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