ECSP972111A - MATRIX METALOPROTEINASES INHIBITORS BY ACIDS 2- (AROILALQUIL) -4 BIARIL-4- OXOBUTIRICOS - Google Patents
MATRIX METALOPROTEINASES INHIBITORS BY ACIDS 2- (AROILALQUIL) -4 BIARIL-4- OXOBUTIRICOSInfo
- Publication number
- ECSP972111A ECSP972111A ECSP972111A ECSP972111A EC SP972111 A ECSP972111 A EC SP972111A EC SP972111 A ECSP972111 A EC SP972111A EC SP972111 A ECSP972111 A EC SP972111A
- Authority
- EC
- Ecuador
- Prior art keywords
- present
- disorders
- disease
- compounds
- pharmaceutical compositions
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 2
- 102000005741 Metalloproteases Human genes 0.000 abstract 2
- 108010006035 Metalloproteases Proteins 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 206010053555 Arthritis bacterial Diseases 0.000 abstract 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 abstract 1
- 206010011091 Coronary artery thrombosis Diseases 0.000 abstract 1
- 208000016192 Demyelinating disease Diseases 0.000 abstract 1
- 206010053177 Epidermolysis Diseases 0.000 abstract 1
- 208000004575 Infectious Arthritis Diseases 0.000 abstract 1
- 206010060820 Joint injury Diseases 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000028911 Temporomandibular Joint disease Diseases 0.000 abstract 1
- 206010064996 Ulcerative keratitis Diseases 0.000 abstract 1
- 208000007474 aortic aneurysm Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000030499 combat disease Diseases 0.000 abstract 1
- 201000007717 corneal ulcer Diseases 0.000 abstract 1
- 208000002528 coronary thrombosis Diseases 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 201000001474 proteinuria Diseases 0.000 abstract 1
- 201000001223 septic arthritis Diseases 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención presenta composiciones farmacéuticas y métodos para tratar ciertos trastornos, que comprenden administrar una cantidad de un compuesto o composición de la presente invención que sea eficaz para inhibir la actividad de por lo menos una metaloproteasa de matriz, que da como resultado la obtención del efecto deseado. Los compuestos de la presente invención tiene la fórmula generalizada (gráfico), donde v es 1,2,3,ó 4 y Ar representa una porción aromática sustituida. Estos compuestos son útiles para inhibir las metaloproteasas de matriz y, por lo tanto, para combatir trastornos a los cuales contribuyen las MMP, tales como la osteoartritis, artritis reumatología, artritis séptica, enfermedad periodontal, úlcera de córnea, proteinuria, enfermedad de aneurisma aórtico, epidermólisis vesicular distrófica, trastornos que producen respuestas inflamatorias, osteopenias en las que media la actividad de las MMP, enfermedad de la articulación temporomandibular, enfermedades desmielinizantes del sistema nervioso, metástasis de tumores o pérdida de catílago posterior a la lesión articular traumática y trombosis coronaria por ruptura de placa aterosclerótica. La presente invención presenta asi mismo composiciones farmacéuticas y métodos para tratar dichas afecciones.The present invention features pharmaceutical compositions and methods of treating certain disorders, which comprise administering an amount of a compound or composition of the present invention that is effective in inhibiting the activity of at least one matrix metalloprotease, resulting in obtaining the desired effect. The compounds of the present invention have the generalized formula (graph), where v is 1,2,3, or 4 and Ar represents a substituted aromatic moiety. These compounds are useful to inhibit matrix metalloproteases and therefore to combat disorders to which MMPs contribute, such as osteoarthritis, rheumatology arthritis, septic arthritis, periodontal disease, corneal ulcer, proteinuria, aortic aneurysm disease , dystrophic vesicular epidermolysis, disorders that produce inflammatory responses, osteopenias in which MMP activity mediates, temporomandibular joint disease, demyelinating diseases of the nervous system, metastasis of tumors or loss of catilage after traumatic joint injury and coronary thrombosis due to atherosclerotic plaque rupture. The present invention also presents pharmaceutical compositions and methods for treating such conditions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972111 ECSP972111A (en) | 1997-05-12 | 1997-05-12 | MATRIX METALOPROTEINASES INHIBITORS BY ACIDS 2- (AROILALQUIL) -4 BIARIL-4- OXOBUTIRICOS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972111 ECSP972111A (en) | 1997-05-12 | 1997-05-12 | MATRIX METALOPROTEINASES INHIBITORS BY ACIDS 2- (AROILALQUIL) -4 BIARIL-4- OXOBUTIRICOS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972111A true ECSP972111A (en) | 1998-04-24 |
Family
ID=42042942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972111 ECSP972111A (en) | 1997-05-12 | 1997-05-12 | MATRIX METALOPROTEINASES INHIBITORS BY ACIDS 2- (AROILALQUIL) -4 BIARIL-4- OXOBUTIRICOS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972111A (en) |
-
1997
- 1997-05-12 EC ECSP972111 patent/ECSP972111A/en unknown
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