EE03263B1 - Erütromütsiini derivaadid, nende valmistamismeetod, farmatseutiline kompositsioon ja vaheühendid - Google Patents

Erütromütsiini derivaadid, nende valmistamismeetod, farmatseutiline kompositsioon ja vaheühendid

Info

Publication number: EE03263B1
Authority: EE; Estonia
Prior art keywords: intermediates; preparation; pharmaceutical composition; erythromycin derivatives; erythromycin
Prior art date: 1994-05-03

Application number

EE9600151A

Other languages

English (en)

Inventor

Agouridas Constantin

Chantot Jean-Fran�Ois

Denis Alexis

Gouin D'ambrieres Solange

Le Martret Odile

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-03

Filing date

1995-05-02

Publication date

2000-04-17

1995-05-02 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

2000-04-17 Publication of EE03263B1 publication Critical patent/EE03263B1/et

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
239000012450 pharmaceutical intermediate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Tropical Medicine & Parasitology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Quinoline Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Indole Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyrrole Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

EE9600151A 1994-05-03 1995-05-02 Erütromütsiini derivaadid, nende valmistamismeetod, farmatseutiline kompositsioon ja vaheühendid EE03263B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9405368A FR2719587B1 (fr)	1994-05-03	1994-05-03	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000565 WO1995029929A1 (fr)	1994-05-03	1995-05-02	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number	Publication Date
EE03263B1 true EE03263B1 (et)	2000-04-17

Family

ID=9462785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9600151A EE03263B1 (et)	1994-05-03	1995-05-02	Erütromütsiini derivaadid, nende valmistamismeetod, farmatseutiline kompositsioon ja vaheühendid

Country Status (42)

Country	Link
US (2)	US5635485A (et)
EP (1)	EP0680967B1 (et)
JP (4)	JP2992540B2 (et)
KR (1)	KR100312267B1 (et)
CN (2)	CN1052984C (et)
AP (1)	AP558A (et)
AT (1)	ATE172203T1 (et)
AU (1)	AU684027B2 (et)
BG (1)	BG63087B1 (et)
BR (1)	BR9507700A (et)
CA (1)	CA2189271C (et)
CZ (1)	CZ293455B6 (et)
DE (2)	DE69505296T2 (et)
DK (1)	DK0680967T3 (et)
DZ (1)	DZ1878A1 (et)
EE (1)	EE03263B1 (et)
ES (1)	ES2122472T3 (et)
FI (1)	FI111263B (et)
FR (1)	FR2719587B1 (et)
GE (1)	GEP19991538B (et)
HU (2)	HU219599B (et)
IL (1)	IL113245A (et)
LU (1)	LU90872I2 (et)
LV (1)	LV11739B (et)
MA (1)	MA23534A1 (et)
MD (1)	MD1233C2 (et)
NL (1)	NL300077I1 (et)
NO (2)	NO308853B1 (et)
NZ (1)	NZ285416A (et)
OA (1)	OA10319A (et)
PL (1)	PL182034B1 (et)
RO (1)	RO113350B1 (et)
RU (1)	RU2144036C1 (et)
SI (1)	SI0680967T1 (et)
SK (1)	SK281707B6 (et)
TJ (1)	TJ313B (et)
TN (1)	TNSN95049A1 (et)
TW (1)	TW341573B (et)
UA (1)	UA51618C2 (et)
WO (1)	WO1995029929A1 (et)
YU (1)	YU49235B (et)
ZA (1)	ZA953501B (et)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6241796A (en) *	1995-06-27	1997-01-30	Takeda Chemical Industries Ltd.	4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists
FR2742757B1 (fr) *	1995-12-22	1998-01-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) *	1996-09-04	2002-12-16	Ебботт Лабораторіз	6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
SK285534B6 (sk) *	1996-09-04	2007-03-01	Abbott Laboratories	6-O-substituované ketolidy s antibakteriálnou aktivitou, farmaceutická kompozícia s ich obsahom, ich použitie a spôsob ich prípravy
FR2757168B1 (fr) *	1996-12-12	1999-06-11	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) *	1997-02-27	1999-04-30	Hoechst Marion Roussel Inc	Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5780605A (en) *	1997-09-08	1998-07-14	Abbott Laboratories	6,9-bridged erythromycin derivatives
FR2771008B1 (fr) *	1997-11-17	2000-04-28	Hoechst Marion Roussel Inc	Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
JP4573925B2 (ja) *	1998-07-09	2010-11-04	アベンティス・ファーマ・ソシエテ・アノニム	新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) *	1998-07-21	2001-08-10	Hoechst Marion Roussel Inc	Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
AU5299499A (en)	1998-09-22	2000-04-10	Pfizer Products Inc.	Carbamate and carbazate ketolide antibiotics
FR2785612A1 (fr) *	1998-11-10	2000-05-12	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) *	1998-11-24	2002-10-31	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TW526202B (en)	1998-11-27	2003-04-01	Shionogi & Amp Co	Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
ES2273964T3 (es)	1998-12-10	2007-05-16	Pfizer Products Inc.	Antibioticos de carbamato y carbazato cetolida.
AP2001002222A0 (en) *	1999-01-27	2001-09-30	Pfizer Prod Inc	Ketolide antibiotics.
FR2789392B1 (fr) *	1999-02-04	2001-10-05	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) *	1999-03-19	2000-04-25	Abbott Laboratories	6-O-substituted macrolides having antibacterial activity
US6939861B2 (en) *	1999-04-16	2005-09-06	Kosan Biosciences, Inc.	Amido macrolides
IL145976A0 (en)	1999-04-16	2002-07-25	Ortho Mcneil Pharm Inc	Ketolide antibacterials
US6451768B1 (en)	1999-04-16	2002-09-17	Kosan Biosciences, Inc.	Macrolide antiinfective agents
US6514944B2 (en)	1999-04-16	2003-02-04	Kosan Biosciences, Inc.	Macrolide antiinfective agents
US6590083B1 (en)	1999-04-16	2003-07-08	Ortho-Mcneil Pharmaceutical, Inc.	Ketolide antibacterials
US6395710B1 (en)	1999-04-16	2002-05-28	Kosan Biosciences, Inc.	Macrolide antiinfective agents
IL145739A0 (en) *	1999-05-24	2002-07-25	Pfizer Prod Inc	13-methyl-erythromycin derivatives
FR2797875B1 (fr) *	1999-08-26	2001-10-19	Hoechst Marion Roussel Inc	Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
US6946446B2 (en)	2000-02-24	2005-09-20	Abbott Laboratories	Anti-infective agents useful against multidrug-resistant strains of bacteria
EP1313751B1 (en) *	2000-08-22	2008-09-17	Basilea Pharmaceutica AG	New macrolides with antibacterial activity
FR2821747B1 (fr) *	2001-03-09	2004-07-02	Ethypharm Lab Prod Ethiques	Suspension de telithromycine a gout masque
JP4509553B2 (ja) *	2001-07-03	2010-07-21	ノバルティスバクシンズアンドダイアグノスティックス，インコーポレーテッド	抗菌活性を有するｃ１２修飾エリスロマイシンマクロライドおよびケトライド
US8063021B2 (en) *	2002-01-17	2011-11-22	Kosan Biosciences Incorporated	Ketolide anti-infective compounds
US6995143B2 (en)	2002-02-28	2006-02-07	Basilea Pharmaceutica Ag	Macrolides with antibacterial activity
AU2003255851B2 (en)	2002-07-08	2009-07-23	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	New compounds, compositions and methods for treatment of inflammatory diseases and conditions
EP1551865B1 (en)	2002-07-08	2009-04-22	GlaxoSmithKline istrazivacki centar Zagreb d.o.o.	Hybrid molecules of macrolides with steroidal/non-steroidal anti-inflammatory molecules
WO2004009059A1 (en) *	2002-07-19	2004-01-29	Aventis Pharma S.A.	Taste masked oral composition of telithromycin
US20040013737A1 (en) *	2002-07-19	2004-01-22	Philippe Becourt	Taste masked oral composition of telithromycin
AR043050A1 (es)	2002-09-26	2005-07-13	Rib X Pharmaceuticals Inc	Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
US6916934B2 (en) *	2003-02-11	2005-07-12	Aventis Pharma Deutschland Gmbh	Process for preparing pyridine-substituted amino ketal derivatives
DE10305391A1 (de) *	2003-02-11	2004-08-19	Aventis Pharma Deutschland Gmbh	Verfahren zur Herstellung von Pyridin-substituierten Aminoketal-Derivaten
EP1638549A4 (en)	2003-03-10	2011-06-15	Optimer Pharmaceuticals Inc	NEW ANTIBACTERIAL AGENTS
EP1618120A2 (en) *	2003-04-25	2006-01-25	Chiron Corporation	Novel ketolide derivatives
EP1670808A1 (en) *	2003-09-12	2006-06-21	Chiron Corporation	Antimicrobial derivatives
GB0402578D0 (en) *	2004-02-05	2004-03-10	Cambridge Theranostics Ltd	Methods of treatment of atherosclerosis
EP2716647A3 (en)	2004-02-27	2014-08-20	Rib-X Pharmaceuticals, Inc.	Macrocyclic compounds and methods of making and using the same
EP1742957B1 (en) *	2004-04-28	2007-09-12	Alembic Limited	Process for the preparation of telithromycin
RU2397987C2 (ru) *	2004-07-28	2010-08-27	Рэнбакси Лабораториз Лимитед	Кетолидные производные в качестве антибактериальных агентов
US20090170790A1 (en) *	2004-10-25	2009-07-02	Biswajit Das	Ketolide derivatives as antibacterial agents
EP2233493A1 (en)	2004-12-21	2010-09-29	Pfizer Products Inc.	Macrolides
JP4726890B2 (ja) *	2005-02-08	2011-07-20	株式会社村田製作所	表面実装型負特性サーミスタ
FR2882522B1 (fr)	2005-02-25	2007-04-13	Aventis Pharma Sa	Composition pharmaceutique solide comprenant de la telithromycine
WO2006129257A2 (en) *	2005-05-30	2006-12-07	Ranbaxy Laboratories Limited	Ketolide derivatives as antibacterial agents
WO2007039914A2 (en) *	2005-10-06	2007-04-12	Alembic Limited	Novel polymorphs of telithromycin
WO2007049296A2 (en) *	2005-10-28	2007-05-03	Alembic Limited	Amorphous form of telithromycin
US20070167382A1 (en) *	2005-11-15	2007-07-19	Nina Finkelstein	Crystalline and amorphous forms of telithromycin
EP1960413A2 (en) *	2005-11-23	2008-08-27	Ranbaxy Laboratories Limited	Macrolides derivatives as antibacterial agents
EP1957508A2 (en) *	2005-11-23	2008-08-20	Ranbaxy Laboratories Limited	Ketolide derivatives as antibacterial agents
WO2007060627A2 (en) *	2005-11-23	2007-05-31	Ranbaxy Laboratories Limited	Use of macrolide derivatives for treating acne
US7595300B2 (en)	2005-12-13	2009-09-29	Kosan Biosciences Incorporated	7-quinolyl ketolide antibacterial agents
GB0600238D0 (en) *	2006-01-06	2006-02-15	Sandoz Ag	Organic compounds
JP5015016B2 (ja) *	2006-02-07	2012-08-29	大正製薬株式会社	１０ａ−アザライド化合物
EP2056844A4 (en)	2006-08-24	2010-11-24	Wockhardt Research Center	NEW MACROLIDS AND KETOLIDS WITH ANTIMICROBIAL EFFECT
WO2008023383A1 (en) *	2006-08-25	2008-02-28	Alembic Limited	Novel process for the preparation of telithromycin
ES2306590B1 (es) *	2006-12-15	2009-08-07	Ercros Industrial,S .A.	Formas cristalinas i y ii de telitromicina.
WO2009019868A1 (ja)	2007-08-06	2009-02-12	Taisho Pharmaceutical Co., Ltd.	１０ａ、１２位架橋型１０ａ－アザライド化合物
US20090075917A1 (en) *	2007-09-19	2009-03-19	Protia, Llc	Deuterium-enriched telithromycin
CN104605647B (zh)	2007-09-20	2019-10-08	赫尔曼米勒有限公司	载荷支撑结构
WO2009053259A1 (en) *	2007-10-25	2009-04-30	Sandoz Ag	Process for the production of telithromycin
CA2703475A1 (en) *	2007-10-25	2009-04-30	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
WO2009139181A1 (ja)	2008-05-15	2009-11-19	大正製薬株式会社	４員環構造を有する１０ａ－アザライド化合物
US8796232B2 (en) *	2008-10-24	2014-08-05	Cempra Pharmaceuticals, Inc.	Methods for treating resistant diseases using triazole containing macrolides
RU2011153353A (ru)	2009-05-27	2013-07-10	Вокхардт Рисерч Сентер	Кетолидные соединения, обладающие противомикробной активностью
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja)	2009-09-10	2016-05-11	センプラファーマシューティカルズ，インコーポレイテッド	マラリア、結核、及びｍａｃ病の治療方法
CN103080122A (zh)	2010-03-22	2013-05-01	森普拉制药公司	大环内脂的结晶形式及其用途
WO2011146829A1 (en)	2010-05-20	2011-11-24	Cempra Pharmaceuticals, Inc.	Processes for preparing macrolides and ketolides and intermediates therefor
JP6042334B2 (ja) *	2010-09-10	2016-12-14	センプラファーマシューティカルズ，インコーポレイテッド	疾患治療のための水素結合形成フルオロケトライド
EP3216798A3 (en)	2010-12-09	2017-10-25	Wockhardt Limited	Ketolide compounds
AR085286A1 (es)	2011-02-21	2013-09-18	Taisho Pharmaceutical Co Ltd	Derivado de macrolido sustituido en la posicion c-4
US9206214B2 (en)	2011-03-01	2015-12-08	Wockhardt Ltd.	Process for preparation of ketolide intermediates
CN103619863B (zh)	2011-03-22	2016-03-16	沃克哈特有限公司	酮内酯化合物的制备方法
CN104470527B (zh)	2012-03-27	2019-05-28	森普拉制药公司	用于施用大环内酯抗生素的肠胃外制剂
RU2015138796A (ru)	2013-03-14	2017-04-19	Семпра Фармасьютикалс, Инк.	Способы и составы для лечения респираторных заболеваний
WO2014145210A1 (en)	2013-03-15	2014-09-18	Cempra Pharmaceuticals, Inc.	Convergent processes for preparing macrolide antibacterial agents
CN105524132B (zh) *	2014-09-30	2019-07-02	中国医学科学院药物研究所	含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用
DE102015201783A1 (de)	2015-02-02	2016-08-04	Friedrich Baur	Verfahren zur Herstellung eines Füllstoffs aus Textilfasern sowie Textil mit einem solchen Füllstoff
CN107129514B (zh) *	2016-03-02	2019-12-13	中国医学科学院药物研究所	红霉素a酮内酯类抗生素衍生物、其制备方法及应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT342770B (de) *	1975-04-07	1978-04-25	Thomae Gmbh Dr K	Verfahren zur herstellung neuer erythromycinderivate
DE2833140A1 (de) *	1978-07-28	1980-02-07	Boehringer Sohn Ingelheim	Neue n-substituierte heterocyclen
US4434174A (en) *	1980-02-11	1984-02-28	Berlex Laboratories, Inc.	Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
IE810250L (en) *	1980-02-11	1981-08-11	Berlex Lab	N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
US4568687A (en) *	1983-02-28	1986-02-04	American Cyanamid Company	N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
ZA84949B (en) *	1983-04-06	1984-09-26	American Cyanamid Co	Substituted-n-(2-4-(1h-imidazol-1-yl)alkyl)substituted amides
US4489089A (en) *	1983-04-06	1984-12-18	American Cyanamid Company	Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides
AU573828B2 (en) *	1984-05-17	1988-06-23	E.R. Squibb & Sons, Inc.	Tetrahydronaphthalenols
GB8425104D0 (en) *	1984-10-04	1984-11-07	Ici America Inc	Amide derivatives
DE3540376A1 (de) *	1985-11-14	1987-05-21	Bayer Ag	Verfahren zur inhibierung der wasserstoffinduzierten korrosion von metallischen werkstoffen
EP0269239B1 (en) *	1986-10-29	1994-06-08	Pfizer Inc.	Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and the crystalline dihydrochloride trihydrate thereof
DE3930669A1 (de) *	1989-09-14	1991-03-28	Basf Ag	Verfahren zur herstellung von uretdiongruppen aufweisenden polyisocyanaten
JP2899028B2 (ja) *	1989-12-01	1999-06-02	協和醗酵工業株式会社	ジベンゾオキセピン誘導体
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
DE69127457T2 (de) *	1990-11-28	1998-01-22	Taisho Pharmaceutical Co., Ltd., Tokio/Tokyo	6-0-methylerythromycin a-derivat
FR2692579B1 (fr) *	1992-06-19	1995-06-02	Roussel Uclaf	Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) *	1992-11-05	1994-12-23	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) *	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
TW444018B (en) *	1992-12-17	2001-07-01	Pfizer	Pyrazolopyrimidines
HRP930014A2 (en) *	1993-01-08	1994-08-31	Pliva Pharm & Chem Works	9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

1994
- 1994-05-03 FR FR9405368A patent/FR2719587B1/fr not_active Expired - Lifetime
1995
- 1995-02-05 UA UA96104110A patent/UA51618C2/uk unknown
- 1995-04-04 IL IL11324595A patent/IL113245A/xx not_active IP Right Cessation
- 1995-04-21 US US08/426,067 patent/US5635485A/en not_active Expired - Lifetime
- 1995-04-27 MA MA23866A patent/MA23534A1/fr unknown
- 1995-04-28 YU YU27095A patent/YU49235B/sh unknown
- 1995-05-01 JP JP7128791A patent/JP2992540B2/ja not_active Expired - Lifetime
- 1995-05-02 DZ DZ950049A patent/DZ1878A1/fr active
- 1995-05-02 DE DE69505296T patent/DE69505296T2/de not_active Expired - Lifetime
- 1995-05-02 RO RO96-02081A patent/RO113350B1/ro unknown
- 1995-05-02 EE EE9600151A patent/EE03263B1/et active Protection Beyond IP Right Term
- 1995-05-02 SK SK1402-96A patent/SK281707B6/sk not_active IP Right Cessation
- 1995-05-02 AP APAP/P/1995/000744A patent/AP558A/en active
- 1995-05-02 MD MD97-0010A patent/MD1233C2/ro unknown
- 1995-05-02 BR BR9507700A patent/BR9507700A/pt not_active IP Right Cessation
- 1995-05-02 AU AU24499/95A patent/AU684027B2/en not_active Expired
- 1995-05-02 CZ CZ19963214A patent/CZ293455B6/cs not_active IP Right Cessation
- 1995-05-02 NZ NZ285416A patent/NZ285416A/en not_active IP Right Cessation
- 1995-05-02 HU HU9904687A patent/HU219599B/hu unknown
- 1995-05-02 PL PL95317071A patent/PL182034B1/pl unknown
- 1995-05-02 ZA ZA953501A patent/ZA953501B/xx unknown
- 1995-05-02 CN CN95193911A patent/CN1052984C/zh not_active Expired - Lifetime
- 1995-05-02 KR KR1019960706191A patent/KR100312267B1/ko not_active Expired - Lifetime
- 1995-05-02 DK DK95400987T patent/DK0680967T3/da active
- 1995-05-02 GE GEAP19953425A patent/GEP19991538B/en unknown
- 1995-05-02 SI SI9530184T patent/SI0680967T1/xx unknown
- 1995-05-02 CA CA002189271A patent/CA2189271C/fr not_active Expired - Lifetime
- 1995-05-02 RU RU96123129A patent/RU2144036C1/ru active
- 1995-05-02 EP EP95400987A patent/EP0680967B1/fr not_active Expired - Lifetime
- 1995-05-02 HU HU9603038A patent/HU227493B1/hu unknown
- 1995-05-02 DE DE2002199001 patent/DE10299001I2/de active Active
- 1995-05-02 TN TNTNSN95049A patent/TNSN95049A1/fr unknown
- 1995-05-02 ES ES95400987T patent/ES2122472T3/es not_active Expired - Lifetime
- 1995-05-02 WO PCT/FR1995/000565 patent/WO1995029929A1/fr not_active Ceased
- 1995-05-02 AT AT95400987T patent/ATE172203T1/de active
- 1995-06-29 TW TW084106692A patent/TW341573B/zh not_active IP Right Cessation
1996
- 1996-10-31 FI FI964395A patent/FI111263B/fi not_active IP Right Cessation
- 1996-11-01 TJ TJ96000417A patent/TJ313B/xx unknown
- 1996-11-01 BG BG100951A patent/BG63087B1/bg unknown
- 1996-11-01 OA OA60917A patent/OA10319A/fr unknown
- 1996-11-01 LV LVP-96-421A patent/LV11739B/lv unknown
- 1996-11-04 NO NO964654A patent/NO308853B1/no not_active IP Right Cessation
1997
- 1997-01-09 US US08/780,861 patent/US6100404A/en not_active Expired - Lifetime
1998
- 1998-08-24 JP JP25181798A patent/JP3998828B2/ja not_active Expired - Lifetime
- 1998-12-07 CN CN98123072A patent/CN1088709C/zh not_active Expired - Lifetime
2001
- 2001-12-28 NL NL300077C patent/NL300077I1/nl unknown
- 2001-12-28 NO NO2001027C patent/NO2001027I1/no unknown
2002
- 2002-01-08 LU LU90872C patent/LU90872I2/xx unknown
2006
- 2006-11-21 JP JP2006314281A patent/JP4658902B2/ja not_active Expired - Lifetime
2007
- 2007-06-06 JP JP2007150991A patent/JP4750755B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI964395L (fi)	1996-10-31
HUT75698A (en)	1997-05-28
DE69505296T2 (de)	1999-04-22
DE69505296D1 (de)	1998-11-19
MA23534A1 (fr)	1995-12-31
YU27095A (sh)	1998-05-15
MX9605208A (es)	1997-09-30
JP3998828B2 (ja)	2007-10-31
TJ313B (en)	2001-08-06
ZA953501B (en)	1996-05-02
CZ293455B6 (cs)	2004-05-12
WO1995029929A1 (fr)	1995-11-09
PL317071A1 (en)	1997-03-03
JPH11152296A (ja)	1999-06-08
OA10319A (fr)	1997-10-07
CN1229082A (zh)	1999-09-22
BG63087B1 (bg)	2001-03-30
NO308853B1 (no)	2000-11-06
RU2144036C1 (ru)	2000-01-10
DE10299001I1 (de)	2012-07-05
NL300077I1 (nl)	2002-03-01
AP558A (en)	1996-11-07
FI111263B (fi)	2003-06-30
ES2122472T3 (es)	1998-12-16
AU2449995A (en)	1995-11-29
PL182034B1 (pl)	2001-10-31
LU90872I2 (fr)	2002-03-12
RO113350B1 (ro)	1998-06-30
CZ321496A3 (en)	1997-08-13
IL113245A (en)	1999-11-30
BG100951A (en)	1997-08-29
HK1010732A1 (en)	1999-06-25
JP4658902B2 (ja)	2011-03-23
JPH0853489A (ja)	1996-02-27
SI0680967T1 (en)	1999-02-28
CN1151746A (zh)	1997-06-11
US6100404A (en)	2000-08-08
MD1233C2 (ro)	2000-10-31
YU49235B (sh)	2004-12-31
DZ1878A1 (fr)	2002-02-17
UA51618C2 (uk)	2002-12-16
EP0680967A1 (fr)	1995-11-08
AP9500744A0 (en)	1995-07-31
LV11739A (lv)	1997-04-20
CN1052984C (zh)	2000-05-31
FR2719587B1 (fr)	1996-07-12
JP4750755B2 (ja)	2011-08-17
EP0680967B1 (fr)	1998-10-14
JP2007045847A (ja)	2007-02-22
KR100312267B1 (ko)	2002-06-22
SK281707B6 (sk)	2001-07-10
AU684027B2 (en)	1997-11-27
NO964654L (no)	1996-11-04
FI964395A0 (fi)	1996-10-31
JP2992540B2 (ja)	1999-12-20
GEP19991538B (en)	1999-03-05
IL113245A0 (en)	1995-07-31
HU9904687D0 (en)	2000-03-28
US5635485A (en)	1997-06-03
LV11739B (en)	1997-08-20
BR9507700A (pt)	1997-08-19
DE10299001I2 (de)	2012-07-05
DK0680967T3 (da)	1999-06-23
NZ285416A (en)	1997-07-27
CA2189271A1 (fr)	1995-11-09
MD1233B1 (en)	1999-05-31
CA2189271C (fr)	2005-12-27
TW341573B (en)	1998-10-01
HU219599B (hu)	2001-05-28
NO964654D0 (no)	1996-11-04
CN1088709C (zh)	2002-08-07
JP2007269810A (ja)	2007-10-18
NO2001027I1 (no)	2002-01-28
FR2719587A1 (fr)	1995-11-10
SK140296A3 (en)	1998-04-08
TNSN95049A1 (fr)	1996-02-06
ATE172203T1 (de)	1998-10-15
HU227493B1 (en)	2011-07-28
HU9603038D0 (en)	1997-01-28

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2004-12-15	AA1Y	Spc filed	Free format text: PRODUCT NAME: KETEK-TELITROMUETSIIN; REG NO/DATE: EU/1/01/191/001 09.07.2001 EU/1/01/191/002 09.07.2001 EU/1/01/191/003 09.07.2001 EU/1/01/191/004 Spc suppl protection certif: C20040002 Filing date: 20040923
2005-02-15	FC1Y	Spc application refused	Free format text: PRODUCT NAME: KETEK-TELITROMUETSIIN; REG NO/DATE: EU/1/01/191/001 09.07.2001 EU/1/01/191/002 09.07.2001 EU/1/01/191/003 09.07.2001 EU/1/01/191/004 Spc suppl protection certif: C20040002 Filing date: 20040923
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2013-10-15	FC1Y	Spc application refused	Free format text: PRODUCT NAME: KETEK-TELITROMUETSIIN;REG NO/DATE: C(2001) 1400 09.07.2001 Spc suppl protection certif: C20040002 Filing date: 20040923

Publication	Publication Date	Title
FI964395L (fi)	1996-10-31	Uudet erytromysiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä
EE04498B1 (et)	2005-06-15	Erütromütsiini derivaadid, nende valmistamismeetod ja neid sisaldav farmatseutiline kompositsioon
EE9500064A (et)	1996-06-17	Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid
EE9800265A (et)	1999-02-15	Erütromütsiini derivaadid, nende valmistamismeetod ja kasutamine ravimitena
EE200000319A (et)	2001-08-15	hGRF-PEG konjugaatide saitspetsiifiline valmistamismeetod, hGRF-PEG konjugaadid, nende vaheühendid, kasutamine ja farmatseutiline kompositsioon
EE03231B1 (et)	1999-10-15	Tetratsüklilised derivaadid, nende valmistamismeetod ja kasutamine
FI954304A7 (fi)	1996-03-16	Uudet bentsopyraanijohdannaiset, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
HUP0102307A3 (en)	2002-02-28	Bispidine derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
EE9800302A (et)	1999-02-15	Arüülglütsiinamiidi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline preparaat
FI952550A7 (fi)	1995-11-28	Uudet N-pyridyylikarboksamidit ja johdannaiset, menetelmät niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
EE9900112A (et)	1999-10-15	2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
FI943688L (fi)	1995-03-21	Uudet 11-bentsaldoksiimi-17beta-metoksi-27alfa-metoksi-metyyli-estradieenijohdannaiset, menetelmät niiden valmistamiseksi ja näitä sisältävät lääkeaineet
EE9800200A (et)	1998-12-15	Bensoüülguanidiini derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
FI950625A7 (fi)	1995-08-15	Polysubstituoituja 3-asyyliamino-5-fenyyli-1,4-bentsodiatsepiini-2-onijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
FI956278L (fi)	1996-06-29	Substituoituja 4-fenyylitiatsolijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
EE04812B1 (et)	2007-04-16	2-fenüülpüraan-4-ooni derivaadid, nende valmistamismeetod ja kasutamine, vaheühendite kasutamine jafarmatseutiline kompositsioon
FI960316L (fi)	1996-03-22	Oksatiolaanit, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
HUT77126A (hu)	1998-03-02	Antibiotikus hatású eritromicin A 9-0-oxim -származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
FI953308A7 (fi)	1996-01-07	Uudet bentsopyraaniyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
EE03996B1 (et)	2003-04-15	Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine
FI955085L (fi)	1996-04-27	Uudet diosmetiiniyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
FI941094L (fi)	1994-09-10	Uudet erytromysiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä
FI964436A7 (fi)	1996-11-27	Uudet hydroksiimijohdannaiset, niitä sisältävät farmaseuttiset koostumukset sekä menetelmä niiden valmistamiseksi
FI971081L (fi)	1997-05-06	Triatsolopyridatsiinit, menetelmä ja välituotteet niiden valmistamiseksi sekä niiden käyttö lääkeaineina
FI951091A7 (fi)	1995-09-12	Uudet alkyyliaminoindaaniyhdisteet, menetelmät niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset