EE03484B1 - Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine - Google Patents

Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine

Info

Publication number: EE03484B1
Authority: EE; Estonia
Prior art keywords: imidazolyl; methyl; protein transferase; farnesyl protein; quinolinone derivatives
Prior art date: 1995-12-08

Application number

EE9800146A

Other languages

English (en)

Estonian (et)

Other versions

EE9800146A (et

Inventor

Gaston Venet Marc

Ren� Angibaud Patrick

Charles Sanz G�rard

Muller Philippe

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-08

Filing date

1996-10-16

Publication date

2001-08-15

1996-10-16 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

1998-10-15 Publication of EE9800146A publication Critical patent/EE9800146A/xx

2001-08-15 Publication of EE03484B1 publication Critical patent/EE03484B1/xx

Links

AVGQUILLCRPWKH-UHFFFAOYSA-N 4-(1h-imidazol-5-yl)-3-methyl-1h-quinolin-2-one Chemical class C12=CC=CC=C2NC(=O)C(C)=C1C1=CN=CN1 AVGQUILLCRPWKH-UHFFFAOYSA-N 0.000 title 1
102000004357 Transferases Human genes 0.000 title 1
108090000992 Transferases Proteins 0.000 title 1
125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EE9800146A 1995-12-08 1996-10-16 Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine EE03484B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP95203427		1995-12-08
PCT/EP1996/004515 WO1997021701A1 (fr)	1995-12-08	1996-10-16	Derives de la (imidazol-5-yl)methyl-2-quinoleinone comme inhibiteur de la proteine farnesyle-transferase

Publications (2)

Publication Number	Publication Date
EE9800146A EE9800146A (et)	1998-10-15
EE03484B1 true EE03484B1 (et)	2001-08-15

Family

ID=8220926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800146A EE03484B1 (et)	1995-12-08	1996-10-16	Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine

Country Status (36)

Country	Link
US (3)	US6037350A (fr)
EP (2)	EP0865440B1 (fr)
JP (1)	JP3257559B2 (fr)
KR (1)	KR100272676B1 (fr)
CN (1)	CN1101392C (fr)
AP (1)	AP1108A (fr)
AR (1)	AR004992A1 (fr)
AT (2)	ATE215541T1 (fr)
AU (1)	AU711142B2 (fr)
BG (1)	BG62615B1 (fr)
BR (1)	BR9610745A (fr)
CA (1)	CA2231105C (fr)
CY (1)	CY2289B1 (fr)
CZ (1)	CZ293296B6 (fr)
DE (2)	DE69620445T2 (fr)
DK (2)	DK0865440T3 (fr)
EA (1)	EA000710B1 (fr)
EE (1)	EE03484B1 (fr)
ES (2)	ES2260156T3 (fr)
HK (1)	HK1042482B (fr)
HR (1)	HRP960576B1 (fr)
HU (1)	HU221227B1 (fr)
IL (1)	IL123568A (fr)
MX (1)	MX9802068A (fr)
MY (1)	MY114444A (fr)
NO (1)	NO314036B1 (fr)
NZ (1)	NZ320244A (fr)
PL (1)	PL184171B1 (fr)
PT (2)	PT865440E (fr)
SI (2)	SI1162201T1 (fr)
SK (1)	SK283335B6 (fr)
TR (1)	TR199800825T2 (fr)
TW (1)	TW494101B (fr)
UA (1)	UA57717C2 (fr)
WO (1)	WO1997021701A1 (fr)
ZA (1)	ZA9610254B (fr)

Families Citing this family (240)

* Cited by examiner, † Cited by third party
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WO2000034437A2 (fr)	1998-12-08	2000-06-15	Merck & Co., Inc.	Inhibiteurs de prenyl-proteine transferase
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EP1420015A1 (fr) *	1999-06-11	2004-05-19	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Dérivés de l'imidazole
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CZ20021550A3 (cs) *	1999-11-09	2003-02-12	Societe De Conseils De Recherches Et D'application	Produkt zahrnující inhibitor transdukce signálů heterotrimerického G proteinu kombinovaný s jiným protirakovinným činidlem pro terapeutické použití v léčbě rakoviny
PT1106612E (pt) *	1999-11-30	2004-06-30	Pfizer Prod Inc	Derivados de quinolina uteis para inibir a farnesil-proteina-transferase
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JP5491681B2 (ja) *	2000-02-04	2014-05-14	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	乳ガンの治療のためのファルネシルタンパク質トランスフェラーゼ阻害剤
US6838467B2 (en)	2000-02-24	2005-01-04	Janssen Pharmaceutica N. V.	Dosing regimen
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US20030078281A1 (en) *	2000-02-29	2003-04-24	Rybak Mary Ellen Margaret	Farnesyl protein transferase inhibitor combinations with anti-tumor alkylating agents
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EP1267871A2 (fr) *	2000-02-29	2003-01-02	Janssen Pharmaceutica N.V.	Combinaisons de farnesyl-proteine transferase avec des derives de podophyllotoxine anti-tumoraux
JP2003525239A (ja) *	2000-02-29	2003-08-26	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	タキサン化合物とのファルネシルタンパク質トランスフェラーゼ阻害剤の組み合わせ剤
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JP2003525252A (ja) *	2000-02-29	2003-08-26	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｈｅｒ２抗体とのファルネシルタンパク質トランスフェラーゼ阻害剤組み合わせ剤
WO2001064196A2 (fr) *	2000-02-29	2001-09-07	Janssen Pharmaceutica N.V.	Combinaisons d'inhibiteurs de farnesyl proteine transferase et de vinca-alcaloides
US20030027808A1 (en) *	2000-02-29	2003-02-06	Palmer Peter Albert	Farnesyl protein transferase inhibitor combinations with platinum compounds
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1996
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2002
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Publication number	Publication date
TW494101B (en)	2002-07-11
CN1203598A (zh)	1998-12-30
JP3257559B2 (ja)	2002-02-18
AP9801257A0 (en)	1998-06-30
HUP9900185A3 (en)	1999-11-29
CZ293296B6 (cs)	2004-03-17
US6169096B1 (en)	2001-01-02
HRP960576A2 (en)	1998-02-28
AU711142B2 (en)	1999-10-07
AU7294896A (en)	1997-07-03
NZ320244A (en)	1999-06-29
DE69620445T2 (de)	2002-12-12
HK1042482A1 (en)	2002-08-16
EP0865440B1 (fr)	2002-04-03
NO980927L (no)	1998-06-08
SK70498A3 (en)	1998-10-07
PL325962A1 (en)	1998-08-17
US6037350A (en)	2000-03-14
CN1101392C (zh)	2003-02-12
CY2289B1 (en)	2003-07-04
HK1012188A1 (en)	1999-07-30
EA000710B1 (ru)	2000-02-28
EP0865440A1 (fr)	1998-09-23
EP1162201A2 (fr)	2001-12-12
JPH10511405A (ja)	1998-11-04
ATE215541T1 (de)	2002-04-15
EP1162201B1 (fr)	2006-03-29
BR9610745A (pt)	1999-07-13
PT865440E (pt)	2002-09-30
EP1162201A9 (fr)	2002-04-03
DE69635966D1 (de)	2006-05-18
AR004992A1 (es)	1999-04-07
CA2231105A1 (fr)	1997-06-19
ZA9610254B (en)	1998-06-05
BG102458A (en)	1999-06-30
PT1162201E (pt)	2006-08-31
SI1162201T1 (sl)	2006-08-31
NO314036B1 (no)	2003-01-20
HUP9900185A2 (hu)	1999-04-28
NO980927D0 (no)	1998-03-04
HU221227B1 (en)	2002-08-28
TR199800825T2 (xx)	1998-08-21
IL123568A (en)	2001-08-08
HK1042482B (en)	2006-06-09
KR100272676B1 (ko)	2000-11-15
PL184171B1 (pl)	2002-09-30
US6420387B1 (en)	2002-07-16
HRP960576B1 (en)	2002-04-30
MX9802068A (es)	1998-08-30
ES2175137T3 (es)	2002-11-16
KR19990063891A (ko)	1999-07-26
SK283335B6 (sk)	2003-06-03
DK0865440T3 (da)	2002-07-22
DE69620445D1 (de)	2002-05-08
UA57717C2 (uk)	2003-07-15
SI0865440T1 (en)	2002-08-31
MY114444A (en)	2002-10-31
WO1997021701A1 (fr)	1997-06-19
EA199800443A1 (ru)	1998-10-29
AP1108A (en)	2002-10-02
BG62615B1 (en)	2000-03-31
DE69635966T2 (de)	2006-11-30
CA2231105C (fr)	2005-09-13
ES2260156T3 (es)	2006-11-01
EP1162201A3 (fr)	2003-11-26
ATE321757T1 (de)	2006-04-15
CZ157398A3 (cs)	1998-10-14
EE9800146A (et)	1998-10-15
DK1162201T3 (da)	2006-07-17
IL123568A0 (en)	1998-10-30

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Publication	Publication Date	Title
EE03484B1 (et)	2001-08-15	Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine
IS4568A (is)	1997-09-24	Farnesýl-prótein transferasa latar
EP0841919A4 (fr)	1999-02-24	Inhibiteurs de la farnesyle-proteine transferase
NO985405D0 (no)	1998-11-20	Inhibitorer av proteinfarnesyltransferase
EP0944388A4 (fr)	2001-08-16	Inhibiteurs de la farnesyl-proteine transferase
EP0833633A4 (fr)	1999-03-24	Inhibiteurs de la farnesyl transferase
EP1011669A4 (fr)	2001-09-12	Inhibiteurs de la farnesyl-proteine transferase
FI952010L (fi)	1995-04-27	Farnesyyliproteiinitransferaasin estäjät
FI952011A7 (fi)	1995-04-27	Farnesyyliproteiinitransferaasin estäjät
EE04309B1 (et)	2004-06-15	Farnesüül-proteiini transferaasi inhibiitorid
FI961621A7 (fi)	1996-04-12	Proteiini:farnesyylitranseraasin substituoidut tetra- ja pentapeptidi- inhibiittorit
FI951554A0 (fi)	1995-03-31	Imidatsolipitoisia farnesyyliproteiinitransferaasi-inhibiittoreita
FI924747A7 (fi)	1993-04-22	PEG-imidaatteja ja niiden proteiinijohdannaisia
EP0777475A4 (fr)	1997-12-03	Inhibiteurs de la farnesyle-proteine transferase
FI941519A0 (fi)	1994-03-31	Farnesyyliproteiinitransferaasin heterosyklisiä inhibiittoreita
EP0784473A4 (fr)	1997-12-17	Inhibiteurs de la farnesyl-transferase proteique
EP0891360A4 (fr)	2002-05-15	Inhibiteurs de la farnesyl-proteine transferase
EP0783318A4 (fr)	1999-10-20	Inhibiteurs de farnesyle-proteine transferase
EP0783305A4 (fr)	1998-04-01	Inhibiteurs de farnesyle-proteine transferase
EP0812203A4 (fr)	1999-04-14	Inhibiteurs de geranylgeranyle-proteine transferase
EP0891352A4 (fr)	2001-08-16	Inhibiteurs de la farnesyl-proteine transferase
EP1035850A4 (fr)	2001-09-12	Inhibiteurs de la transferase de la farnesyl-proteine
EP1035852A4 (fr)	2001-09-12	Inhibiteurs de la farnesyl-proteine transferase
EP0891353A4 (fr)	2001-08-08	Inhibiteurs de farnesyle-proteine transferase
EP0787123A4 (fr)	1999-10-13	Inhibiteurs de farnesyle-proteine transferase