EE04193B1 - Triasolo[4,5-d]pürimidiini ühendid, neid sisaldavad ravimkoostised ja nende valmistamise meetodid - Google Patents

Triasolo[4,5-d]pürimidiini ühendid, neid sisaldavad ravimkoostised ja nende valmistamise meetodid

Info

Publication number
EE04193B1
EE04193B1 EEP200000044A EEP200000044A EE04193B1 EE 04193 B1 EE04193 B1 EE 04193B1 EE P200000044 A EEP200000044 A EE P200000044A EE P200000044 A EEP200000044 A EE P200000044A EE 04193 B1 EE04193 B1 EE 04193B1
Authority
EE
Estonia
Prior art keywords
triazolo
preparation
methods
pharmaceutical compositions
compositions containing
Prior art date
Application number
EEP200000044A
Other languages
English (en)
Estonian (et)
Inventor
Guile Simon
Ingall Anthony
Springthorpe Brian
Willis Paul
Original Assignee
Astra Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26663042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE04193(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE9702773A external-priority patent/SE9702773D0/xx
Priority claimed from SE9702775A external-priority patent/SE9702775D0/xx
Application filed by Astra Pharmaceuticals Limited filed Critical Astra Pharmaceuticals Limited
Publication of EE200000044A publication Critical patent/EE200000044A/xx
Publication of EE04193B1 publication Critical patent/EE04193B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
EEP200000044A 1997-07-22 1998-07-15 Triasolo[4,5-d]pürimidiini ühendid, neid sisaldavad ravimkoostised ja nende valmistamise meetodid EE04193B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9702773A SE9702773D0 (sv) 1997-07-22 1997-07-22 Novel compounds
SE9702775A SE9702775D0 (sv) 1997-07-22 1997-07-22 Novel compounds
PCT/SE1998/001393 WO1999005143A1 (en) 1997-07-22 1998-07-15 Novel compounds

Publications (2)

Publication Number Publication Date
EE200000044A EE200000044A (et) 2000-10-16
EE04193B1 true EE04193B1 (et) 2003-12-15

Family

ID=26663042

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000044A EE04193B1 (et) 1997-07-22 1998-07-15 Triasolo[4,5-d]pürimidiini ühendid, neid sisaldavad ravimkoostised ja nende valmistamise meetodid

Country Status (30)

Country Link
EP (1) EP0996621B1 (cs)
JP (1) JP4187406B2 (cs)
KR (2) KR100535837B1 (cs)
CN (1) CN1154650C (cs)
AR (2) AR017014A1 (cs)
AT (1) ATE251161T1 (cs)
AU (1) AU745381B2 (cs)
BR (1) BR9810802B1 (cs)
CA (1) CA2296665C (cs)
CZ (1) CZ302629B6 (cs)
DE (1) DE69818668T2 (cs)
DK (1) DK0996621T3 (cs)
EE (1) EE04193B1 (cs)
EG (1) EG24412A (cs)
ES (1) ES2207846T3 (cs)
HU (1) HU230074B1 (cs)
IL (2) IL133959A0 (cs)
IS (1) IS2236B (cs)
MY (1) MY123196A (cs)
NO (1) NO315854B1 (cs)
NZ (1) NZ502381A (cs)
PL (1) PL200325B1 (cs)
PT (1) PT996621E (cs)
RU (1) RU2225407C2 (cs)
SA (1) SA98190487B1 (cs)
SK (1) SK284199B6 (cs)
TR (1) TR200000197T2 (cs)
TW (1) TW530058B (cs)
UA (1) UA66801C2 (cs)
WO (1) WO1999005143A1 (cs)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
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TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9903290D0 (sv) * 1999-09-15 1999-09-15 Astra Pharma Prod Novel compounds
SE9904129D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
SE9904128D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
GB0013487D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Novel process
TWI290549B (en) * 2000-06-02 2007-12-01 Astrazeneca Ab Process for the preparation of cyclopropyl carboxylic acid ester and derivatives
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
GB0013488D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
IT1317049B1 (it) 2000-06-23 2003-05-26 Sigma Tau Ind Farmaceuti Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.
SE0004099D0 (sv) * 2000-11-09 2000-11-09 Astrazeneca Ab Novel compounds
SE0004098D0 (sv) 2000-11-09 2000-11-09 Astrazeneca Ab Novel compounds
GB0100624D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds VII
GB0219746D0 (en) 2002-08-23 2002-10-02 Inst Of Ex Botany Ascr Azapurine derivatives
US7504497B2 (en) 2003-10-21 2009-03-17 Inspire Pharmaceuticals, Inc. Orally bioavailable compounds and methods for inhibiting platelet aggregation
EP1685135B1 (en) 2003-10-21 2010-05-26 Inspire Pharmaceuticals, Inc. TETRAHYDRO-FURO[3,4-d]DIOXOLE COMPOUNDS AND COMPOSITIONS AND METHOD FOR INHIBITING PLATELET AGGREGATION
US7335648B2 (en) 2003-10-21 2008-02-26 Inspire Pharmaceuticals, Inc. Non-nucleotide composition and method for inhibiting platelet aggregation
US7749981B2 (en) 2003-10-21 2010-07-06 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound
SE0401001D0 (sv) 2004-03-31 2004-03-31 Astrazeneca Ab Chemical process
US7932376B2 (en) 2005-05-05 2011-04-26 Inspire Pharmaceuticals, Inc. Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation
GB0615620D0 (en) 2006-08-05 2006-09-13 Astrazeneca Ab A process for the preparation of optically active intermediates
JP2010508350A (ja) 2006-10-31 2010-03-18 ヤンセン ファーマシューティカ エヌ．ベー． Ａｄｐｐ２ｙ１２レセプターアンタゴニストとしてのトリアゾロピリミジン誘導体
UA100864C2 (uk) * 2007-12-03 2013-02-11 Астразенека Аб Спосіб лікування або запобігання аневризмі черевної аорти
CA2734454C (en) 2008-09-09 2016-09-13 Astrazeneca Ab A process for preparing [1s-[1-alpha,2-alpha,3-beta(1s*,2r*)5-beta]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3h-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol and to its intermediates
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
WO2010084160A1 (en) 2009-01-21 2010-07-29 Oryzon Genomics S.A. Phenylcyclopropylamine derivatives and their medical use
US8389580B2 (en) 2009-06-02 2013-03-05 Duke University Arylcyclopropylamines and methods of use
EP2305376A1 (en) 2009-09-23 2011-04-06 Lonza Ltd. Process and catalyst for the catalytic hydrogenation of aromatic and heteroaromatic nitro compounds
JP5699152B2 (ja) 2009-09-25 2015-04-08 オリゾン・ジェノミックス・ソシエダッド・アノニマＯｒｙｚｏｎ Ｇｅｎｏｍｉｃｓ Ｓ．Ａ． リジン特異的デメチラーゼ−１阻害剤およびその使用
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
EP2507242A1 (en) 2009-12-03 2012-10-10 AstraZeneca AB Co - crystals of a triazolo [4,5 - d]pyrimidine platelet aggregation inhibitor
EA026094B1 (ru) 2009-12-23 2017-03-31 Рациофарм Гмбх Твердая лекарственная форма тикагрелора
EP2536695A1 (en) 2010-02-16 2012-12-26 Actavis Group Ptc Ehf Improved processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine
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US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
JP5868948B2 (ja) 2010-04-19 2016-02-24 オリゾン・ジェノミックス・ソシエダッド・アノニマＯｒｙｚｏｎ Ｇｅｎｏｍｉｃｓ Ｓ．Ａ． リジン特異的脱メチル化酵素１阻害薬およびその使用
CA2796504A1 (en) 2010-04-20 2011-10-27 Actavis Group Ptc Ehf Novel process for preparing phenylcyclopropylamine derivatives using novel intermediates
RU2013103794A (ru) 2010-06-30 2014-08-10 Актавис Груп Птс Ехф Новые способы получения производных фенилциклопропиламина и их применение для получения тикагрелора
WO2012013728A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use
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WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
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EP2712315B1 (en) 2011-02-08 2021-11-24 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
CN102731510B (zh) * 2011-04-07 2015-12-16 博瑞生物医药（苏州）股份有限公司 替卡格雷的衍生物、制备方法及其药物用途
JP2014516982A (ja) 2011-06-01 2014-07-17 アストラゼネカ アクチボラグ 新規なチカグレロル共結晶
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CN102924457A (zh) * 2011-08-12 2013-02-13 上海恒瑞医药有限公司 三唑并嘧啶类衍生物、其制备方法及其用途
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CN102675321B (zh) * 2012-05-11 2014-12-10 上海皓元化学科技有限公司 一种替卡格雷的制备方法
CN103626743B (zh) * 2012-08-23 2018-06-08 广东东阳光药业有限公司 替卡格雷的新型中间体及其制备方法
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CN103965198A (zh) * 2013-02-05 2014-08-06 郝聪梅 替卡格雷的中间体及其制备方法以及利用该中间体制备替卡格雷的方法
CN103183679A (zh) * 2013-03-20 2013-07-03 西藏海思科药业集团股份有限公司 抗凝血化合物及其应用
CN107573333B (zh) * 2013-04-10 2019-10-18 江苏恒瑞医药股份有限公司 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法
EA201501164A1 (ru) 2013-05-29 2016-08-31 Рациофарм Гмбх Твердая фармацевтическая лекарственная форма
WO2014206187A1 (zh) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
CN103588751B (zh) * 2013-11-07 2014-12-17 苏州明锐医药科技有限公司 替格瑞洛中间体的制备方法
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
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CN105272985B (zh) * 2014-06-24 2017-11-21 珠海联邦制药股份有限公司 三唑并[4,5‑d]嘧啶化合物及其合成方法、用途、组合物
KR102594117B1 (ko) 2014-10-01 2023-10-26 메디뮨 리미티드 티카그렐로에 대한 항체 및 이의 사용 방법
WO2016116942A1 (en) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin
CN105985346B (zh) * 2015-03-06 2019-10-18 苏州朗科生物技术股份有限公司 一种新的替格瑞洛化合物制备方法及其中间体化合物
TR201601835A2 (tr) 2016-02-12 2017-08-21 Ali Raif Ilac Sanayi Ve Ticaret Anonim Sirketi Ti̇kagrelor i̇çeren formülasyonlar i̇çi̇n üreti̇m yöntemi̇
CR20180452A (es) 2016-03-22 2019-02-06 Merck Sharp & Dohme Moduladores alostéricos de receptores de acetilcolina nicotícos
WO2018167447A1 (en) 2017-03-14 2018-09-20 University Of Sheffield Low dose aspirin (1-50 mg) together with antiplatelets such as ticagrelor of anticoagulants
CN107141298A (zh) * 2017-07-24 2017-09-08 苏州信恩医药科技有限公司 一种替格瑞洛的合成方法
TWI641327B (zh) * 2017-09-30 2018-11-21 双邦實業股份有限公司 Socks that are comfortable and comfortable to wear
EP3527571A1 (en) * 2018-02-14 2019-08-21 Université de Liège Pyrimidine derivatives for prevention and treatment of bacterial infection
WO2023213198A1 (zh) * 2022-05-04 2023-11-09 华东师范大学 芳香稠环化合物作为trek-1激活剂的用途、包含其的药物组合物、镇痛剂
CN114805367B (zh) * 2022-05-24 2023-04-07 郑州大学 一种三氮唑并嘧啶类衍生物及其制备方法和应用
CN115710275B (zh) * 2022-11-21 2024-02-02 河南中医药大学 一种嘧啶-tcp类化合物、制备方法和医药用途

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Also Published As

Publication number Publication date
SA98190487B1 (ar) 2006-08-20
ES2207846T3 (es) 2004-06-01
KR20010022083A (ko) 2001-03-15
EG24412A (en) 2009-05-25
NO315854B1 (no) 2003-11-03
IS2236B (is) 2007-05-15
EE200000044A (et) 2000-10-16
TR200000197T2 (tr) 2000-06-21
CN1270590A (zh) 2000-10-18
AR077553A2 (es) 2011-09-07
BR9810802A (pt) 2000-09-12
EP0996621A1 (en) 2000-05-03
PL338516A1 (en) 2000-11-06
KR20050084540A (ko) 2005-08-26
IL133959A (en) 2007-10-31
SK188199A3 (en) 2000-10-09
HUP0004333A3 (en) 2001-11-28
AR017014A1 (es) 2001-08-22
RU2225407C2 (ru) 2004-03-10
TW530058B (en) 2003-05-01
JP4187406B2 (ja) 2008-11-26
WO1999005143A1 (en) 1999-02-04
CA2296665A1 (en) 1999-02-04
AU745381B2 (en) 2002-03-21
UA66801C2 (uk) 2004-06-15
NO20000312D0 (no) 2000-01-21
DK0996621T3 (da) 2004-02-02
NO20000312L (no) 2000-03-21
SK284199B6 (sk) 2004-10-05
PL200325B1 (pl) 2008-12-31
AU8370698A (en) 1999-02-16
HUP0004333A2 (hu) 2001-04-28
MY123196A (en) 2006-05-31
CZ2000233A3 (cs) 2000-07-12
HK1026421A1 (en) 2000-12-15
NZ502381A (en) 2001-12-21
BR9810802B1 (pt) 2010-10-19
HU230074B1 (hu) 2015-06-29
DE69818668D1 (de) 2003-11-06
PT996621E (pt) 2004-02-27
IL133959A0 (en) 2001-04-30
EP0996621B1 (en) 2003-10-01
JP2001510842A (ja) 2001-08-07
CZ302629B6 (cs) 2011-08-10
KR100535837B1 (ko) 2006-01-12
CN1154650C (zh) 2004-06-23
DE69818668T2 (de) 2004-08-12
IS5354A (is) 2000-01-20
CA2296665C (en) 2008-06-10
ATE251161T1 (de) 2003-10-15

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