EE04264B1 - Naatriumkloriidi kasutamine aine valmistamiseks kamptotetsiini derivaatide manustamisest tingitud gastrointestinaalsete kõrvaltoimete vähendamiseks - Google Patents

Naatriumkloriidi kasutamine aine valmistamiseks kamptotetsiini derivaatide manustamisest tingitud gastrointestinaalsete kõrvaltoimete vähendamiseks

Info

Publication number: EE04264B1
Authority: EE; Estonia
Prior art keywords: sodium chloride; administration; side effects; substance; preparation
Prior art date: 1998-08-05

Application number

EEP200100066A

Other languages

English (en)

Estonian (et)

Inventor

Toutain Herv�

Guffroy Magali

Original Assignee

Aventis Pharma S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-05

Filing date

1999-08-03

Publication date

2004-04-15

1998-08-05 Priority claimed from FR9810043A external-priority patent/FR2782009B1/fr

1999-08-03 Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.

2002-06-17 Publication of EE200100066A publication Critical patent/EE200100066A/xx

2004-04-15 Publication of EE04264B1 publication Critical patent/EE04264B1/xx

Links

FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 title abstract 6
239000011780 sodium chloride Substances 0.000 title abstract 3
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
230000000694 effects Effects 0.000 title abstract 2
230000002496 gastric effect Effects 0.000 title abstract 2
239000000126 substance Substances 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

EEP200100066A 1998-08-05 1999-08-03 Naatriumkloriidi kasutamine aine valmistamiseks kamptotetsiini derivaatide manustamisest tingitud gastrointestinaalsete kõrvaltoimete vähendamiseks EE04264B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9810043A FR2782009B1 (fr)	1998-08-05	1998-08-05	Utilisation de derives de la comptothecine, avec une toxicite gastro-intestinale reduite
US9631898P	1998-08-12	1998-08-12
PCT/FR1999/001916 WO2000007605A1 (fr)	1998-08-05	1999-08-03	Utilisation de derives de la camptothecine, avec une toxicite gastro-intestinale reduite

Publications (2)

Publication Number	Publication Date
EE200100066A EE200100066A (et)	2002-06-17
EE04264B1 true EE04264B1 (et)	2004-04-15

Family

ID=26234482

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100066A EE04264B1 (et)	1998-08-05	1999-08-03	Naatriumkloriidi kasutamine aine valmistamiseks kamptotetsiini derivaatide manustamisest tingitud gastrointestinaalsete kõrvaltoimete vähendamiseks

Country Status (24)

Country	Link
US (1)	US6476043B1 (de)
EP (1)	EP1102594B1 (de)
JP (1)	JP2002522392A (de)
KR (1)	KR20010072228A (de)
AT (1)	ATE217531T1 (de)
AU (1)	AU771195B2 (de)
BG (1)	BG64641B1 (de)
CA (1)	CA2340020A1 (de)
CZ (1)	CZ295775B6 (de)
DE (1)	DE69901506T2 (de)
DK (1)	DK1102594T3 (de)
EA (1)	EA002917B1 (de)
EE (1)	EE04264B1 (de)
ES (1)	ES2176009T3 (de)
GE (1)	GEP20043254B (de)
HU (1)	HUP0103314A3 (de)
ID (1)	ID27253A (de)
IL (1)	IL141232A0 (de)
NO (1)	NO20010454D0 (de)
NZ (1)	NZ509859A (de)
PT (1)	PT1102594E (de)
SK (1)	SK1732001A3 (de)
TR (1)	TR200100331T2 (de)
WO (1)	WO2000007605A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1749540B1 (de)	1999-05-17	2010-10-13	Cancer Research Ventures Limited	Zubereitungen zur Erhöhung der Bioverfügbarkeit von oral verabreichten pharmazeutischen Verbindungen
CA2295429A1 (en) *	2000-01-06	2001-07-06	Michael Michael	Treatment or prevention of diarrhea
EP1714653B1 (de) *	2004-02-13	2010-11-24	Kabushiki Kaisha Yakult Honsha	Wässrige lösung mit einem camptothecin
US20050197355A1 (en) *	2004-03-02	2005-09-08	Henegar Kevin E.	Compounds useful in preparing camptothecin derivatives
US20070207149A1 (en)	2004-04-27	2007-09-06	Wellstat Biologics Corporation	Cancer treatment using viruses and camptothecins
JP2006151950A (ja) *	2004-11-05	2006-06-15	Oto Corporation:Kk	納豆菌培養エキス含有製剤及び納豆菌培養エキスの保存方法
ATE446299T1 (de) *	2005-02-07	2009-11-15	Fermion Oy	Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin
JP5133704B2 (ja) *	2005-02-08	2013-01-30	フェルミオンオサケユキチュア	製造方法
CA2591071C (en) *	2005-02-08	2014-04-29	Fermion Oy	Process for producing [1,4'] bipiperidinyl-1'-carbonyl chloride or hydrochloride thereof
US7994186B2 (en) *	2005-04-18	2011-08-09	Kabushiki Kaisha Yakult Honsha	Pharmaceutical compositions containing camptothecins
CA2612949C (en)	2005-07-14	2015-04-28	Wellstat Biologics Corporation	Cancer treatment using viruses, fluoropyrimidines and camptothecins

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4284579A (en) *	1979-07-17	1981-08-18	The United States Of America As Represented By The Of The Department Of Health & Human Services	(N-Phosphonacetyl-L-aspartato)(1,2-diaminocyclchexane)platinum(II) or alkali metal salt
US4399276A (en) *	1981-01-09	1983-08-16	Kabushiki Kaisha Yakult Honsha	7-Substituted camptothecin derivatives
JPS58154582A (ja) *	1982-03-10	1983-09-14	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体およびその製造法
JPS6019790A (ja) *	1983-07-14	1985-01-31	Yakult Honsha Co Ltd	新規なカンプトテシン誘導体
CH663353A5 (de) *	1984-03-28	1987-12-15	Joaquin Amat Larraz	Mittel gegen krebs.
CA1332413C (en) *	1987-06-25	1994-10-11	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives and process for preparing same
US5004758A (en) *	1987-12-01	1991-04-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
US5225404A (en) *	1989-11-06	1993-07-06	New York University	Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
IT1247937B (it) *	1991-05-16	1995-01-05	Ist Naz Ric Sul Cancro	Associazione farmaceutica ad attivita' antineoplastica
JP3359955B2 (ja) *	1992-07-16	2002-12-24	第一製薬株式会社	抗腫瘍剤
WO1996011005A2 (en) *	1994-10-06	1996-04-18	Atlas Leon T	Use of camptothecin or derivatives thereof for the manufacture of a medicament for the treatment of viral diseases

1999
- 1999-08-03 IL IL14123299A patent/IL141232A0/xx unknown
- 1999-08-03 CA CA002340020A patent/CA2340020A1/fr not_active Abandoned
- 1999-08-03 GE GEAP19995779A patent/GEP20043254B/en unknown
- 1999-08-03 AT AT99936674T patent/ATE217531T1/de not_active IP Right Cessation
- 1999-08-03 AU AU51687/99A patent/AU771195B2/en not_active Ceased
- 1999-08-03 EE EEP200100066A patent/EE04264B1/xx not_active IP Right Cessation
- 1999-08-03 JP JP2000563290A patent/JP2002522392A/ja active Pending
- 1999-08-03 SK SK173-2001A patent/SK1732001A3/sk unknown
- 1999-08-03 ES ES99936674T patent/ES2176009T3/es not_active Expired - Lifetime
- 1999-08-03 ID IDW20010273A patent/ID27253A/id unknown
- 1999-08-03 NZ NZ509859A patent/NZ509859A/en unknown
- 1999-08-03 DK DK99936674T patent/DK1102594T3/da active
- 1999-08-03 PT PT99936674T patent/PT1102594E/pt unknown
- 1999-08-03 EA EA200100214A patent/EA002917B1/ru unknown
- 1999-08-03 EP EP99936674A patent/EP1102594B1/de not_active Expired - Lifetime
- 1999-08-03 WO PCT/FR1999/001916 patent/WO2000007605A1/fr not_active Ceased
- 1999-08-03 US US09/762,092 patent/US6476043B1/en not_active Expired - Fee Related
- 1999-08-03 HU HU0103314A patent/HUP0103314A3/hu unknown
- 1999-08-03 DE DE69901506T patent/DE69901506T2/de not_active Expired - Fee Related
- 1999-08-03 KR KR1020017001471A patent/KR20010072228A/ko not_active Ceased
- 1999-08-03 TR TR2001/00331T patent/TR200100331T2/xx unknown
- 1999-08-03 CZ CZ2001382A patent/CZ295775B6/cs not_active IP Right Cessation
2001
- 2001-01-26 NO NO20010454A patent/NO20010454D0/no not_active Application Discontinuation
- 2001-02-05 BG BG105216A patent/BG64641B1/bg unknown

Also Published As

Publication number	Publication date
AU5168799A (en)	2000-02-28
ID27253A (id)	2001-03-22
ES2176009T3 (es)	2002-11-16
NO20010454L (no)	2001-01-26
BG105216A (en)	2001-10-31
WO2000007605A1 (fr)	2000-02-17
ATE217531T1 (de)	2002-06-15
US6476043B1 (en)	2002-11-05
BG64641B1 (bg)	2005-10-31
AU771195B2 (en)	2004-03-18
DE69901506T2 (de)	2002-11-28
DE69901506D1 (de)	2002-06-20
NO20010454D0 (no)	2001-01-26
HUP0103314A3 (en)	2002-07-29
NZ509859A (en)	2003-09-26
EA002917B1 (ru)	2002-10-31
EP1102594A1 (de)	2001-05-30
CZ295775B6 (cs)	2005-11-16
KR20010072228A (ko)	2001-07-31
HUP0103314A2 (hu)	2002-01-28
EP1102594B1 (de)	2002-05-15
IL141232A0 (en)	2002-03-10
SK1732001A3 (en)	2001-06-11
TR200100331T2 (tr)	2001-07-23
GEP20043254B (en)	2004-06-25
CA2340020A1 (fr)	2000-02-17
PT1102594E (pt)	2002-10-31
CZ2001382A3 (en)	2001-05-16
DK1102594T3 (da)	2002-08-26
JP2002522392A (ja)	2002-07-23
EA200100214A1 (ru)	2001-08-27
EE200100066A (et)	2002-06-17

Legal Events

Date	Code	Title	Description
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-04-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20070803

Publication	Publication Date	Title
ES2152412T3 (es)	2001-02-01	Preparacion farmaceuticamente estable de oxaliplatino.
TR200102603T2 (tr)	2002-01-21	Antitümör aktiviteye sahip olan kamptotesin türevleri
SE9503143D0 (sv)	1995-09-12	New preparation
HUP9803044A2 (hu)	1999-09-28	Ibuprofentartalmú készítmény
BR0115910A (pt)	2004-01-20	Compostos orgânicos
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
MXPA03011510A (es)	2004-03-18	Derivados de5-halo-triptamina usados como ligandos de receptores de serotonina 5-ht-6 y/o 5-ht-7.
MY121517A (en)	2006-01-28	Anticonvulsant derivatives useful in reducing blood glucose levels
DK1383752T3 (da)	2005-10-17	Deutererede 3-piperidinopropiophenoner samt lægemidler indeholdende disse forbindelser
IL160085A0 (en)	2004-06-20	Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain
GR1003658B (el)	2001-09-05	Δισκιο μητρας που καθιστα δυνατη την παρατεταμενη απελευθερωση της τριμεταζιδινης μετα χορηγηση δια της στοματικης οδου
TR200002969T2 (tr)	2001-01-22	Farmasötik bileşim.
EE200100066A (et)	2002-06-17	Naatriumkloriidi kasutamine kamptotetsiini derivaatide manustamisest tingitud gastrointestinaalsetekõrvaltoimete vähendamiseks
KR970025615A (ko)	1997-06-24	암 전이 억제제
CO5560554A2 (es)	2005-09-30	Composicion farmaceutica que comprende lumiracoxib
NO20031410D0 (no)	2003-03-27	Antitumorterapi innbefattende distamycinderivater
HUP9802736A2 (hu)	1999-03-29	1,4-Dihidropiridin-származékok alkalmazása artériafal ateroszklerózisos degradálódásának megelőzésére és gyógyítására alkalmas gyógyszerkészítmény előállítására
DE50005076D1 (de)	2004-02-26	Pharmazeutische, metamizol enthaltende brauseformulierung
HUP9802005A2 (hu)	1999-04-28	Nátrium/hidrogén-csere inhibitorok alkalmazása különböző anyagok által a szívre gyakorolt nem kívánt hatások csökkentésére alkalmas gyógyszerkészítmények előállítására
TR200200111T2 (tr)	2002-08-21	Neoplazmalar için terapötik ve profilaktik maddeler
MEP1108A (en)	2011-02-10	Use of specific dose of fondaparinux sodium for the treatment of acs
BR9912765A (pt)	2001-05-15	Utilização de cloreto de sódio
TR200102262T2 (tr)	2002-02-21	Koroner müdahale ile ilgili kardiovasküler olayların önlenmesi veya azaltılması için yöntem.
WO2001035937A3 (en)	2001-12-20	Lipid complex of alkycyclines
TH45067A (th)	2001-05-03	วิธีสำหรับการลดไฟบริโนเจน