EE04282B1 - Pürasoolpürimidiinid, nende valmistamine ja kasutamine ravimina ning neid sisaldav kompositsioon - Google Patents

Pürasoolpürimidiinid, nende valmistamine ja kasutamine ravimina ning neid sisaldav kompositsioon

Info

Publication number: EE04282B1
Authority: EE; Estonia
Prior art keywords: pharmaceutical; preparation; composition containing; pyrimidines; pyrazole
Prior art date: 1996-02-07

Application number

EE9800124A

Other languages

English (en)

Estonian (et)

Other versions

EE9800124A (et

Inventor

R. Webb Thomas

R. Mccarthy James

J. Moran Terence

M. Wilcoxen Keith

Chen Chen

Huang Charles

Original Assignee

Janssen Pharmaceutica N.V.

Neurocrine Biosciences Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-07

Filing date

1997-01-30

Publication date

2004-04-15

1997-01-30 Application filed by Janssen Pharmaceutica N.V., Neurocrine Biosciences Inc. filed Critical Janssen Pharmaceutica N.V.

1998-10-15 Publication of EE9800124A publication Critical patent/EE9800124A/xx

2004-04-15 Publication of EE04282B1 publication Critical patent/EE04282B1/xx

Links

KEUDMLLLHGLIGH-UHFFFAOYSA-N 1h-pyrazole;pyrimidine Chemical class C=1C=NNC=1.C1=CN=CN=C1 KEUDMLLLHGLIGH-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Nutrition Science (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

EE9800124A 1996-02-07 1997-01-30 Pürasoolpürimidiinid, nende valmistamine ja kasutamine ravimina ning neid sisaldav kompositsioon EE04282B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1127996P	1996-02-07	1996-02-07
US2768896P	1996-10-08	1996-10-08
PCT/EP1997/000459 WO1997029109A1 (en)	1996-02-07	1997-01-30	Pyrazolopyrimidines as crf receptor antagonists

Publications (2)

Publication Number	Publication Date
EE9800124A EE9800124A (et)	1998-10-15
EE04282B1 true EE04282B1 (et)	2004-04-15

Family

ID=26682204

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800124A EE04282B1 (et)	1996-02-07	1997-01-30	Pürasoolpürimidiinid, nende valmistamine ja kasutamine ravimina ning neid sisaldav kompositsioon

Country Status (27)

Country	Link
EP (1)	EP0880523B1 (id)
JP (2)	JP3356291B2 (id)
KR (1)	KR100421626B1 (id)
CN (1)	CN1090189C (id)
AR (1)	AR008577A1 (id)
AT (1)	ATE336495T1 (id)
AU (1)	AU713673B2 (id)
BG (1)	BG102349A (id)
BR (1)	BR9707391A (id)
CA (1)	CA2233285C (id)
CZ (1)	CZ244598A3 (id)
DE (2)	DE69736513T2 (id)
DK (1)	DK0880523T3 (id)
EA (1)	EA000803B1 (id)
EE (1)	EE04282B1 (id)
ES (1)	ES2168237T3 (id)
HU (1)	HUP9900575A3 (id)
ID (1)	ID15905A (id)
IL (1)	IL123835A0 (id)
NO (1)	NO310292B1 (id)
NZ (1)	NZ330119A (id)
PL (1)	PL191271B1 (id)
PT (1)	PT880523E (id)
SK (1)	SK106398A3 (id)
TR (1)	TR199800792T2 (id)
TW (1)	TW449599B (id)
WO (1)	WO1997029109A1 (id)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6191131B1 (en)	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
US7094782B1 (en)	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
US6124289A (en) *	1996-07-24	2000-09-26	Dupont Pharmaceuticals Co.	Azolo triazines and pyrimidines
US6060478A (en) *	1996-07-24	2000-05-09	Dupont Pharmaceuticals	Azolo triazines and pyrimidines
US6313124B1 (en)	1997-07-23	2001-11-06	Dupont Pharmaceuticals Company	Tetrazine bicyclic compounds
HU228962B1 (en) *	1996-07-24	2013-07-29	Bristol Myers Squibb Pharma Co	Azolo triazines, pharmaceutical compositions containing them and use of the compounds
US6492520B1 (en)	1996-08-06	2002-12-10	Pfizer Inc	Substituted pyrido-or pyrimido-containing 6,6- or 6,7-bicyclic derivatives
US5723608A (en) *	1996-12-31	1998-03-03	Neurogen Corporation	3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
JP2001511813A (ja)	1997-02-18	2001-08-14	ニューロクラインバイオサイエンシーズ，インコーポレイテッド	Ｃｒｆレセプターアンタゴニストおよびそれらに関連する方法
US6235741B1 (en) *	1997-05-30	2001-05-22	Merck & Co., Inc.	Angiogenesis inhibitors
CA2291709A1 (en) *	1997-05-30	1998-12-03	Merck & Co., Inc.	Novel angiogenesis inhibitors
NL1010018C2 (nl) *	1997-09-09	1999-03-10	Duphar Int Res	Chinoline en chinazoline derivaten met corticotropine releasing factor (CRF) antagonistische werking.
US6380203B1 (en)	1998-01-14	2002-04-30	Merck & Co., Inc.	Angiogenesis inhibitors
EP1049699B1 (en) *	1998-01-28	2004-04-21	Bristol-Myers Squibb Pharma Company	Pyrazolotriazines as crf antagonists
WO1999045007A1 (en) *	1998-03-06	1999-09-10	Janssen Pharmaceutica N.V.	Crf antagonistic pyrazolo[4,3-b]pyridines
JP2002510686A (ja)	1998-04-02	2002-04-09	ニューロゲンコーポレイション	アミノアルキルで置換された５，６，７，８−テトラヒドロ−９Ｈ−ピリジノ［２，３−ｂ］インドール及び５，６，７，８−テトラヒドロ−９Ｈピリミジノ［４，５−Ｂ］インドール誘導体：ＣＲＦ１特異的配位子
US6472402B1 (en)	1998-04-02	2002-10-29	Neurogen Corporation	Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives
AU2321000A (en) *	1999-01-29	2000-08-18	Sumitomo Chemical Company, Limited	Fat accumulation inhibitory agents
WO2000059907A2 (en)	1999-04-06	2000-10-12	Du Pont Pharmaceuticals Company	Pyrazolotriazines as crf antagonists
WO2000059908A2 (en)	1999-04-06	2000-10-12	Du Pont Pharmaceuticals Company	Pyrazolopyrimidines as crf antagonists
US6432989B1 (en)	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
JP2003510325A (ja)	1999-09-30	2003-03-18	ニューロジェン・コーポレーション	ある種のアルキレンジアミン−置換ピラゾロ［１，５−ａ］−１，５−ピリミジン及びピラゾロ［１，５−ａ］−１，３，５−トリアジン
CO5271670A1 (es)	1999-10-29	2003-04-30	Pfizer Prod Inc	Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas
TWI271406B (en)	1999-12-13	2007-01-21	Eisai Co Ltd	Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
CA2398956A1 (en) *	2000-02-14	2001-08-16	Japan Tobacco Inc.	A pharmaceutical composition for prophylaxis or therapy of a postoperative stress
KR20040034594A (ko)	2001-01-26	2004-04-28	브리스톨-마이어스스퀴브컴파니	코르티코트로핀 방출 인자 억제제로서의 이미다졸릴 유도체
TWI312347B (en)	2001-02-08	2009-07-21	Eisai R&D Man Co Ltd	Bicyclic nitrogen-containing condensed ring compounds
WO2002088121A1 (en)	2001-04-27	2002-11-07	Eisai Co., Ltd.	Pyrazolo[1,5-a]pyridines and medicines containing the same
US6872827B2 (en)	2002-04-26	2005-03-29	Chembridge Research Laboratories, Inc.	Somatostatin analogue compounds
US7161003B1 (en) *	2002-09-04	2007-01-09	Schering Corporation	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7176216B2 (en)	2002-10-22	2007-02-13	Eisai Co., Ltd.	7-phenylpyrazolopyridine compounds
SI1555265T1 (sl)	2002-10-22	2009-06-30	Eisai R&D Man Co Ltd	7-fenil pirazolopiridinske spojine
MXPA05007485A (es)	2003-01-14	2006-01-30	Arena Pharm Inc	Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia.
US20070179161A1 (en) *	2003-03-31	2007-08-02	Vernalis (Cambridge) Limited.	Pyrazolopyrimidine compounds and their use in medicine
AR045047A1 (es)	2003-07-11	2005-10-12	Arena Pharm Inc	Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
US7132426B2 (en)	2003-07-14	2006-11-07	Arena Pharmaceuticals, Inc.	Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
US7329662B2 (en)	2003-10-03	2008-02-12	Hoffmann-La Roche Inc.	Pyrazolo-pyridine
US20070293511A1 (en) *	2003-12-22	2007-12-20	Sb Pharmco Puerto Rico Inc. And Neurocrine Biosciences, Inc., A Corporation	Crf Receptor Antagonists and Methods
CA2550948A1 (en)	2003-12-22	2005-07-14	Sb Pharmco Puerto Rico Inc.	Crf receptor antagonists and methods relating thereto
WO2005079868A2 (en) *	2004-02-13	2005-09-01	Sb Pharmco Puerto Rico Inc	Crf receptor antagonists, their preparations, their pharmaceutical composition and their uses
GB0519957D0 (en)	2005-09-30	2005-11-09	Sb Pharmco Inc	Chemical compound
CN101115755B (zh)	2005-02-11	2013-01-16	弗·哈夫曼-拉罗切有限公司	作为mglur2拮抗剂的吡唑并-嘧啶衍生物
AU2006227300B2 (en) *	2005-03-21	2012-02-02	Eli Lilly And Company	Imidazopyridazine compounds
DE602006012815D1 (de)	2005-03-23	2010-04-22	Hoffmann La Roche	Acetylenylpyrazolopyrimidinderivate als mglur2-antagonsten
WO2006107784A1 (en) *	2005-04-05	2006-10-12	Eli Lilly And Company	Imidazopyridazine compounds
WO2007017678A1 (en) *	2005-08-09	2007-02-15	Eirx Therapeutics Limited	Pyrazolo[1,5-a] pyrimidine compounds and pharmaceutical compositions containing them
AU2006298829B2 (en)	2005-09-27	2011-03-03	F. Hoffmann-La Roche Ag	Oxadiazolyl pyrazolo-pyrimidines as mGluR2 antagonists
AU2007297481B2 (en) *	2006-09-20	2012-03-08	Eli Lilly And Company	Thiophene pyrazolopyrimidine compounds
EP2094709B1 (en) *	2006-09-20	2010-09-15	Eli Lilly And Company	Thiazole pyrazolopyrimidines as crf1 receptor antagonists
ES2375425T3 (es)	2007-07-26	2012-02-29	Novartis Ag	Compuestos org�?nicos.
RS52561B (sr)	2008-04-15	2013-04-30	Eisai R&D Management Co., Ltd.	Jedinjenje 3-fenilpirazolo[5,1-b]tiazol
AR078521A1 (es)	2009-10-08	2011-11-16	Eisai R&D Man Co Ltd	Compuesto pirazolotiazol
PH12013500547A1 (en)	2010-09-22	2013-06-10	Arena Pharm Inc	Modulators of the gpr119 receptor and the treatment of disorders related thereto
GB201210686D0 (en)	2012-06-15	2012-08-01	Holsboermaschmeyer Neurochemie Gmbh	V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
GB201310782D0 (en)	2013-06-17	2013-07-31	Max Planck Innovation Gmbh	Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms
MX386419B (es)	2015-01-06	2025-03-18	Arena Pharm Inc	Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
PL236355B1 (pl) *	2015-04-02	2021-01-11	Celon Pharma Spolka Akcyjna	Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3
EP3939965A1 (en)	2015-06-22	2022-01-19	Arena Pharmaceuticals, Inc.	Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in sipi receptor-associated disorders
KR102598895B1 (ko)	2016-07-12	2023-11-07	레볼루션 메디슨즈, 인크.	다른자리 입체성 shp2 억제제로서의 2,5-이치환 3-메틸 피라진 및 2,5,6-3치환 3-메틸 피라진
MX2019008696A (es)	2017-01-23	2019-09-13	Revolution Medicines Inc	Compuestos de piridina como inhibidores de shp2 alostericos.
MX2019008695A (es)	2017-01-23	2019-09-11	Revolution Medicines Inc	Compuestos biciclicos como inhibidores alostericos de shp2.
CN118845788A (zh)	2017-08-14	2024-10-29	云杉生物科学公司	促肾上腺皮质激素释放因子受体拮抗剂
EA202090321A1 (ru) *	2017-08-14	2020-09-24	Спрюс Биосайнсес, Инк.	Антагонисты рецептора кортикотропин-рилизинг фактора
CA3074690A1 (en)	2017-09-07	2019-03-14	Revolution Medicines, Inc.	Shp2 inhibitor compositions and methods for treating cancer
MX2020003579A (es)	2017-10-12	2020-07-22	Revolution Medicines Inc	Compuestos de piridina, pirazina, y triazina como inhibidores de shp2 alostericos.
BR112020009757A2 (pt)	2017-12-15	2020-11-03	Revolution Medicines, Inc.	compostos policíclicos como inibidores alostéricos de shp2
EP4438124A3 (en)	2018-04-27	2024-12-18	Spruce Biosciences, Inc.	Methods for treating testicular and ovarian adrenal rest tumors
ES2987794T3 (es)	2018-06-06	2024-11-18	Arena Pharm Inc	Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1
BR112023002497A2 (pt)	2020-08-12	2023-05-02	Spruce Biosciences Inc	Métodos e composições para tratamento da síndrome dos ovários policísticos
US11708372B2 (en)	2021-11-19	2023-07-25	Spruce Biosciences, Inc.	Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4211753Y1 (id) *	1964-06-06	1967-06-30
JPS6157587A (ja) *	1984-08-29	1986-03-24	Shionogi & Co Ltd	縮合複素環誘導体および抗潰瘍剤
JPH0211753A (ja) *	1988-06-29	1990-01-16	Raimuzu:Kk	ＴｉＡｌ系複合部材及びその製造方法
TW370529B (en) *	1992-12-17	1999-09-21	Pfizer	Pyrazolopyrimidines

1997
- 1997-01-30 JP JP52812397A patent/JP3356291B2/ja not_active Expired - Fee Related
- 1997-01-30 NZ NZ330119A patent/NZ330119A/en not_active IP Right Cessation
- 1997-01-30 CZ CZ982445A patent/CZ244598A3/cs unknown
- 1997-01-30 PL PL327284A patent/PL191271B1/pl not_active IP Right Cessation
- 1997-01-30 DE DE69736513T patent/DE69736513T2/de not_active Expired - Lifetime
- 1997-01-30 EP EP97902295A patent/EP0880523B1/en not_active Expired - Lifetime
- 1997-01-30 HU HU9900575A patent/HUP9900575A3/hu unknown
- 1997-01-30 SK SK1063-98A patent/SK106398A3/sk unknown
- 1997-01-30 BR BR9707391A patent/BR9707391A/pt not_active Application Discontinuation
- 1997-01-30 DE DE0880523T patent/DE880523T1/de active Pending
- 1997-01-30 IL IL12383597A patent/IL123835A0/xx active IP Right Grant
- 1997-01-30 WO PCT/EP1997/000459 patent/WO1997029109A1/en not_active Ceased
- 1997-01-30 DK DK97902295T patent/DK0880523T3/da active
- 1997-01-30 TR TR1998/00792T patent/TR199800792T2/xx unknown
- 1997-01-30 EA EA199800394A patent/EA000803B1/ru not_active IP Right Cessation
- 1997-01-30 CN CN97191382A patent/CN1090189C/zh not_active Expired - Fee Related
- 1997-01-30 AT AT97902295T patent/ATE336495T1/de active
- 1997-01-30 ES ES97902295T patent/ES2168237T3/es not_active Expired - Lifetime
- 1997-01-30 CA CA002233285A patent/CA2233285C/en not_active Expired - Fee Related
- 1997-01-30 EE EE9800124A patent/EE04282B1/xx not_active IP Right Cessation
- 1997-01-30 AU AU15991/97A patent/AU713673B2/en not_active Ceased
- 1997-01-30 PT PT97902295T patent/PT880523E/pt unknown
- 1997-01-30 KR KR10-1998-0703401A patent/KR100421626B1/ko not_active Expired - Fee Related
- 1997-02-05 TW TW086101373A patent/TW449599B/zh not_active IP Right Cessation
- 1997-02-06 AR ARP970100473A patent/AR008577A1/es not_active Application Discontinuation
- 1997-02-07 ID IDP970392A patent/ID15905A/id unknown
1998
- 1998-03-25 BG BG102349A patent/BG102349A/xx unknown
- 1998-03-25 NO NO19981357A patent/NO310292B1/no not_active IP Right Cessation
2001
- 2001-09-03 JP JP2001265611A patent/JP2002121194A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
ID15905A (id)	1997-08-14
EA199800394A1 (ru)	1998-10-29
DE880523T1 (de)	2002-07-04
PT880523E (pt)	2007-01-31
JP3356291B2 (ja)	2002-12-16
KR100421626B1 (ko)	2004-05-20
ES2168237T1 (es)	2002-06-16
WO1997029109A1 (en)	1997-08-14
EP0880523B1 (en)	2006-08-16
NO981357D0 (no)	1998-03-25
PL191271B1 (pl)	2006-04-28
AR008577A1 (es)	2000-02-09
EE9800124A (et)	1998-10-15
IL123835A0 (en)	1998-10-30
JP2002121194A (ja)	2002-04-23
HUP9900575A3 (en)	2001-11-28
AU1599197A (en)	1997-08-28
JP2000503661A (ja)	2000-03-28
NO310292B1 (no)	2001-06-18
BG102349A (en)	1999-02-26
BR9707391A (pt)	1999-07-20
TR199800792T2 (xx)	1998-07-21
KR19990067391A (ko)	1999-08-16
PL327284A1 (en)	1998-12-07
CN1205009A (zh)	1999-01-13
EA000803B1 (ru)	2000-04-24
CN1090189C (zh)	2002-09-04
SK106398A3 (en)	1998-12-02
NZ330119A (en)	2000-02-28
HUP9900575A2 (hu)	1999-06-28
AU713673B2 (en)	1999-12-09
EP0880523A1 (en)	1998-12-02
NO981357L (no)	1998-08-03
CZ244598A3 (cs)	1998-10-14
DE69736513D1 (de)	2006-09-28
ATE336495T1 (de)	2006-09-15
DK0880523T3 (da)	2007-03-26
CA2233285C (en)	2006-07-04
ES2168237T3 (es)	2007-04-01
TW449599B (en)	2001-08-11
DE69736513T2 (de)	2007-04-05
CA2233285A1 (en)	1997-08-14

Legal Events

Date	Code	Title	Description
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2005-10-17	MM4A	Lapsed by not paying the annual fees	Effective date: 20050130

Publication	Publication Date	Title
EE04282B1 (et)	2004-04-15	Pürasoolpürimidiinid, nende valmistamine ja kasutamine ravimina ning neid sisaldav kompositsioon
EE200000168A (et)	2001-04-16	Karboksamidotiasoolderivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
EE05183B1 (et)	2009-06-15	Asabitsklilised hendid, nende valmistamine ja kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
EE04673B1 (et)	2006-08-15	Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
HUP9701169A3 (en)	1999-07-28	Cycloalkano-pyridine derivatives, intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds
EE200200138A (et)	2003-06-16	Kinolüülpropüülpiperidiini derivaadid, nende valmistamine ja neid sisaldavad kompositsioonid
HUP0002272A3 (en)	2002-03-28	Aroyl-piperazine derivatives, their preparation pharmaceutical compositions containing them and their use
SI0918059T1 (en)	2003-12-31	Substituted imidazoline derivatives, their preparation, their use, and pharmaceutical compositions containing them
HUP9801900A3 (en)	2001-02-28	2-methoxybenzophenone derivatives, intermediates, preparation thereof and fungicide compositions containing them
HUP9901243A3 (en)	2001-11-28	Quinazoline derivatives, preparation and use thereof, pharmaceutical compositions containing these compounds
IL190216A0 (en)	2008-11-03	Novel substituted imidazole compounds, their preparation and pharmaceutical compositions comprising them
EE200200065A (et)	2003-04-15	3-aminopürasooli derivaadid, nende valmistamine ja kasutamine vähivastaste toimeainetena ning neid sisaldav farmatseutiline kompositsioon
IL112384A0 (en)	1995-03-30	Tetracyclic derivatives, their preparation and pharmaceutical compositions containing them
EE04399B1 (et)	2004-12-15	Spiroasabitsüklilised heterotsüklilised ühendid, nende valmistamise protsess, neid sisaldavad ravimkoostised ja nende kasutamine ravis
EE200000037A (et)	2000-10-16	Atsüülpiperasinüülpürimidiinide derivaadid, nende valmistamine ja kasutamine ravimitena
EE04276B1 (et)	2004-04-15	Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
ATE240315T1 (de)	2003-05-15	Substituierte 4-amino-2-aryl-pyrimidine, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
EE03929B1 (et)	2002-12-16	Sünteetilised polüsahhariidid, nende valmistamisemeetod ja neid sisaldavad farmatseutilised kompositsioonid
HUP9904694A3 (en)	2001-12-28	Spiropyrrolidine derivatives, their use and pharmaceutical compositions containing them
IL122740A (en)	2003-09-17	16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
HUP0101960A3 (en)	2003-03-28	Metabolites of ecteinascidin 743, their use and pharmaceutical compositions containing them
IL112443A0 (en)	1995-03-30	Heterocyclic compounds, their preparation and pharmaceutical compositions containing them
FI951967L (fi)	1995-10-27	Uudet kaksirenkaiset aromaattiset yhdisteet, niitä sisältävät farmaseuttiset ja kosmeettiset koostumukset ja niiden käyttö
IL112589A0 (en)	1995-05-26	Polysubstituted 3-acylamino-5-phenyl-1, 4-benzodiazepin-2-one derivatives, their preparation and pharmaceutical compositions containing them
HUP9802132A3 (en)	2000-04-28	Biphenyl-sulfonyl-cyanamides, their use and pharmaceutical compositions containing them