EE04498B1 - Erütromütsiini derivaadid, nende valmistamismeetod ja neid sisaldav farmatseutiline kompositsioon - Google Patents

Erütromütsiini derivaadid, nende valmistamismeetod ja neid sisaldav farmatseutiline kompositsioon

Info

Publication number
EE04498B1
EE04498B1 EE9500080A EE9500080A EE04498B1 EE 04498 B1 EE04498 B1 EE 04498B1 EE 9500080 A EE9500080 A EE 9500080A EE 9500080 A EE9500080 A EE 9500080A EE 04498 B1 EE04498 B1 EE 04498B1
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical composition
composition containing
erythromycin derivatives
erythromycin
Prior art date
Application number
EE9500080A
Other languages
English (en)
Estonian (et)
Other versions
EE9500080A (et
Inventor
Agouridas Constantin
Benedetti Yannick
Chantot Jean-Fran�Ois
Denis Alexis
Le Martret Odile
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of EE9500080A publication Critical patent/EE9500080A/xx
Publication of EE04498B1 publication Critical patent/EE04498B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EE9500080A 1994-04-08 1995-04-06 Erütromütsiini derivaadid, nende valmistamismeetod ja neid sisaldav farmatseutiline kompositsioon EE04498B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
EE9500080A EE9500080A (et) 1996-12-16
EE04498B1 true EE04498B1 (et) 2005-06-15

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9500080A EE04498B1 (et) 1994-04-08 1995-04-06 Erütromütsiini derivaadid, nende valmistamismeetod ja neid sisaldav farmatseutiline kompositsioon

Country Status (49)

Country Link
US (2) US5656607A (ro)
EP (1) EP0676409B1 (ro)
JP (1) JP3000023B2 (ro)
KR (1) KR100317148B1 (ro)
CN (1) CN1059445C (ro)
AP (1) AP587A (ro)
AT (1) ATE234853T1 (ro)
AU (1) AU684939B2 (ro)
BG (1) BG61916B1 (ro)
BR (1) BR9506147A (ro)
CA (1) CA2164638C (ro)
CO (1) CO4370097A1 (ro)
CZ (1) CZ296005B6 (ro)
DE (1) DE69529934T2 (ro)
DK (1) DK0676409T3 (ro)
DZ (1) DZ1869A1 (ro)
EE (1) EE04498B1 (ro)
ES (1) ES2189820T3 (ro)
FI (1) FI111264B (ro)
FR (1) FR2718450B1 (ro)
GB (1) GB2288174A (ro)
GE (1) GEP19991836B (ro)
HR (1) HRP950217B1 (ro)
HU (1) HU215396B (ro)
IL (1) IL112954A (ro)
IS (1) IS1865B (ro)
JO (1) JO1850B1 (ro)
LV (1) LV11182B (ro)
MA (1) MA23501A1 (ro)
MD (1) MD663G2 (ro)
MY (1) MY114672A (ro)
NO (1) NO308361B1 (ro)
NZ (1) NZ284498A (ro)
OA (1) OA10200A (ro)
PE (1) PE2896A1 (ro)
PL (1) PL180837B1 (ro)
PT (1) PT676409E (ro)
RO (1) RO115634B1 (ro)
RU (1) RU2141965C1 (ro)
SA (1) SA97170757A (ro)
SI (1) SI0676409T1 (ro)
SK (1) SK284079B6 (ro)
SV (1) SV1995000018A (ro)
TN (1) TNSN95026A1 (ro)
TW (1) TW316908B (ro)
UA (1) UA44705C2 (ro)
WO (1) WO1995027720A1 (ro)
YU (1) YU49221B (ro)
ZA (1) ZA952059B (ro)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
PT922050E (pt) * 1996-05-07 2003-12-31 Abbott Lab Derivados de 3-descladinose-2,3-anidroeritromicina
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
ATE296831T1 (de) * 1996-09-04 2005-06-15 Abbott Lab 6-0-substituierte ketoliden mit antibakteriellen wirkung
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998042720A1 (fr) * 1997-03-24 1998-10-01 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
US6162794A (en) * 1997-05-09 2000-12-19 Pfizer Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
EP0988308A1 (en) * 1997-06-11 2000-03-29 Pfizer Products Inc. 9-oxime erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
AU5299499A (en) 1998-09-22 2000-04-10 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
EP1137654A1 (en) 1998-12-10 2001-10-04 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
JP2002542197A (ja) 1999-04-16 2002-12-10 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ケトライド抗菌剤
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
AU775637B2 (en) * 1999-04-16 2004-08-12 Kosan Biosciences, Inc. Macrolide antiinfective agents
TR200103395T2 (tr) * 1999-05-24 2002-04-22 Pfizer Products Inc. 13-metil eritromisin türevleri.
JP4509553B2 (ja) 2001-07-03 2010-07-21 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 抗菌活性を有するｃ１２修飾エリスロマイシンマクロライドおよびケトライド
KR101035043B1 (ko) 2002-07-01 2011-05-19 아르키온 라이프 사이언씨즈 엘엘씨 글루코사민 및 ｎ-아세틸글루코사민의 제조를 위한 물질및 공정
EP3738591A3 (en) * 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
CA2523134A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Pyridyl substituted ketolide antibiotics
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
DK2358379T3 (en) * 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
BR112012023950A2 (pt) 2010-03-22 2016-07-05 Cempra Pharmaceuticals Inc formas cristalinas de um macrolídeo, e usos dos mesmos
PL2571506T3 (pl) 2010-05-20 2017-10-31 Cempra Pharmaceuticals Inc Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
BR112015023670A2 (pt) 2013-03-15 2017-07-18 Cempra Pharmaceuticals Inc processo para preparar um composto
BR112015025159A2 (pt) 2013-04-04 2017-07-18 Harvard College macrolídeos e métodos de sua preparação e uso
HK1242920A1 (zh) * 2014-10-08 2018-07-06 哈佛大学的校长及成员们 14-元酮内酯及其制备和使用方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
JP3000023B2 (ja) 2000-01-17
IL112954A (en) 2000-07-16
WO1995027720A1 (fr) 1995-10-19
FR2718450A1 (fr) 1995-10-13
RU2141965C1 (ru) 1999-11-27
DZ1869A1 (fr) 2002-02-17
DE69529934T2 (de) 2003-09-04
ZA952059B (en) 1996-03-13
UA44705C2 (uk) 2002-03-15
HU9503505D0 (en) 1996-02-28
SA97170757A (ar) 2005-12-03
ES2189820T3 (es) 2003-07-16
MA23501A1 (fr) 1995-12-31
SK154695A3 (en) 1996-10-02
CN1059445C (zh) 2000-12-13
CA2164638C (fr) 2003-12-30
NO954942L (no) 1996-02-07
PT676409E (pt) 2003-08-29
PL180837B1 (pl) 2001-04-30
BR9506147A (pt) 1996-04-16
CN1126997A (zh) 1996-07-17
AP587A (en) 1997-04-29
US5656607A (en) 1997-08-12
FR2718450B1 (fr) 1997-01-10
GEP19991836B (en) 1999-11-05
FI955913A7 (fi) 1995-12-08
DE69529934D1 (de) 2003-04-24
BG100150A (bg) 1996-06-28
HUT73772A (en) 1996-09-30
GB9506856D0 (en) 1995-05-24
SK284079B6 (sk) 2004-09-08
IS1865B (is) 2003-05-02
FI955913A0 (fi) 1995-12-08
CO4370097A1 (es) 1996-10-07
NO308361B1 (no) 2000-09-04
SI0676409T1 (en) 2003-06-30
RO115634B1 (ro) 2000-04-28
IL112954A0 (en) 1995-06-29
HRP950217A2 (en) 1997-08-31
YU49221B (sh) 2004-11-25
FI111264B (fi) 2003-06-30
CZ322395A3 (en) 1996-08-14
MD663F1 (ro) 1997-01-31
EE9500080A (et) 1996-12-16
TNSN95026A1 (fr) 1996-02-06
NO954942D0 (no) 1995-12-06
HRP950217B1 (en) 2004-06-30
AU684939B2 (en) 1998-01-08
AU2310795A (en) 1995-10-30
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
PE2896A1 (es) 1996-02-12
MY114672A (en) 2002-12-31
LV11182A (lv) 1996-04-20
AP9500743A0 (en) 1995-07-31
ATE234853T1 (de) 2003-04-15
CA2164638A1 (fr) 1995-10-19
CZ296005B6 (cs) 2005-12-14
GB2288174A (en) 1995-10-11
BG61916B1 (bg) 1998-09-30
IS4309A (is) 1995-11-17
DK0676409T3 (da) 2003-06-23
KR100317148B1 (ko) 2002-06-22
MD663G2 (ro) 1997-07-31
YU21695A (sh) 1997-12-05
LV11182B (en) 1997-04-20
OA10200A (fr) 1996-12-18
NZ284498A (en) 1997-07-27
EP0676409A1 (fr) 1995-10-11
TW316908B (ro) 1997-10-01
JPH07278177A (ja) 1995-10-24
PL311871A1 (en) 1996-03-18
US5760233A (en) 1998-06-02
HU215396B (hu) 1998-12-28
SV1995000018A (es) 1997-10-24

Similar Documents

Publication Publication Date Title
EE04498B1 (et) Erütromütsiini derivaadid, nende valmistamismeetod ja neid sisaldav farmatseutiline kompositsioon
EE03263B1 (et) Erütromütsiini derivaadid, nende valmistamismeetod, farmatseutiline kompositsioon ja vaheühendid
EE200000707A (et) Oksasolidinooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
EE9700333A (et) Substitueeritud 4-fenüülaminotiasoolid, nende valmistamise meetod ja neid sisaldavad farmakoloogilised kompositsioonid
EE04489B1 (et) Atsüülpseudodipeptiidid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
HUP0000721A3 (en) Gemcitabine derivatives, process for their preparation and pharmaceutical compositions containing them
EE200000168A (et) Karboksamidotiasoolderivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
EE9900015A (et) Sünteetilised polüsahhariidid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
FI954304A7 (fi) Uudet bentsopyraanijohdannaiset, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
FI953898A7 (fi) Glysiiniamidijohdannaisia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä lääkeaineita
EE9800265A (et) Erütromütsiini derivaadid, nende valmistamismeetod ja kasutamine ravimitena
FI952550A7 (fi) Uudet N-pyridyylikarboksamidit ja johdannaiset, menetelmät niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
EE9800426A (et) Asendatud 2,4-tiasolidiindiooni derivaadid, nende valmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid
FI943688L (fi) Uudet 11-bentsaldoksiimi-17beta-metoksi-27alfa-metoksi-metyyli-estradieenijohdannaiset, menetelmät niiden valmistamiseksi ja näitä sisältävät lääkeaineet
FI950625L (fi) Polysubstituoituja 3-asyyliamino-5-fenyyli-1,4-bentsodiatsepiini-2-onijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
FI930974A7 (fi) Substituoidut aminofosonaattijohdannaiset, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
EE03825B1 (et) 2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
FI956278A0 (fi) Substituoituja 4-fenyylitiatsolijohdannaisia, menetelmä niiden valmistamiseksi ja niitä sisältäviä farmaseuttisia koostumuksia
EE9800069A (et) Bensotiasolooni derivaadid, protsessid ja kasutatud vaheühendid nende saamiseks ning neid sisaldavad ravimkoostised
HUT77126A (hu) Antibiotikus hatású eritromicin A 9-0-oxim -származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
EE9800264A (et) Taksoidid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
FI960316L (fi) Oksatiolaanit, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
FI955085L (fi) Uudet diosmetiiniyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
EE9400148A (et) Tienotiasiini derivaadid, nende valmistamise meetod ja neid sisaldavad farmatseutilised preparaadid
FI941094L (fi) Uudet erytromysiinijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231