EE04770B1 - Tritsüklilised delta3-piperidiinid, nende valmistamismeetod, kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod - Google Patents

Tritsüklilised delta3-piperidiinid, nende valmistamismeetod, kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod

Info

Publication number: EE04770B1
Authority: EE; Estonia
Prior art keywords: preparation; piperidines; pharmaceutical composition; delta3; tricyclic
Prior art date: 1998-10-06

Application number

EEP200100209A

Other languages

English (en)

Estonian (et)

Inventor

Edmond Josephine Kennis Ludo

Carolus Mertens Josephus

Maria Alfons Van Den Keybus Frans

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-06

Filing date

1999-10-01

Publication date

2007-02-15

1999-10-01 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2002-06-17 Publication of EE200100209A publication Critical patent/EE200100209A/xx

2007-02-15 Publication of EE04770B1 publication Critical patent/EE04770B1/xx

Links

238000000034 method Methods 0.000 title 2
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Gynecology & Obstetrics (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

EEP200100209A 1998-10-06 1999-10-01 Tritsüklilised delta3-piperidiinid, nende valmistamismeetod, kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod EE04770B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98203370		1998-10-06
PCT/EP1999/007419 WO2000020421A2 (en)	1998-10-06	1999-10-01	TRICYCLIC Δ3-PIPERIDINES AS α2-ANTAGONISTS

Publications (2)

Publication Number	Publication Date
EE200100209A EE200100209A (et)	2002-06-17
EE04770B1 true EE04770B1 (et)	2007-02-15

Family

ID=8234191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100209A EE04770B1 (et)	1998-10-06	1999-10-01	Tritsüklilised delta3-piperidiinid, nende valmistamismeetod, kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod

Country Status (30)

Country	Link
US (1)	US6495555B1 (id)
EP (1)	EP1119571B1 (id)
JP (1)	JP4590101B2 (id)
KR (1)	KR20010071843A (id)
CN (1)	CN1131230C (id)
AR (1)	AR024216A1 (id)
AT (1)	ATE232869T1 (id)
AU (1)	AU760502B2 (id)
BG (1)	BG64872B1 (id)
BR (1)	BR9913507A (id)
CA (1)	CA2345622C (id)
CZ (1)	CZ20011104A3 (id)
DE (1)	DE69905478T2 (id)
DK (1)	DK1119571T3 (id)
EE (1)	EE04770B1 (id)
ES (1)	ES2193751T3 (id)
HU (1)	HUP0104002A3 (id)
ID (1)	ID28032A (id)
IL (1)	IL142443A0 (id)
NO (1)	NO20011270D0 (id)
NZ (1)	NZ510115A (id)
PL (1)	PL347894A1 (id)
PT (1)	PT1119571E (id)
RU (1)	RU2230744C2 (id)
SI (1)	SI1119571T1 (id)
SK (1)	SK285585B6 (id)
TR (1)	TR200100952T2 (id)
TW (1)	TWI248441B (id)
UA (1)	UA69420C2 (id)
WO (1)	WO2000020421A2 (id)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE269337T1 (de) *	1998-10-06	2004-07-15	Janssen Pharmaceutica Nv	Trizyclische delta3-pyridine als arzneimittel
US20050203100A1 (en) *	2002-04-03	2005-09-15	Jukka Sallinen	Use of an alfa2-adrenoreceptor antagonist for cns-related diseases
JP4816453B2 (ja)	2004-04-12	2011-11-16	大正製薬株式会社	環状アミン化合物
WO2006006740A1 (ja) *	2004-07-14	2006-01-19	Japan Tobacco Inc.	３−アミノベンズアミド化合物及びバニロイド受容体１型(ｖｒ１)活性阻害剤
KR101042490B1 (ko) *	2004-07-15	2011-06-16	니뽄 다바코 산교 가부시키가이샤	축합 벤즈아미드 화합물 및 바닐로이드 수용체 1형(ｖｒ1)활성 저해제
US7906508B2 (en) *	2005-12-28	2011-03-15	Japan Tobacco Inc.	3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
MX2011012190A (es)	2009-05-14	2011-12-08	Janssen Pharmaceutica Nv	Compuestos con dos porciones de heteroarilo biciclico fusionado como moduladores de la leucotrieno a4 hidrolasa.
CA2934134A1 (en)	2013-12-19	2015-06-25	Bayer Pharma Aktiengesellschaft	Substituted bipiperidinyl derivatives as adrenoreceptor alpha 2c antagonists
JP2017501164A (ja) *	2013-12-19	2017-01-12	バイエルファーマアクチエンゲゼルシャフト	置換されたピペリジニルテトラヒドロキノリン類
SG11201604978QA (en)	2013-12-19	2016-07-28	Bayer Pharma AG	Substituted piperidinyl-tetrahydroquinolines and their use as alpha-2c adrenoreceptor antagonists
CN114276359B (zh) *	2022-01-05	2023-05-05	浙江大学	一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU926914A1 (ru) *	1980-05-26	1992-04-23	Научно-исследовательский институт фармакологии АМН СССР	Производные 1,2,3,4-тетрагидробензофуро[3,2-с]-пиридина или хлоргидрат, обладающие р дом свойств анальгетиков и антагонистов морфина
DE3522959A1 (de) *	1985-06-27	1987-01-08	Merck Patent Gmbh	Indolderivate
US4673680A (en) *	1985-09-18	1987-06-16	Pendleton Robert G	α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
EP0339959A3 (en) *	1988-04-27	1991-03-20	Glaxo Group Limited	Lactam derivatives
US4971974A (en) *	1988-06-16	1990-11-20	Neurex Corporation	Benzothiophenes as appetite suppressants
US5100891A (en) *	1991-01-18	1992-03-31	Hoechst-Roussel Pharmaceuticals Inc.	Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
WO1998024791A1 (en) *	1996-12-06	1998-06-11	Abbott Laboratories	Benzopyranopyrrole and benzopyranopyridine alpha-1 adrenergic compounds
WO1999033804A1 (en) *	1997-12-25	1999-07-08	Meiji Seika Kaisha, Ltd.	Tetrahydrobenzindole derivatives
ATE269337T1 (de) *	1998-10-06	2004-07-15	Janssen Pharmaceutica Nv	Trizyclische delta3-pyridine als arzneimittel

1999
- 1999-01-10 UA UA2001031999A patent/UA69420C2/uk unknown
- 1999-10-01 HU HU0104002A patent/HUP0104002A3/hu unknown
- 1999-10-01 SI SI9930264T patent/SI1119571T1/xx unknown
- 1999-10-01 NZ NZ510115A patent/NZ510115A/xx unknown
- 1999-10-01 ES ES99950627T patent/ES2193751T3/es not_active Expired - Lifetime
- 1999-10-01 BR BR9913507-8A patent/BR9913507A/pt not_active IP Right Cessation
- 1999-10-01 EE EEP200100209A patent/EE04770B1/xx not_active IP Right Cessation
- 1999-10-01 DK DK99950627T patent/DK1119571T3/da active
- 1999-10-01 AT AT99950627T patent/ATE232869T1/de not_active IP Right Cessation
- 1999-10-01 PL PL99347894A patent/PL347894A1/xx not_active Application Discontinuation
- 1999-10-01 CZ CZ20011104A patent/CZ20011104A3/cs unknown
- 1999-10-01 CA CA002345622A patent/CA2345622C/en not_active Expired - Fee Related
- 1999-10-01 AU AU63341/99A patent/AU760502B2/en not_active Ceased
- 1999-10-01 US US09/806,547 patent/US6495555B1/en not_active Expired - Lifetime
- 1999-10-01 DE DE69905478T patent/DE69905478T2/de not_active Expired - Lifetime
- 1999-10-01 ID IDW20010780A patent/ID28032A/id unknown
- 1999-10-01 SK SK432-2001A patent/SK285585B6/sk unknown
- 1999-10-01 PT PT99950627T patent/PT1119571E/pt unknown
- 1999-10-01 TR TR2001/00952T patent/TR200100952T2/xx unknown
- 1999-10-01 IL IL14244399A patent/IL142443A0/xx not_active IP Right Cessation
- 1999-10-01 KR KR1020017000442A patent/KR20010071843A/ko not_active Ceased
- 1999-10-01 JP JP2000574533A patent/JP4590101B2/ja not_active Expired - Fee Related
- 1999-10-01 TW TW088116898A patent/TWI248441B/zh not_active IP Right Cessation
- 1999-10-01 WO PCT/EP1999/007419 patent/WO2000020421A2/en not_active Ceased
- 1999-10-01 RU RU2001111812/04A patent/RU2230744C2/ru not_active IP Right Cessation
- 1999-10-01 EP EP99950627A patent/EP1119571B1/en not_active Expired - Lifetime
- 1999-10-01 CN CN99811682A patent/CN1131230C/zh not_active Expired - Fee Related
- 1999-10-05 AR ARP990105038A patent/AR024216A1/es not_active Application Discontinuation
2001
- 2001-03-12 BG BG105332A patent/BG64872B1/bg unknown
- 2001-03-13 NO NO20011270A patent/NO20011270D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2193751T3 (es)	2003-11-01
EE200100209A (et)	2002-06-17
SK285585B6 (sk)	2007-04-05
NO20011270L (no)	2001-03-13
DK1119571T3 (da)	2003-05-26
CA2345622A1 (en)	2000-04-13
AU6334199A (en)	2000-04-26
RU2230744C2 (ru)	2004-06-20
HUP0104002A3 (en)	2003-12-29
CZ20011104A3 (cs)	2001-12-12
JP2002526545A (ja)	2002-08-20
NZ510115A (en)	2002-11-26
PL347894A1 (en)	2002-04-22
EP1119571B1 (en)	2003-02-19
SI1119571T1 (en)	2003-08-31
AR024216A1 (es)	2002-09-25
IL142443A0 (en)	2002-03-10
JP4590101B2 (ja)	2010-12-01
ATE232869T1 (de)	2003-03-15
HK1038010A1 (en)	2002-03-01
WO2000020421A3 (en)	2000-08-03
SK4322001A3 (en)	2002-01-07
PT1119571E (pt)	2003-06-30
TR200100952T2 (tr)	2001-10-22
TWI248441B (en)	2006-02-01
CA2345622C (en)	2007-12-04
KR20010071843A (ko)	2001-07-31
ID28032A (id)	2001-05-03
US6495555B1 (en)	2002-12-17
WO2000020421A2 (en)	2000-04-13
NO20011270D0 (no)	2001-03-13
BG105332A (en)	2001-11-30
DE69905478D1 (de)	2003-03-27
DE69905478T2 (de)	2004-03-18
EP1119571A2 (en)	2001-08-01
CN1131230C (zh)	2003-12-17
CN1332744A (zh)	2002-01-23
UA69420C2 (uk)	2004-09-15
BR9913507A (pt)	2001-06-05
BG64872B1 (bg)	2006-07-31
AU760502B2 (en)	2003-05-15
HUP0104002A2 (hu)	2002-03-28

Legal Events

Date	Code	Title	Description
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-06-16	MM4A	Lapsed by not paying the annual fees	Effective date: 20071001

Publication	Publication Date	Title
EE05214B1 (et)	2009-10-15	Polool-IFN- β konjugaat, selle valmistamismeetod ja farmatseutiline kompositsioon
EE05086B1 (et)	2008-10-15	Primidiini derivaadid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod, kombinatsioon ning saadus
EE9800136A (et)	1998-10-15	Depooravimiks sobiv farmatseutiline kompositsioon, selle valmistamismeetod ja kasutamine
EE200000596A (et)	2002-06-17	Tienüülasolüülalkoksüetaanamiinderivaadid, nende ja nende soolade valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja kasutamine ning vaheühend ja selle valmistamismeetod
EE9800180A (et)	1998-12-15	Gonadotropiini riliisinghormooni antagonist, selle kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod
EE9800181A (et)	1998-12-15	Gonadotropiini riliisinghormooni antagonist, selle kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod
EE05021B1 (et)	2008-06-16	Enterokattega ravimkoostis ja selle valmistamise meetod
EE200000680A (et)	2002-10-15	Enterokattega ravimkoostis ja selle valmistamise meetod
EE03338B1 (et)	2001-02-15	Tromboosivastane ravim, selle valmistamise protsess ja kasutamine
EE200300207A (et)	2003-08-15	Heterotsüklüülalküülpiperidiini derivaadid, nendevalmistamismeetodid ja farmatseutiline kompositsioon
EE04721B1 (et)	2006-10-16	Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
EE200000621A (et)	2002-06-17	Pikornaviirusevastased ühendid, nende valmistamine ja kasutamine
FI962908L (fi)	1998-01-20	Mikrobinvastainen koostumus, sen valmistusmenetelmä ja sen käyttö
EE04717B1 (et)	2006-10-16	Indolüülpiperidiinühendid, nende valmistamismeetod, kompositsioon ja nende kasutamine
EE200000767A (et)	2002-06-17	Asendatud triasolopüridasiini derivaat, selle valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon
EE03825B1 (et)	2002-08-15	2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE200100314A (et)	2002-08-15	Meetod farmatseutilise kompositsiooni valmistamiseks, farmatseutiline kompositsioon ja selle kasutamine
EE04681B1 (et)	2006-08-15	3,6-poolketaalid 9a-asaliidide klassist, nende valmistamismeetod ja farmatseutiline kompositsioon
EE04346B1 (et)	2004-08-16	Asoolid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
EE200000099A (et)	2000-12-15	Antimükootiline kompositsioon, selle kasutamine ja valmistamismeetod ning antimükootiline toode
EE03691B1 (et)	2002-04-15	1,2,3,4-tetrahüdrobensofuro[3,4-c]püridiini derivaadid, nende valmistamismeetod, kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod
EE200100209A (et)	2002-06-17	Tritsüklilised 3-piperidiinid, nende valmistamismeetod, kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod
EE9800075A (et)	1998-10-15	Kombineeritud ravimpreparaat, selle kasutamine ja meetod selle valmistamiseks
EE03996B1 (et)	2003-04-15	Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine
EE04260B1 (et)	2004-04-15	Farmatseutiline kompositsioon, selle valmistamisemeetod ja kasutamine