EE05361B1 - Meetod kamptotetsiini analoogide snteesimiseks kasutatavate hendite valmistamiseks ning kamptotetsiini analoogide terviksntees - Google Patents
Meetod kamptotetsiini analoogide snteesimiseks kasutatavate hendite valmistamiseks ning kamptotetsiini analoogide terviksnteesInfo
- Publication number
- EE05361B1 EE05361B1 EEP200300373A EEP200300373A EE05361B1 EE 05361 B1 EE05361 B1 EE 05361B1 EE P200300373 A EEP200300373 A EE P200300373A EE P200300373 A EEP200300373 A EE P200300373A EE 05361 B1 EE05361 B1 EE 05361B1
- Authority
- EE
- Estonia
- Prior art keywords
- synthesis
- camptothecin
- compounds
- preparation
- whole
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 2
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 2
- 238000003786 synthesis reaction Methods 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
- C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001045430 | 2001-02-21 | ||
| JP2001309322 | 2001-10-05 | ||
| PCT/JP2002/001538 WO2002066416A1 (fr) | 2001-02-21 | 2002-02-21 | Procede de synthese de composes se rapportant a la camptothecine (cpt) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200300373A EE200300373A (et) | 2003-10-15 |
| EE05361B1 true EE05361B1 (et) | 2010-12-15 |
Family
ID=26609837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200300373A EE05361B1 (et) | 2001-02-21 | 2002-02-21 | Meetod kamptotetsiini analoogide snteesimiseks kasutatavate hendite valmistamiseks ning kamptotetsiini analoogide terviksntees |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7126000B2 (fr) |
| EP (1) | EP1378505B1 (fr) |
| JP (2) | JP4210119B2 (fr) |
| KR (2) | KR100864692B1 (fr) |
| CN (1) | CN100408550C (fr) |
| AR (2) | AR035684A1 (fr) |
| AU (1) | AU2002237527B2 (fr) |
| BG (2) | BG108031A (fr) |
| BR (1) | BR0207470A (fr) |
| CA (2) | CA2437702C (fr) |
| CZ (1) | CZ20032470A3 (fr) |
| EE (1) | EE05361B1 (fr) |
| HU (1) | HUP0302755A3 (fr) |
| IL (2) | IL156949A0 (fr) |
| MX (1) | MXPA03007528A (fr) |
| NO (2) | NO328628B1 (fr) |
| NZ (2) | NZ527615A (fr) |
| PL (2) | PL217238B1 (fr) |
| RO (2) | RO125158A2 (fr) |
| RU (1) | RU2308447C2 (fr) |
| SK (2) | SK288073B6 (fr) |
| TW (1) | TWI245768B (fr) |
| WO (1) | WO2002066416A1 (fr) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ299329B6 (cs) * | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
| CZ299593B6 (cs) * | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
| WO2006016203A1 (fr) * | 2004-08-09 | 2006-02-16 | Shilpa Medicare Limited | Procédé amélioré de preparation de chlorhydrate trihydraté d'irinotécan |
| EP1824485B1 (fr) * | 2004-11-05 | 2012-09-19 | Samyang Biopharmaceuticals Corporation | Formulation pharmaceutique permettant d'augmenter la solubilite de composes de 10-hydroxycamptothecine dans des solvants polaires non aqueux |
| ATE446299T1 (de) | 2005-02-07 | 2009-11-15 | Fermion Oy | Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin |
| CA2591071C (fr) | 2005-02-08 | 2014-04-29 | Fermion Oy | Procede de production de chlorure de [1,4'] bipiperidinyl-1'-carbonyl ou d'hydrochlorure correspondant |
| JP5133704B2 (ja) * | 2005-02-08 | 2013-01-30 | フェルミオン オサケ ユキチュア | 製造方法 |
| US8112154B2 (en) * | 2005-04-13 | 2012-02-07 | The Cleveland Clinic Foundation | Systems and methods for neuromodulation using pre-recorded waveforms |
| TWI375678B (en) * | 2005-06-09 | 2012-11-01 | Yakult Honsha Kk | A method of preparation of a tricyclic ketone |
| US7608740B2 (en) | 2005-08-03 | 2009-10-27 | Avra Laboratories Pvt. Ltd | Method of synthesizing key intermediates for the production of camptothecin derivatives |
| EP1803725A1 (fr) * | 2005-12-13 | 2007-07-04 | W.C. Heraeus GmbH | Procédé pour la preparation d'irinotecan |
| US9220889B2 (en) | 2008-02-11 | 2015-12-29 | Intelect Medical, Inc. | Directional electrode devices with locating features |
| CN101824038B (zh) * | 2009-03-06 | 2013-08-21 | 复旦大学 | 喜树碱及其类似物的制备方法 |
| CA2772330A1 (fr) | 2009-08-27 | 2011-03-03 | The Cleveland Clinic Foundation | Systeme et procede d?estimation d?une region d?activation tissulaire |
| JP5599094B2 (ja) * | 2010-05-20 | 2014-10-01 | 国立大学法人 千葉大学 | ニトリル化合物の製造方法 |
| WO2011159688A2 (fr) | 2010-06-14 | 2011-12-22 | Boston Scientific Neuromodulation Corporation | Interface de programmation pour la neuromodulation de la moelle épinière |
| WO2013023081A1 (fr) | 2011-08-09 | 2013-02-14 | Boston Scientific Neuromodulation Corporation | Commande à distance d'essais cliniques à l'aveugle de stimulation électrique |
| EP2890454B1 (fr) | 2012-08-28 | 2017-11-08 | Boston Scientific Neuromodulation Corporation | Programmation de pointer-cliquer pour stimulation cérébrale profonde au moyen de lignes de tendance de compte-rendus monopolaires en temps réel |
| US9792412B2 (en) | 2012-11-01 | 2017-10-17 | Boston Scientific Neuromodulation Corporation | Systems and methods for VOA model generation and use |
| US8722886B1 (en) * | 2012-11-13 | 2014-05-13 | Bionumerik Pharmaceuticals, Inc. | Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin |
| US9959388B2 (en) | 2014-07-24 | 2018-05-01 | Boston Scientific Neuromodulation Corporation | Systems, devices, and methods for providing electrical stimulation therapy feedback |
| US10265528B2 (en) | 2014-07-30 | 2019-04-23 | Boston Scientific Neuromodulation Corporation | Systems and methods for electrical stimulation-related patient population volume analysis and use |
| US10272247B2 (en) | 2014-07-30 | 2019-04-30 | Boston Scientific Neuromodulation Corporation | Systems and methods for stimulation-related volume analysis, creation, and sharing with integrated surgical planning and stimulation programming |
| US9974959B2 (en) | 2014-10-07 | 2018-05-22 | Boston Scientific Neuromodulation Corporation | Systems, devices, and methods for electrical stimulation using feedback to adjust stimulation parameters |
| SG11201702105QA (en) * | 2014-10-22 | 2017-05-30 | Vivacitas Oncology Inc | Methods and systems for camptothecin analog synthesis |
| AU2016268259B2 (en) | 2015-05-26 | 2019-01-31 | Boston Scientific Neuromodulation Corporation | Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation |
| US10780283B2 (en) | 2015-05-26 | 2020-09-22 | Boston Scientific Neuromodulation Corporation | Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation |
| ES2940303T3 (es) | 2015-06-29 | 2023-05-05 | Boston Scient Neuromodulation Corp | Sistemas de selección de parámetros de estimulación por uso de dianas y direccionamiento |
| US20160375248A1 (en) | 2015-06-29 | 2016-12-29 | Boston Scientific Neuromodulation Corporation | Systems and methods for selecting stimulation parameters based on stimulation target region, effects, or side effects |
| US10071249B2 (en) | 2015-10-09 | 2018-09-11 | Boston Scientific Neuromodulation Corporation | System and methods for clinical effects mapping for directional stimulation leads |
| US10716942B2 (en) | 2016-04-25 | 2020-07-21 | Boston Scientific Neuromodulation Corporation | System and methods for directional steering of electrical stimulation |
| JP6905541B2 (ja) | 2016-06-24 | 2021-07-21 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 臨床効果の視覚分析のためのシステム及び方法 |
| US10350404B2 (en) | 2016-09-02 | 2019-07-16 | Boston Scientific Neuromodulation Corporation | Systems and methods for visualizing and directing stimulation of neural elements |
| US10780282B2 (en) | 2016-09-20 | 2020-09-22 | Boston Scientific Neuromodulation Corporation | Systems and methods for steering electrical stimulation of patient tissue and determining stimulation parameters |
| JP6828149B2 (ja) | 2016-10-14 | 2021-02-10 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 電気刺激システムに対する刺激パラメータ設定の閉ループ決定のためのシステム及び方法 |
| AU2017391436B2 (en) | 2017-01-03 | 2020-06-18 | Boston Scientific Neuromodulation Corporation | Systems and methods for selecting MRI-compatible stimulation parameters |
| WO2018132334A1 (fr) | 2017-01-10 | 2018-07-19 | Boston Scientific Neuromodulation Corporation | Systèmes et procédés pour créer des programmes de stimulation basés sur des zones ou des volumes définis par l'utilisateur |
| US10625082B2 (en) | 2017-03-15 | 2020-04-21 | Boston Scientific Neuromodulation Corporation | Visualization of deep brain stimulation efficacy |
| US11357986B2 (en) | 2017-04-03 | 2022-06-14 | Boston Scientific Neuromodulation Corporation | Systems and methods for estimating a volume of activation using a compressed database of threshold values |
| EP3651849B1 (fr) | 2017-07-14 | 2023-05-31 | Boston Scientific Neuromodulation Corporation | Estimation des effets cliniques d'une stimulation électrique |
| US10960214B2 (en) | 2017-08-15 | 2021-03-30 | Boston Scientific Neuromodulation Corporation | Systems and methods for controlling electrical stimulation using multiple stimulation fields |
| WO2019210202A1 (fr) | 2018-04-27 | 2019-10-31 | Boston Scientific Neuromodulation Corporation | Systèmes de stimulation électrique multimode et leurs procédés de fabrication et d'utilisation |
| US11285329B2 (en) | 2018-04-27 | 2022-03-29 | Boston Scientific Neuromodulation Corporation | Systems and methods for visualizing and programming electrical stimulation |
| EP3911660B1 (fr) * | 2019-01-15 | 2023-05-10 | Laurus Labs Limited | Procédé de préparation de 2-amino-5-hydroxy propiophénone |
| EP4291294A1 (fr) | 2021-04-27 | 2023-12-20 | Boston Scientific Neuromodulation Corporation | Systèmes et procédés de programmation automatisée de stimulation électrique |
| US12403313B2 (en) | 2021-06-15 | 2025-09-02 | Boston Scientific Neuromodulation Corporation | Methods and systems for estimating neural activation by stimulation using a stimulation system |
| CN118251257A (zh) | 2021-12-09 | 2024-06-25 | 波士顿科学神经调制公司 | 用于使用刺激系统监测或评估运动障碍或其他生理参数的方法和系统 |
| US12690801B2 (en) | 2021-12-10 | 2026-07-28 | Boston Scientific Neuromodulation Corporation | Methods and systems for determining and using an intensity index for electrical stimulation |
| US12471831B2 (en) | 2021-12-10 | 2025-11-18 | Boston Scientific Neuromodulation Corporation | Systems and methods for generating and using response maps for electrical stimulation |
| WO2023167872A1 (fr) | 2022-03-02 | 2023-09-07 | Boston Scientific Neuromodulation Corporation | Systèmes et procédés de surveillance de dérive de stimulation dans un système de stimulation électrique |
| CN118108705A (zh) * | 2024-01-29 | 2024-05-31 | 浙江工业大学 | 一种富马酸沃诺拉赞的制备方法 |
| CN120887897B (zh) * | 2025-07-30 | 2026-07-10 | 德阳悦合生物医药科技有限公司 | 医药中间体(r)-7-乙基喜树碱的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2061678C1 (ru) * | 1992-05-14 | 1996-06-10 | Валерий Павлович Севодин | Способ получения 2-амино-5-нитробензофенона |
| US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
| JPH07101956A (ja) * | 1993-10-05 | 1995-04-18 | Tanabe Seiyaku Co Ltd | ヒドロキシカンプトテシン化合物の製法 |
| KR960029336A (ko) * | 1995-01-09 | 1996-08-17 | 김충환 | 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제 |
| JPH08225482A (ja) * | 1995-02-22 | 1996-09-03 | Dai Ichi Seiyaku Co Ltd | テトラロン関連化合物及びその製法 |
| IL117684A (en) * | 1995-04-07 | 2002-02-10 | Pharmacia & Upjohn Inc | Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds |
| SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| WO1997016454A1 (fr) | 1995-11-02 | 1997-05-09 | Glaxo Wellcome Inc. | Procede pour preparer des derives de camptothecine |
| SG88737A1 (en) * | 1996-10-30 | 2002-05-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
-
2002
- 2002-02-20 AR ARP020100579A patent/AR035684A1/es active IP Right Grant
- 2002-02-20 TW TW091102967A patent/TWI245768B/zh not_active IP Right Cessation
- 2002-02-21 CA CA2437702A patent/CA2437702C/fr not_active Expired - Fee Related
- 2002-02-21 CN CNB028053230A patent/CN100408550C/zh not_active Expired - Fee Related
- 2002-02-21 WO PCT/JP2002/001538 patent/WO2002066416A1/fr not_active Ceased
- 2002-02-21 CZ CZ20032470A patent/CZ20032470A3/cs unknown
- 2002-02-21 PL PL399009A patent/PL217238B1/pl unknown
- 2002-02-21 RO ROA200900165A patent/RO125158A2/ro unknown
- 2002-02-21 MX MXPA03007528A patent/MXPA03007528A/es active IP Right Grant
- 2002-02-21 NZ NZ52761502A patent/NZ527615A/xx not_active IP Right Cessation
- 2002-02-21 AU AU2002237527A patent/AU2002237527B2/en not_active Ceased
- 2002-02-21 BR BRPI0207470-2A patent/BR0207470A/pt not_active IP Right Cessation
- 2002-02-21 JP JP2002565934A patent/JP4210119B2/ja not_active Expired - Fee Related
- 2002-02-21 SK SK1147-2003A patent/SK288073B6/sk not_active IP Right Cessation
- 2002-02-21 SK SK5001-2011A patent/SK288149B6/sk not_active IP Right Cessation
- 2002-02-21 RU RU2003128530/04A patent/RU2308447C2/ru not_active IP Right Cessation
- 2002-02-21 KR KR1020077030609A patent/KR100864692B1/ko not_active Expired - Fee Related
- 2002-02-21 HU HU0302755A patent/HUP0302755A3/hu unknown
- 2002-02-21 KR KR1020037010841A patent/KR100858972B1/ko not_active Expired - Fee Related
- 2002-02-21 US US10/467,987 patent/US7126000B2/en not_active Expired - Lifetime
- 2002-02-21 IL IL15694902A patent/IL156949A0/xx unknown
- 2002-02-21 EE EEP200300373A patent/EE05361B1/xx not_active IP Right Cessation
- 2002-02-21 PL PL363440A patent/PL218065B1/pl unknown
- 2002-02-21 EP EP02703874.4A patent/EP1378505B1/fr not_active Expired - Lifetime
- 2002-02-21 CA CA2683768A patent/CA2683768C/fr not_active Expired - Fee Related
- 2002-02-21 RO ROA200300695A patent/RO122639B9/ro unknown
-
2003
- 2003-07-15 IL IL156949A patent/IL156949A/en not_active IP Right Cessation
- 2003-07-25 BG BG108031A patent/BG108031A/bg unknown
- 2003-08-13 NO NO20033579A patent/NO328628B1/no not_active IP Right Cessation
- 2003-08-14 NZ NZ534374A patent/NZ534374A/xx not_active IP Right Cessation
-
2006
- 2006-09-08 US US11/517,621 patent/US7378555B2/en not_active Expired - Lifetime
-
2008
- 2008-03-28 JP JP2008085358A patent/JP4805967B2/ja not_active Expired - Lifetime
-
2009
- 2009-11-24 NO NO20093402A patent/NO331656B1/no not_active IP Right Cessation
-
2011
- 2011-08-11 AR ARP110102927A patent/AR082663A2/es not_active Application Discontinuation
-
2013
- 2013-04-23 BG BG10111453A patent/BG111453A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
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| MM4A | Lapsed by not paying the annual fees |
Effective date: 20150221 |