SK288073B6 - Method of synthesizing campothecin-relating compounds - Google Patents

Method of synthesizing campothecin-relating compounds Download PDF

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Publication number
SK288073B6
SK288073B6 SK1147-2003A SK11472003A SK288073B6 SK 288073 B6 SK288073 B6 SK 288073B6 SK 11472003 A SK11472003 A SK 11472003A SK 288073 B6 SK288073 B6 SK 288073B6
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SK
Slovakia
Prior art keywords
compound
mixture
reaction
solvent
stirring
Prior art date
Application number
SK1147-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK11472003A3 (sk
Inventor
Takanori Ogawa
Hiroyuki Nishiyama
Miyuki Uchida
Seigo Sawada
Original Assignee
Kabushiki Kaisha Yakult Honsha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabushiki Kaisha Yakult Honsha filed Critical Kabushiki Kaisha Yakult Honsha
Publication of SK11472003A3 publication Critical patent/SK11472003A3/sk
Publication of SK288073B6 publication Critical patent/SK288073B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SK1147-2003A 2001-02-21 2002-02-21 Method of synthesizing campothecin-relating compounds SK288073B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001045430 2001-02-21
JP2001309322 2001-10-05
PCT/JP2002/001538 WO2002066416A1 (fr) 2001-02-21 2002-02-21 Procede de synthese de composes se rapportant a la camptothecine (cpt)

Publications (2)

Publication Number Publication Date
SK11472003A3 SK11472003A3 (sk) 2004-03-02
SK288073B6 true SK288073B6 (sk) 2013-05-03

Family

ID=26609837

Family Applications (2)

Application Number Title Priority Date Filing Date
SK1147-2003A SK288073B6 (sk) 2001-02-21 2002-02-21 Method of synthesizing campothecin-relating compounds
SK5001-2011A SK288149B6 (sk) 2001-02-21 2002-02-21 Process for preparing tricyclic ketone to synthesize camptothecin analogs

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK5001-2011A SK288149B6 (sk) 2001-02-21 2002-02-21 Process for preparing tricyclic ketone to synthesize camptothecin analogs

Country Status (23)

Country Link
US (2) US7126000B2 (fr)
EP (1) EP1378505B1 (fr)
JP (2) JP4210119B2 (fr)
KR (2) KR100864692B1 (fr)
CN (1) CN100408550C (fr)
AR (2) AR035684A1 (fr)
AU (1) AU2002237527B2 (fr)
BG (2) BG108031A (fr)
BR (1) BR0207470A (fr)
CA (2) CA2437702C (fr)
CZ (1) CZ20032470A3 (fr)
EE (1) EE05361B1 (fr)
HU (1) HUP0302755A3 (fr)
IL (2) IL156949A0 (fr)
MX (1) MXPA03007528A (fr)
NO (2) NO328628B1 (fr)
NZ (2) NZ527615A (fr)
PL (2) PL217238B1 (fr)
RO (2) RO125158A2 (fr)
RU (1) RU2308447C2 (fr)
SK (2) SK288073B6 (fr)
TW (1) TWI245768B (fr)
WO (1) WO2002066416A1 (fr)

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CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
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ATE446299T1 (de) 2005-02-07 2009-11-15 Fermion Oy Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin
CA2591071C (fr) 2005-02-08 2014-04-29 Fermion Oy Procede de production de chlorure de [1,4'] bipiperidinyl-1'-carbonyl ou d'hydrochlorure correspondant
JP5133704B2 (ja) * 2005-02-08 2013-01-30 フェルミオン オサケ ユキチュア 製造方法
US8112154B2 (en) * 2005-04-13 2012-02-07 The Cleveland Clinic Foundation Systems and methods for neuromodulation using pre-recorded waveforms
TWI375678B (en) * 2005-06-09 2012-11-01 Yakult Honsha Kk A method of preparation of a tricyclic ketone
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CN101824038B (zh) * 2009-03-06 2013-08-21 复旦大学 喜树碱及其类似物的制备方法
CA2772330A1 (fr) 2009-08-27 2011-03-03 The Cleveland Clinic Foundation Systeme et procede d?estimation d?une region d?activation tissulaire
JP5599094B2 (ja) * 2010-05-20 2014-10-01 国立大学法人 千葉大学 ニトリル化合物の製造方法
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AU2016268259B2 (en) 2015-05-26 2019-01-31 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
US10780283B2 (en) 2015-05-26 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation
ES2940303T3 (es) 2015-06-29 2023-05-05 Boston Scient Neuromodulation Corp Sistemas de selección de parámetros de estimulación por uso de dianas y direccionamiento
US20160375248A1 (en) 2015-06-29 2016-12-29 Boston Scientific Neuromodulation Corporation Systems and methods for selecting stimulation parameters based on stimulation target region, effects, or side effects
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JP6905541B2 (ja) 2016-06-24 2021-07-21 ボストン サイエンティフィック ニューロモデュレイション コーポレイション 臨床効果の視覚分析のためのシステム及び方法
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JP6828149B2 (ja) 2016-10-14 2021-02-10 ボストン サイエンティフィック ニューロモデュレイション コーポレイション 電気刺激システムに対する刺激パラメータ設定の閉ループ決定のためのシステム及び方法
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US10625082B2 (en) 2017-03-15 2020-04-21 Boston Scientific Neuromodulation Corporation Visualization of deep brain stimulation efficacy
US11357986B2 (en) 2017-04-03 2022-06-14 Boston Scientific Neuromodulation Corporation Systems and methods for estimating a volume of activation using a compressed database of threshold values
EP3651849B1 (fr) 2017-07-14 2023-05-31 Boston Scientific Neuromodulation Corporation Estimation des effets cliniques d'une stimulation électrique
US10960214B2 (en) 2017-08-15 2021-03-30 Boston Scientific Neuromodulation Corporation Systems and methods for controlling electrical stimulation using multiple stimulation fields
WO2019210202A1 (fr) 2018-04-27 2019-10-31 Boston Scientific Neuromodulation Corporation Systèmes de stimulation électrique multimode et leurs procédés de fabrication et d'utilisation
US11285329B2 (en) 2018-04-27 2022-03-29 Boston Scientific Neuromodulation Corporation Systems and methods for visualizing and programming electrical stimulation
EP3911660B1 (fr) * 2019-01-15 2023-05-10 Laurus Labs Limited Procédé de préparation de 2-amino-5-hydroxy propiophénone
EP4291294A1 (fr) 2021-04-27 2023-12-20 Boston Scientific Neuromodulation Corporation Systèmes et procédés de programmation automatisée de stimulation électrique
US12403313B2 (en) 2021-06-15 2025-09-02 Boston Scientific Neuromodulation Corporation Methods and systems for estimating neural activation by stimulation using a stimulation system
CN118251257A (zh) 2021-12-09 2024-06-25 波士顿科学神经调制公司 用于使用刺激系统监测或评估运动障碍或其他生理参数的方法和系统
US12690801B2 (en) 2021-12-10 2026-07-28 Boston Scientific Neuromodulation Corporation Methods and systems for determining and using an intensity index for electrical stimulation
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Also Published As

Publication number Publication date
RU2308447C2 (ru) 2007-10-20
BG111453A (en) 2013-09-30
US7126000B2 (en) 2006-10-24
NZ527615A (en) 2004-12-24
HUP0302755A2 (hu) 2003-12-29
RO122639B9 (ro) 2014-03-28
NO20033579D0 (no) 2003-08-13
SK288149B6 (sk) 2013-12-02
NO328628B1 (no) 2010-04-12
AU2002237527B2 (en) 2007-01-04
JPWO2002066416A1 (ja) 2004-09-24
KR100864692B1 (ko) 2008-10-23
CA2437702C (fr) 2010-04-06
CZ20032470A3 (cs) 2004-02-18
EP1378505A4 (fr) 2006-09-27
KR100858972B1 (ko) 2008-09-17
PL399009A1 (pl) 2012-09-10
SK11472003A3 (sk) 2004-03-02
IL156949A (en) 2009-09-01
US20070010674A1 (en) 2007-01-11
IL156949A0 (en) 2004-02-08
CN100408550C (zh) 2008-08-06
JP2008273952A (ja) 2008-11-13
JP4805967B2 (ja) 2011-11-02
AR082663A2 (es) 2012-12-26
EE05361B1 (et) 2010-12-15
CA2683768A1 (fr) 2002-08-29
BR0207470A (pt) 2008-04-08
BG108031A (bg) 2005-04-30
WO2002066416A1 (fr) 2002-08-29
NO20093402L (no) 2003-10-10
RU2003128530A (ru) 2005-03-27
CN1492851A (zh) 2004-04-28
MXPA03007528A (es) 2003-12-11
KR20030077631A (ko) 2003-10-01
CA2437702A1 (fr) 2002-08-29
PL363440A1 (en) 2004-11-15
JP4210119B2 (ja) 2009-01-14
NO331656B1 (no) 2012-02-13
PL217238B1 (pl) 2014-06-30
TWI245768B (en) 2005-12-21
RO125158A2 (ro) 2010-01-29
NO20033579L (no) 2003-10-10
HUP0302755A3 (en) 2008-03-28
US20040106830A1 (en) 2004-06-03
EP1378505B1 (fr) 2014-11-05
NZ534374A (en) 2004-12-24
US7378555B2 (en) 2008-05-27
PL218065B1 (pl) 2014-10-31
EE200300373A (et) 2003-10-15
KR20080012383A (ko) 2008-02-11
EP1378505A1 (fr) 2004-01-07
RO122639B1 (ro) 2009-10-30
CA2683768C (fr) 2013-05-28
AR035684A1 (es) 2004-06-23

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Effective date: 20150221