EE200100002A - Ileumi sapihappetranspordi ja taurokolaadi imendumise inhibiitoritena toimivad bensotiepiinid - Google Patents

Ileumi sapihappetranspordi ja taurokolaadi imendumise inhibiitoritena toimivad bensotiepiinid

Info

Publication number: EE200100002A
Authority: EE; Estonia
Prior art keywords: benzothiepines; inhibitors; acting; bile acid; acid transport
Prior art date: 1998-07-02

Application number

EEP200100002A

Other languages

English (en)

Estonian (et)

Inventor

F. Lee Len

C. Banerjee Shyamal

Huang Horng-Chih

J. Li Jinglin

E. Miller Raymond

B. Reitz David

J. Tremont Samuel

Original Assignee

G.D. Searle & Co.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-02

Filing date

1999-06-29

Publication date

2002-06-17

1999-06-29 Application filed by G.D. Searle & Co. filed Critical G.D. Searle & Co.

2002-06-17 Publication of EE200100002A publication Critical patent/EE200100002A/xx

Links

HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
NIGNBCLEMMGDQP-UHFFFAOYSA-N 1-benzothiepine Chemical class S1C=CC=CC2=CC=CC=C12 NIGNBCLEMMGDQP-UHFFFAOYSA-N 0.000 title 1
238000010521 absorption reaction Methods 0.000 title 1
239000003613 bile acid Substances 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
WBWWGRHZICKQGZ-HZAMXZRMSA-N taurocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 WBWWGRHZICKQGZ-HZAMXZRMSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655381—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring
- C07F9/65539—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Polymers & Plastics (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EEP200100002A 1998-07-02 1999-06-29 Ileumi sapihappetranspordi ja taurokolaadi imendumise inhibiitoritena toimivad bensotiepiinid EE200100002A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/109,551 US5994391A (en)	1994-09-13	1998-07-02	Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
PCT/US1999/012828 WO2000001687A1 (en)	1998-07-02	1999-06-29	Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Publications (1)

Publication Number	Publication Date
EE200100002A true EE200100002A (et)	2002-06-17

Family

ID=22328263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100002A EE200100002A (et)	1998-07-02	1999-06-29	Ileumi sapihappetranspordi ja taurokolaadi imendumise inhibiitoritena toimivad bensotiepiinid

Country Status (37)

Country	Link
US (1)	US5994391A (is)
EP (2)	EP1466911A3 (is)
JP (3)	JP2002519418A (is)
KR (1)	KR20010083084A (is)
CN (1)	CN1312805A (is)
AP (1)	AP2001002062A0 (is)
AR (1)	AR019880A1 (is)
AT (1)	ATE256122T1 (is)
AU (2)	AU766957B2 (is)
BG (1)	BG105206A (is)
BR (1)	BR9911737A (is)
CA (1)	CA2336315A1 (is)
CO (2)	CO4950537A1 (is)
DE (1)	DE69913530T2 (is)
DK (1)	DK1091953T3 (is)
EA (2)	EA200400149A1 (is)
EE (1)	EE200100002A (is)
ES (1)	ES2213373T3 (is)
GE (1)	GEP20032925B (is)
HK (1)	HK1039614A1 (is)
HR (1)	HRP20010004A2 (is)
HU (1)	HUP0102840A2 (is)
ID (1)	ID28221A (is)
IL (1)	IL140576A0 (is)
IS (1)	IS5798A (is)
NO (1)	NO20010016L (is)
NZ (1)	NZ509621A (is)
OA (1)	OA11629A (is)
PL (1)	PL346324A1 (is)
PT (1)	PT1091953E (is)
SG (1)	SG108309A1 (is)
SK (1)	SK20302000A3 (is)
TR (1)	TR200100824T2 (is)
TW (1)	TWI229670B (is)
WO (1)	WO2000001687A1 (is)
YU (1)	YU84400A (is)
ZA (1)	ZA200100028B (is)

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1998
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1999
- 1999-06-29 SK SK2030-2000A patent/SK20302000A3/sk unknown
- 1999-06-29 DK DK99931769T patent/DK1091953T3/da active
- 1999-06-29 PL PL99346324A patent/PL346324A1/xx unknown
- 1999-06-29 BR BR9911737-1A patent/BR9911737A/pt not_active IP Right Cessation
- 1999-06-29 ID IDW20010002A patent/ID28221A/id unknown
- 1999-06-29 WO PCT/US1999/012828 patent/WO2000001687A1/en not_active Ceased
- 1999-06-29 PT PT99931769T patent/PT1091953E/pt unknown
- 1999-06-29 NZ NZ509621A patent/NZ509621A/en unknown
- 1999-06-29 CA CA002336315A patent/CA2336315A1/en not_active Abandoned
- 1999-06-29 YU YU84400A patent/YU84400A/sh unknown
- 1999-06-29 HR HR20010004A patent/HRP20010004A2/hr not_active Application Discontinuation
- 1999-06-29 EA EA200400149A patent/EA200400149A1/ru unknown
- 1999-06-29 CN CN99809602A patent/CN1312805A/zh active Pending
- 1999-06-29 JP JP2000558091A patent/JP2002519418A/ja active Pending
- 1999-06-29 AT AT99931769T patent/ATE256122T1/de not_active IP Right Cessation
- 1999-06-29 GE GEAP19995707A patent/GEP20032925B/en unknown
- 1999-06-29 EP EP03026649A patent/EP1466911A3/en not_active Withdrawn
- 1999-06-29 EE EEP200100002A patent/EE200100002A/xx unknown
- 1999-06-29 ES ES99931769T patent/ES2213373T3/es not_active Expired - Lifetime
- 1999-06-29 TR TR2001/00824T patent/TR200100824T2/xx unknown
- 1999-06-29 HU HU0102840A patent/HUP0102840A2/hu unknown
- 1999-06-29 IL IL14057699A patent/IL140576A0/xx unknown
- 1999-06-29 SG SG200207701A patent/SG108309A1/en unknown
- 1999-06-29 KR KR1020017000027A patent/KR20010083084A/ko not_active Ceased
- 1999-06-29 OA OA1200000365A patent/OA11629A/en unknown
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- 1999-06-29 EA EA200100002A patent/EA004650B1/ru not_active IP Right Cessation
- 1999-06-29 AP APAP/P/2001/002062A patent/AP2001002062A0/en unknown
- 1999-06-29 DE DE69913530T patent/DE69913530T2/de not_active Expired - Fee Related
- 1999-06-29 AU AU48202/99A patent/AU766957B2/en not_active Ceased
- 1999-06-29 HK HK02100948.1A patent/HK1039614A1/zh unknown
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- 1999-07-02 CO CO99041717D patent/CO5080807A1/es unknown
2000
- 2000-01-07 TW TW088111293A patent/TWI229670B/zh not_active IP Right Cessation
- 2000-12-29 IS IS5798A patent/IS5798A/is unknown
2001
- 2001-01-02 NO NO20010016A patent/NO20010016L/no not_active Application Discontinuation
- 2001-01-02 ZA ZA200100028A patent/ZA200100028B/xx unknown
- 2001-01-31 BG BG105206A patent/BG105206A/bg unknown
2004
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- 2004-02-25 JP JP2004050473A patent/JP2004203891A/ja active Pending
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Also Published As

Publication number	Publication date
JP2002519418A (ja)	2002-07-02
HRP20010004A2 (en)	2001-12-31
SK20302000A3 (sk)	2001-11-06
YU84400A (sh)	2002-12-10
ID28221A (id)	2001-05-10
IS5798A (is)	2000-12-29
ATE256122T1 (de)	2003-12-15
NO20010016D0 (no)	2001-01-02
CO5080807A1 (es)	2001-09-25
HK1039614A1 (zh)	2002-05-03
TWI229670B (en)	2005-03-21
AP2001002062A0 (en)	2001-03-31
WO2000001687A1 (en)	2000-01-13
BG105206A (bg)	2001-09-28
OA11629A (en)	2004-11-10
CN1312805A (zh)	2001-09-12
ES2213373T3 (es)	2004-08-16
BR9911737A (pt)	2001-12-11
EA200100002A1 (ru)	2001-08-27
DE69913530T2 (de)	2004-09-23
EP1091953B1 (en)	2003-12-10
EA200400149A1 (ru)	2004-10-28
AU766957B2 (en)	2003-10-30
SG108309A1 (en)	2005-01-28
AR019880A1 (es)	2002-03-20
PT1091953E (pt)	2004-04-30
CA2336315A1 (en)	2000-01-13
US5994391A (en)	1999-11-30
EP1091953A1 (en)	2001-04-18
KR20010083084A (ko)	2001-08-31
JP2004203891A (ja)	2004-07-22
PL346324A1 (en)	2002-02-11
ZA200100028B (en)	2001-07-25
EP1466911A3 (en)	2005-09-07
GEP20032925B (en)	2003-03-25
HUP0102840A2 (hu)	2002-01-28
EP1466911A2 (en)	2004-10-13
NZ509621A (en)	2003-08-29
NO20010016L (no)	2001-03-02
WO2000001687A9 (en)	2000-07-20
AU2004200346A1 (en)	2004-02-26
DK1091953T3 (da)	2004-04-13
CO4950537A1 (es)	2000-09-01
JP2004359694A (ja)	2004-12-24
DE69913530D1 (de)	2004-01-22
IL140576A0 (en)	2002-02-10
TR200100824T2 (tr)	2001-07-23
EA004650B1 (ru)	2004-06-24
AU4820299A (en)	2000-01-24

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