EE200100543A - Madala molekulmassiga trombiini inhibiitorit ja selle eelravimit sisaldav ravivorm - Google Patents

Madala molekulmassiga trombiini inhibiitorit ja selle eelravimit sisaldav ravivorm

Info

Publication number
EE200100543A
EE200100543A EEP200100543A EEP200100543A EE200100543A EE 200100543 A EE200100543 A EE 200100543A EE P200100543 A EEP200100543 A EE P200100543A EE P200100543 A EEP200100543 A EE P200100543A EE 200100543 A EE200100543 A EE 200100543A
Authority
EE
Estonia
Prior art keywords
prodrug
molecular weight
dosage form
low molecular
thrombin inhibitor
Prior art date
Application number
EEP200100543A
Other languages
English (en)
Estonian (et)
Inventor
Gustafsson David
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9901442A external-priority patent/SE523811C2/sv
Priority claimed from SE9904419A external-priority patent/SE9904419D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of EE200100543A publication Critical patent/EE200100543A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EEP200100543A 1999-04-21 2000-04-19 Madala molekulmassiga trombiini inhibiitorit ja selle eelravimit sisaldav ravivorm EE200100543A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9901442A SE523811C2 (sv) 1999-04-21 1999-04-21 Beredning innehållande en trombininhibitor med låg molekylvikt tillsammans med en prodrog av densamma
SE9904419A SE9904419D0 (sv) 1999-12-03 1999-12-03 New use
PCT/SE2000/000756 WO2000064470A1 (en) 1999-04-21 2000-04-19 A pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug

Publications (1)

Publication Number Publication Date
EE200100543A true EE200100543A (et) 2003-02-17

Family

ID=26663557

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100543A EE200100543A (et) 1999-04-21 2000-04-19 Madala molekulmassiga trombiini inhibiitorit ja selle eelravimit sisaldav ravivorm

Country Status (29)

Country Link
US (3) US6962905B1 (de)
EP (2) EP1200118B1 (de)
JP (1) JP2002542298A (de)
KR (1) KR20010110788A (de)
CN (1) CN100377742C (de)
AR (1) AR023510A1 (de)
AT (1) ATE383868T1 (de)
AU (1) AU754405B2 (de)
BR (1) BR0009847A (de)
CA (1) CA2371008A1 (de)
CZ (1) CZ20013757A3 (de)
DE (1) DE60037816T2 (de)
DK (1) DK1200118T3 (de)
EE (1) EE200100543A (de)
ES (1) ES2298141T3 (de)
HK (1) HK1045465B (de)
HU (1) HUP0200955A3 (de)
IL (1) IL145840A0 (de)
IS (1) IS6111A (de)
MY (1) MY128061A (de)
NO (1) NO20015107D0 (de)
NZ (1) NZ514827A (de)
PL (1) PL201793B1 (de)
PT (1) PT1200118E (de)
RU (1) RU2252783C2 (de)
SA (1) SA00210092B1 (de)
SK (1) SK14962001A3 (de)
TR (1) TR200103017T2 (de)
WO (1) WO2000064470A1 (de)

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
SE9900070D0 (sv) 1999-01-13 1999-01-13 Astra Ab New use
AR023510A1 (es) * 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US20020116222A1 (en) * 2000-10-22 2002-08-22 Standing Stone, Inc. Method and system for administering anticoagulation therapy
US6462021B1 (en) * 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
SE0101762D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab New use
SE0101932D0 (sv) * 2001-05-31 2001-05-31 Astrazeneca Ab Pharmaceutical combinations
SE0103590D0 (sv) 2001-10-26 2001-10-26 Astrazeneca Ab New Combination
CA2478409C (en) 2002-03-11 2012-07-31 Curacyte Ag Inhibitors of urokinase, their preparation and use
SE0203349D0 (sv) * 2002-11-12 2002-11-12 Astrazeneca Ab New use
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
GB0306615D0 (en) * 2003-03-22 2003-04-30 Astrazeneca Ab New use
DE10342108A1 (de) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102005044319A1 (de) 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
RU2639876C2 (ru) * 2010-03-30 2017-12-25 Версеон Корпорейшн Мультизамещенные ароматические соединения в качестве ингибиторов тромбина
DK2968297T3 (en) 2013-03-15 2019-01-07 Verseon Inc MULTI-SUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS
CN105209440B (zh) 2013-03-15 2019-07-23 维颂公司 作为凝血酶抑制剂的卤代吡唑
SG11201701940UA (en) 2014-09-17 2017-04-27 Verseon Corp Pyrazolyl-substituted pyridone compounds as serine protease inhibitors
ES2931460T3 (es) 2015-02-27 2022-12-29 Verseon Int Corporation Compuestos de pirazol sustituido como inhibidores de serina proteasa

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Also Published As

Publication number Publication date
EP1886691A3 (de) 2008-03-05
SK14962001A3 (sk) 2002-06-04
CZ20013757A3 (cs) 2002-05-15
NO20015107L (no) 2001-10-19
HK1045465A1 (en) 2002-11-29
NO20015107D0 (no) 2001-10-19
IL145840A0 (en) 2002-07-25
AR023510A1 (es) 2002-09-04
KR20010110788A (ko) 2001-12-13
PT1200118E (pt) 2008-03-18
US20060009397A1 (en) 2006-01-12
US20080113960A1 (en) 2008-05-15
HK1045465B (en) 2008-08-01
ATE383868T1 (de) 2008-02-15
WO2000064470A1 (en) 2000-11-02
BR0009847A (pt) 2002-01-08
ES2298141T3 (es) 2008-05-16
AU4633600A (en) 2000-11-10
AU754405B2 (en) 2002-11-14
EP1886691A2 (de) 2008-02-13
CN1356908A (zh) 2002-07-03
NZ514827A (en) 2005-01-28
EP1200118A1 (de) 2002-05-02
HUP0200955A3 (en) 2006-07-28
US6962905B1 (en) 2005-11-08
DK1200118T3 (da) 2008-04-21
PL201793B1 (pl) 2009-05-29
SA00210092B1 (ar) 2006-11-11
EP1200118B1 (de) 2008-01-16
TR200103017T2 (tr) 2002-05-21
MY128061A (en) 2007-01-31
PL351917A1 (en) 2003-06-30
IS6111A (is) 2001-10-19
DE60037816T2 (de) 2009-01-08
RU2252783C2 (ru) 2005-05-27
DE60037816D1 (de) 2008-03-06
CA2371008A1 (en) 2000-11-02
HUP0200955A2 (en) 2002-09-28
CN100377742C (zh) 2008-04-02
JP2002542298A (ja) 2002-12-10

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