EE200200605A - Asendatud akrüloüüldistamütsiini derivaadi kasutamine ravimi valmistamiseks, mis on ette nähtud glutatiooni kõrge tasemega seotud kasvajate raviks - Google Patents

Asendatud akrüloüüldistamütsiini derivaadi kasutamine ravimi valmistamiseks, mis on ette nähtud glutatiooni kõrge tasemega seotud kasvajate raviks

Info

Publication number: EE200200605A
Authority: EE; Estonia
Prior art keywords: glutathione; medicament; substituted; manufacture; treatment
Prior art date: 2000-05-08

Application number

EEP200200605A

Other languages

English (en)

Estonian (et)

Inventor

Cristina Rosa Geroni Maria

Cozzi Paolo

Beria Italo

Original Assignee

Pharmacia Italia S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-08

Filing date

2001-04-19

Publication date

2004-04-15

2001-04-19 Application filed by Pharmacia Italia S.P.A. filed Critical Pharmacia Italia S.P.A.

2004-04-15 Publication of EE200200605A publication Critical patent/EE200200605A/xx

Links

RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 title 2
108010024636 Glutathione Proteins 0.000 title 1
206010028980 Neoplasm Diseases 0.000 title 1
239000003814 drug Substances 0.000 title 1
229960003180 glutathione Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Oncology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrrole Compounds (AREA)

EEP200200605A 2000-05-08 2001-04-19 Asendatud akrüloüüldistamütsiini derivaadi kasutamine ravimi valmistamiseks, mis on ette nähtud glutatiooni kõrge tasemega seotud kasvajate raviks EE200200605A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0011059.3A GB0011059D0 (en)	2000-05-08	2000-05-08	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
PCT/EP2001/004470 WO2001085144A2 (en)	2000-05-08	2001-04-19	Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione

Publications (1)

Publication Number	Publication Date
EE200200605A true EE200200605A (et)	2004-04-15

Family

ID=9891173

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200605A EE200200605A (et)	2000-05-08	2001-04-19	Asendatud akrüloüüldistamütsiini derivaadi kasutamine ravimi valmistamiseks, mis on ette nähtud glutatiooni kõrge tasemega seotud kasvajate raviks

Country Status (29)

Country	Link
US (1)	US7030089B2 (pl)
EP (1)	EP1280527B1 (pl)
JP (1)	JP2003532669A (pl)
KR (1)	KR100776184B1 (pl)
CN (1)	CN1258362C (pl)
AR (1)	AR029518A1 (pl)
AT (1)	ATE300944T1 (pl)
AU (2)	AU2001260227B2 (pl)
BR (1)	BR0110628A (pl)
CA (1)	CA2409664C (pl)
CZ (1)	CZ300791B6 (pl)
DE (1)	DE60112423T2 (pl)
DK (1)	DK1280527T3 (pl)
EA (1)	EA007506B1 (pl)
EE (1)	EE200200605A (pl)
ES (1)	ES2244618T3 (pl)
GB (1)	GB0011059D0 (pl)
HK (1)	HK1054193B (pl)
HU (1)	HUP0301882A2 (pl)
IL (2)	IL152388A0 (pl)
MX (1)	MXPA02010962A (pl)
NO (1)	NO20025303L (pl)
NZ (1)	NZ522234A (pl)
PL (1)	PL201289B1 (pl)
PT (1)	PT1280527E (pl)
SK (1)	SK286501B6 (pl)
TW (1)	TWI284643B (pl)
WO (1)	WO2001085144A2 (pl)
ZA (1)	ZA200208531B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0011059D0 (en)	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015447D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0016447D0 (en)	2000-07-04	2000-08-23	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
IT1318696B1 (it)	2000-09-15	2003-08-27	Pharmacia & Upjohn Spa	Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale.
US6969592B2 (en)	2001-09-26	2005-11-29	Pharmacia Italia S.P.A.	Method for predicting the sensitivity to chemotherapy
PL373998A1 (pl) *	2002-04-02	2005-09-19	Pharmacia Italia Spa	Skojarzona terapia przeciw nowotworom obejmująca podstawione pochodne akryloilodystamycyny i radioterapię
CA3001204C (en) *	2015-10-15	2023-08-29	Advanced Biodesign	Aminothiolester compounds or pharmaceutically acceptable salts thereof, for use in the treatment of cancer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE468642B (sv)	1985-07-16	1993-02-22	Erba Farmitalia	Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en)	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents
DE3768419D1 (de)	1986-10-07	1991-04-11	Boehringer Biochemia Srl	Pharmazeutische zusammensetzungen mit antineoplastischer wirkung.
GB8906709D0 (en)	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja)	1989-09-27	1999-07-19	千寿製薬株式会社	抗腫瘍剤
IT1272234B (it) *	1994-05-02	1997-06-16	Consiglio Nazionale Ricerche	Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en)	1994-08-08	1994-09-28	Erba Carlo Spa	Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) *	1996-01-04	1999-03-09	Terrapin Techologies, Inc.	Tethered prodrugs
JP2000503999A (ja)	1996-02-02	2000-04-04	フアルマシア・エ・アツプジヨン・エツセ・ピー・アー	ジスタマイシン誘導体、その調製方法、および抗腫瘍および抗ウイルス剤としてのその使用
GB9610079D0 (en)	1996-05-14	1996-07-17	Pharmacia Spa	Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en) *	1996-07-25	1996-09-04	Pharmacia Spa	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) *	1996-11-11	1997-01-08	Pharmacia & Upjohn Spa	Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en)	1997-12-31	1998-02-25	Pharmacia & Upjohn Spa	Synergistic antitumor composition containing a biologically active ureido compound
GB9806689D0 (en) *	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en) *	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9816653D0 (en)	1998-07-30	1998-09-30	Pharmacia & Upjohn Spa	Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816652D0 (en)	1998-07-30	1998-09-30	Pharmacia & Upjohn Spa	Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) *	1999-12-03	2000-02-02	Pharmacia & Upjohn Spa	Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en)	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione

2000
- 2000-05-08 GB GBGB0011059.3A patent/GB0011059D0/en not_active Ceased
2001
- 2001-04-19 CZ CZ20023629A patent/CZ300791B6/cs not_active IP Right Cessation
- 2001-04-19 EA EA200201184A patent/EA007506B1/ru not_active IP Right Cessation
- 2001-04-19 US US10/258,620 patent/US7030089B2/en not_active Expired - Fee Related
- 2001-04-19 EP EP01933856A patent/EP1280527B1/en not_active Expired - Lifetime
- 2001-04-19 HK HK03106491.8A patent/HK1054193B/zh not_active IP Right Cessation
- 2001-04-19 DE DE60112423T patent/DE60112423T2/de not_active Expired - Lifetime
- 2001-04-19 CA CA002409664A patent/CA2409664C/en not_active Expired - Fee Related
- 2001-04-19 AU AU2001260227A patent/AU2001260227B2/en not_active Ceased
- 2001-04-19 JP JP2001581798A patent/JP2003532669A/ja not_active Abandoned
- 2001-04-19 WO PCT/EP2001/004470 patent/WO2001085144A2/en not_active Ceased
- 2001-04-19 MX MXPA02010962A patent/MXPA02010962A/es active IP Right Grant
- 2001-04-19 DK DK01933856T patent/DK1280527T3/da active
- 2001-04-19 SK SK1600-2002A patent/SK286501B6/sk not_active IP Right Cessation
- 2001-04-19 EE EEP200200605A patent/EE200200605A/xx unknown
- 2001-04-19 ES ES01933856T patent/ES2244618T3/es not_active Expired - Lifetime
- 2001-04-19 HU HUP0301882 patent/HUP0301882A2/hu unknown
- 2001-04-19 AT AT01933856T patent/ATE300944T1/de not_active IP Right Cessation
- 2001-04-19 BR BR0110628-7A patent/BR0110628A/pt not_active Application Discontinuation
- 2001-04-19 IL IL15238801A patent/IL152388A0/xx active IP Right Grant
- 2001-04-19 AU AU6022701A patent/AU6022701A/xx active Pending
- 2001-04-19 KR KR1020027015026A patent/KR100776184B1/ko not_active Expired - Fee Related
- 2001-04-19 CN CNB018092039A patent/CN1258362C/zh not_active Expired - Fee Related
- 2001-04-19 NZ NZ522234A patent/NZ522234A/en unknown
- 2001-04-19 PT PT01933856T patent/PT1280527E/pt unknown
- 2001-04-19 PL PL365831A patent/PL201289B1/pl not_active IP Right Cessation
- 2001-05-03 TW TW090110601A patent/TWI284643B/zh active
- 2001-05-07 AR ARP010102143A patent/AR029518A1/es unknown
2002
- 2002-10-21 IL IL152388A patent/IL152388A/en not_active IP Right Cessation
- 2002-10-22 ZA ZA200208531A patent/ZA200208531B/en unknown
- 2002-11-05 NO NO20025303A patent/NO20025303L/no unknown

Also Published As

Publication number	Publication date
PL201289B1 (pl)	2009-03-31
NO20025303D0 (no)	2002-11-05
US20030207794A1 (en)	2003-11-06
CA2409664A1 (en)	2001-11-15
KR20030019371A (ko)	2003-03-06
PT1280527E (pt)	2005-10-31
NZ522234A (en)	2004-09-24
SK286501B6 (sk)	2008-11-06
WO2001085144A2 (en)	2001-11-15
AU2001260227B2 (en)	2005-10-27
CA2409664C (en)	2010-01-12
AR029518A1 (es)	2003-07-02
ZA200208531B (en)	2003-10-22
HK1054193A1 (en)	2003-11-21
AU6022701A (en)	2001-11-20
BR0110628A (pt)	2003-03-18
CZ300791B6 (cs)	2009-08-12
MXPA02010962A (es)	2003-03-27
TWI284643B (en)	2007-08-01
IL152388A0 (en)	2003-05-29
CN1258362C (zh)	2006-06-07
IL152388A (en)	2008-04-13
CN1427719A (zh)	2003-07-02
ES2244618T3 (es)	2005-12-16
EA007506B1 (ru)	2006-10-27
GB0011059D0 (en)	2000-06-28
WO2001085144A3 (en)	2002-05-16
DE60112423D1 (de)	2005-09-08
US7030089B2 (en)	2006-04-18
NO20025303L (no)	2002-11-05
HUP0301882A2 (hu)	2003-09-29
HK1054193B (zh)	2007-02-02
EA200201184A1 (ru)	2003-04-24
JP2003532669A (ja)	2003-11-05
EP1280527A2 (en)	2003-02-05
ATE300944T1 (de)	2005-08-15
DK1280527T3 (da)	2005-10-17
CZ20023629A3 (cs)	2003-03-12
DE60112423T2 (de)	2006-05-24
SK16002002A3 (sk)	2003-04-01
PL365831A1 (pl)	2005-01-10
KR100776184B1 (ko)	2007-11-16
EP1280527B1 (en)	2005-08-03

Legal Events

Date	Code	Title	Description
2007-12-17	GB1A	Change in the ownership or in the address of the owner

Publication	Publication Date	Title
AR028238A1 (es)	2003-04-30	Tratamiento para el tabaco
EP1469812A4 (en)	2010-09-29	ORAL INSULIN THERAPY
MXPA03002814A (es)	2003-10-14	Derivados de morfolin-acetamida para el tratamiento de enfermedades inflamatorias.
PT1459751E (pt)	2005-11-30	(s,s)-reboxetina para tratar as enxaquecas
NO20032909D0 (no)	2003-06-24	Glukopyranosyloksypyrazolderivater samt medikamentell anvendelse derav
BR0014930B1 (pt)	2009-01-13	cÂnula.
EE200200673A (et)	2004-06-15	Kinasoliini derivaadid kasvajate raviks
EP1308168A4 (en)	2004-09-01	NEW MEDICINES FOR CANCER
DK1596870T4 (da)	2011-06-14	Højdosis-ibandronatformulering
IT1311921B1 (it)	2002-03-20	Composti farmaceutici.
AR028321A1 (es)	2003-05-07	Medicamentos intracorporeos para el tratamiento fototerapeutico de alta energia de enfermedades
AU4498201A (en)	2001-10-15	Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment ofpain
EE05241B1 (et)	2009-12-15	Distamtsiini a-halogenoakrlolderivaadi kasutamine
HRP20080597T3 (en)	2008-12-31	Cancer combination therapy comprising azd2171 and zd1839
ITMI20001848A0 (it)	2000-08-08	Faramaci per l'incontinenza.
NO20025303L (no)	2002-11-05	Anvendelse av substituerte akryloyl-distamycin-derivater i behandlingen avtumorer assosiert med höye nivåer av glutation
ES1044983Y (es)	2000-12-16	Aparato de termoestimulacion para tratamientos terapeuticos.
MA26931A1 (fr)	2004-12-20	Agent therapeutique cristallin.
MXPA03000650A (es)	2003-06-06	Compuesto farmaceuticamente activo.
EE200100082A (et)	2002-06-17	Taksoidi derivaatide kasutamine ravimi valmistamiseks, mis on ette nähtud rakkude ebaloomuliku proliferatsiooni raviks laiaspektrilise ravimresistentsusega P-glükoproteiini ekspresseerivates rakuliinides
ITGE20010007U4 (it)	2000-05-04	Apparato per trattamenti fisiologici.
ES1051471Y (es)	2002-12-01	Sandalia multiforme perfeccionada
ES1043699Y (es)	2000-06-16	Dispositivo nebulizador.
IT1319368B1 (it)	2003-10-10	Gioco del bingo perfezionato
LV12535A (lv)	2000-10-20	Treatment having antioxidant effect for stregthening capillars