PL365831A1 - Zastosowanie pochodnych podstawionej akryloilodystamycyny w leczeniu nowotworów związanych z wysokimi poziomami glutationu - Google Patents

Zastosowanie pochodnych podstawionej akryloilodystamycyny w leczeniu nowotworów związanych z wysokimi poziomami glutationu

Info

Publication number: PL365831A1
Authority: PL; Poland
Prior art keywords: treatment; sub; glutathione; high levels; distamycin
Prior art date: 2000-05-08

Application number

PL01365831A

Other languages

English (en)

Other versions

PL201289B1 (pl

Inventor

Maria Cristina Rosa Geroni

Paolo Cozzi

Italo Beria

Original Assignee

Pharmacia Italia S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-08

Filing date

2001-04-19

Publication date

2005-01-10

2001-04-19 Application filed by Pharmacia Italia S.P.A. filed Critical Pharmacia Italia S.P.A.

2005-01-10 Publication of PL365831A1 publication Critical patent/PL365831A1/pl

2009-03-31 Publication of PL201289B1 publication Critical patent/PL201289B1/pl

Links

206010028980 Neoplasm Diseases 0.000 title abstract 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 title 2
108010024636 Glutathione Proteins 0.000 title 1
-1 acryloyl distamycin derivatives Chemical class 0.000 title 1
229960003180 glutathione Drugs 0.000 title 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical class CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 abstract 2
230000000259 anti-tumor effect Effects 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940127089 cytotoxic agent Drugs 0.000 abstract 1
239000002254 cytotoxic agent Substances 0.000 abstract 1
231100000599 cytotoxic agent Toxicity 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
108010042747 stallimycin Proteins 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Oncology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrrole Compounds (AREA)

PL365831A 2000-05-08 2001-04-19 Zastosowanie pochodnej a-halogenoakryloilodystamycyny do wytwarzania leku do leczenia nowotworów u ludzi PL201289B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0011059.3A GB0011059D0 (en)	2000-05-08	2000-05-08	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
PCT/EP2001/004470 WO2001085144A2 (en)	2000-05-08	2001-04-19	Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione

Publications (2)

Publication Number	Publication Date
PL365831A1 true PL365831A1 (pl)	2005-01-10
PL201289B1 PL201289B1 (pl)	2009-03-31

Family

ID=9891173

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL365831A PL201289B1 (pl)	2000-05-08	2001-04-19	Zastosowanie pochodnej a-halogenoakryloilodystamycyny do wytwarzania leku do leczenia nowotworów u ludzi

Country Status (29)

Country	Link
US (1)	US7030089B2 (pl)
EP (1)	EP1280527B1 (pl)
JP (1)	JP2003532669A (pl)
KR (1)	KR100776184B1 (pl)
CN (1)	CN1258362C (pl)
AR (1)	AR029518A1 (pl)
AT (1)	ATE300944T1 (pl)
AU (2)	AU2001260227B2 (pl)
BR (1)	BR0110628A (pl)
CA (1)	CA2409664C (pl)
CZ (1)	CZ300791B6 (pl)
DE (1)	DE60112423T2 (pl)
DK (1)	DK1280527T3 (pl)
EA (1)	EA007506B1 (pl)
EE (1)	EE200200605A (pl)
ES (1)	ES2244618T3 (pl)
GB (1)	GB0011059D0 (pl)
HK (1)	HK1054193B (pl)
HU (1)	HUP0301882A2 (pl)
IL (2)	IL152388A0 (pl)
MX (1)	MXPA02010962A (pl)
NO (1)	NO20025303L (pl)
NZ (1)	NZ522234A (pl)
PL (1)	PL201289B1 (pl)
PT (1)	PT1280527E (pl)
SK (1)	SK286501B6 (pl)
TW (1)	TWI284643B (pl)
WO (1)	WO2001085144A2 (pl)
ZA (1)	ZA200208531B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0011059D0 (en)	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015447D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0016447D0 (en)	2000-07-04	2000-08-23	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
IT1318696B1 (it)	2000-09-15	2003-08-27	Pharmacia & Upjohn Spa	Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale.
US6969592B2 (en)	2001-09-26	2005-11-29	Pharmacia Italia S.P.A.	Method for predicting the sensitivity to chemotherapy
PL373998A1 (pl) *	2002-04-02	2005-09-19	Pharmacia Italia Spa	Skojarzona terapia przeciw nowotworom obejmująca podstawione pochodne akryloilodystamycyny i radioterapię
CA3001204C (en) *	2015-10-15	2023-08-29	Advanced Biodesign	Aminothiolester compounds or pharmaceutically acceptable salts thereof, for use in the treatment of cancer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE468642B (sv)	1985-07-16	1993-02-22	Erba Farmitalia	Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en)	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents
DE3768419D1 (de)	1986-10-07	1991-04-11	Boehringer Biochemia Srl	Pharmazeutische zusammensetzungen mit antineoplastischer wirkung.
GB8906709D0 (en)	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja)	1989-09-27	1999-07-19	千寿製薬株式会社	抗腫瘍剤
IT1272234B (it) *	1994-05-02	1997-06-16	Consiglio Nazionale Ricerche	Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en)	1994-08-08	1994-09-28	Erba Carlo Spa	Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) *	1996-01-04	1999-03-09	Terrapin Techologies, Inc.	Tethered prodrugs
JP2000503999A (ja)	1996-02-02	2000-04-04	フアルマシア・エ・アツプジヨン・エツセ・ピー・アー	ジスタマイシン誘導体、その調製方法、および抗腫瘍および抗ウイルス剤としてのその使用
GB9610079D0 (en)	1996-05-14	1996-07-17	Pharmacia Spa	Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en) *	1996-07-25	1996-09-04	Pharmacia Spa	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) *	1996-11-11	1997-01-08	Pharmacia & Upjohn Spa	Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en)	1997-12-31	1998-02-25	Pharmacia & Upjohn Spa	Synergistic antitumor composition containing a biologically active ureido compound
GB9806689D0 (en) *	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en) *	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9816653D0 (en)	1998-07-30	1998-09-30	Pharmacia & Upjohn Spa	Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816652D0 (en)	1998-07-30	1998-09-30	Pharmacia & Upjohn Spa	Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) *	1999-12-03	2000-02-02	Pharmacia & Upjohn Spa	Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en)	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione

2000
- 2000-05-08 GB GBGB0011059.3A patent/GB0011059D0/en not_active Ceased
2001
- 2001-04-19 CZ CZ20023629A patent/CZ300791B6/cs not_active IP Right Cessation
- 2001-04-19 EA EA200201184A patent/EA007506B1/ru not_active IP Right Cessation
- 2001-04-19 US US10/258,620 patent/US7030089B2/en not_active Expired - Fee Related
- 2001-04-19 EP EP01933856A patent/EP1280527B1/en not_active Expired - Lifetime
- 2001-04-19 HK HK03106491.8A patent/HK1054193B/zh not_active IP Right Cessation
- 2001-04-19 DE DE60112423T patent/DE60112423T2/de not_active Expired - Lifetime
- 2001-04-19 CA CA002409664A patent/CA2409664C/en not_active Expired - Fee Related
- 2001-04-19 AU AU2001260227A patent/AU2001260227B2/en not_active Ceased
- 2001-04-19 JP JP2001581798A patent/JP2003532669A/ja not_active Abandoned
- 2001-04-19 WO PCT/EP2001/004470 patent/WO2001085144A2/en not_active Ceased
- 2001-04-19 MX MXPA02010962A patent/MXPA02010962A/es active IP Right Grant
- 2001-04-19 DK DK01933856T patent/DK1280527T3/da active
- 2001-04-19 SK SK1600-2002A patent/SK286501B6/sk not_active IP Right Cessation
- 2001-04-19 EE EEP200200605A patent/EE200200605A/xx unknown
- 2001-04-19 ES ES01933856T patent/ES2244618T3/es not_active Expired - Lifetime
- 2001-04-19 HU HUP0301882 patent/HUP0301882A2/hu unknown
- 2001-04-19 AT AT01933856T patent/ATE300944T1/de not_active IP Right Cessation
- 2001-04-19 BR BR0110628-7A patent/BR0110628A/pt not_active Application Discontinuation
- 2001-04-19 IL IL15238801A patent/IL152388A0/xx active IP Right Grant
- 2001-04-19 AU AU6022701A patent/AU6022701A/xx active Pending
- 2001-04-19 KR KR1020027015026A patent/KR100776184B1/ko not_active Expired - Fee Related
- 2001-04-19 CN CNB018092039A patent/CN1258362C/zh not_active Expired - Fee Related
- 2001-04-19 NZ NZ522234A patent/NZ522234A/en unknown
- 2001-04-19 PT PT01933856T patent/PT1280527E/pt unknown
- 2001-04-19 PL PL365831A patent/PL201289B1/pl not_active IP Right Cessation
- 2001-05-03 TW TW090110601A patent/TWI284643B/zh active
- 2001-05-07 AR ARP010102143A patent/AR029518A1/es unknown
2002
- 2002-10-21 IL IL152388A patent/IL152388A/en not_active IP Right Cessation
- 2002-10-22 ZA ZA200208531A patent/ZA200208531B/en unknown
- 2002-11-05 NO NO20025303A patent/NO20025303L/no unknown

Also Published As

Publication number	Publication date
PL201289B1 (pl)	2009-03-31
NO20025303D0 (no)	2002-11-05
US20030207794A1 (en)	2003-11-06
CA2409664A1 (en)	2001-11-15
KR20030019371A (ko)	2003-03-06
PT1280527E (pt)	2005-10-31
NZ522234A (en)	2004-09-24
SK286501B6 (sk)	2008-11-06
WO2001085144A2 (en)	2001-11-15
AU2001260227B2 (en)	2005-10-27
CA2409664C (en)	2010-01-12
AR029518A1 (es)	2003-07-02
ZA200208531B (en)	2003-10-22
HK1054193A1 (en)	2003-11-21
AU6022701A (en)	2001-11-20
BR0110628A (pt)	2003-03-18
CZ300791B6 (cs)	2009-08-12
MXPA02010962A (es)	2003-03-27
TWI284643B (en)	2007-08-01
IL152388A0 (en)	2003-05-29
CN1258362C (zh)	2006-06-07
IL152388A (en)	2008-04-13
CN1427719A (zh)	2003-07-02
ES2244618T3 (es)	2005-12-16
EA007506B1 (ru)	2006-10-27
GB0011059D0 (en)	2000-06-28
WO2001085144A3 (en)	2002-05-16
DE60112423D1 (de)	2005-09-08
EE200200605A (et)	2004-04-15
US7030089B2 (en)	2006-04-18
NO20025303L (no)	2002-11-05
HUP0301882A2 (hu)	2003-09-29
HK1054193B (zh)	2007-02-02
EA200201184A1 (ru)	2003-04-24
JP2003532669A (ja)	2003-11-05
EP1280527A2 (en)	2003-02-05
ATE300944T1 (de)	2005-08-15
DK1280527T3 (da)	2005-10-17
CZ20023629A3 (cs)	2003-03-12
DE60112423T2 (de)	2006-05-24
SK16002002A3 (sk)	2003-04-01
KR100776184B1 (ko)	2007-11-16
EP1280527B1 (en)	2005-08-03

Legal Events

Date	Code	Title	Description
2012-06-29	LAPS	Decisions on the lapse of the protection rights	Effective date: 20110419

Publication	Publication Date	Title
KR930003912A (ko)	1993-03-22	울혈성 심장 마비 치료법
LU91417I2 (fr)	2008-04-22	"Maraviroc, optionnellement sous forme d'un sel pharmaceutiquement acceptable CELSENTRI"
JO2503B1 (en)	2009-10-05	Benzathiazole derivatives
GB0225475D0 (en)	2002-12-11	Therapeutic agents
BG106586A (en)	2003-01-31	Pyrazolopyramidines as therapeutic agents
GEP20084357B (en)	2008-04-29	Pyrimidine derivatives for the treatment of abnormal cell growth
WO2006067165A3 (en)	2007-04-26	Indolidone derivatives for the treatment or prevention of fibrotic diseases
UA84141C2 (ru)	2008-09-25	Применение ингибитора пктжк для лечения или профилактики запора
MY133473A (en)	2007-11-30	Haterocyclic glycyl beta-alanine derivatives.
DE602004011394D1 (en)	2008-03-06	Thiazolderivate
AU6500298A (en)	1999-09-15	Derivatives of azetidine and pyrrolidine
TR200002466T2 (tr)	2000-12-21	Azetidin ve pirolidin türevleri
BRPI0409959A (pt)	2006-04-25	uso de derivados de azetidinacarboxamida em terapia
IL159880A0 (en)	2004-06-20	Arylsulfonyl derivatives with 5-ht6 receptor affinity
GB0011059D0 (en)	2000-06-28	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
AU8186701A (en)	2002-01-02	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents
AU2002211493A1 (en)	2002-05-15	Indole derivatives as pde5-inhibitors
MX2008001956A (es)	2008-04-07	Dihidroxiantraquinonas y su uso.
MXPA04005077A (es)	2004-08-19	Derivados de benzotiazol.
GB0522908D0 (en)	2005-12-21	Therapeutic agents
NO20054086L (no)	2005-11-09	Depigmenteringsmidler
DE69707509D1 (de)	2001-11-22	2-phenyl-3-azoylbenzothiophene zur minderung des intraokularen drucks
HU9400006D0 (en)	1994-05-30	Ketorolac derivatives with considerably reduced gastro-investinal irritation and ulceration
AU4485101A (en)	2001-09-24	Antiviral therapy
IT1314204B1 (it)	2002-12-06	Complessi di rutenio con elevata attivita' antitumorale