EE200400043A - Uudsed heterotsüklilised ühendid kui selektiivsedbakteriaalsed DHFR inhibiitorid ning nende kasutamine - Google Patents

Uudsed heterotsüklilised ühendid kui selektiivsedbakteriaalsed DHFR inhibiitorid ning nende kasutamine

Info

Publication number
EE200400043A
EE200400043A EEP200400043A EEP200400043A EE200400043A EE 200400043 A EE200400043 A EE 200400043A EE P200400043 A EEP200400043 A EE P200400043A EE P200400043 A EEP200400043 A EE P200400043A EE 200400043 A EE200400043 A EE 200400043A
Authority
EE
Estonia
Prior art keywords
heterocyclic compounds
novel heterocyclic
dhfr inhibitors
bacterial dhfr
selective bacterial
Prior art date
Application number
EEP200400043A
Other languages
English (en)
Inventor
T. Moe Scott
J. Clement Jacob
H. Faerman Carlos
Perola Emanuele
A. Navia Manuel
J. Ala Paul
S. Magee Andrew
M. Will Paul
A. Marchese Salvatore
V. Gazzaniga John
Original Assignee
Essential Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Essential Therapeutics, Inc. filed Critical Essential Therapeutics, Inc.
Publication of EE200400043A publication Critical patent/EE200400043A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200400043A 2001-06-28 2002-06-28 Uudsed heterotsüklilised ühendid kui selektiivsedbakteriaalsed DHFR inhibiitorid ning nende kasutamine EE200400043A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30168501P 2001-06-28 2001-06-28
PCT/US2002/020479 WO2003002064A2 (en) 2001-06-28 2002-06-28 Fused pyrimidine dhfr inhibitors as antibacterials

Publications (1)

Publication Number Publication Date
EE200400043A true EE200400043A (et) 2004-10-15

Family

ID=23164426

Family Applications (2)

Application Number Title Priority Date Filing Date
EEP200400042A EE200400042A (et) 2001-06-28 2002-06-28 8/17 heterotsüklilised ühendid ning nende kasutamine D-alanüül-D-alaniini ligaasi inhibiitoritena
EEP200400043A EE200400043A (et) 2001-06-28 2002-06-28 Uudsed heterotsüklilised ühendid kui selektiivsedbakteriaalsed DHFR inhibiitorid ning nende kasutamine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EEP200400042A EE200400042A (et) 2001-06-28 2002-06-28 8/17 heterotsüklilised ühendid ning nende kasutamine D-alanüül-D-alaniini ligaasi inhibiitoritena

Country Status (16)

Country Link
US (3) US20030176436A1 (et)
EP (2) EP1411949A4 (et)
CN (2) CN1543465A (et)
BG (1) BG108548A (et)
BR (1) BR0211310A (et)
CA (2) CA2451840A1 (et)
CZ (2) CZ200443A3 (et)
EA (1) EA200400094A1 (et)
EE (2) EE200400042A (et)
HU (2) HUP0700040A2 (et)
IL (2) IL159538A0 (et)
MX (1) MXPA04000159A (et)
PL (2) PL374589A1 (et)
SK (1) SK302004A3 (et)
WO (2) WO2003002064A2 (et)
YU (2) YU102503A (et)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0217703D0 (en) * 2002-07-31 2002-09-11 Univ Liverpool Pharmaceutical composition
KR100915481B1 (ko) * 2004-11-09 2009-09-03 에프. 호프만-라 로슈 아게 아미노퀴나졸린 화합물
WO2007009911A1 (en) * 2005-07-21 2007-01-25 F. Hoffmann-La Roche Ag PYRIDO [2 , 3-D] PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS
GB0608822D0 (en) * 2006-05-04 2006-06-14 Chroma Therapeutics Ltd Inhibitors of DHFR
SI22338A (sl) * 2006-08-18 2008-02-29 Univerza V Ljubljani, Fakulteta Za Farmacijo Diazendikarboksamidi kot inhibitorji d-alanil-d-alanin ligaze
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
CN101084901B (zh) * 2007-06-22 2011-12-21 复旦大学 一种葡萄球菌抑制剂
WO2009097578A1 (en) 2008-02-01 2009-08-06 Takeda Pharmaceutical Company Limited Oxim derivatives as hsp90 inhibitors
US8426044B2 (en) 2009-03-20 2013-04-23 Board Of Regents, The University Of Texas System Method for imparting antimicrobial activity to a medical device
MX2012002544A (es) * 2009-08-31 2012-04-11 Dow Agrosciences Llc Pteridinas y sus usos como agroquimicos.
SG11201606876RA (en) 2015-03-04 2016-10-28 Gilead Sciences Inc Toll like receptor modulator compounds
CN106316966A (zh) * 2015-06-15 2017-01-11 董运勤 医药中间体n-(2-吡嗪甲基)苄胺磷酸盐化合物制备方法
SI3507276T1 (sl) 2016-09-02 2022-01-31 Gilead Sciences, Inc. Spojine modulatorja toličnih receptorjev
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
JP7630906B2 (ja) 2017-02-01 2025-02-18 イェール・ユニヴァーシティー 利尿薬耐性の治療
SG11202006157VA (en) 2018-01-05 2020-07-29 Corvidia Therapeutics Inc Methods for treating il-6 mediated inflammation without immunosuppression
MA54864A (fr) * 2019-02-01 2021-12-22 Fmc Corp Pyridines et pyrimidines diamino-substituées à titre d'herbicides
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
GB2626567A (en) * 2023-01-26 2024-07-31 De Montfort Univ Quinazoline derivatives for use as a medicament

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949466A (en) * 1958-03-04 1960-08-16 Parke Davis & Co Pyrimidine compounds and means of producing the same
US3134778A (en) * 1963-08-20 1964-05-26 Smith Kline French Lab 2,5,7-triamino-4-phenyl (or thienyl)-pyrimido[4,5-d]pyrimidines
RO56210A2 (et) 1970-12-28 1974-08-01
US4079056A (en) * 1975-03-31 1978-03-14 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making pteridine compounds
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3445298A1 (de) 1984-12-12 1986-06-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
WO1992017478A1 (en) 1991-04-08 1992-10-15 Duquesne University Of The Holy Ghost 5-ALKYL-6-[[AMINO]METHYL]PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AND METHODS OF PREPARING AND USING THESE DERIVATIVES
US5547954A (en) * 1994-05-26 1996-08-20 Fmc Corporation 2,4-Diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides
ES2207657T3 (es) * 1995-02-27 2004-06-01 F. Hoffmann-La Roche Ag Pirrolderivados de dioxopirrolo.
WO1999050264A1 (en) * 1998-03-30 1999-10-07 Kyowa Hakko Kogyo Co., Ltd. Quinazoline derivatives
JP2000239277A (ja) * 1999-02-19 2000-09-05 Kyowa Hakko Kogyo Co Ltd イミダゾキナゾリン誘導体
GB0219893D0 (en) 2002-08-27 2002-10-02 Melacure Therapeutics Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
EP1411949A2 (en) 2004-04-28
PL374259A1 (en) 2005-10-03
YU102503A (sh) 2006-08-17
HUP0700040A2 (en) 2007-05-29
WO2003001887A2 (en) 2003-01-09
EP1432713A2 (en) 2004-06-30
YU102303A (sh) 2006-08-17
SK302004A3 (sk) 2005-07-01
US20030181470A1 (en) 2003-09-25
US7345048B2 (en) 2008-03-18
CN1543465A (zh) 2004-11-03
HUP0700061A2 (en) 2007-05-02
CZ200442A3 (cs) 2004-10-13
US20080090847A1 (en) 2008-04-17
CA2451800A1 (en) 2003-01-09
EP1432713A4 (en) 2005-05-11
WO2003002064A3 (en) 2003-10-23
WO2003001887A3 (en) 2003-08-21
CA2451840A1 (en) 2003-01-09
PL374589A1 (en) 2005-10-31
BG108548A (bg) 2005-05-31
IL159538A0 (en) 2004-06-01
BR0211310A (pt) 2006-10-31
US20030176436A1 (en) 2003-09-18
EE200400042A (et) 2004-10-15
CN1547472A (zh) 2004-11-17
EA200400094A1 (ru) 2005-08-25
CZ200443A3 (cs) 2004-08-18
IL159540A0 (en) 2004-06-01
WO2003002064A2 (en) 2003-01-09
EP1411949A4 (en) 2004-11-24
MXPA04000159A (es) 2005-01-07

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