EE9700375A - Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid - Google Patents

Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid

Info

Publication number
EE9700375A
EE9700375A EE9700375A EE9700375A EE9700375A EE 9700375 A EE9700375 A EE 9700375A EE 9700375 A EE9700375 A EE 9700375A EE 9700375 A EE9700375 A EE 9700375A EE 9700375 A EE9700375 A EE 9700375A
Authority
EE
Estonia
Prior art keywords
dialkyl ethers
terminal carboxyl
containing terminal
ethers containing
tetrazolyl groups
Prior art date
Application number
EE9700375A
Other languages
English (en)
Other versions
EE03520B1 (et
Inventor
Larry Bisgaier Charles
Leroy Creger Paul
Robert Saltiel Alan
Rae Tafuri Sherrie
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of EE9700375A publication Critical patent/EE9700375A/et
Publication of EE03520B1 publication Critical patent/EE03520B1/et

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/20Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/28Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/37Saturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235Saturated compounds containing more than one carboxyl group
    • C07C59/305Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235Saturated compounds containing more than one carboxyl group
    • C07C59/305Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C07C59/315Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235Saturated compounds containing more than one carboxyl group
    • C07C59/347Saturated compounds containing more than one carboxyl group containing keto groups
    • C07C59/353Saturated compounds containing more than one carboxyl group containing keto groups containing rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708Ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Dental Preparations (AREA)
  • Medicinal Preparation (AREA)
EE9700375A 1995-03-24 1996-02-05 Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid EE03520B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/409,780 US5648387A (en) 1995-03-24 1995-03-24 Carboxyalkylethers, formulations, and treatment of vascular diseases
PCT/US1996/001639 WO1996030328A1 (en) 1995-03-24 1996-02-05 Terminal carboxy or tetrazole groups containing dialkyl ethers

Publications (2)

Publication Number Publication Date
EE9700375A true EE9700375A (et) 1998-06-15
EE03520B1 EE03520B1 (et) 2001-10-15

Family

ID=23621941

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700375A EE03520B1 (et) 1995-03-24 1996-02-05 Terminaalseid karboksüül- või tetrasolüülrühmi sisaldavad dialküüleetrid

Country Status (26)

Country Link
US (4) US5648387A (et)
EP (1) EP0820428B1 (et)
JP (1) JP3885115B2 (et)
KR (1) KR100408612B1 (et)
CN (1) CN1100747C (et)
AT (1) ATE192732T1 (et)
AU (1) AU692359B2 (et)
BG (1) BG63534B1 (et)
CA (1) CA2215233C (et)
CZ (1) CZ289556B6 (et)
DE (1) DE69608268T2 (et)
DK (1) DK0820428T3 (et)
EE (1) EE03520B1 (et)
ES (1) ES2148733T3 (et)
FI (1) FI973713A7 (et)
GR (1) GR3034109T3 (et)
HU (1) HUP9801825A3 (et)
NO (1) NO307878B1 (et)
NZ (1) NZ302170A (et)
PL (1) PL181673B1 (et)
PT (1) PT820428E (et)
RU (1) RU2191772C2 (et)
SK (1) SK282897B6 (et)
UA (1) UA46020C2 (et)
WO (1) WO1996030328A1 (et)
ZA (1) ZA962275B (et)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
NZ503982A (en) * 1997-12-12 2002-03-28 Warner Lambert Co Statin-carboxyalkylether combinations useful for treating vascular disorders and diabetes mellitus
EP1037623A1 (en) * 1997-12-12 2000-09-27 Warner-Lambert Company Antihyperlipidemic statin-lp(a) inhibitor combinations
US20030105154A1 (en) * 2001-10-24 2003-06-05 Bisgaier Charles Larry Statin-carboxyalkylether combinations
SI1045691T1 (en) * 1997-12-12 2005-04-30 Warner-Lambert Company Llc Statin-carboxyalkylether combinations
US6861555B2 (en) * 2000-01-25 2005-03-01 Warner-Lambert Company Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
ATE320803T1 (de) * 1998-01-28 2006-04-15 Warner Lambert Co Verfahren zur behandlung von alzheimerschen krankheit
YU23901A (sh) * 1998-09-30 2003-07-07 Warner-Lambert Company Upotreba sredstva za snižavanje holesterola u sprečavanju i odlaganju revaskularizacije pomoću katetera
EP1862444A3 (en) * 1999-04-01 2008-01-09 Esperion Therapeutics, Inc. Ether compounds, compositions, and uses thereof
US6410802B1 (en) * 1999-04-01 2002-06-25 Esperion Therapeutics, Inc. Methods for synthesizing ether compounds and intermediates therefor
SK10622002A3 (sk) 2000-01-25 2003-07-01 Warner-Lambert Company Étery dikarboxylátu vápenatého, metódy ich výroby a ich využitie na liečbu vaskulárnych chorôb a diabetu
US20040092574A1 (en) * 2000-02-07 2004-05-13 Bisgaier Charles Larry Statin-Lp(a) inhibitor combinations
EP1280522B1 (en) * 2000-04-26 2004-12-01 Warner-Lambert Company Combination of carboxyalkylethers with antihypertensives and pharmaceutical use
KR20030023698A (ko) * 2000-07-14 2003-03-19 워너-램버트 캄파니 카르복시알킬에테르를 사용하여 섭식 장애를 치료하는 방법
CA2425311C (en) 2000-10-11 2011-06-14 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
CN101426763A (zh) 2000-10-11 2009-05-06 埃斯佩里安医疗公司 用于胆固醇治疗和相关应用的硫化物和二硫化物化合物和组合物
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
JP2004531459A (ja) * 2000-10-11 2004-10-14 エスペリオン セラピューティクス,インコーポレイテッド コレステロールマネージメント用スルホキシドおよびビススルホキシド化合物ならびに組成物および関連する使用
CN1894195A (zh) * 2000-10-11 2007-01-10 埃斯佩里安医疗公司 用于控制胆固醇以及相关用途的醚化合物以及组合物
US20030225123A1 (en) * 2001-03-22 2003-12-04 Auerbach Bruce Jeffrey Antihypertensive agents and use
US20040072903A1 (en) * 2001-05-08 2004-04-15 Auerbach Bruce Jeffrey Carboxyalkylether-acat inhibitors combinations
US20040204502A1 (en) * 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20050020694A1 (en) * 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
US20040192771A1 (en) * 2001-10-11 2004-09-30 Dasseux Jean-Louis Henri Ether compounds and compositions for cholesterol management and related uses
JP2005522504A (ja) * 2002-04-10 2005-07-28 エスペリオン セラピューティクス,インコーポレイテッド パントラクトンおよびパントテン酸誘導体を含むアシル補酵素−aのミミック、その組成物、ならびにコレステロール管理の方法および関連の使用
US20040048910A1 (en) * 2002-08-22 2004-03-11 Bove Susan Elizabeth Method of treating osteoarthritis
EP1539127A1 (en) * 2002-08-22 2005-06-15 Warner-Lambert Company Llc Method of treating osteoarthritis
AU2003266165A1 (en) * 2002-09-13 2004-04-30 Hossein Dovlatabadi Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels
EP1572189A1 (en) * 2002-11-15 2005-09-14 Warner-Lambert Company LLC Method of lowering crp and reducing systemic inflammation
ES2625429T3 (es) * 2003-01-23 2017-07-19 Esperion Therapeutics Inc. Compuestos de hidroxilo y composiciones para el control del colesterol y utilizaciones correspondientes
US20040229954A1 (en) * 2003-05-16 2004-11-18 Macdougall Diane Elaine Selective manipulation of triglyceride, HDL and LDL parameters with 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt
WO2005002557A1 (en) * 2003-07-03 2005-01-13 Warner-Lambert Company Llc Pharmaceutical compositions including an ether and selective cox-2 inhibitor and uses thereof
US20050026979A1 (en) * 2003-07-31 2005-02-03 Maha Ghazzi Methods for treating inflammation and inflammation-associated diseases with a statin and ether
ATE428411T1 (de) * 2003-11-07 2009-05-15 Jj Pharma Inc Hdl-verstärkende kombinationstherapie-komplexe
US20050192347A1 (en) * 2003-12-23 2005-09-01 Dasseux Jean-Louis H. Urea and thiourea compounds and compositions for cholesterol management and related uses
JP2007525408A (ja) 2003-12-24 2007-09-06 エスペリオン セラピューティクス,インコーポレイテッド コレステロール管理および関連使用のためのケトン化合物および組成物
AU2003300438A1 (en) * 2003-12-24 2005-08-03 Esperion Therapeutics, Inc. Ether compounds and compositions for cholesterol management and related uses
TW200603794A (en) * 2004-06-09 2006-02-01 Avanir Pharmaceuticals Small molecules for treatment of hypercholesterolemia and related diseases
US20060009487A1 (en) * 2004-06-09 2006-01-12 Sircar Jagadish C Heterocyclic derivatives for treatment of hyperlipidemia and related diseases
EP1753782A1 (en) * 2004-06-09 2007-02-21 Avanir Pharmaceuticals Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
WO2006045010A2 (en) * 2004-10-20 2006-04-27 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
US8410109B2 (en) * 2005-07-29 2013-04-02 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US7777071B2 (en) * 2006-08-11 2010-08-17 Ssv Therapeutics, Inc. Production of carnitine conjugate intermediates
PT2118074E (pt) * 2007-02-01 2014-03-20 Resverlogix Corp Compostos para a prevenção e tratamento de doenças cardiovasculares
US8481084B2 (en) 2007-05-23 2013-07-09 Amcol International Corporation Cholesterol-interacting layered phyllosilicates and methods of reducing hypercholesteremia in a mammal
US9173890B2 (en) * 2007-09-20 2015-11-03 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US7985727B1 (en) 2007-09-20 2011-07-26 Abbott Cardiovascular Systems Inc. Apo A-I mimetic peptides and methods of treatment
US8101565B2 (en) * 2007-09-20 2012-01-24 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US7985728B1 (en) 2007-09-20 2011-07-26 Abbott Cardiovascular Systems Inc. Sustained release of Apo A-I mimetic peptides and methods of treatment
US8044021B2 (en) * 2007-09-20 2011-10-25 Abbott Cardiovascular Systems Inc. Sustained release of apo A-I mimetic peptides and methods of treatment
SI2346837T1 (sl) 2008-06-26 2015-05-29 Resverlogix Corporation Postopki pripravljanja kinazolinonskih derivatov
US8952021B2 (en) 2009-01-08 2015-02-10 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
KR101913109B1 (ko) 2009-03-18 2018-10-31 리스버로직스 코퍼레이션 신규한 소염제
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
WO2011027257A2 (en) 2009-09-03 2011-03-10 Pfizer Vaccines Llc Pcsk9 vaccine
JP2013537240A (ja) 2010-09-20 2013-09-30 カリウス セラピューティクス エスエー 糖尿病および脂質異常症の処置のための方法および組成物
SG189019A1 (en) 2010-10-18 2013-05-31 Cerenis Therapeutics Holding Sa Compounds, compositions and methods useful for cholesterol mobilisation
AU2011352449B2 (en) 2010-12-27 2015-06-18 Gemphire Therapeutics Inc. Gemcabene and derivatives for treating pancreatitis
WO2012131504A1 (en) 2011-03-02 2012-10-04 Pfizer Inc. Pcsk9 vaccine
CA2851996C (en) 2011-11-01 2020-01-07 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
MX367352B (es) 2012-01-06 2019-08-16 Gemphire Therapeutics Inc Metodos para reducir el riesgo de padecer una enfermedad cardiovascular.
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションZenith Epigenetics Corp. ブロモドメイン阻害剤としての新規複素環式化合物
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
CA2947127A1 (en) 2014-05-02 2015-11-19 Cerenis Therapeutics Holding Sa Hdl therapy markers
WO2016077832A2 (en) * 2014-11-14 2016-05-19 Gemphire Therapeutics Inc. PROCESSES AND INTERMEDIATES FOR PREPARING α,ω-DICARBOXYLIC ACID-TERMINATED DIALKANE ETHERS
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
EP3267989A4 (en) 2015-03-13 2018-11-07 Esperion Therapeutics, Inc. Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
HK1257929A1 (zh) * 2015-11-06 2019-11-01 Gemphire Therapeutics Inc. 治疗混合性血脂异常
WO2018165120A1 (en) * 2017-03-06 2018-09-13 Gemphire Therapeutics Inc. Effect of carboxyalkylethers on obesity symptoms and lipodystropy
CA3059073A1 (en) * 2017-04-18 2018-10-25 Gemphire Therapeutics Inc. Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor
MX2021015936A (es) 2019-06-21 2022-04-26 Esperion Therapeutics Inc Metodos para preparar acido bempedoico y composiciones del mismo.
US11098002B2 (en) 2019-07-26 2021-08-24 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and their use for the prevention or treatment of disease
WO2021262992A1 (en) 2020-06-24 2021-12-30 Neurobo Pharmaceuticals, Inc. Gemcabene for treatment of cytokine storms and viral-induced inflammation
CA3209453A1 (en) 2021-01-25 2022-07-28 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives therof, and their use for the prevention or treatment of disease
WO2022159811A1 (en) 2021-01-25 2022-07-28 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2466419A (en) * 1948-02-07 1949-04-05 Eastman Kodak Co beta, beta'-oxydipropionic acids and process of preparation
US3320079A (en) * 1960-07-11 1967-05-16 Eastman Kodak Co Ether-acid polyester composition
US3431298A (en) * 1965-01-05 1969-03-04 Asahi Chemical Ind Process for the preparation of oxadicarboxylic acids
US3674836A (en) * 1968-05-21 1972-07-04 Parke Davis & Co 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
US3930024A (en) * 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
BE755997A (fr) * 1969-09-11 1971-03-10 Bp Chem Int Ltd Production d'acides dicarboxyliques
US3742068A (en) * 1970-04-17 1973-06-26 G Moersch Ethers of 2,2,9,9-tetramethyl-1,10-decanediol
IT1168389B (it) * 1981-05-06 1987-05-20 Alfa Farmaceutici Spa Derivati di alcandioli con attivita' ipolipidemizzante,metodi per la loro preparazione e composizioni farmaceutiche che li contengono
DE3423166A1 (de) * 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
IL84953A (en) * 1987-12-28 1992-01-15 Bromine Compounds Ltd 3,3'-oxy-bis((2,2'-di(bromomethyl)propanoic acid)derivatives,processes for their preparation and their use as flame retardant agents
DE3814498A1 (de) * 1988-04-29 1989-11-09 Basf Ag Verfahren zur herstellung von hydroxicarbonsaeureestern
DE4142913A1 (de) * 1991-12-24 1993-07-01 Basf Ag Verfahren zur herstellung von oxadimethacrylsaeure
US5395917A (en) * 1993-05-21 1995-03-07 E. I. Du Pont De Nemours And Company Polyimides from 4-(3-aminophenoxy)benzoic acid

Also Published As

Publication number Publication date
NO307878B1 (no) 2000-06-13
CA2215233A1 (en) 1996-10-03
WO1996030328A1 (en) 1996-10-03
NO974397L (no) 1997-11-20
AU692359B2 (en) 1998-06-04
FI973713A0 (fi) 1997-09-17
NZ302170A (en) 1999-04-29
EP0820428B1 (en) 2000-05-10
DE69608268T2 (de) 2000-11-09
UA46020C2 (uk) 2002-05-15
HK1009438A1 (en) 1999-09-10
BG63534B1 (bg) 2002-04-30
GR3034109T3 (en) 2000-11-30
BG101993A (bg) 1998-05-29
US5648387A (en) 1997-07-15
SK128697A3 (en) 1999-02-11
EP0820428A1 (en) 1998-01-28
CN1182415A (zh) 1998-05-20
EE03520B1 (et) 2001-10-15
MX9707198A (es) 1997-11-29
RU2191772C2 (ru) 2002-10-27
ES2148733T3 (es) 2000-10-16
AU4776896A (en) 1996-10-16
DE69608268D1 (de) 2000-06-15
JPH11502532A (ja) 1999-03-02
FI973713L (fi) 1997-09-24
NO974397D0 (no) 1997-09-23
ATE192732T1 (de) 2000-05-15
CZ289556B6 (cs) 2002-02-13
US5756544A (en) 1998-05-26
SK282897B6 (sk) 2003-01-09
HUP9801825A3 (en) 2001-01-29
CA2215233C (en) 2006-07-11
PL181673B1 (pl) 2001-08-31
PT820428E (pt) 2000-09-29
PL322407A1 (en) 1998-01-19
US5783600A (en) 1998-07-21
HUP9801825A2 (hu) 1998-12-28
DK0820428T3 (da) 2000-08-28
ZA962275B (en) 1996-11-27
US5750569A (en) 1998-05-12
CZ292297A3 (cs) 1998-10-14
KR100408612B1 (ko) 2004-03-26
KR19980703233A (ko) 1998-10-15
CN1100747C (zh) 2003-02-05
JP3885115B2 (ja) 2007-02-21
FI973713A7 (fi) 1997-09-24

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