EE9900027A - Asendatud triasolopüridasiini derivaadid GABA retseptorite ligandidena - Google Patents

Asendatud triasolopüridasiini derivaadid GABA retseptorite ligandidena

Info

Publication number: EE9900027A
Authority: EE; Estonia
Prior art keywords: ligands; gaba receptors; triazolopyridazine derivatives; substituted; substituted triazolopyridazine
Prior art date: 1996-07-25

Application number

EEP199900027A

Other languages

English (en)

Estonian (et)

Inventor

Barff Broughton Howard

Robert Carling William

Richard Guiblin Alexander

William Moore Kevin

Geoffrey Russell Michael

Joseph Street Leslie

Luis Castro Pineiro Jose

Madin Andrew

Original Assignee

Merck Sharp & Dohme Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1997-07-17

Publication date

1999-08-16

1996-07-25 Priority claimed from GBGB9615645.0A external-priority patent/GB9615645D0/en

1996-12-06 Priority claimed from GBGB9625397.6A external-priority patent/GB9625397D0/en

1997-07-09 Priority claimed from GBGB9714420.8A external-priority patent/GB9714420D0/en

1997-07-17 Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited

1999-08-16 Publication of EE9900027A publication Critical patent/EE9900027A/xx

Links

239000003446 ligand Substances 0.000 title abstract 2
CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical class N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title 1
102000005915 GABA Receptors Human genes 0.000 title 1
108010005551 GABA Receptors Proteins 0.000 title 1
102000004300 GABA-A Receptors Human genes 0.000 abstract 1
108090000839 GABA-A Receptors Proteins 0.000 abstract 1
-1 triazolo-pyridazine derivative compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EEP199900027A 1996-07-25 1997-07-17 Asendatud triasolopüridasiini derivaadid GABA retseptorite ligandidena EE9900027A (et)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9615645.0A GB9615645D0 (en)	1996-07-25	1996-07-25	Therapeutic agents
GBGB9625397.6A GB9625397D0 (en)	1996-12-06	1996-12-06	Therapeutic agents
GBGB9714420.8A GB9714420D0 (en)	1997-07-09	1997-07-09	Therapeutic agents
PCT/GB1997/001946 WO1998004559A2 (en)	1996-07-25	1997-07-17	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number	Publication Date
EE9900027A true EE9900027A (et)	1999-08-16

Family

ID=27268403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900027A EE9900027A (et)	1996-07-25	1997-07-17	Asendatud triasolopüridasiini derivaadid GABA retseptorite ligandidena

Country Status (24)

Country	Link
US (1)	US6255305B1 (cs)
EP (1)	EP0915875B1 (cs)
JP (1)	JP4216905B2 (cs)
KR (1)	KR20000029548A (cs)
CN (1)	CN1251589A (cs)
AT (1)	ATE236904T1 (cs)
AU (1)	AU723098B2 (cs)
BG (1)	BG103112A (cs)
BR (1)	BR9710729A (cs)
CZ (1)	CZ18199A3 (cs)
DE (1)	DE69720732T2 (cs)
EA (1)	EA002436B1 (cs)
EE (1)	EE9900027A (cs)
ES (1)	ES2194205T3 (cs)
HU (1)	HUP0600527A2 (cs)
IL (1)	IL127911A0 (cs)
IS (1)	IS4949A (cs)
NO (1)	NO990304L (cs)
NZ (1)	NZ333768A (cs)
PL (1)	PL331072A1 (cs)
SK (1)	SK9399A3 (cs)
TR (1)	TR199900047T2 (cs)
WO (1)	WO1998004559A2 (cs)
YU (1)	YU2899A (cs)

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CA2288789C (en) *	1997-05-08	2009-07-21	Merck Sharp & Dohme Limited	Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as gaba alpha 5 ligands
GB9715977D0 (en) *	1997-07-29	1997-10-01	Merck Sharp & Dohme	Therapeutic agents
US6297235B1 (en) *	1997-08-28	2001-10-02	Merck Sharp & Dohme Ltd.	Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9718254D0 (en)	1997-08-28	1997-11-05	Merck Sharp & Dohme	Therapeutic agents
GB9723999D0 (en)	1997-11-13	1998-01-14	Merck Sharp & Dohme	Therapeutic use
GB9726701D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726699D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
WO1999025353A1 (en) *	1997-11-13	1999-05-27	Merck Sharp & Dohme Limited	Therapeutic uses of triazolo-pyridazine derivatives
US6110915A (en) *	1997-12-18	2000-08-29	Merck & Co., Inc.	Antiemetic use of triazolo-pyridazine derivatives
CA2315219A1 (en)	1998-01-14	1999-07-22	Merck Sharp & Dohme Limited	Triazolo-pyridazine derivatives as ligands for gaba receptors
HUP0100575A3 (en) *	1998-01-21	2003-03-28	Merck Sharp & Dohme Ltd Hoddes	Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801210D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801202D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801234D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801208D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801397D0 (en)	1998-01-22	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801538D0 (en)	1998-01-23	1998-03-25	Merck Sharp & Dohme	Pharmaceutical product
EP1087968A1 (en) *	1998-06-16	2001-04-04	MERCK SHARP & DOHME LTD.	Triazolo-pyridine derivatives as ligands for gaba receptors
GB9813006D0 (en) *	1998-06-16	1998-08-12	Merck Sharp & Dohme	Therapeutic agents
GB9813576D0 (en)	1998-06-24	1998-08-19	Merck Sharp & Dohme	Therapeutic agents
GB9821179D0 (en) *	1998-09-30	1998-11-25	Merck Sharp & Dohme	Therapeutic use
CA2346659A1 (en) *	1998-10-06	2000-04-13	Michiyo Gyoten	Condensed pyridazine compounds, their production and use
ATE371659T1 (de) *	1998-10-16	2007-09-15	Merck Sharp & Dohme	Pyrazolotriazinderivate als gaba-rezeptorliganden
IT1303272B1 (it) *	1998-10-29	2000-11-06	Zambon Spa	Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en) *	1998-11-12	1999-01-06	Merck Sharp & Dohme	Therapeutic compounds
GB2345443A (en) *	1999-01-08	2000-07-12	Merck Sharp & Dohme	Use of triazolo-pyridazines for treating premenstrual syndrome
ATE284403T1 (de) *	1999-01-27	2004-12-15	Merck Sharp & Dohme	Triazolopyridazinderivate als liganden für gaba- rezeptoren
GB9903119D0 (en) *	1999-02-11	1999-04-07	Merck Sharp & Dohme	Therapeutic agents
US6737242B1 (en)	1999-05-07	2004-05-18	Neurogen Corporation	Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9919957D0 (en) *	1999-08-23	1999-10-27	Merck Sharp & Dohme	Therapeutic agents
GB9921351D0 (en)	1999-09-09	1999-11-10	Merck Sharp & Dohme	Therapeutic agents
US6355638B1 (en) *	1999-11-25	2002-03-12	Merck Sharp & Dohme Ltd.	Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
GB9929569D0 (en)	1999-12-14	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929685D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929687D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB0000564D0 (en) *	2000-01-11	2000-03-01	Merck Sharp & Dohme	Therapeutic agents
GB0008696D0 (en)	2000-04-07	2000-05-31	Merck Sharp & Dohme	Therapeutic agents
GB0017518D0 (en) *	2000-07-17	2000-08-30	Merck Sharp & Dohme	Therapeutic agents
GB0018473D0 (en)	2000-07-27	2000-09-13	Merck Sharp & Dohme	Therapeutic agents
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CN101103033B (zh)	2005-01-05	2010-08-04	尼科梅德有限责任公司	作为pde2抑制剂的三唑并酞嗪
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1997
- 1997-07-17 KR KR1019997000606A patent/KR20000029548A/ko not_active Withdrawn
- 1997-07-17 EE EEP199900027A patent/EE9900027A/xx unknown
- 1997-07-17 JP JP50858598A patent/JP4216905B2/ja not_active Expired - Fee Related
- 1997-07-17 IL IL12791197A patent/IL127911A0/xx unknown
- 1997-07-17 AU AU35539/97A patent/AU723098B2/en not_active Ceased
- 1997-07-17 YU YU2899A patent/YU2899A/sh unknown
- 1997-07-17 ES ES97931960T patent/ES2194205T3/es not_active Expired - Lifetime
- 1997-07-17 DE DE69720732T patent/DE69720732T2/de not_active Expired - Lifetime
- 1997-07-17 HU HU0600527A patent/HUP0600527A2/hu unknown
- 1997-07-17 CN CN97196641A patent/CN1251589A/zh active Pending
- 1997-07-17 TR TR1999/00047T patent/TR199900047T2/xx unknown
- 1997-07-17 CZ CZ99181A patent/CZ18199A3/cs unknown
- 1997-07-17 PL PL97331072A patent/PL331072A1/xx unknown
- 1997-07-17 WO PCT/GB1997/001946 patent/WO1998004559A2/en not_active Ceased
- 1997-07-17 AT AT97931960T patent/ATE236904T1/de not_active IP Right Cessation
- 1997-07-17 NZ NZ333768A patent/NZ333768A/xx unknown
- 1997-07-17 SK SK93-99A patent/SK9399A3/sk unknown
- 1997-07-17 BR BR9710729A patent/BR9710729A/pt unknown
- 1997-07-17 US US09/155,587 patent/US6255305B1/en not_active Expired - Lifetime
- 1997-07-17 EP EP97931960A patent/EP0915875B1/en not_active Expired - Lifetime
- 1997-07-17 EA EA199900164A patent/EA002436B1/ru not_active IP Right Cessation
1999
- 1999-01-19 IS IS4949A patent/IS4949A/is unknown
- 1999-01-22 NO NO990304A patent/NO990304L/no not_active Application Discontinuation
- 1999-01-25 BG BG103112A patent/BG103112A/xx unknown

Also Published As

Publication number	Publication date
BR9710729A (pt)	1999-08-17
CN1251589A (zh)	2000-04-26
US6255305B1 (en)	2001-07-03
NZ333768A (en)	2000-09-29
IL127911A0 (en)	1999-11-30
AU723098B2 (en)	2000-08-17
NO990304D0 (no)	1999-01-22
DE69720732T2 (de)	2004-01-29
YU2899A (sh)	2000-03-21
EP0915875B1 (en)	2003-04-09
SK9399A3 (en)	2000-04-10
ES2194205T3 (es)	2003-11-16
TR199900047T2 (xx)	1999-03-22
PL331072A1 (en)	1999-06-21
EP0915875A2 (en)	1999-05-19
NO990304L (no)	1999-03-25
EA199900164A1 (ru)	2000-04-24
AU3553997A (en)	1998-02-20
JP2002514169A (ja)	2002-05-14
HUP0600527A2 (en)	2006-11-28
BG103112A (en)	1999-09-30
WO1998004559A2 (en)	1998-02-05
KR20000029548A (ko)	2000-05-25
EA002436B1 (ru)	2002-04-25
JP4216905B2 (ja)	2009-01-28
ATE236904T1 (de)	2003-04-15
DE69720732D1 (de)	2003-05-15
IS4949A (is)	1999-01-19
CZ18199A3 (cs)	1999-06-16

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DE69705312D1 (de)	2001-07-26	N6-heterocyclisch-substituierte adenosin-derivate
IS4963A (is)	1999-01-29	Setnar 6,5-heteró-bísýklískar afleiður
DK0920429T3 (da)	2003-05-12	Substituerede pyrido- eller pyrimidoholdige, 6,6- eller 6,7-bicykliske derivater
PT901474E (pt)	2006-07-31	Derivados de aril-pirimidina.
TR199800085A3 (tr)	1998-08-21	8-Sübstitüye edilmis-1,3,8-triaza- spiro(4,5)dekan-4-on türevleri.
NL300214I1 (nl)	2006-03-01	Chinazolinederivaten.
AR006390A1 (es)	1999-08-25	Derivados de lactama
NO975293D0 (no)	1997-11-18	Fremgangsmåte for mottaking, samt mottaker
NO976110D0 (no)	1997-12-29	Nettverk med server, spesielt for oppsetting av anrop
TR199802520A3 (tr)	1999-06-21	1,3,8-Triaza-spiro(4,5) dekan -4-on türevleri.
ATE246199T1 (de)	2003-08-15	3-descladinose-2,3-anhydroerythromycin-derivate
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NO982843D0 (no)	1998-06-19	2,7-Substituerte oktahydro-pyrrol£1,2-a\|pyrazin-derivater
DE69628458D1 (de)	2003-07-03	25-hydroxy-16-ene-26,27-bishome-cholecalceriferol derivate
TR199600373A2 (tr)	1996-12-21	Ensektisid olarak benzofenon hidrazon türevleri.
FI955688A0 (fi)	1995-11-24	Menetelmä puunrungon käsittelemiseksi lastuamalla
FI970092A7 (fi)	1997-01-09	Pyrido(3,2,1-i,j)(3,1)bentsoksatsiinijohdannaiset
TR199700219A3 (tr)	1997-10-21	1,25-Dihidroksi-16, 22, 23-Trisdihidro-kolkalsiferol türevleri.
ES1035356Y (es)	1997-10-16	Parchis modular.
DE59508591D1 (de)	2000-08-24	2-arylcyclopentan-1,3-dion-derivate
ES1030734Y (es)	1996-03-01	Tapon-llavero, perfeccionado.
ES1031926Y (es)	1996-08-01	Luminaria empotrada, perfeccionada.
ES1033228Y (es)	1997-01-16	Lampara piloto perfeccionada.
TR199700927A3 (tr)	1999-03-22	N-Benzilazolyum türevleri.