IS4949A - Setnar tríazóló-pýridazín afleiður sem bindlar fyrir GABA viðtaka - Google Patents

Setnar tríazóló-pýridazín afleiður sem bindlar fyrir GABA viðtaka

Info

Publication number: IS4949A
Authority: IS; Iceland
Prior art keywords: triazolo; establishes; bind; pyridazine derivatives; gaba receptors
Prior art date: 1996-07-25

Application number

IS4949A

Other languages

English (en)

Inventor

Barff Broughton Howard

Richard Guiblin Alexander

Geoffrey Russell Michael

Robert Carling William

Madin Andrew

Joseph Street Leslie

Luis Castro Pineiro Jose

William Moore Kevin

Original Assignee

Merck Sharp & Dohme Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1999-01-19

Publication date

1999-01-19

1996-07-25 Priority claimed from GBGB9615645.0A external-priority patent/GB9615645D0/en

1996-12-06 Priority claimed from GBGB9625397.6A external-priority patent/GB9625397D0/en

1997-07-09 Priority claimed from GBGB9714420.8A external-priority patent/GB9714420D0/en

1999-01-19 Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited

1999-01-19 Publication of IS4949A publication Critical patent/IS4949A/is

Links

CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical class N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title 1
102000005915 GABA Receptors Human genes 0.000 title 1
108010005551 GABA Receptors Proteins 0.000 title 1
102000004300 GABA-A Receptors Human genes 0.000 abstract 1
108090000839 GABA-A Receptors Proteins 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
-1 triazolo-pyridazine derivative compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IS4949A 1996-07-25 1999-01-19 Setnar tríazóló-pýridazín afleiður sem bindlar fyrir GABA viðtaka IS4949A (is)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9615645.0A GB9615645D0 (en)	1996-07-25	1996-07-25	Therapeutic agents
GBGB9625397.6A GB9625397D0 (en)	1996-12-06	1996-12-06	Therapeutic agents
GBGB9714420.8A GB9714420D0 (en)	1997-07-09	1997-07-09	Therapeutic agents
PCT/GB1997/001946 WO1998004559A2 (en)	1996-07-25	1997-07-17	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number	Publication Date
IS4949A true IS4949A (is)	1999-01-19

Family

ID=27268403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS4949A IS4949A (is)	1996-07-25	1999-01-19	Setnar tríazóló-pýridazín afleiður sem bindlar fyrir GABA viðtaka

Country Status (24)

Country	Link
US (1)	US6255305B1 (is)
EP (1)	EP0915875B1 (is)
JP (1)	JP4216905B2 (is)
KR (1)	KR20000029548A (is)
CN (1)	CN1251589A (is)
AT (1)	ATE236904T1 (is)
AU (1)	AU723098B2 (is)
BG (1)	BG103112A (is)
BR (1)	BR9710729A (is)
CZ (1)	CZ18199A3 (is)
DE (1)	DE69720732T2 (is)
EA (1)	EA002436B1 (is)
EE (1)	EE9900027A (is)
ES (1)	ES2194205T3 (is)
HU (1)	HUP0600527A2 (is)
IL (1)	IL127911A0 (is)
IS (1)	IS4949A (is)
NO (1)	NO990304L (is)
NZ (1)	NZ333768A (is)
PL (1)	PL331072A1 (is)
SK (1)	SK9399A3 (is)
TR (1)	TR199900047T2 (is)
WO (1)	WO1998004559A2 (is)
YU (1)	YU2899A (is)

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WO1998050385A1 (en) *	1997-05-08	1998-11-12	Merck Sharp & Dohme Limited	SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS
GB9715977D0 (en) *	1997-07-29	1997-10-01	Merck Sharp & Dohme	Therapeutic agents
GB9718254D0 (en)	1997-08-28	1997-11-05	Merck Sharp & Dohme	Therapeutic agents
US6297235B1 (en) *	1997-08-28	2001-10-02	Merck Sharp & Dohme Ltd.	Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726699D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9723999D0 (en)	1997-11-13	1998-01-14	Merck Sharp & Dohme	Therapeutic use
WO1999025353A1 (en) *	1997-11-13	1999-05-27	Merck Sharp & Dohme Limited	Therapeutic uses of triazolo-pyridazine derivatives
GB9726701D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
US6110915A (en) *	1997-12-18	2000-08-29	Merck & Co., Inc.	Antiemetic use of triazolo-pyridazine derivatives
AU746866B2 (en) *	1998-01-14	2002-05-02	Merck Sharp & Dohme Limited	Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801202D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801234D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
MXPA00007135A (es) *	1998-01-21	2002-11-07	Merck Sharp & Dohme	Derivados de triazolo-piridazina como ligandos para receptores gaba.
GB9801210D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801208D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801397D0 (en)	1998-01-22	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801538D0 (en)	1998-01-23	1998-03-25	Merck Sharp & Dohme	Pharmaceutical product
GB9813006D0 (en) *	1998-06-16	1998-08-12	Merck Sharp & Dohme	Therapeutic agents
US6479506B1 (en)	1998-06-16	2002-11-12	Merck Sharp & Dohme Ltd.	Triazolo-pyridine derivatives as ligands for GABA receptors
GB9813576D0 (en)	1998-06-24	1998-08-19	Merck Sharp & Dohme	Therapeutic agents
GB9821179D0 (en) *	1998-09-30	1998-11-25	Merck Sharp & Dohme	Therapeutic use
AU6003099A (en) *	1998-10-06	2000-04-26	Takeda Chemical Industries Ltd.	Fused pyridazine compounds, process for the preparation of the same and uses thereof
DE69936998T2 (de)	1998-10-16	2008-05-21	Merck Sharp & Dohme Ltd., Hoddesdon	Pyrazolotriazinderivate als gaba-rezeptorliganden
IT1303272B1 (it) *	1998-10-29	2000-11-06	Zambon Spa	Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en)	1998-11-12	1999-01-06	Merck Sharp & Dohme	Therapeutic compounds
GB2345443A (en) *	1999-01-08	2000-07-12	Merck Sharp & Dohme	Use of triazolo-pyridazines for treating premenstrual syndrome
JP2002535407A (ja) *	1999-01-27	2002-10-22	メルクシャープエンドドームリミテッド	Ｇａｂａ受容体のリガンドとしてのトリアゾロピリダジン誘導体
GB9903119D0 (en) *	1999-02-11	1999-04-07	Merck Sharp & Dohme	Therapeutic agents
US6737242B1 (en)	1999-05-07	2004-05-18	Neurogen Corporation	Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9919957D0 (en) *	1999-08-23	1999-10-27	Merck Sharp & Dohme	Therapeutic agents
GB9921351D0 (en) *	1999-09-09	1999-11-10	Merck Sharp & Dohme	Therapeutic agents
US6355638B1 (en) *	1999-11-25	2002-03-12	Merck Sharp & Dohme Ltd.	Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
GB9929569D0 (en)	1999-12-14	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929685D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929687D0 (en)	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB0000564D0 (en)	2000-01-11	2000-03-01	Merck Sharp & Dohme	Therapeutic agents
GB0008696D0 (en)	2000-04-07	2000-05-31	Merck Sharp & Dohme	Therapeutic agents
GB0017518D0 (en) *	2000-07-17	2000-08-30	Merck Sharp & Dohme	Therapeutic agents
GB0018473D0 (en) *	2000-07-27	2000-09-13	Merck Sharp & Dohme	Therapeutic agents
GB0028583D0 (en)	2000-11-23	2001-01-10	Merck Sharp & Dohme	Therapeutic compounds
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AU2003297161B8 (en)	2002-12-18	2011-03-31	Vertex Pharmaceuticals Incorporated	Triazolopyridazines as protein kinases inhibitors
PT1697371E (pt)	2003-12-19	2007-08-03	Bristol Myers Squibb Co	Heterocíclos azabicíclicos como moduladores do receptor de canabinóides
WO2006024640A2 (en) *	2004-09-02	2006-03-09	Altana Pharma Ag	Triazolophthalazines
WO2006061428A2 (en) *	2004-12-10	2006-06-15	Universität Zürich	Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
MX2007008137A (es)	2005-01-05	2007-07-19	Altana Pharma Ag	Triazoloftalazinas como inhibidores de pde2.
JP5130053B2 (ja)	2005-01-05	2013-01-30	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	トリアゾロフタラジン
US7572807B2 (en)	2005-06-09	2009-08-11	Bristol-Myers Squibb Company	Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
EP2275096A3 (en)	2005-08-26	2011-07-13	Braincells, Inc.	Neurogenesis via modulation of the muscarinic receptors
EP2258357A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
WO2007047978A2 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by pde inhibition
EP2314289A1 (en)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
US7678808B2 (en)	2006-05-09	2010-03-16	Braincells, Inc.	5 HT receptor mediated neurogenesis
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US7638541B2 (en)	2006-12-28	2009-12-29	Metabolex Inc.	5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
AU2008279447A1 (en) *	2007-07-19	2009-01-29	Metabolex, Inc.	N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders
PL2288612T3 (pl) *	2008-04-04	2015-12-31	Gabather Ab	Modulatory receptora GABAA
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BR112018015386A2 (pt) *	2016-01-27	2019-03-19	Universität Zürich	uso de moduladores de receptor gabaa para tratamento de prurido
CN107344938B (zh) *	2016-05-06	2022-05-06	上海赛默罗生物科技有限公司	吡唑-三嗪类衍生物、其制备方法、药物组合物和用途
CN107344936B (zh) *	2016-05-06	2022-06-03	上海赛默罗生物科技有限公司	三唑哒嗪类衍生物、其制备方法、药物组合物和用途
WO2018026890A1 (en)	2016-08-03	2018-02-08	Cymabay Therapeutics	Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
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CA1080712A (en)	1976-09-22	1980-07-01	Jay D. Albright	Hypotensive agents
PH21834A (en)	1982-01-18	1988-03-17	Lepetit Spa	New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
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GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use

1997
- 1997-07-17 EP EP97931960A patent/EP0915875B1/en not_active Expired - Lifetime
- 1997-07-17 YU YU2899A patent/YU2899A/sh unknown
- 1997-07-17 ES ES97931960T patent/ES2194205T3/es not_active Expired - Lifetime
- 1997-07-17 HU HU0600527A patent/HUP0600527A2/hu unknown
- 1997-07-17 WO PCT/GB1997/001946 patent/WO1998004559A2/en not_active Ceased
- 1997-07-17 US US09/155,587 patent/US6255305B1/en not_active Expired - Lifetime
- 1997-07-17 KR KR1019997000606A patent/KR20000029548A/ko not_active Withdrawn
- 1997-07-17 AU AU35539/97A patent/AU723098B2/en not_active Ceased
- 1997-07-17 NZ NZ333768A patent/NZ333768A/xx unknown
- 1997-07-17 SK SK93-99A patent/SK9399A3/sk unknown
- 1997-07-17 PL PL97331072A patent/PL331072A1/xx unknown
- 1997-07-17 JP JP50858598A patent/JP4216905B2/ja not_active Expired - Fee Related
- 1997-07-17 AT AT97931960T patent/ATE236904T1/de not_active IP Right Cessation
- 1997-07-17 EA EA199900164A patent/EA002436B1/ru not_active IP Right Cessation
- 1997-07-17 EE EEP199900027A patent/EE9900027A/xx unknown
- 1997-07-17 CN CN97196641A patent/CN1251589A/zh active Pending
- 1997-07-17 TR TR1999/00047T patent/TR199900047T2/xx unknown
- 1997-07-17 BR BR9710729A patent/BR9710729A/pt unknown
- 1997-07-17 IL IL12791197A patent/IL127911A0/xx unknown
- 1997-07-17 DE DE69720732T patent/DE69720732T2/de not_active Expired - Lifetime
- 1997-07-17 CZ CZ99181A patent/CZ18199A3/cs unknown
1999
- 1999-01-19 IS IS4949A patent/IS4949A/is unknown
- 1999-01-22 NO NO990304A patent/NO990304L/no not_active Application Discontinuation
- 1999-01-25 BG BG103112A patent/BG103112A/xx unknown

Also Published As

Publication number	Publication date
PL331072A1 (en)	1999-06-21
DE69720732T2 (de)	2004-01-29
WO1998004559A2 (en)	1998-02-05
EE9900027A (et)	1999-08-16
US6255305B1 (en)	2001-07-03
ES2194205T3 (es)	2003-11-16
JP2002514169A (ja)	2002-05-14
DE69720732D1 (de)	2003-05-15
BG103112A (en)	1999-09-30
ATE236904T1 (de)	2003-04-15
EA199900164A1 (ru)	2000-04-24
SK9399A3 (en)	2000-04-10
TR199900047T2 (xx)	1999-03-22
AU723098B2 (en)	2000-08-17
NZ333768A (en)	2000-09-29
YU2899A (sh)	2000-03-21
BR9710729A (pt)	1999-08-17
KR20000029548A (ko)	2000-05-25
AU3553997A (en)	1998-02-20
JP4216905B2 (ja)	2009-01-28
EP0915875B1 (en)	2003-04-09
IL127911A0 (en)	1999-11-30
NO990304L (no)	1999-03-25
EP0915875A2 (en)	1999-05-19
CZ18199A3 (cs)	1999-06-16
HUP0600527A2 (en)	2006-11-28
CN1251589A (zh)	2000-04-26
EA002436B1 (ru)	2002-04-25
NO990304D0 (no)	1999-01-22

Publication	Publication Date	Title
EE9900027A (et)	1999-08-16	Asendatud triasolopüridasiini derivaadid GABA retseptorite ligandidena
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