EE9900027A - Asendatud triasolopüridasiini derivaadid GABA retseptorite ligandidena - Google Patents

Asendatud triasolopüridasiini derivaadid GABA retseptorite ligandidena

Info

Publication number: EE9900027A
Authority: EE; Estonia
Prior art keywords: ligands; gaba receptors; triazolopyridazine derivatives; substituted; substituted triazolopyridazine
Prior art date: 1996-07-25

Application number

EEP199900027A

Other languages

English (en)

Estonian (et)

Inventor

Barff Broughton Howard

Robert Carling William

Richard Guiblin Alexander

William Moore Kevin

Geoffrey Russell Michael

Joseph Street Leslie

Luis Castro Pineiro Jose

Madin Andrew

Original Assignee

Merck Sharp & Dohme Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1997-07-17

Publication date

1999-08-16

1996-07-25 Priority claimed from GBGB9615645.0A external-priority patent/GB9615645D0/en

1996-12-06 Priority claimed from GBGB9625397.6A external-priority patent/GB9625397D0/en

1997-07-09 Priority claimed from GBGB9714420.8A external-priority patent/GB9714420D0/en

1997-07-17 Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited

1999-08-16 Publication of EE9900027A publication Critical patent/EE9900027A/xx

Links

239000003446 ligand Substances 0.000 title abstract 2
CBHTTYDJRXOHHL-UHFFFAOYSA-N 2h-triazolo[4,5-c]pyridazine Chemical class N1=NC=CC2=C1N=NN2 CBHTTYDJRXOHHL-UHFFFAOYSA-N 0.000 title 1
102000005915 GABA Receptors Human genes 0.000 title 1
108010005551 GABA Receptors Proteins 0.000 title 1
102000004300 GABA-A Receptors Human genes 0.000 abstract 1
108090000839 GABA-A Receptors Proteins 0.000 abstract 1
-1 triazolo-pyridazine derivative compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EEP199900027A 1996-07-25 1997-07-17 Asendatud triasolopüridasiini derivaadid GABA retseptorite ligandidena EE9900027A (et)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9615645.0A GB9615645D0 (en)	1996-07-25	1996-07-25	Therapeutic agents
GBGB9625397.6A GB9625397D0 (en)	1996-12-06	1996-12-06	Therapeutic agents
GBGB9714420.8A GB9714420D0 (en)	1997-07-09	1997-07-09	Therapeutic agents
PCT/GB1997/001946 WO1998004559A2 (en)	1996-07-25	1997-07-17	Substituted triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number	Publication Date
EE9900027A true EE9900027A (et)	1999-08-16

Family

ID=27268403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900027A EE9900027A (et)	1996-07-25	1997-07-17	Asendatud triasolopüridasiini derivaadid GABA retseptorite ligandidena

Country Status (24)

Country	Link
US (1)	US6255305B1 (is)
EP (1)	EP0915875B1 (is)
JP (1)	JP4216905B2 (is)
KR (1)	KR20000029548A (is)
CN (1)	CN1251589A (is)
AT (1)	ATE236904T1 (is)
AU (1)	AU723098B2 (is)
BG (1)	BG103112A (is)
BR (1)	BR9710729A (is)
CZ (1)	CZ18199A3 (is)
DE (1)	DE69720732T2 (is)
EA (1)	EA002436B1 (is)
EE (1)	EE9900027A (is)
ES (1)	ES2194205T3 (is)
HU (1)	HUP0600527A2 (is)
IL (1)	IL127911A0 (is)
IS (1)	IS4949A (is)
NO (1)	NO990304L (is)
NZ (1)	NZ333768A (is)
PL (1)	PL331072A1 (is)
SK (1)	SK9399A3 (is)
TR (1)	TR199900047T2 (is)
WO (1)	WO1998004559A2 (is)
YU (1)	YU2899A (is)

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GB9715977D0 (en) *	1997-07-29	1997-10-01	Merck Sharp & Dohme	Therapeutic agents
US6297235B1 (en) *	1997-08-28	2001-10-02	Merck Sharp & Dohme Ltd.	Triazolopyridazine derivatives for treating anxiety and enhancing cognition
GB9718254D0 (en)	1997-08-28	1997-11-05	Merck Sharp & Dohme	Therapeutic agents
AU1041599A (en) *	1997-11-13	1999-06-07	Jose Luis Castro Pineiro	Therapeutic uses of triazolo-pyridazine derivatives
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726699D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726701D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9723999D0 (en)	1997-11-13	1998-01-14	Merck Sharp & Dohme	Therapeutic use
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EP1047697A1 (en) *	1998-01-14	2000-11-02	MERCK SHARP & DOHME LTD.	Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801202D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
AU748737B2 (en) *	1998-01-21	2002-06-13	Merck Sharp & Dohme Limited	Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801208D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801234D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801210D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801397D0 (en)	1998-01-22	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801538D0 (en)	1998-01-23	1998-03-25	Merck Sharp & Dohme	Pharmaceutical product
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GB9813006D0 (en) *	1998-06-16	1998-08-12	Merck Sharp & Dohme	Therapeutic agents
GB9813576D0 (en)	1998-06-24	1998-08-19	Merck Sharp & Dohme	Therapeutic agents
GB9821179D0 (en) *	1998-09-30	1998-11-25	Merck Sharp & Dohme	Therapeutic use
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AU760688B2 (en)	1998-10-16	2003-05-22	Merck Sharp & Dohme Limited	Pyrazolo-triazine derivatives as ligands for GABA receptors
IT1303272B1 (it) *	1998-10-29	2000-11-06	Zambon Spa	Derivati triciclici inibitori della fosfodiesterasi 4
GB9824897D0 (en) *	1998-11-12	1999-01-06	Merck Sharp & Dohme	Therapeutic compounds
GB2345443A (en) *	1999-01-08	2000-07-12	Merck Sharp & Dohme	Use of triazolo-pyridazines for treating premenstrual syndrome
EP1149102B1 (en) *	1999-01-27	2004-12-08	MERCK SHARP & DOHME LTD.	Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9903119D0 (en) *	1999-02-11	1999-04-07	Merck Sharp & Dohme	Therapeutic agents
US6737242B1 (en)	1999-05-07	2004-05-18	Neurogen Corporation	Methods for screening GABA-modulatory compounds for specified pharmacological activities
GB9919957D0 (en)	1999-08-23	1999-10-27	Merck Sharp & Dohme	Therapeutic agents
GB9921351D0 (en)	1999-09-09	1999-11-10	Merck Sharp & Dohme	Therapeutic agents
US6355638B1 (en) *	1999-11-25	2002-03-12	Merck Sharp & Dohme Ltd.	Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition
GB9929569D0 (en)	1999-12-14	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929687D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB9929685D0 (en) *	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB0000564D0 (en) *	2000-01-11	2000-03-01	Merck Sharp & Dohme	Therapeutic agents
GB0008696D0 (en)	2000-04-07	2000-05-31	Merck Sharp & Dohme	Therapeutic agents
GB0017518D0 (en) *	2000-07-17	2000-08-30	Merck Sharp & Dohme	Therapeutic agents
GB0018473D0 (en) *	2000-07-27	2000-09-13	Merck Sharp & Dohme	Therapeutic agents
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WO2006061428A2 (en) *	2004-12-10	2006-06-15	Universität Zürich	Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
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JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
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JP5489997B2 (ja)	2007-07-19	2014-05-14	シマベイセラピューティクス，インコーポレーテッド	糖尿病および代謝疾患の治療のためのＲＵＰ３またはＧＰＲｌ１９受容体のアゴニストとしてのＮ−アザ環状置換ピロール、ピラゾール、イミダゾール、トリアゾールおよびテトラゾール誘導体
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1997
- 1997-07-17 AU AU35539/97A patent/AU723098B2/en not_active Ceased
- 1997-07-17 IL IL12791197A patent/IL127911A0/xx unknown
- 1997-07-17 KR KR1019997000606A patent/KR20000029548A/ko not_active Withdrawn
- 1997-07-17 WO PCT/GB1997/001946 patent/WO1998004559A2/en not_active Ceased
- 1997-07-17 NZ NZ333768A patent/NZ333768A/xx unknown
- 1997-07-17 CZ CZ99181A patent/CZ18199A3/cs unknown
- 1997-07-17 ES ES97931960T patent/ES2194205T3/es not_active Expired - Lifetime
- 1997-07-17 HU HU0600527A patent/HUP0600527A2/hu unknown
- 1997-07-17 EE EEP199900027A patent/EE9900027A/xx unknown
- 1997-07-17 EP EP97931960A patent/EP0915875B1/en not_active Expired - Lifetime
- 1997-07-17 BR BR9710729A patent/BR9710729A/pt unknown
- 1997-07-17 EA EA199900164A patent/EA002436B1/ru not_active IP Right Cessation
- 1997-07-17 DE DE69720732T patent/DE69720732T2/de not_active Expired - Lifetime
- 1997-07-17 CN CN97196641A patent/CN1251589A/zh active Pending
- 1997-07-17 JP JP50858598A patent/JP4216905B2/ja not_active Expired - Fee Related
- 1997-07-17 YU YU2899A patent/YU2899A/sh unknown
- 1997-07-17 SK SK93-99A patent/SK9399A3/sk unknown
- 1997-07-17 PL PL97331072A patent/PL331072A1/xx unknown
- 1997-07-17 TR TR1999/00047T patent/TR199900047T2/xx unknown
- 1997-07-17 US US09/155,587 patent/US6255305B1/en not_active Expired - Lifetime
- 1997-07-17 AT AT97931960T patent/ATE236904T1/de not_active IP Right Cessation
1999
- 1999-01-19 IS IS4949A patent/IS4949A/is unknown
- 1999-01-22 NO NO990304A patent/NO990304L/no not_active Application Discontinuation
- 1999-01-25 BG BG103112A patent/BG103112A/xx unknown

Also Published As

Publication number	Publication date
AU723098B2 (en)	2000-08-17
NZ333768A (en)	2000-09-29
EA199900164A1 (ru)	2000-04-24
EP0915875A2 (en)	1999-05-19
ATE236904T1 (de)	2003-04-15
JP2002514169A (ja)	2002-05-14
WO1998004559A2 (en)	1998-02-05
KR20000029548A (ko)	2000-05-25
ES2194205T3 (es)	2003-11-16
EP0915875B1 (en)	2003-04-09
JP4216905B2 (ja)	2009-01-28
SK9399A3 (en)	2000-04-10
AU3553997A (en)	1998-02-20
US6255305B1 (en)	2001-07-03
IS4949A (is)	1999-01-19
BR9710729A (pt)	1999-08-17
TR199900047T2 (xx)	1999-03-22
BG103112A (en)	1999-09-30
HUP0600527A2 (en)	2006-11-28
CZ18199A3 (cs)	1999-06-16
CN1251589A (zh)	2000-04-26
NO990304D0 (no)	1999-01-22
DE69720732T2 (de)	2004-01-29
DE69720732D1 (de)	2003-05-15
EA002436B1 (ru)	2002-04-25
YU2899A (sh)	2000-03-21
IL127911A0 (en)	1999-11-30
PL331072A1 (en)	1999-06-21
NO990304L (no)	1999-03-25

Publication	Publication Date	Title
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