EE9900188A - HIV proteaasi inhibiitoritena kasulikud 1-(3-aminoindasool-5-üül)-3-fenüülmetüül-tsüklilised uuread - Google Patents

HIV proteaasi inhibiitoritena kasulikud 1-(3-aminoindasool-5-üül)-3-fenüülmetüül-tsüklilised uuread

Info

Publication number: EE9900188A
Authority: EE; Estonia
Prior art keywords: hiv protease; aminoindazol; phenylmethyl; protease inhibitors; cyclic ureas
Prior art date: 1996-11-08

Application number

EEP199900188A

Other languages

English (en)

Estonian (et)

Inventor

David Rodgers James

Frank Iii Kaltenbach Robert

Original Assignee

Dupont Pharmaceuticals Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-08

Filing date

1997-11-04

Publication date

1999-12-15

1997-11-04 Application filed by Dupont Pharmaceuticals Company filed Critical Dupont Pharmaceuticals Company

1999-12-15 Publication of EE9900188A publication Critical patent/EE9900188A/xx

Links

-1 3-Aminoindazol-5-yl Chemical group 0.000 title 1
235000013877 carbamide Nutrition 0.000 title 1
239000004030 hiv protease inhibitor Substances 0.000 title 1
238000009007 Diagnostic Kit Methods 0.000 abstract 1
108010010369 HIV Protease Proteins 0.000 abstract 1
208000036142 Viral infection Diseases 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)

EEP199900188A 1996-11-08 1997-11-04 HIV proteaasi inhibiitoritena kasulikud 1-(3-aminoindasool-5-üül)-3-fenüülmetüül-tsüklilised uuread EE9900188A (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US74710496A	1996-11-08	1996-11-08
US2974596P	1996-11-08	1996-11-08
PCT/US1997/020035 WO1998020008A1 (en)	1996-11-08	1997-11-04	1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors

Publications (1)

Publication Number	Publication Date
EE9900188A true EE9900188A (et)	1999-12-15

Family

ID=26705293

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900188A EE9900188A (et)	1996-11-08	1997-11-04	HIV proteaasi inhibiitoritena kasulikud 1-(3-aminoindasool-5-üül)-3-fenüülmetüül-tsüklilised uuread

Country Status (21)

Country	Link
EP (1)	EP0937067B1 (de)
JP (1)	JP2001503428A (de)
KR (1)	KR20000053122A (de)
CN (1)	CN1235602A (de)
AT (1)	ATE244714T1 (de)
AU (1)	AU5165198A (de)
BR (1)	BR9712910A (de)
CA (1)	CA2270966A1 (de)
CZ (1)	CZ157599A3 (de)
DE (1)	DE69723456T2 (de)
EA (1)	EA199900452A1 (de)
EE (1)	EE9900188A (de)
ES (1)	ES2202645T3 (de)
HU (1)	HUP9904676A2 (de)
IL (1)	IL129727A0 (de)
LV (1)	LV12375B (de)
NO (1)	NO992228L (de)
PL (1)	PL333421A1 (de)
SI (1)	SI20074A (de)
SK (1)	SK59699A3 (de)
WO (1)	WO1998020008A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6870098A (en) *	1997-03-31	1998-10-22	Du Pont Merck Pharmaceutical Company, The	Indazoles of cyclic ureas useful as hiv protease inhibitors
US7135575B2 (en)	2003-03-03	2006-11-14	Array Biopharma, Inc.	P38 inhibitors and methods of use thereof
AU2007210073B2 (en)	2006-01-31	2011-10-06	Array Biopharma Inc.	Kinase inhibitors and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5610294A (en) *	1991-10-11	1997-03-11	The Du Pont Merck Pharmaceutical Company	Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
US5532357A (en) *	1995-06-07	1996-07-02	The Dupont Merck Pharmaceutical Company	Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas

1997
- 1997-11-04 EE EEP199900188A patent/EE9900188A/xx unknown
- 1997-11-04 WO PCT/US1997/020035 patent/WO1998020008A1/en not_active Ceased
- 1997-11-04 EA EA199900452A patent/EA199900452A1/ru unknown
- 1997-11-04 AT AT97946494T patent/ATE244714T1/de not_active IP Right Cessation
- 1997-11-04 EP EP97946494A patent/EP0937067B1/de not_active Expired - Lifetime
- 1997-11-04 CZ CZ991575A patent/CZ157599A3/cs unknown
- 1997-11-04 CA CA002270966A patent/CA2270966A1/en not_active Abandoned
- 1997-11-04 BR BR9712910A patent/BR9712910A/pt not_active Application Discontinuation
- 1997-11-04 DE DE69723456T patent/DE69723456T2/de not_active Expired - Fee Related
- 1997-11-04 KR KR1019990704048A patent/KR20000053122A/ko not_active Withdrawn
- 1997-11-04 HU HU9904676A patent/HUP9904676A2/hu unknown
- 1997-11-04 CN CN97199419A patent/CN1235602A/zh active Pending
- 1997-11-04 ES ES97946494T patent/ES2202645T3/es not_active Expired - Lifetime
- 1997-11-04 IL IL12972797A patent/IL129727A0/xx unknown
- 1997-11-04 JP JP52168198A patent/JP2001503428A/ja active Pending
- 1997-11-04 SK SK596-99A patent/SK59699A3/sk unknown
- 1997-11-04 AU AU51651/98A patent/AU5165198A/en not_active Abandoned
- 1997-11-04 PL PL97333421A patent/PL333421A1/xx unknown
- 1997-11-04 SI SI9720072A patent/SI20074A/sl unknown
1999
- 1999-04-29 LV LVP-99-76A patent/LV12375B/en unknown
- 1999-05-07 NO NO992228A patent/NO992228L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CZ157599A3 (cs)	1999-11-17
WO1998020008A1 (en)	1998-05-14
BR9712910A (pt)	2000-03-21
DE69723456T2 (de)	2004-05-27
KR20000053122A (ko)	2000-08-25
PL333421A1 (en)	1999-12-06
IL129727A0 (en)	2000-02-29
NO992228D0 (no)	1999-05-07
JP2001503428A (ja)	2001-03-13
ATE244714T1 (de)	2003-07-15
NO992228L (no)	1999-06-07
SK59699A3 (en)	1999-12-10
AU5165198A (en)	1998-05-29
SI20074A (sl)	2000-04-30
LV12375A (lv)	1999-11-20
ES2202645T3 (es)	2004-04-01
EP0937067B1 (de)	2003-07-09
LV12375B (en)	2000-04-20
CA2270966A1 (en)	1998-05-14
CN1235602A (zh)	1999-11-17
HUP9904676A2 (hu)	2000-06-28
DE69723456D1 (de)	2003-08-14
EP0937067A1 (de)	1999-08-25
EA199900452A1 (ru)	2000-02-28

Publication	Publication Date	Title
WO1998045276A3 (en)	1999-01-14	4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinones useful as hiv reverse transcriptase inhibitors
BR9713465A (pt)	2000-03-28	Inibidores metalotprotease de amina cìclica sibstituìda
ATE284690T1 (de)	2005-01-15	Antithrombotische diamine
PT966465E (pt)	2003-11-28	Inibidores do enzima imfdh
AP2003002915A0 (en)	2003-12-31	HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis.
ES2104946T3 (es)	1997-10-16	Ureas ciclicas y similares utiles como inhibidores de la proteasa retrovirica.
BG100455A (en)	1997-09-30	Hiv protease inhibitors
BR9806752A (pt)	2000-03-14	Ftalazinonas.
DE69823344D1 (de)	2004-05-27	Substituierte benzimidazol-derivaten und ihre verwendung zur behandlung retroviraler infektionen
DE69830751D1 (de)	2005-08-04	Polyaromatische Verbindungen zur Behandlung von Herpes-Infektionen
DE69840603D1 (de)	2009-04-09	Alpha-ketoamidhaltige multikatalytische protease inhibitoren
EE200200208A (et)	2003-06-16	Oligosahhariidid, nende valmistamismeetod ja kasutamine ning farmatseutilised kompositsioonid
ATE232873T1 (de)	2003-03-15	Phosphonsaürederivate als ptp-1b-inhibitoren
ES2243579T3 (es)	2005-12-01	Derivados de pirazolopirideno.
ES2151600T3 (es)	2001-01-01	Derivados de n-(3-amino-2-hidroxibutil)sulfonamida utilizados como inhibidores de proteasa de vih.
YU62504A (sh)	2006-08-17	Triciklična 2-pirimidonska jedinjenja korisna kao inhibitori hiv reverzne transkriptoze
BR9813719A (pt)	2000-10-17	Agentes terapêuticos
ATE253359T1 (de)	2003-11-15	Antithrombotische mittel
TR200003065T2 (tr)	2001-02-21	Nöraminidazların inhibitörleri olarak pirolidinler.
SE9604582D0 (sv)	1996-12-13	Novel compounds
SE9904128D0 (sv)	1999-11-15	Novel compounds
LT2003003A (en)	2003-11-25	Tricyclic 2-pyridone compounds useful as hiv reverse transcriptase inhibitors
IL129727A0 (en)	2000-02-29	1-(3-Aminoindazol-5-YL)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
EA200600560A1 (ru)	2006-08-25	Ингибиторы проникновения вируса вич
DE69828522D1 (de)	2005-02-10	Antithrombotische mittel