NO992228L - 1-(3-aminoindazol-5-yl)-3-fenylmetyl-syklisk urea egnet som HIV protease inhibitor - Google Patents

1-(3-aminoindazol-5-yl)-3-fenylmetyl-syklisk urea egnet som HIV protease inhibitor

Info

Publication number
NO992228L
NO992228L NO992228A NO992228A NO992228L NO 992228 L NO992228 L NO 992228L NO 992228 A NO992228 A NO 992228A NO 992228 A NO992228 A NO 992228A NO 992228 L NO992228 L NO 992228L
Authority
NO
Norway
Prior art keywords
hiv protease
phenylmethylcyclic
aminoindazol
protease inhibitor
urea suitable
Prior art date
Application number
NO992228A
Other languages
English (en)
Other versions
NO992228D0 (no
Inventor
James David Rodgers
Iii Robert Frank Kaltenbach
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of NO992228D0 publication Critical patent/NO992228D0/no
Publication of NO992228L publication Critical patent/NO992228L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det er beskrevet en oppfinnelse vedrorende forbindelser av formel (I) og (II) eller farmasøytiske godtagbare saltformer eller prodrugformer herav, som er egnede som inhibitorer av HIV protease og til farmasøytiske sammensetninger og diagnosesetter omfattende den selv samme og fremgangsmåter for anvendelse av den selv samme til behandling av virusinfeksjon eller som en analysestandard eller et reagens.
NO992228A 1996-11-08 1999-05-07 1-(3-aminoindazol-5-yl)-3-fenylmetyl-syklisk urea egnet som HIV protease inhibitor NO992228L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74710496A 1996-11-08 1996-11-08
US2974596P 1996-11-08 1996-11-08
PCT/US1997/020035 WO1998020008A1 (en) 1996-11-08 1997-11-04 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as hiv protease inhibitors

Publications (2)

Publication Number Publication Date
NO992228D0 NO992228D0 (no) 1999-05-07
NO992228L true NO992228L (no) 1999-06-07

Family

ID=26705293

Family Applications (1)

Application Number Title Priority Date Filing Date
NO992228A NO992228L (no) 1996-11-08 1999-05-07 1-(3-aminoindazol-5-yl)-3-fenylmetyl-syklisk urea egnet som HIV protease inhibitor

Country Status (21)

Country Link
EP (1) EP0937067B1 (no)
JP (1) JP2001503428A (no)
KR (1) KR20000053122A (no)
CN (1) CN1235602A (no)
AT (1) ATE244714T1 (no)
AU (1) AU5165198A (no)
BR (1) BR9712910A (no)
CA (1) CA2270966A1 (no)
CZ (1) CZ157599A3 (no)
DE (1) DE69723456T2 (no)
EA (1) EA199900452A1 (no)
EE (1) EE9900188A (no)
ES (1) ES2202645T3 (no)
HU (1) HUP9904676A2 (no)
IL (1) IL129727A0 (no)
LV (1) LV12375B (no)
NO (1) NO992228L (no)
PL (1) PL333421A1 (no)
SI (1) SI20074A (no)
SK (1) SK59699A3 (no)
WO (1) WO1998020008A1 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6870098A (en) * 1997-03-31 1998-10-22 Du Pont Merck Pharmaceutical Company, The Indazoles of cyclic ureas useful as hiv protease inhibitors
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
AU2007210073B2 (en) 2006-01-31 2011-10-06 Array Biopharma Inc. Kinase inhibitors and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
US5532357A (en) * 1995-06-07 1996-07-02 The Dupont Merck Pharmaceutical Company Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas

Also Published As

Publication number Publication date
CZ157599A3 (cs) 1999-11-17
EE9900188A (et) 1999-12-15
WO1998020008A1 (en) 1998-05-14
BR9712910A (pt) 2000-03-21
DE69723456T2 (de) 2004-05-27
KR20000053122A (ko) 2000-08-25
PL333421A1 (en) 1999-12-06
IL129727A0 (en) 2000-02-29
NO992228D0 (no) 1999-05-07
JP2001503428A (ja) 2001-03-13
ATE244714T1 (de) 2003-07-15
SK59699A3 (en) 1999-12-10
AU5165198A (en) 1998-05-29
SI20074A (sl) 2000-04-30
LV12375A (lv) 1999-11-20
ES2202645T3 (es) 2004-04-01
EP0937067B1 (en) 2003-07-09
LV12375B (en) 2000-04-20
CA2270966A1 (en) 1998-05-14
CN1235602A (zh) 1999-11-17
HUP9904676A2 (hu) 2000-06-28
DE69723456D1 (de) 2003-08-14
EP0937067A1 (en) 1999-08-25
EA199900452A1 (ru) 2000-02-28

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application