EG17811A - Benzothiazine dioxide derivatives - Google Patents

Benzothiazine dioxide derivatives

Info

Publication number: EG17811A
Authority: EG; Egypt
Prior art keywords: methyl; ethyl; amino; methylpyridinium; pyridyl
Prior art date: 1985-05-29

Application number

EG318/86A

Other languages

English (en)

Inventor

George Lambardino Joseph

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-05-29

Filing date

1986-05-28

Publication date

1990-08-30

1986-05-28 Application filed by Pfizer filed Critical Pfizer

1990-08-30 Application granted granted Critical

1990-08-30 Publication of EG17811A publication Critical patent/EG17811A/xx

Links

GHNLJDPNIAIWOQ-UHFFFAOYSA-N 2h-1$l^{6},2-benzothiazine 1,1-dioxide Chemical class C1=CC=C2S(=O)(=O)NC=CC2=C1 GHNLJDPNIAIWOQ-UHFFFAOYSA-N 0.000 title 1
-1 6-methyl-2-pyridyl Chemical group 0.000 abstract 15
125000004432 carbon atom Chemical group C* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
BWZVCCNYKMEVEX-UHFFFAOYSA-N 2,4,6-Trimethylpyridine Chemical compound CC1=CC(C)=NC(C)=C1 BWZVCCNYKMEVEX-UHFFFAOYSA-N 0.000 abstract 1
OISVCGZHLKNMSJ-UHFFFAOYSA-O 2,6-dimethylpyridin-1-ium Chemical compound CC1=CC=CC(C)=[NH+]1 OISVCGZHLKNMSJ-UHFFFAOYSA-O 0.000 abstract 1
BSKHPKMHTQYZBB-UHFFFAOYSA-O 2-methylpyridin-1-ium Chemical compound CC1=CC=CC=[NH+]1 BSKHPKMHTQYZBB-UHFFFAOYSA-O 0.000 abstract 1
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
MFEIKQPHQINPRI-UHFFFAOYSA-N 3-Ethylpyridine Chemical compound CCC1=CC=CN=C1 MFEIKQPHQINPRI-UHFFFAOYSA-N 0.000 abstract 1
JDQNYWYMNFRKNQ-UHFFFAOYSA-N 3-ethyl-4-methylpyridine Chemical compound CCC1=CN=CC=C1C JDQNYWYMNFRKNQ-UHFFFAOYSA-N 0.000 abstract 1
ITQTTZVARXURQS-UHFFFAOYSA-O 3-methylpyridin-1-ium Chemical compound CC1=CC=C[NH+]=C1 ITQTTZVARXURQS-UHFFFAOYSA-O 0.000 abstract 1
KNCHDRLWPAKSII-UHFFFAOYSA-N 4-ethyl-2-methylpyridine Chemical compound CCC1=CC=NC(C)=C1 KNCHDRLWPAKSII-UHFFFAOYSA-N 0.000 abstract 1
VJXRKZJMGVSXPX-UHFFFAOYSA-N 4-ethylpyridine Chemical compound CCC1=CC=NC=C1 VJXRKZJMGVSXPX-UHFFFAOYSA-N 0.000 abstract 1
FKNQCJSGGFJEIZ-UHFFFAOYSA-O 4-methylpyridin-1-ium Chemical compound CC1=CC=[NH+]C=C1 FKNQCJSGGFJEIZ-UHFFFAOYSA-O 0.000 abstract 1
NTSLROIKFLNUIJ-UHFFFAOYSA-N 5-Ethyl-2-methylpyridine Chemical compound CCC1=CC=C(C)N=C1 NTSLROIKFLNUIJ-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005505 thiomorpholino group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/20—Quaternary compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Compositions Of Macromolecular Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Dental Preparations (AREA)

EG318/86A 1985-05-29 1986-05-28 Benzothiazine dioxide derivatives EG17811A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/738,805 US4623486A (en)	1985-05-29	1985-05-29	[4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity

Publications (1)

Publication Number	Publication Date
EG17811A true EG17811A (en)	1990-08-30

Family

ID=24969564

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG318/86A EG17811A (en)	1985-05-29	1986-05-28	Benzothiazine dioxide derivatives

Country Status (25)

Country	Link
US (1)	US4623486A (fr)
EP (1)	EP0208404B1 (fr)
JP (1)	JPS61277683A (fr)
KR (1)	KR870000913B1 (fr)
CN (1)	CN1004628B (fr)
AT (1)	ATE56010T1 (fr)
AU (1)	AU557396B1 (fr)
CA (1)	CA1270485A (fr)
DD (1)	DD247451A5 (fr)
DE (1)	DE3673710D1 (fr)
DK (1)	DK249086A (fr)
EG (1)	EG17811A (fr)
ES (1)	ES8707211A1 (fr)
FI (1)	FI86065C (fr)
GR (1)	GR861389B (fr)
HU (2)	HU200178B (fr)
IL (1)	IL78912A (fr)
NO (1)	NO165240C (fr)
NZ (1)	NZ216310A (fr)
PH (1)	PH23146A (fr)
PL (1)	PL147843B1 (fr)
PT (1)	PT82649B (fr)
SU (2)	SU1538896A3 (fr)
YU (1)	YU44576B (fr)
ZA (1)	ZA863986B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2650589A1 (fr) *	1989-08-04	1991-02-08	Esteve Labor Dr	Derives benzothiaziniques, leur preparation et leurs applications comme medicaments ou comme intermediaires de synthese de medicaments
JPH069600A (ja) *	1992-05-06	1994-01-18	Bristol Myers Squibb Co	タクソールのベンゾエート誘導体
FR2795412B1 (fr) *	1999-06-23	2001-07-13	Adir	Nouveaux derives d'ammonium quaternaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0031107D0 (en) *	2000-12-20	2001-01-31	Glaxo Group Ltd	Chemical compounds
FR2818641B1 (fr) *	2000-12-21	2004-03-05	Servier Lab	Nouveaux derives de 1,1-dioxo-2h-1,2-benzothiazine 3-carboxamides, leur procede de preparation et les compositions pharmaceutiques que les contiennent
GB0202873D0 (en)	2002-02-07	2002-03-27	Novartis Ag	Organic compounds
US20090221703A1 (en)	2006-07-09	2009-09-03	Chongxi Yu	High penetration composition and uses thereof
US20090238763A1 (en) *	2006-07-09	2009-09-24	Chongxi Yu	High penetration compositions and uses thereof
WO2008024830A2 (fr) *	2006-08-23	2008-02-28	Board Of Regents, The University Of Texas System	Halogénoimatinibes radiomarqués et leurs procédés de synthèse et d'utilisation dans l'imagerie par tep de cancers
EP2084165B1 (fr) *	2006-10-11	2013-06-12	Techfields Biochem Co. Ltd	Pro-médicaments d'oxicams solubles dans l'eau et chargés positivement et composés apparentés avec une vitesse de pénétration de la peau très élevée
CN103980228B (zh) *	2006-10-11	2020-03-17	于崇曦	具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药
WO2008051597A1 (fr) *	2006-10-26	2008-05-02	Sicor Inc.	Procédé pour la préparation d'imatinib
US8466154B2 (en)	2006-10-27	2013-06-18	The Board Of Regents Of The University Of Texas System	Methods and compositions related to wrapping of dehydrons
JP5235423B2 (ja) *	2007-01-25	2013-07-10	株式会社資生堂	皮膚外用組成物
JP2010529101A (ja) *	2007-06-04	2010-08-26	テックフィールズインコーポレイテッド	非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
CN108191846B (zh)	2008-12-04	2021-08-20	于崇曦	高穿透性组合物及其应用
CN101665472B (zh) *	2009-06-15	2011-08-24	威海迪素制药有限公司	2-甲基-3，4-二氢-4-氧代-2h-1，2-苯并噻嗪-3-羧酸乙酯-1,1-二氧化物的制备方法
US8609842B2 (en)	2010-04-23	2013-12-17	Fujian South Pharmaceutical Co., Ltd.	Method for synthesizing Imatinib
WO2013008242A1 (fr)	2011-07-12	2013-01-17	Natco Pharma Limited	Procédé de préparation d'un dichlorhydrate d'acide 4-(4-méthylpipérazino- méthyl)benzoïque très pur
WO2013035102A1 (fr)	2011-09-05	2013-03-14	Natco Pharma Limited	Procédés pour la préparation d'imatinib sous forme de base et leurs intermédiaires

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH93751A (de) *	1921-02-24	1922-04-01	Hoffmann La Roche	Verfahren zur Darstellung des p-Diäthylaminomethylbenzoesäurebenzylesters.
CH93438A (de) *	1921-02-24	1922-04-01	Hoffmann La Roche	Verfahren zur Darstellung des p-Dimethylaminomethylbenzoesäurebenzylesters.
US2406627A (en) *	1942-04-16	1946-08-27	American Cyanamid Co	Alkamine derivatives of para aminomethyl benzoic acid
US3591584A (en) *	1968-08-27	1971-07-06	Pfizer	Benzothiazine dioxides
US3787324A (en) *	1971-03-01	1974-01-22	Warner Lambert Co	4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
JPS4810078U (fr) *	1971-06-17	1973-02-03
US3788324A (en) *	1972-05-05	1974-01-29	P Lim	External catheter device
JPS5070888A (fr) *	1973-10-27	1975-06-12
US3900470A (en) *	1974-09-23	1975-08-19	Mcneilab Inc	Esters of benzothiazine-1,1-dioxides derivatives
US3925371A (en) *	1974-09-23	1975-12-09	Mcneilab Inc	Benzothiazine-1,1-dioxides
AU518216B2 (en) *	1977-09-06	1981-09-17	Hafslund Nycomed Pharma Aktiengesellschaft	Thienothiazine derivatives
IT1126509B (it) *	1979-12-07	1986-05-21	Medea Res Srl	Benzimidi ad attivita' anestetica locale e antiaritmica,processo per la loro preparazione e composizioni farmaceutiche che le contengono
JPS5714589A (en) *	1980-06-27	1982-01-25	Mitsui Toatsu Chem Inc	Benzothiazine derivative, its preparation and drug composition
JPS5770888A (en) *	1980-10-18	1982-05-01	Shinichi Ito	Benzothiazine derivative, its preparation and medicinal composition
US4309427A (en) *	1981-01-15	1982-01-05	Pfizer Inc.	Benzothiazine dioxide derivatives
US4434164A (en) *	1981-06-01	1984-02-28	Pfizer Inc.	Crystalline benzothiazine dioxide salts
IT1168064B (it) *	1981-11-12	1987-05-20	Prodotti Antibiotici Spa	Composto ad azione antinfiammatoria
IT8219486A0 (it) *	1982-02-05	1982-02-05	Chiesi Farma Spa	Nuovi composti ad attivita'antiinfiammatoria, procedimento per la loro preparazione e relative composizioni farmaceutiche.
JPS59193879A (ja) *	1983-03-31	1984-11-02	Fujisawa Pharmaceut Co Ltd	トロポン誘導体
US4551452A (en) *	1983-12-21	1985-11-05	Pfizer Inc.	Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
JPS60184077A (ja) *	1984-02-23	1985-09-19	フアイザー・インコーポレーテツド	抗炎症性オキシム前駆薬

1985
- 1985-05-29 US US06/738,805 patent/US4623486A/en not_active Expired - Lifetime
1986
- 1986-05-26 IL IL78912A patent/IL78912A/xx unknown
- 1986-05-27 CA CA000510033A patent/CA1270485A/fr not_active Expired - Lifetime
- 1986-05-27 AT AT86304017T patent/ATE56010T1/de not_active IP Right Cessation
- 1986-05-27 PL PL1986259740A patent/PL147843B1/pl unknown
- 1986-05-27 PT PT82649A patent/PT82649B/pt not_active IP Right Cessation
- 1986-05-27 DE DE8686304017T patent/DE3673710D1/de not_active Expired - Lifetime
- 1986-05-27 NZ NZ216310A patent/NZ216310A/xx unknown
- 1986-05-27 EP EP86304017A patent/EP0208404B1/fr not_active Expired - Lifetime
- 1986-05-27 ES ES555374A patent/ES8707211A1/es not_active Expired
- 1986-05-28 EG EG318/86A patent/EG17811A/xx active
- 1986-05-28 HU HU862250A patent/HU200178B/hu not_active IP Right Cessation
- 1986-05-28 YU YU906/86A patent/YU44576B/xx unknown
- 1986-05-28 JP JP61123215A patent/JPS61277683A/ja active Granted
- 1986-05-28 FI FI862252A patent/FI86065C/fi not_active IP Right Cessation
- 1986-05-28 DD DD86290676A patent/DD247451A5/de not_active IP Right Cessation
- 1986-05-28 SU SU864027578A patent/SU1538896A3/ru active
- 1986-05-28 PH PH33823A patent/PH23146A/en unknown
- 1986-05-28 ZA ZA863986A patent/ZA863986B/xx unknown
- 1986-05-28 KR KR1019860004181A patent/KR870000913B1/ko not_active Expired
- 1986-05-28 CN CN86103603.4A patent/CN1004628B/zh not_active Expired
- 1986-05-28 NO NO862124A patent/NO165240C/no not_active IP Right Cessation
- 1986-05-28 GR GR861389A patent/GR861389B/el unknown
- 1986-05-28 AU AU58013/86A patent/AU557396B1/en not_active Ceased
- 1986-05-28 HU HU872418A patent/HU199839B/hu unknown
- 1986-05-28 DK DK249086A patent/DK249086A/da not_active Application Discontinuation
1987
- 1987-04-24 SU SU874202427A patent/SU1531855A3/ru active

Also Published As

Publication number	Publication date
PL147843B1 (en)	1989-08-31
NZ216310A (en)	1988-10-28
IL78912A (en)	1990-07-12
YU44576B (en)	1990-10-31
SU1538896A3 (ru)	1990-01-23
ES555374A0 (es)	1987-07-16
CN1004628B (zh)	1989-06-28
EP0208404A2 (fr)	1987-01-14
ES8707211A1 (es)	1987-07-16
DK249086A (da)	1986-11-30
JPS61277683A (ja)	1986-12-08
FI862252A7 (fi)	1986-11-30
DE3673710D1 (de)	1990-10-04
EP0208404A3 (en)	1987-04-15
HU199839B (en)	1990-03-28
KR860009012A (ko)	1986-12-19
YU90686A (en)	1987-10-31
PH23146A (en)	1989-05-11
FI86065C (fi)	1992-07-10
NO165240B (no)	1990-10-08
CN86103603A (zh)	1987-01-21
DD247451A5 (de)	1987-07-08
DK249086D0 (da)	1986-05-28
PT82649A (en)	1986-06-01
CA1270485A (fr)	1990-06-19
ATE56010T1 (de)	1990-09-15
GR861389B (en)	1986-09-17
FI862252A0 (fi)	1986-05-28
PT82649B (pt)	1988-08-17
HUT43597A (en)	1987-11-30
NO862124L (no)	1986-12-01
KR870000913B1 (ko)	1987-05-06
NO165240C (no)	1991-01-16
ZA863986B (en)	1988-01-27
EP0208404B1 (fr)	1990-08-29
US4623486A (en)	1986-11-18
AU557396B1 (en)	1986-12-18
FI86065B (fi)	1992-03-31
HU200178B (en)	1990-04-28
SU1531855A3 (ru)	1989-12-23
JPH0575754B2 (fr)	1993-10-21

Publication	Publication Date	Title
AU557396B1 (en)	1986-12-18	Novel benzothiazine derivatives
FI102175B (fi)	1998-10-30	Menetelmä terapeuttisesti käyttökelpoisten piperatsiinijohdannaisten v almistamiseksi
FI901761A0 (fi)	1990-04-06	Menetelmä lääkeaineina käyttökelpoisten pyridiinijohdannaisten valmistamiseksi
FI900365A0 (fi)	1990-01-24	Menetelmä terapeuttisesti käyttökelpoisten 3-fenyyli-5,6-dihydrobents/C/akridiini-7-karboksyylihappojohdannnaisten valmistamiseksi
GB1466493A (en)	1977-03-09	1-h-tetrazole derivatives
FR2675504B1 (fr)	1995-01-27	Derives d'aryl-3 oxazolidinone, leur procede de preparation et leur application en therapeutique.
IE852852L (en)	1986-05-16	Benzothiazine dioxide salt.
ES554311A0 (es)	1987-07-01	Un procedimiento para preparar derivados de piridina
GR880100409A (en)	1990-05-11	Method for the synthesis of 1-cyclopropyl-6-fluoro-1,4 dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid as basis for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quinoline-3-carboxylic acids
NO905128L (no)	1991-05-29	Fremgangsmaate og mellomprodukter for fremstilling og anvendelse av heksahydro-1h-quino(4,3,2-ef)(1,4)benzoksazepiner samt beslektede forbindelser.